Clinical trials: Colchicine
Cirrhosis, Liver Cirrhosis
Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis
OBJECTIVES: I. Investigate the efficacy and safety of colchicine therapy in improving hepatic function and reducing hepatic fibrosis (scarring) in children with hepatic cirrhosis.
- Trial name
- NCT00004368
- Testing
- colchicine
- Volunteers
- 15 people
- Sponsor
- National Center for Research Resources (NCRR)
COVID - 19
EFFICACY OF COLCHICINE IN IMPROVING CLINICAL OUTCOMES IN PATIENTS WITH MILD TO MODERATE COVID-19 PNEUMONIA IN LAHORE: A RANDOMIZED CONTROL TRIAL
This study is for patients suffering from COVID-19 pneumonia (mild to moderate cases) ; especially in developing countries where expensive drugs are not available.
- Trial name
- Colchicine (NCT06847204)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Zaeema Kanwal
COVID-19
Probiotic and Colchicine in COVID-19
Probiotics and or Colchicine may be considered as an option of treatment since they have anti-viral effect anti-inflammatory and immunomodulatory effect.
- Trial name
- NCT05911022
- Testing
- Colchicine 0.5 MG, Probiotic Formula, Standard protocol
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Pharmacokinetics
Drug-Drug Interaction Study of Colchicine and Azithromycin
Azithromycin is a possible weak to moderate inhibitor of CYP3A4, one of the enzymes responsible for the metabolism of colchicine.
- Trial name
- NCT00983294
- Testing
- Colchicine, Azithromycin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Pharmacokinetics
Pharmacokinetic Study With Colchicine in Healthy Volunteers
This open label, single group, sequential dose study will compare the single dose pharmacokinetics of colchicine 0.6 mg given orally to colchicine pharmacokinetics after 10 days of a standard prophylactic dose (0.6 mg every 12…
- Trial name
- NCT01017003
- Testing
- colchicine tablets
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Chemotherapy Induced Systolic Dysfunction
Colchicine Versus Beta-blockers, Angiotensin-converting Enzyme Inhibitors, and Statins for Prevention of Chemotherapy-Induced Cardiomyopathy
BASiC-CIC Trial is a multicenter, double-blinded, randomized, placebo-controlled clinical trial to investigate whether repurposing colchicine or a combination of beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, and…
- Trial name
- BASiC-CIC (NCT06304896)
- Testing
- Carvedilol, Ramipril, Rosuvastatin
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Arab Contractors Medical Centre
Pericarditis
Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences
The purpose of the study is to determine whether colchicine is safe and effective in the treatment of acute pericarditis and the prevention of subsequent recurrences.
- Trial name
- NCT00128453
- Testing
- Colchicine (for 3 months)
- Where
- 4 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Sanitaria Locale 3, Torino
Myocardium; Injury, Myocardial Infarction
Effect of Colchicine in Patients With Myocardial Infarction
Over the past years, a substantial volume of evidence has accumulated identifying inflammatory processes as key mediators of the deleterious effects of ischemia/reperfusion-related phenomena in patients presenting with…
- Conditions
- Myocardium; Injury, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT04218786
- Testing
- Colchicine
- Where
- Pakistan
- Sponsor
- Shifa Tameer-e-Millat University
Mediterranean Fever, Colchicine Resistance
Study of Colchicine Resistance in Familial Mediterranean Fever
Five to 10% of familial mediterranean patients are considered colchicine-resistant (i.e. patients with a persistent inflammatory syndrome, despite taking the maximum tolerated dose of colchicine daily).
- Trial name
- COLCHI-RESIST (NCT05418686)
- Testing
- Capillary colchicine dosage in colchicine-resistant Familial Mediterranean Fever patients.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aortic Valve Disease, Aortic Valve Stenosis
Colchicine and Inflammation in Aortic Stenosis
Aortic stenosis (AS) is the most common valvular heart disease in the developed world. Once symptomatic, untreated patients have a poor prognosis with five-year survival rate of 25%.
- Conditions
- Aortic Valve Disease, Aortic Valve Stenosis, Aortic Valve Calcification, Inflammation
- Trial name
- CHIANTI (NCT05162742)
- Testing
- Colchicine
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Acute Myocarditis
Colchicine Versus Placebo in Acute Myocarditis Patients
Myocarditis is an inflammatory disease of the heart, mostly caused by viruses. Patients with acute myocarditis are exposed to several complications: recurrence, ventricular arrhythmias (from 5 to 30%), heart failure (5-10%)…
- Trial name
- ARGO (NCT05855746)
- Testing
- Colchicine Pill
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris