Clinical trials: Collagen Diseases
Hyperopia, Hyperopic Astigmatism
Safety and Efficacy of Corneal Collagen Cross-linking Following LASIK for Treatment of Hyperopia and Hyperopic Astigmatism
The objectives of this study are to evaluate the safety and efficacy, with regards to regression of refractive outcome, as measured by manifest refraction spherical equivalent (MRSE), of two treatment regimens for hyperopic and…
- Trial name
- NCT01893359
- Testing
- riboflavin ophthalmic solution, 0% dextran, UVA Irradiation (30 mW/cm2 for 2 minutes continuous UVA), UVA Irradiation (30 mW/cm2 for 3 minutes pulsed UVA with an on/off cycle of 2 seconds UVA on/1 second UVA off)
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Glaukos Corporation
Gingival Recession
Treatment of Multiple Gingival Recession Defects Using a New Xenogenic Collagen Membrane Compared to Connective Tissue Graft: a Randomized Controlled Split-mouth Clinical Study
Limitation of donor site and significant postoperative morbidity are often described in connective tissue graft. We want to show if mucogain matrix used in tunnel technique to recover RTI Cairo recessions defects could be an…
- Trial name
- Mucogreffe (NCT04800250)
- Testing
- Treatment of gingival recessions
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Keratoconus
Simultaneous TransPRK and Corneal Collagen Cross-Linking
Young patients with keratoconus face two problems: disease progression and corneal shape irregularity leading to poor vision even in spectacles.
- Trial name
- TransPRKCXL (NCT02208089)
- Testing
- Transepithelial Photorefractive Keratectomy (TransPRK), Corneal Collagen Cross-Linking (CXL)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Bruce Allan
Hair Care, Hair Loss
Olistic_2025 for Hair Loss, Hair Growth, and Skin Improvement
The goal of this randomized, double-blind, placebo-controlled clinical trial is to find out whether daily oral intake of the nutraceutical Olistic Next Women can reduce hair loss, improve hair growth and quality, and improve…
- Conditions
- Hair Care, Hair Loss, Female Pattern Hair Loss
- Trial name
- NCT07300813
- Testing
- Olistic Next Women
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Osteogenesis Imperfecta
The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta
Osteogenesis imperfecta (OI) is an inherited disease of the connective tissue. Symptoms are fractures, growth retardation, blue sclera, bad teeth, impaired hearing a.o.
- Trial name
- NCT01679080
- Testing
- Zoledronic acid, Teriparatide, No active treatment
- Where
- 3 sites in Denmark
- Volunteers
- 9 people
- Sponsor
- University of Aarhus
Furcation Defects
Bovine Pericardium Membrane Versus Native Collagen Membrane in Conjunction With Sticky Bone Graft in Treatment of Class II Furcation Defects in Lower Molars.
Materials and methods: Twenty five patients (n=25) were selected from the outpatient clinic of the department of oral medicine and periodontology at Mansoura university's faculty of dentistry, 5 patients (n=5) were excluded as…
- Trial name
- NCT06681532
- Testing
- Native collagen membrane and bovine bone graft in treatment of class II furcation defects in lower molars, Bovine pericardium membrane and bovine bone graft in treatment of class II furcation defects in lower molars
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ibrahim Ahmed Zein Elabdin Ahmed
Gingival Diseases
Xenogeneic Collagen Matrix as an Alternative to Free Gingival Grafting for Oral Soft Tissue Augmentation
A split-mouth study comparing soft tissue augmentation results using free gingival graft (FGG) versus xenogeneic collagen matrix (CM) for the generation of keratinized tissue (KT) around teeth with insufficient (< 2mm) KT.
- Trial name
- NCT01952301
- Testing
- Xenogeneic Collagen Matrix, Free Gingival Graft
- Volunteers
- 30 people
- Sponsor
- Perio Health Professionals, PLLC
Hypertension, Diabetes Mellitus
Effect of Recombinant Human Bone Morphogenetic Protein-2 With an Absorbable Collagen Sponge on Stability of Dental Implant: (Split Mouth Randomized Clinical Trial Study.
Effect of Recombinant Human Bone Morphogenetic Protein-2 with an Absorbable Collagen Sponge on Stability of Dental Implant: (Split Mouth Randomized Clinical Trial Study.
- Conditions
- Hypertension, Diabetes Mellitus, Blood Disease
- Trial name
- rhBMP-2 (NCT05719181)
- Testing
- rhBMP-2
- Where
- Iraq
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Keratoconus
Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus
This study compares the outcomes of the Vedera KXS procedure (a microwave-based procedure, also known as Keraflex) combined with corneal collagen crosslinking to corneal collagen crosslinking alone for the treatment of…
- Trial name
- NCT01672814
- Testing
- riboflavin ophthalmic solution, Vedera KXS Microwave System
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Osteoarthritis (OA) of the Knee
Collagen-PVP vs Hylan G-F 20 in the Treatment of Knee Osteoarthritis
Abstract Title: "Efficacy of intra-articular polyvinylpyrrilidone collagen in the treatment of Kellgren-Lawrence grade II-III primary knee osteoarthritis compared to Hilano G-F 20: a controlled clinical trial." Investigators…
- Trial name
- 26092023 (NCT07692009)
- Testing
- Collagen-polyvinylpyrrolidone, Hylan G-F 20
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan S.
Physical Activity, Adolescent
Development of The Pediatric Physical Activity Tracking Platform (Pedi@Ctivity) and Smartwatch-based Big Data Analysis
Regular physical activity is extremely important for the protection and development of physical and psychosocial health. In addition, acquiring regular physical activity habits in the early years of life allows maintaining…
- Conditions
- Physical Activity, Adolescent, Childhood Rheumatic Disease
- Trial name
- NCT05509907
- Testing
- Pedi@ctivity Analysis and Tracking Mobile Applications and Web Platform
- Where
- Turkey (Türkiye)
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Keloid, Cicatrix
Photobiomodulation and the Intralesional Administration of Corticoid in the Keloid Surgery.
A randomized, controlled, double-blind, clinical trial will be conducted to study the evaluate the effect of blue light combined with corticoid treatment in the preoperative and postoperative period of keloid removal surgery.
- Trial name
- NCT04824612
- Testing
- Photobiomodulation with blue led, Triamcinolone Hexacetonide
- Where
- Brazil
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Keloid
Web Based Investigation of Natural History of Keloid Disorder, an Online Survey
This trial intends to gather very basic clinical information about keloid, its patterns of presentation, family history, ethnic background and correlation with the type of keloid, as well as prior treatment results that patients…
- Trial name
- NCT01423981
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Tirgan, Michael H., M.D.
Gingival Recession, Plastic Surgery
Non-Inferiority of Fibroguide Collagen Membrane Compared to Autologous Connective Tissue Graft for Coverage of Multiple Adjacent Recession. Multicenter Trial.
This study deals with coverage of multiple denuded roots. The current standard treatment requires surgical correction and uses soft tissue taken from the roof of the mouth to enhance results.
- Trial name
- NCT07083050
- Testing
- Volume stable collagen matrix, Autologous Connective Tissue Graft from the Hard Palate
- Where
- 2 sites in Italy, Spain
- Volunteers
- 160 people
- Sponsor
- Maurizio Tonetti
Breast Tumors, Wound Healing
HealiAid Collagen Wound Dressing in Patients Undergoing Breast Tumor Surgery
The goal of this clinical trial is to evaluate the safety of the collagen wound dressing (HealiAid) in breast tumor patients with surgical treatment. The main questions it aims to answer are: 1.
- Conditions
- Breast Tumors, Wound Healing, Collagen Wound Dressing
- Trial name
- NCT07209020
- Testing
- HealiAid Collagen Wound Dressing
- Where
- 3 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Maxigen Biotech Inc.
Corneal Ulcer
ACRO Biocornea Clinical Trial in Taiwan
The goal of this clinical trial is to investigate the safety and clinical performance of ABCcolla Collagen Ophthalmic Matrix used for anterior lamellar keratoplasty in patients suffering from corneal ulcer.
- Trial name
- NCT04054817
- Testing
- Lamellar keratoplasty-ABCcolla® Collagen Ophthalmic Matrix
- Where
- 3 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- ACRO Biomedical Co. Ltd
Epidermolysis Bullosa, Epidermolysis Bullosa Acquisita
Targeting Collagen VII Antibodies With IV IgG in Dystrophic Epidermolysis Bullosa
The study objective is to see if IV IgG treatment in Recessive Dystrophic Epidermolysis Bullosa (RDEB) skin in conjunction with VYJUVEK treatment improves wound healing and affects the levels of C7 and HSV-1 antibody levels in…
- Conditions
- Epidermolysis Bullosa, Epidermolysis Bullosa Acquisita, Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
- Trial name
- IV IgG (NCT06834035)
- Testing
- Immunoglobulin G
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M. Peter Marinkovich
Keratoconus, Post LASIK Keratectasia
Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus
The objectives of this study are to evaluate the safety of and efficacy of the KXL system with vibeX Rapid (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in eyes having: 1. Keratoconus (KC) , 2.
- Trial name
- NCT02638376
- Testing
- 0.1% Riboflavin ophthalmic solution (KXL System With vibeX Rapid), simultaneous KXL and topography-guided transepithelial photorefractive keratectomy(PRK)
- Where
- Singapore
- Volunteers
- 66 people
- Sponsor
- Singapore Eye Research Institute
Autoimmune Rheumatologic Disease, Immune Deficiency
Pilot Study of a New Device (Buzzy®) for Procedural Pain Relief During Needle-Related Procedures in Paediatric Patients
Needle-related procedures are the most important source of pain and anxiety in pediatric patients. Consequently, needle-phobia and anxiety are common in children with auto-immune disease and immune deficiency and may be barriers…
- Conditions
- Autoimmune Rheumatologic Disease, Immune Deficiency, Pain Due to Certain Specified Procedures, Child/Adolescent Problems
- Trial name
- NCT02771600
- Testing
- Buzzy, Topical anaesthetic cream
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Justine's Hospital
Dupuytren Contracture, Collagen Shrinkage
Registry of Patient With M. Dupuytren and Validation of the Brief MHQ
The purpose of this study is the validation of the Brief Michigan Hand Questionnaire by patient with Morbus Dupuytren and to build up a register.
- Conditions
- Dupuytren Contracture, Collagen Shrinkage, CRF
- Trial name
- NCT01876498
- Testing
- Xiaflex surgery
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Schulthess Klinik
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