Clinical trials: Collagen Diseases
Inflammatory Rheumatism
HIIT for Inflammatory Rheumatic Disease: Man vs Machine
The purpose of this study is to compare two modes of delivering high-intensity interval training (HIIT) in a population with inflammatory rheumatic disease over 10 weeks.
- Trial name
- NCT04649528
- Testing
- Effective endurance 4x4 training - Supervised, Effective endurance 4x4 training - APP
- Where
- Norway
- Volunteers
- 49 people
- Sponsor
- Molde University College
Gingival Recession
Coronally Advanced Flap With or Without Porcine Collagen Matrix for Root Coverage
The purpose of this study is to compare the clinical outcomes after coronally advanced flap technique (CAF) associated or not to a porcine collagen matrix graft (CM) in the treatment of single gingival recessions.
- Trial name
- NCT02242500
- Testing
- Coronally Advanced Flap, Mucograft
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Enilson Antonio Sallum
Metabolic Syndrome
Effects of Arom Digest Slim on Metabolic Profile and Food Behaviour in Overweight Persons
The present study aims to evaluate the efficacy of Arom Digest Slim in facilitating weight reduction along with a series of minimal nutritional interventions.
- Trial name
- NCT03533881
- Testing
- Arom Digest Slim, Nutritional changes
- Where
- Romania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SC Aromaarmony SRL
Missing Teeth
Assessment of Hard and Soft Tissue Changes Following XCM Versus FGG Simultaneous With Delayed Dental Implant Placement
Teeth loss are usually associated with alterations of extraction sockets result in obviously absorbed alveolar ridges and are often accompanied with soft tissue atrophy such as narrow keratinized tissue and a shallow vestibule.
- Trial name
- NCT07080177
- Testing
- Free gingival graft simultaneous with delayed implant placement, Xenogeneic collagen matrix simultaneous with delayed implant placement
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Allergy Skin, Allergy
NeoMatriX Wound Matrix Collagen Dressing Skin Prick Test
The objective of this study is to investigate the potential of NeoMatriXTM Wound Matrix to cause an allergic response to healthy volunteers using a skin prick test.
- Conditions
- Allergy Skin, Allergy, Dermatitis, Allergic Contact
- Trial name
- NCT03522675
- Testing
- NeoMatriX Wound MatriX Collagen Dressing
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- NeXtGen Biologics, Inc.
Systemic Autoimmune Disease, Chronic Inflammatory Rheumatism
Study of Leukocyte Populations in Patients With Chronic Inflammatory
Exploration of pathophysiological mechanisms in chronic inflammatory rheumatism and rare systemic autoimmune diseases with the objective of identifying therapeutic targets.
- Conditions
- Systemic Autoimmune Disease, Chronic Inflammatory Rheumatism, Sjogren's Syndrome, Spondyloarthritis
- Trial name
- LIMA (NCT04749875)
- Testing
- blood sample
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Degenerative Changes, Stenosis
OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra's OsteoStrux Collagen Ceramic Scaffold combined with bone marrow aspirate as an adjunct for instrumented posterolateral spine fusion, as compared…
- Conditions
- Degenerative Changes, Stenosis, Spondylosis
- Trial name
- NCT01873586
- Testing
- Posterolateral Fusion
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- SeaSpine, Inc.
Tattoo, Acne Keloidalis Nuchae
7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream
The purpose of this study is to compare the efficacy of 7% lidocaine / 7% tetracaine cream and 2,5% lidocaine / 2,5% prilocaine cream in reducing self-reported pain during a single laser procedure in the treatment of acne…
- Trial name
- OPTICA (NCT02372786)
- Testing
- 2,5% lidocaine / 2,5% prilocaine cream, 7% lidocaine / 7% tetracaine cream, Neodymium-doped yttrium aluminium garnet (Nd:Yag) laser
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Keloids, Hypertrophic Scars
Effect of Pulse Width on Scar Treatment Using a 595-nm Pulsed Dye Laser
To investigate the effect of pulse width on the treatment response of keloidal and hypertrophic sternotomy scars to a 595-nm pulsed dye laser
- Trial name
- NCT00142441
- Testing
- Pulsed dye laser
- Where
- Thailand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Multiple Osteochondroma, Ollier Disease
Ready to Sail: Evaluating Sailing's Feasibility as Ergotherapy
Background Individuals with rare skeletal disorders frequently experience psychological distress, social isolation, unmet needs, and significant challenges due to limited treatment options.
- Conditions
- Multiple Osteochondroma, Ollier Disease, Osteogenesis Imperfecta
- Trial name
- PaS (NCT06397443)
- Testing
- 5-day sailing activity
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Istituto Ortopedico Rizzoli
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Adolescent Idiopathic Scoliosis, Osteogenesis Imperfecta
Experimental Evaluation of Back Braces for the Treatment of Spinal Deformity Produced With 3D Printing Technology
The proposed investigation is a pilot study that involves pediatric patients affected by spinal deformity (Adolescent Idiopathic Scoliosis and Osteogenesis Imperfecta).
- Trial name
- NCT04282408
- Testing
- Scoliosis back brace
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- IRCCS Eugenio Medea
Hypersensitivity
Open-Label Study to Evaluate the Immunogenicity of Bovine Collagen in ArteFill® by Skin Testing
The purpose of this study is to assess the clinical utility of the ArteFill® pre-treatment Skin Test in predicting and preventing hypersensitivity reactions to treatment with ArteFill® implant
- Trial name
- NCT00778089
- Testing
- ArteFill® Skin Test
- Where
- United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Suneva Medical, Inc.
Gingival Diseases, Traumatic Injury
Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.
This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF…
- Trial name
- NCT05389059
- Testing
- CAF+CM, I-PRF
- Where
- Iraq
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Systemic Lupus, Rheumatoid Arthritis
Yellow Fever Vaccine in Patients With Rheumatic Diseases
According to World Health Organization (WHO), since December 2016, Brazil is showing a significant increase in cases of yellow fever in humans.
- Conditions
- Systemic Lupus, Rheumatoid Arthritis, Spondyloarthritis, Inflammatory Myopathy
- Trial name
- NCT03430388
- Testing
- Yellow Fever vaccine (17D)
- Where
- Brazil
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Alport Syndrome
A Study of RG-012 in Subjects With Alport Syndrome
This is a Phase 1, open-label, multi-center study of the safety, pharmacodynamics, and pharmacokinetics of RG-012 administered to subjects with Alport syndrome.
- Trial name
- NCT03373786
- Testing
- RG012
- Where
- 7 sites in United States
- Volunteers
- 4 people
- Sponsor
- Genzyme, a Sanofi Company
Keloid
Analyse of Diagnosis Value of Keloid on 68Ga- FAPI-04 PET-CT
Keloid scars are common benign fibroproliferative reticular dermal lesions. Fibroblasts are considered to be the key cellular mediators of fibrogenesis in keloid scars.
- Trial name
- NCT05275699
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Peking Union Medical College Hospital
Epidermolysis Bullosa Dystrophica
Recessive Dystrophic Epidermolysis Bullosa Screening for Possible Gene Transfer
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a severe inherited blistering skin disease caused by absence of type VII collagen.
- Trial name
- NCT00533572
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Keloid
Compressive Device to Prevent Keloïd Scars Recurrence [SCARWARS]
SCARWARS study deals with the first on-human evaluation of a compressive device dedicated to the prevention of keloïd scars recurrence after surgery. The tested device is made with clinical grade silicon.
- Trial name
- SCARWARS (NCT03312166)
- Testing
- Compression device
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Tooth Socket, Dental Implants
Impact of Soft Tissue Grafts on Tissue Alterations After Immediate Tooth Replacement
This study evaluates the impact of soft tissue grafts on soft tissue recession following immediate implant, provisional and bone graft placement in compromised sockets.
- Trial name
- NCT02922075
- Testing
- Connective tissue graft, Collagen matrix graft, Immediate implant
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- São Paulo State University
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