Clinical trials: Coinfection, HIV
Hepatitis C Infection With HIV Co-Infection
Safety and Efficacy of Ledipasvir/Sofosbuvir (LDV/SOF) Fixed-Dose Combination (FDC) for 6 Weeks in Adults With Acute Genotype 1 or 4 Hepatitis C Virus (HCV) and Chronic Human Immunodeficiency Virus (HIV)-1 Co-Infection
The primary objectives of this study are to determine the antiviral efficacy, safety, and tolerability of ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) in adults with acute genotype 1 or 4 hepatitis C virus (HCV)…
- Trial name
- NCT02457611
- Testing
- LDV/SOF
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 26 people
- Sponsor
- Gilead Sciences
HIV-hepatitis Co-infection, HIV Infections
Innate Immunity in HIV Positive Patients Co-infected With Hepatitis C Virus (HCV) or Hepatitis B Virus (HBV)
Data from this study will provide the first information how the innate immune system may be altered in HIV-HCV and HIV-HBV co-infected individuals, and describe Toll-like receptor changes with HIV co-infection therapy.
- Trial name
- NCT00662194
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Bayside Health
Pharmaceutical Care, HIV/AIDS
The Impact of Pharmacists' Interventions on the Quality of Life of HIV-TB Co-infection Outpatients in Indonesia
Rationale: The co-infection of human immunodeficiency virus (HIV) and tuberculosis (TB) diseases presents further problems to patient's adherence due to high pill burden and adverse effects in the drug combination therapy.
- Conditions
- Pharmaceutical Care, HIV/AIDS, Tuberculosis
- Trial name
- NCT04325438
- Testing
- Pharmaceutical Care
- Where
- 3 sites in Indonesia
- Volunteers
- 25 people
- Sponsor
- Bekasi City Public Hospital
Liver Cirrhosis, Hepatocellular Carcinoma
Natural History of Liver Cirrhosis Diagnosed by Transient Elastography in HIV/HCV-coinfected Patients
Prospective multicenter cohort recruiting consecutive patients from 7 hospitals in Andalusia, southern Spain, according to following criteria: 1) HIV infection, 2) Chronic active HCV infection, 3) Older than 18 years, 4) New…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, HIV, HCV Coinfection
- Trial name
- NCT02693847
- Where
- 8 sites in Spain
- Volunteers
- 446 people
- Sponsor
- Hospital Universitario de Valme
HIV Coinfection
A Study Of Maraviroc In HIV Co-Infected Subjects With Hepatitis C And/Or Hepatitis B
To describe liver enzyme elevations in patients who are coinfected with HIV and either Hepatitis C (HCV) and/or Hepatitis B (HBV) receiving maraviroc or placebo in combination with their current suppressive anti-HIV drug therapy.
- Trial name
- NCT01327547
- Testing
- Maraviroc
- Where
- 48 sites in United States, Czechia and 7 more
- Volunteers
- 138 people
- Sponsor
- ViiV Healthcare
HIV Infections, SARS-CoV-2 Infection
COVID-19 Serology in People Living with HIV in Hong Kong
Immunodeficiency associated with human immunodeficiency virus (HIV) infection could predispose people living with HIV/AIDS (PLHA) to defective serological responses following infection or vaccination.
- Conditions
- HIV Infections, SARS-CoV-2 Infection, Vaccination; Infection
- Trial name
- NCT05028881
- Testing
- blood sampling
- Where
- China
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Human Immunodeficiency Virus (HIV), Hepatitis C, Chronic
The Effect of HIV Tat Protein on HCV Replication in an In-vitro Model System
Investigators in the Division of Infectious Diseases and the Departments of Biochemistry and Molecular Biology of The George Washington University Medical Center are carrying out a research study to determine why patients with…
- Trial name
- NCT01206933
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- George Washington University
Hepatitis C, Human Immunodeficiency Virus
Treatment of Acute Hepatitis C Virus in HIV Co-Infection
This study is designed to test the hypothesis that treatment of hepatitis C virus (HCV) infection during the first 6 months after acquiring HCV among people who already have pre-existing HIV infection will result in improved…
- Conditions
- Hepatitis C, Human Immunodeficiency Virus, HIV Infections
- Trial name
- NCT00845676
- Testing
- Pegylated interferon alfa-2a + Ribavirin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, San Francisco
AIDS, Hepatitis B
Functional Cure of Hepatitis B in HIV/HBV Co-infected Patients
Evaluate the potential of ART combined with interferon therapy to achieve functional cure of hepatitis B in HIV/HBV co-infected patients
- Trial name
- NCT05988879
- Testing
- Peginterferon alfa-2b Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou 8th People's Hospital
HIV-1-infection, Hepatitis C, Chronic
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current…
- Conditions
- HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence, Opioid Dependence
- Trial name
- NCT03549312
- Testing
- Genvoya, Epclusa, Biktarvy
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Hepatitis C, HIV
Control and Elimination Within Australia of Hepatitis C From People Living With HIV
The purpose of this study is to evaluate the feasibility of rapid scale-up of new hepatitis C (HCV) treatments, known as interferon-free Direct Acting Antiviral (DAA) drugs, and impact on the proportion of people with HCV within…
- Conditions
- Hepatitis C, HIV, HIV-HCV Coinfection
- Trial name
- CEASE (NCT02102451)
- Where
- 18 sites in Australia
- Volunteers
- 492 people
- Sponsor
- Kirby Institute
Human Immunodeficiency Virus, Mycobacterium Tuberculosis
Characteristics and Outcomes of TB and HIV Co-infections
People Living with HIV (PLHIV) are prone to several opportunistic infections depending on the degree of immunosuppression as well as infections prevalent in their geographic area/country.
- Trial name
- NCT06531772
- Testing
- Antitubercular Agents
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hepatitis C
Evaluation Study of RDTs Detecting Antibodies Against HCV
The study aims to evaluate 13 different HCV RDTs (10 on-market, 3 under development) for their diagnostic performance and operational characteristics in archived EDTA plasma samples, originating from patients from different…
- Trial name
- NCT04033887
- Testing
- 13 Rapid Diagnostic Tests and reference tests
- Where
- 3 sites in Belgium, Georgia and 1 more
- Volunteers
- 1,710 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Tuberculosis, Human Immunodeficiency Virus
Adequacy of the New Pediatric Isoniazid/Rifampin/Pyrazinamide (HRZ) Tablet
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800381
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 92 people
- Sponsor
- University of Florida
Tuberculosis, HIV Coinfection
Closing -TB GAPs - for People Living With HIV: TB Guidance for Adaptable Patient-Centered Service
Tuberculosis (TB) is the world's leading infectious cause of mortality and responsible for 1/3 of deaths in people living with human immunodeficiency virus (PLHIV).
- Conditions
- Tuberculosis, HIV Coinfection, Tuberculosis Infection
- Trial name
- TB_GAPS (NCT05342064)
- Testing
- patient-centered TB preventive therapy, TB preventive therapy adherence support
- Where
- 5 sites in Eswatini, Lesotho and 3 more
- Volunteers
- 5,733 people
- Sponsor
- Baylor College of Medicine
HIV Infections, Malaria
Differences in Malaria Infection Levels in HIV-infected Infants and Children Receiving PI- and NNRTI-based HAART
More than 1.5 million deaths of African children under 5 years of age have been due to Plasmodium falciparum malaria. When HIV and malaria are present as coinfections, they enhance each other's progression.
- Trial name
- NCT00719602
- Testing
- Lamivudine, Lopinavir/Ritonavir, Nevirapine
- Where
- 3 sites in Malawi, Uganda and 1 more
- Volunteers
- 105 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
HIV/TB Co-infection
Efficacy and Safety of Concomitant Use of Nevirapine and Rifampicin With HIV-TB
The purpose of the study is to evaluate the efficacy and safety of Nevarapine and Rifampicin vs Efavirenz and Rifampicin in antiretroviral naive patients co-infected with HIV and TB and to investigate whether Rifampicin…
- Trial name
- "NVP" (NCT01805258)
- Testing
- Nevirapine, Efavirenz
- Where
- India
- Volunteers
- 135 people
- Sponsor
- All India Institute of Medical Sciences
HIV and Tuberculosis Co-infection
Nutritional Support for HIV-Tuberculosis Co-infected Adults in Senegal, West Africa
Food insecurity can contribute to poor adherence to both tuberculosis treatment and antiretroviral therapy (ART). Interventions that target food insecurity have the potential to improve treatment adherence and decrease mortality.
- Trial name
- NCT03711721
- Testing
- Food basket, Ready-to-Use Therapeutic Food
- Volunteers
- 26 people
- Sponsor
- University of Washington
Tuberculosis, HIV Infections
Pharmacokinetics of Emtricitabine/Tenofovir/Efavirenz in HIV-infected Patients With Tuberculosis
In this pilot study the pharmacokinetics and safety of the antiretroviral combination of co-formulated emtricitabine/tenofovir/efavirenz will be studied in HIV-positive patients with pulmonary tuberculosis (TB) who are…
- Trial name
- PETE (NCT00474435)
- Testing
- Emtricitabine/tenofovir/efavirenz
- Where
- Tanzania
- Volunteers
- 30 people
- Sponsor
- African Poverty Related Infection Oriented Research Initiative
HIV Infections, Hepatitis B
Virological and Clinical Anti-Hepatitis B Virus (HBV) Efficacy of Tenofovir and Emtricitabine in Patients With HIV/HBV co-Infection
This is a randomized multicentre trial of emtricitabine (FTC) versus tenofovir (TDF)/FTC in antiretroviral naive subjects with HIV/HBV co-infection over 48 weeks (Clinical Trial A).
- Trial name
- NCT00127959
- Testing
- tenofovir, emtricitabine, zidovudine
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- International Antiviral Therapy Evaluation Center