Clinical trials: Colitis, active
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Ulcerative Colitis (UC), Crohn's Disease
Stopping PPI Therapy in Inactive IBD
To investigate the feasibility of proton pump inhibitor (PPI) withdrawal in inflammatory bowel disease (IBD); the data collected will provide valuable information to inform a future multi-centre randomised controlled trial.
- Trial name
- STOP-IT (NCT07691138)
- Testing
- Continue PPI Therapy, Withdraw PPI Therapy
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Nottingham
Ulcerative Colitis, Inflammatory Bowel Diseases
Comparison of Ustekinumab, Infliximab and Combination Therapy in Moderately to Severely Active Ulcerative Colitis
The goal of this clinical trial is to learn if combined therapy with infliximab and ustekinumab works better than using these drugs alone in adult patients with ulcerative colitis.
- Trial name
- COMBO-UC (NCT06453317)
- Testing
- Infliximab, Ustekinumab
- Where
- Poland
- Volunteers
- 172 people
- Sponsor
- Medical University of Lodz
Ulcerative Colitis, Ileal Pouch
Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation
Ulcerative colitis (UC) is a disease that causes long-term inflammation in the digestive tract, and many people with this condition require surgery to remove the colon and create a new J-pouch for stool.
- Trial name
- NCT07501078
- Testing
- Aquamin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Muhammad N Aslam, MD
Fecal Incontinence
Functional Outcomes in Ulcerative Colitis Patients With Ileal Pouch Anal Anastomosis Treated With High Intensity Focused Electromagnetic Stimulation
The purpose of this research is to evaluate functional outcomes in patients with Ulcerative Colitis and IBDU who have received an ileal pouch anal anastomosis (IPAA), commonly referred to as a J pouch, after treatment with the…
- Trial name
- NCT07034443
- Testing
- High Intensity Focused Electromagnetic Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Ulcerative Colitis (UC), Crohn Disease (CD)
Impact of Exclusion Diet in Addition to Anti-TNF Therapy in Crohn's Disease and Ulcerative Colitis: a Prospective, Randomized, Double-arm, Open-label Study
This clinical study protocol aims to prospectively compare the efficacy of standard therapy with anti-TNF agents combined with the Crohn's Disease Exclusion Diet (CDED) versus anti-TNF therapy alone in adult patients with active…
- Trial name
- IDEA-TNF (NCT06896305)
- Testing
- CDED (Crohn's Disease Exclusion Diet) in addition to anti-TNF therapy, Anti-TNF Therapy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Ospedale San Raffaele
Irritable Bowel Syndrome, Inflammatory Bowel Diseases
A Personalized Approach to Abdominal Pain in Irritable Bowel Syndrome
Apart from its use to provide insight in IBS disease courses and in clinical research, ESM can provide patients with feedback about individual triggers of their symptoms, and thereby function as part of a personalized therapeutic…
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PERCEPTIvE (NCT05998577)
- Testing
- ESM and Traqq
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Immune Checkpoint Inhibitor-Related Colitis
Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial
The goal of this clinical trial is to compare the effectiveness and safety of Vedolizumab with a short course of steroids compared to standard course of steroids for the treatment of immune checkpoint inhibitor colitis (ICI…
- Trial name
- EVITA (NCT06841705)
- Testing
- Vedolizumab 300 MG Injection [Entyvio], Prednisone (and methylprednisolone), Prednisone Taper
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Shilpa Grover, MD, MPH
Ulcerative Colitis (UC), Crohn's Disease
Efficacy and Safety of Discontinuing 5-ASA in Patients With Inflammatory Bowel Disease
This study aims to evaluate the long-term outcomes of discontinuing 5-ASA in UC and CD patients receiving stable biologic or immunomodulator therapy using a prospective cohort based in the Busan-Ulsan-Gyeongnam region.
- Conditions
- Ulcerative Colitis (UC), Crohn's Disease, Inflammatory Bowel Disease (IBD)
- Trial name
- NCT06878495
- Testing
- Discontinuation of 5-ASA
- Volunteers
- 100 people
- Sponsor
- Pusan National University Hospital
Ulcerative Colitis
ABTECT - Maintenance
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active…
- Trial name
- NCT05535946
- Testing
- ABX464
- Where
- 413 sites in United States, Argentina and 32 more
- Volunteers
- 1,116 people
- Sponsor
- Abivax S.A.
Inflammatory Bowel Diseases, Clostridioides Difficile Infection
Xylitol Use for Decolonization of C. Difficile in Patients With IBD
This is a randomized, placebo-controlled, dose-ranging study to assess the safety and efficacy of xylitol as an oral therapeutic for decolonization of C. difficile in IBD patients.
- Trial name
- NCT05852587
- Testing
- Xylitol
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Brigham and Women's Hospital
Colitis, Ulcerative, Sleep Quality
Clinical Characteristics of Sleep Disorders in Patients With Ulcerative Colitis
Ulcerative colitis(UC) is one of the two main forms of inflammatory bowel disease(IBD), which seriously affects the quality of life of patients.
- Conditions
- Colitis, Ulcerative, Sleep Quality, Gastrointestinal Microbiome, Autonomic Nervous System Imbalance
- Trial name
- NCT06359808
- Where
- China
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Colitis, Ulcerative
A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis
The purpose of this real world non-interventional study is to learn about the effects of etrasimod as treatment for patients with moderate to severe ulcerative colitis.
- Trial name
- EFFECT-UC (NCT06294925)
- Testing
- Etrasimod
- Where
- 41 sites in Canada, Germany and 1 more
- Volunteers
- 360 people
- Sponsor
- Pfizer
Inflammatory Bowel Disease, Colitis, Ulcerative
A Study to Assess Real-world Outcomes for Long-Term Use of Guselkumab
The purpose of this study is to evaluate how long guselkumab remains in participants with moderate to severe crohn's disease (CD) or ulcerative colitis (UC) in real-world setting.
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn Disease
- Trial name
- LUNAR (NCT07532213)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Janssen-Cilag A.G., Switzerland
Crohn Disease, Ulcerative Colitis
Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Ulcerative Colitis and Crohn Disease
The goal of the study is to evaluate the safety and efficacy of multimodal (cytokine and lipopolysaccharide) hemoperfusion using the Efferon® LPS device in patients with ulcerative colitis and Crohn disease.
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT07383597
- Testing
- Efferon LPS
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Efferon JSC
Eosinophilic Gastrointestinal Disorders (EGIDs), Eosinophilic Esophagitis
OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing.
- Conditions
- Eosinophilic Gastrointestinal Disorders (EGIDs), Eosinophilic Esophagitis, Eosinophilic Gastritis, Eosinophilic Gastroenteritis
- Trial name
- OMEGA (NCT02523118)
- Where
- 19 sites in United States
- Volunteers
- 1,350 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Ulcerative Colitis
Prognostic Value of Confocal Endomicroscopy in Ulcerative Colitis: the CONF-UC Study
This study employs a prospective, single-center, interventional design to investigate the prognostic value of confocal endomicroscopy in assessing treatment response in ulcerative colitis (UC) patients receiving small molecules .
- Trial name
- CONF-UC (NCT06624579)
- Testing
- confocal endomicroscopy
- Volunteers
- 26 people
- Sponsor
- FEDERICA FURFARO
Colitis, Ulcerative, Crohn Disease
A Study to Assess Guselkumab in Participants With Moderate-to-Severe Inflammatory Bowel Disease in Real Life Italian Setting
The purpose of this study is to characterize participants with Crohn's Disease (CD) and Ulcerative Colitis (UC) receiving guselkumab in a real-world setting, and to evaluate treatment persistence (continuation) and clinical…
- Conditions
- Colitis, Ulcerative, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- GLAMOUR (NCT07851207)
- Volunteers
- 200 people
- Sponsor
- Janssen-Cilag Ltd.
Inflammatory Bowel Diseases, Ulcerative Colitis
IBD Strong Peer2Peer for Self-Management of Psychological Distress
Psychological distress (PD) as a result of inflammatory bowel disease (IBD) is prevalent and associated with worse disease-related outcomes.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT05722236
- Testing
- IBD Strong Peer2Peer, Waitlist control
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Jennifer Jones
Exclusive Enteral Nutrition, Ulcerative Colitis
Combined Application of EEN in the Induction of Remission in PUC
The role of exclusive enteral nutrition (EEN) in the induction of remission in pediatric patients with Crohn's disease had been well documented. But the role of EEN in children with Ulcerative Colitis (UC) was not clear.
- Conditions
- Exclusive Enteral Nutrition, Ulcerative Colitis, Children
- Trial name
- NCT04999241
- Testing
- exclusive enteral nutrition, regular food
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Fudan University