Clinical trials: Collagen Diseases
Recessive Dystrophic Epidermolysis Bullosa
Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCC
This pilot trial studies how rigsertib sodium works in treating patients with Recessive Dystrophic Epidermolysis bullosa (RDEB) with locally advanced Squamous Cell Carcinoma (SCC).
- Trial name
- NCT04177498
- Testing
- Rigosertib Sodium, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Thomas Jefferson University
Keloid
Radiotherapy for Keloids
The purpose of this pilot study is to evaluate the safety and efficacy of radiation therapy (RT) in the treatment of unresected keloids.
- Trial name
- NCT04722263
- Testing
- Radiotherapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Montefiore Medical Center
Anterior Cruciate Ligament Injuries, Hallux Rigidus
Collagen for Treatment of Musculoskeletal Injuries
The purpose of the study: Evaluation of the clinical efficacy and safety of the use of collagen matrix/membrane in the surgical treatment of the consequences of injuries and diseases of the musculoskeletal system (anterior…
- Trial name
- NCT06331741
- Testing
- Anterior cruciate ligament reconstruction, using graft, augmented with collagen membrane, Anterior cruciate ligament reconstruction, using graft, not augmented with collagen membrane (control group), Resection arthroplasty of the first metatarsophalangeal joint with the introduction of a collagen membrane into the joint cavity
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Alveolar Bone Loss, Gingival Recession
Xenogenic Collagen Matrix vs. Connective Tissue Graft for Soft Tissue Augmentation Around Early Maxillary Implants
This study compares two methods used to improve gingival tissue around dental implants placed in (the maxillary esthetic zone). After a tooth is removed and a dental implant is placed early (usually 4-8 weeks later), additional…
- Conditions
- Alveolar Bone Loss, Gingival Recession, Peri-implant Mucositis
- Trial name
- NCT07024186
- Testing
- Xenogeneic Collagen Matrix, subepithelial connective tissue graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Minia University
Healthy, Prediabetic State
Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile in Prediabetic and Healthy Subjects
To investigate the effect of two different dosages collagen hydrolysate (CH) on postprandial blood glucose and insulin profile in prediabetic and normo-glycaemic subjects.This will be investigated in a cross-over randomized…
- Trial name
- NCT05887791
- Testing
- Collagen hydrolysate
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Hair Thinning
Study Evaluating the Effects of Dietary Supplement on Hair Thickness and Hair Strength in Individuals With Self-Perceived Thinning Hair
The Nutra Harmony "Biotin, Collagen \& Keratin Beauty Complex" is an oral food/dietary supplement specifically designed to promote hair growth for people suffering from temporary thinning hair.
- Trial name
- NCT06605768
- Testing
- Complex with Biotin, Collagen, Keratin, Hyaluronic Acid.
- Where
- Ukraine
- Volunteers
- 80 people
- Sponsor
- Nutra Harmony LLC
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
The Natural History of Wounds in Patients With Dystrophic Epidermolysis Bullosa (DEB)
This study is a non-interventional, observational study that will evaluate the natural history of wounds in patients with Dystrophic Epidermolysis Bullosa (DEB) for inclusion into the Krystal Biotech Phase III protocol of B-VEC…
- Trial name
- NCT04214002
- Where
- United States
- Sponsor
- Krystal Biotech, Inc.
Systemic Lupus Erythematosus, Sjogren's Syndrome
COVID-19 Vaccination in Rheumatic Disease Patients
The research is being done to study the immune responses to COVID-19 vaccination in patients with rheumatic diseases.
- Conditions
- Systemic Lupus Erythematosus, Sjogren's Syndrome, Inflammatory Myositis, Psoriatic Arthritis
- Trial name
- NCT04839315
- Testing
- mRNA COVD19 vaccine
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Autoimmune Rheumatologic Disease
Safety and Immunogenicity of PCV20 in Pediatric Patients With Autoimmune Rheumatic Diseases
This clinical trial evaluates the immunogenicity (humoral and cellular) and safety of the 20-valent pneumococcal conjugate vaccine (PCV20) in children, adolescents, and young adults aged 2-25 years with autoimmune rheumatic…
- Trial name
- PCV20-PARD (NCT07252791)
- Testing
- Pneumococcal Vaccine
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Osteogenesis Imperfecta
Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Osteogenesis Imperfecta
This research study aims to evaluate the effect of a 6-month adapted physical activity program (APA) on the endurance capacities (evaluated as the maximum oxygen consumption [VO2 peak]) of children and adolescents with…
- Trial name
- BONeMOVE (NCT05927389)
- Testing
- Adapted Physical Activity program
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Progressive Keratoconus, Corneal Ectasia
Corneal Crosslinking in Keratoconus and Corneal Ectasia
Prospective, randomized, single site to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes progressive keratoconus or corneal ectasia.
- Trial name
- CXL (NCT00679666)
- Testing
- Riboflavin
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Dental Implants, Peri-Implant Tissues
CTG vs VCMX for Peri-implant Soft Tissue Thickness
This investigator-initiated randomized controlled clinical trial evaluated changes in peri-implant soft tissue thickness in the aesthetic zone following soft tissue augmentation.
- Conditions
- Dental Implants, Peri-Implant Tissues, Missing Tooth/Teeth
- Trial name
- NCT07324187
- Testing
- Connective Tissue Graft, Volume-Stable Collagen Matrix
- Where
- Poland
- Volunteers
- 36 people
- Sponsor
- Medical Innovation Center Wroclaw
Goiter
Hemostatic Patch/Collagen Sealant and Polyethylene Glycol (Hemopatch) in the Postoperative of the Thyroidectomy.
Observational study with non-inferiority, prospective, randomized (1: 1) and open-label medical device. The study has 2 treatment groups (HEMOPATCH® versus standard hemostasis).
- Trial name
- NCT05103956
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Vascular Ehlers-Danlos Syndrome
Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome
This is a prospective, Phase 3, randomized, double-blind, placebo-controlled efficacy study to evaluate celiprolol in patients genetically confirmed as COL3A1-positive vEDS using a decentralized clinical trial design.
- Trial name
- DiSCOVER (NCT05432466)
- Testing
- ACER-002 (celiprolol) 200 mg BID
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Acer Therapeutics Inc.
Skin Condition, Collagen Synthesis
Effects of Oral Collagen Drinks on Human Skin
The objective of this study is to evaluate the effect of oral collagen drink and MAXI collagen drink on human skin condition improvement.
- Trial name
- NCT07605871
- Testing
- Collagen Drink, MAXI Collagen Drink, MAXI Collagen Drink_High dose
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Osteogenesis Imperfecta
Setrusumab vs Placebo for Osteogenesis Imperfecta
The primary objectives of the study are to identify a setrusumab dosing strategy in participants with OI and to evaluate the effect of setrusumab vs placebo on reduction in fracture rate.
- Trial name
- Orbit (NCT05125809)
- Testing
- Setrusumab
- Where
- 43 sites in United States, Australia and 9 more
- Volunteers
- 183 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Infection
Next Generation Pathogen Sequencing for Prediction of Infection in Rheumatic Disease
The majority of patients diagnosed with rheumatic disease, such as systemic lupus erythematosus, inflammatory myositis, and vasculitis, will experience fever or infection during their course of therapy.
- Trial name
- NCT04226261
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Rheumatoid Arthritis
Aminopterin Dose Finding Treatment for Methotrexate-Naïve Rheumatoid Arthritis
The purpose of this study is to determine whether aminopterin is effective in the treatment of rheumatoid arthritis (RA).
- Trial name
- NCT01724931
- Testing
- LD-aminopterin
- Where
- 15 sites in Ukraine
- Volunteers
- 175 people
- Sponsor
- Syntrix Biosystems, Inc.
Rheumatologic Disease, Pediatric ALL
Turkish Cultural Adaptation, Validity and Reliability of the "Gait Outcomes Assessment List"
The ultimate goal of treating children with lower extremity differences is to improve quality of life, optimize function, and maximize participation by addressing the physical, social, and psychological effects of lower extremity…
- Conditions
- Rheumatologic Disease, Pediatric ALL, Children, Only, Lower Extremity Problem
- Trial name
- NCT05846672
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
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