Clinical trials: Collagen Diseases
Keratoconus
MyoRing Implantation With Corneal Collagen Crosslinking for Keratoconus
A complete intrastromal ring, MyoRing (Dioptex, GmbH, Linz, Austria), suggested by Albert Daxer in 2007, is a relatively new technique that has been demonstrated to treat keratoconus safely and effectively.Corneal collagen…
- Trial name
- NCT02590549
- Testing
- Corneal Collagen Crosslinking, Ufalink
- Volunteers
- 16 people
- Sponsor
- Ufa Eye Research Institute
Osteogenesis Imperfecta
Osteogenesis Imperfecta Blood Pressure Study
Osteogenesis Imperfecta (OI) is a genetic disorder caused by mutations to the alpha-1 or alpha-2 chain of type I collagen. Clinically, the disorder is characterized by bones that fracture easily, often from little or no apparent…
- Trial name
- NCT04169568
- Testing
- Manual cuff blood pressure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Alport Syndrome
A Study to Learn About How Well BAY 3401016 Works in Adults With Alport Syndrome
Alport syndrome (AS) is a rare genetic condition that causes kidney disease, hearing loss, and eye abnormalities that occur due to changes in specific genes (COL4A3, COL4A4, and COL4A5).
- Trial name
- ASSESS (NCT07211685)
- Testing
- BAY 3401016
- Where
- 51 sites in United States, Argentina and 13 more
- Volunteers
- 60 people
- Sponsor
- Bayer
Dystrophic Epidermolysis Bullosa
A Pilot Study of HP802-247 in Dystrophic Epidermolysis Bullosa
This is a pilot study designed to see if HP802-247, an investigational treatment with living human skin cells, helps to heal blisters or wounds in subjects with Dystrophic Epidermolysis Bullosa (DEB).
- Trial name
- NCT01528306
- Testing
- HP802-247
- Sponsor
- Healthpoint
Pressure Ulcers, Venous Ulcers
Prospective PuraPly™ AM Case Series Study
The PuraPly AM case series is a prospective, observational study for patients who have received PuraPly AM which consists of a collagen sheet coated with polyhexamethylene biguanide hydrochloride (PHMB) and is intended for the…
- Conditions
- Pressure Ulcers, Venous Ulcers, Diabetic Ulcers, Surgical Wounds
- Trial name
- NCT03070925
- Testing
- PuraPly™ Antimicrobial Wound Matrix
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Organogenesis
Allergic Reaction
Allergy Potential of Omeza Collagen Matrix in Human Subjects Using the Skin Prick Method
Single-center, monadic, one day study utilizing the skin prick method to assess the allergy potential of Omeza Collagen Matrix in Human Subjects
- Trial name
- NCT04510376
- Testing
- Test Article, Positive Control, Negative Control
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Dystrophic Epidermolysis Bullosa, Wound Heal
Effect of Ev.FV on Wound Healing in Dystrophic Epidermolysis Bullosa
Epidermolysis bullosa (EB) is a hereditary disease of skin tissues that causes painful bleeding blisters in the skin and mucous membrane. The prevalence of this disease is 1 in 50,000.
- Trial name
- NCT07230223
- Testing
- Ev.FV 1.0 x 1011 par/ml
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Isfahan University of Medical Sciences
Exotropia or Intermittent Exotropia
Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery
This study is to investigate protective effect of biodegradable collagen implant in scleral showing after lateral rectus recession in patients with exotropia.
- Trial name
- NCT02699580
- Testing
- lateral rectus recession with biodegradable collagen implant, Lateral rectus recession without biodegradable collagen implantation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Pressure Ulcers
Increasing Fluids in Older Adults to Prevent & Treat Pressure Ulcers
The purpose of this study is to determine whether providing extra fluid to nursing home residents will help prevent or heal pressure ulcers.
- Trial name
- NCT00507650
- Testing
- Fluid intervention, Fluid intervention plus 10 ml/kg/day
- Volunteers
- 63 people
- Sponsor
- University of California, San Francisco
Anal Fistula, Complex Perianal Fistula
Evaluating an rhPDGF-BB-enhanced Collagen Plug for Perianal Fistula Healing
The average success rate for healing and remission of complex perianal fistulas, idiopathic or Crohn's-related, is approximately 50%.
- Trial name
- NCT06632418
- Testing
- RhPDGF-BB
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Alexander Hawkins
Keloids
Bevacizumab Versus Triamcinolone Acetonide for the Treatment of Keloids.
The study compares the efficacy and safety of intralesional bevacizumab versus corticosteroids for the treatment of keloids. Assessment will be done clinically by the use of Modified Vancouver Scar Scale.
- Trial name
- NCT07014280
- Testing
- Bevacizumab, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Kasr El Aini Hospital
Rheumatic Diseases, Arthritis
Studies of the Natural History of Rheumatic Diseases
This study will explore the causes of rheumatic diseases and why many of them affect certain minority communities more severely. Rheumatic diseases may cause joint pain, stiffness or swelling.
- Trial name
- NCT00024479
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Pulmonary Fibrosis
Lung Disease Associated With Rheumatoid Arthritis
Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA).
- Trial name
- NCT00001876
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Apical Periodontitis
Bone Regenerative Techniques in Endodontic Microsurgery
The purpose of this randomized controlled clinical trial was to evaluate two dimensionally and 3-dimensionally the effect of resorbable collagen-based bone filling material on periapical healing following endodontic microsurgery…
- Trial name
- NCT04514991
- Testing
- Foundation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Collagen Supplementation, Whey Protein
Effects of Rehabilitation and Supplementation With Hydrolyzed Collagen vs. Whey Protein on the Cardiopulmonary, Renal, Muscular, and Immunohematological Response of COPD Patients
Chronic obstructive pulmonary disease (COPD) induces a severe loss of muscle strength and mass, in addition to reflecting significant pulmonary changes and causing cardiovascular, immunohematological, and renal alterations.
- Conditions
- Collagen Supplementation, Whey Protein, Pulmonary Rehabilitation, COPD - Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07011225
- Testing
- Verisol Collagen 2,5 g/day, Peptech Collagen 2,5 g/day, Peptech Collagen 10 g/day
- Where
- Brazil
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Temporomandibular Disorder
A Comparison of Collagen, Lidocaine and Saline, in Trigger Points in Masseter Muscle.
An intramusclular injection of three solutions were performed( collagen, lidocaine, saline) in musculoskeletal trigger points, in patients suffering from temporomandibular disorders(TMD).
- Trial name
- NCT03323567
- Testing
- MD Muscle GUNA collagen, Lidocaine 2% Injectable Solution, Saline Solution, Hypertonic
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Medical University of Silesia
Pulmonary Hypertension Due to Lung Diseases
Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients
Chronic lung diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension.
- Trial name
- NCT07498244
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Keloid, Scar
Safety and Efficacy of AIV001 on Scar Formation and Keloid Recurrence Following Keloidectomy
To evaluate the saftye and effectiveness of AIV001 treatment on scar formation and/or keloid scar recurrence following keloidectomy.
- Conditions
- Keloid, Scar, Incision, Excision Margin
- Trial name
- NCT04827875
- Testing
- AIV001
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- AiViva BioPharma, Inc.
Anal Fistula
Treatment of Perirectal Fistula With Cutting Seton vs. Collagen Plug
The purpose of this study is to determine if the collagen plug method heals perirectal fistulae as well as the conventional seton method.
- Trial name
- NCT00450671
- Testing
- Collagen Plug Placement, Seton placement
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Southern California
Vascular Ehlers-Danlos Syndrome
Heart Coherence Training on Vascular Ehlers-Danlos Syndrome Patients
Vascular Ehlers-Danlos Syndrome (VEDS) is caused by pathogenic variants of the COL3A1 gene, resulting abnormal Type III collagen protein.
- Trial name
- NCT05994664
- Testing
- Heartmath Intervention, Control Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
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