Clinical trials: Collagen Diseases
Brain Injury
Injectable Collagen Scaffold™ Combined With MSCs Transplantation for Brain Injury
The purpose of this study is to assess the safety and efficacy of injectable collagen scaffold combined with Mesenchymal stem cells (MSCs) transplantation in patients with brain injury.
- Trial name
- NCT02767817
- Testing
- Stereotactic Hematoma Evacuation, MSCs Transplantation, Injectable Collagen Scaffold with MSCs Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese Academy of Sciences
Rheumatoid Arthritis
Phase 1 Trial of Type II Collagen (CII) APL A12 in Rheumatoid Arthritis Patients
This is a Phase I clinical trial to determine whether orally administered APL A12 at one or more doses is superior to placebo in effecting a 25% reduction in interferon (IFN) stimulation index in 1(II)-stimulated culture of…
- Trial name
- NCT01123655
- Testing
- APLA12
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Office of Research and Development
Keloid
Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars
This trial will assess the safety and efficacy of 50 and 200ng Juvista per linear cm of wound margin administered by intradermal injection following the excision of keloid scars on the ear lobe.
- Trial name
- NCT00469235
- Testing
- Avotermin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Renovo
Scleroderma, Scleroderma, Systemic
Effectiveness of Telerehabilitation on Scleroderma
The effects of exercises performed by telerehabilitation on individuals with hand-affected scleroderma on range of motion, grip strength, function, sensation, daily life activities and general health will be compared with the…
- Conditions
- Scleroderma, Scleroderma, Systemic, Scleroderma Associated Digital Ulcer, Hand Rheumatism
- Trial name
- NCT04563481
- Testing
- Hand Therapy via Telerehabilitation, Hand Therapy by Physiotherapist
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University
Keratoconus
Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus
Transepithelial CXL (performed without epithelial removal) seem to have similar clinical effect on keratoconic eyes compared to the standard CXL (which includes epithelial removal).
- Trial name
- NCT01181219
- Testing
- CXL without epithelial removal, CXL with epithelial removal
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University Hospital of North Norway
Steroid Induced Glaucoma
Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Provisc in Steroid Induced Glaucoma
The purpose of this prospective randomized study is to assess and compare the clinical efficacy and safety of primary trabeculectomy with Ologen® collagen implant and cohesive viscoelastic (Provisc®) - augmented trabeculectomy in…
- Trial name
- NCT01912638
- Testing
- Ologen Collagen Matrix, Provisc
- Where
- Azerbaijan
- Volunteers
- 17 people
- Sponsor
- National Centre of Ophthalmology named after academician Zarifa Aliyeva
Pulmonary Arterial Hypertension
The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study
The purpose of this study is to find out if spironolactone added to ambrisentan for Pulmonary Arterial Hypertension (PAH) will increase exercise capacity.
- Trial name
- NCT02253394
- Testing
- Ambrisentan plus Spironolactone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data.
- Conditions
- Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated, Cardiomyopathy Restrictive, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- RENOMICA-Hcor (NCT06546137)
- Testing
- whole genome sequencing
- Where
- 27 sites in Brazil
- Volunteers
- 1,211 people
- Sponsor
- Hospital do Coracao
Myopia, Corneal Crosslinking
Advanced Cross Linking for Low-grade Myopia
To evaluate the improvement in myopic refractive error and the corneal endothelial safety with a corneal crosslinking treatment regimen for mild myopia.
- Trial name
- PiXLO2 (NCT03197272)
- Testing
- PiXL
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Umeå University
Peri-Implantitis, Surgery
Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen Membrane
The objective of the present randomized clinical trial will be to compare two surgical methods of treating peri-implantitis. This study will determine if surgical debridement of peri-implantitis bone defects, including air powder…
- Trial name
- NCT05699343
- Testing
- InterOss Collagen (Bone xenograft) and InterOss Collagen Guide (Collagen membrane), InterOss Collagen (Bone xenograft)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Andrea Ravida
Knee Osteoarthritis, Gonarthrosis
Collagen-PVP vs Hylan G-F 20 in the Treatment of Knee Osteoarthritis
Articular cartilage degradation is the main characteristic of osteoarthritis (OA), involving enzymatic and inflammatory mechanisms that change it into a chronic disease.
- Trial name
- NCT04019782
- Testing
- Collagen-PVP, Hylan G-F 20
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Scar Keloid, Hypertrophic Scar
Botulinum Toxins Intralesional Injection for Scar Pain
Botulinum toxins has been approved by the FDA to treat chronic migraine. Botox had been shown to inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerve to treat neuropathic pain.
- Trial name
- NCT03982862
- Testing
- Triamcinolone, Lidocaine, Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Kaohsiung Medical University
Gingival Recession
A Comparision of Collagen Matrix and Connective Tissue Graft With Modified Coronally Advanced Tunnel for Root Coverage
Recently porcine derived bioresorbable collagen matrices have shown predictable outcomes for augmenting keratinzed gingiva , improved wound healing, recession coverage in localized gingival recessions and multiple recession…
- Trial name
- NCT02876562
- Testing
- root coverage with collagen matrix
- Where
- India
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Axial Spondyloarthritis (axSPA)
Effects of Yoga Therapy in Rehabilitation Compared to Physiotherapy in Moderate Axial Spondyloarthritis (axSPA)
A few studies have evaluated the effectiveness of yoga therapy in patients with axial spondyloarthritis (axSPA). On the other hand, studies conducted in other chronic rheumatisms such as low back pain, rheumatoid arthritis or…
- Trial name
- YOKISPA (NCT06083090)
- Testing
- Yogatherapy, Physiotherapy
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Missing Teeth
Enhancing Soft Tissues Around Inserted Implants by Two Different Methods
This randomized controlled clinical trial investigates the efficacy of xenogeneic collagen matrix (XCM) versus autogenous subepithelial connective tissue graft (SCTG) in enhancing the peri-implant soft tissue profile around…
- Trial name
- NCT06837688
- Testing
- Peri-implant soft tissue augmentation using connective tissue graft, Peri-implant soft tissue augmentation using xenogenic collagen matrix
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Damascus University
Back Pain, Low Back Pain
Neck and Low Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica
The purpose of this study is to identify the prevalence of neck and low back pain in medical students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and…
- Conditions
- Back Pain, Low Back Pain, Neck Pain, Neck Pain Musculoskeletal
- Trial name
- NCT03707288
- Testing
- Clinical Control Group (Group A), Spine Exercise Program (Group B)
- Where
- 2 sites in Jamaica
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Keloid Scar
Proof of Concept (POC) Study of the Soliton's Acoustic Scar Reduction (ASR) Treatment for the Treatment of Keloid Scar
To evaluate the safety, and efficacy of the ASR device for the temporary improvement in the appearance of a keloids.
- Trial name
- ASR (NCT04016610)
- Testing
- Soliton's Acoustic Scar Reduction (SAR)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Soliton
Glaucomas, Pterygium
Ologen(Oculusgen)-Glaucoma and Pterygium Historical Control Study in China Shanghai Sixth People's Hospital
The purpose of this study is to determine whether the ologen (OculusGen) Collagen Matrix are effective and safe to implant as an aid of glaucoma surgery and pterygium excision surgery.
- Trial name
- NCT00478790
- Testing
- ologen™ Collagen matrix implantation in glaucoma filtering surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Pro Top & Mediking Company Limited
Keloids, Hypertrophic Scars
Effect of Pulse Width on Scar Treatment Using a 595-nm Pulsed Dye Laser
To investigate the effect of pulse width on the treatment response of keloidal and hypertrophic sternotomy scars to a 595-nm pulsed dye laser
- Trial name
- NCT00142441
- Testing
- Pulsed dye laser
- Where
- Thailand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Gingival Recession, Inadequately Attached Gingiva
Efficacy of Collagen Sponge on Palatal Wound Healing
The aim of this study is to compare the efficacy of collagen sponge and gelatin sponge on the palatal wound healing and postoperative pain following gingival graft harvesting.
- Trial name
- NCT05287763
- Testing
- Palatal soft tissue graft harvesting
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
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