Clinical trials: Collagen Disorder
Keratoconus, Corneal Ectasia
Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been proposed as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT01464268
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Axial Spondyloarthritis (axSPA)
Effects of Yoga Therapy in Rehabilitation Compared to Physiotherapy in Moderate Axial Spondyloarthritis (axSPA)
A few studies have evaluated the effectiveness of yoga therapy in patients with axial spondyloarthritis (axSPA). On the other hand, studies conducted in other chronic rheumatisms such as low back pain, rheumatoid arthritis or…
- Trial name
- YOKISPA (NCT06083090)
- Testing
- Yogatherapy, Physiotherapy
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis of Knee
Clinical Efficacy and Safety of NEOIAL HC for Intra-articular Use in the Treatment of Severe Knee Osteoarthritis
Osteoarthritis (OA) is one of the most frequent causes of pain and disability in adults. According to the Osteoarthritis Research Society International (OARSI), at least 40% of people over the age of 65 suffer from symptomatic…
- Trial name
- NCT05936762
- Testing
- Neoial HC
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nextrasearch S.r.l.s.
Keloid, Autologus Adipose Derived Stem Cells
Autologous Adipose Derived Stem Cells Transplantation in the Treatment of Keloids.
Keloids are the most common disfiguring skin disorder affecting colored population with a prevalence of upto 16%. Autologous adipose derived stem cells have been found to have potential therapeutic benefits however limited…
- Conditions
- Keloid, Autologus Adipose Derived Stem Cells, Feasibility, Safety
- Trial name
- NCT04553159
- Testing
- Autologous adipose derived stem cells
- Where
- Uganda
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Makerere University
Scar Prevention, Scar Reduction
A Study to Evaluate the Safety and Efficacy of AZX100 Drug Product Following Excision of Keloid Scars
The purpose of this study was to determine the safety of AZX100 Drug Product and to determine whether it was effective in preventing or reducing re-growth of surgically removed keloid scars.
- Trial name
- NCT00825916
- Testing
- AZX100 Drug Product
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Capstone Therapeutics
Dystrophic Epidermolysis Bullosa
Study to Evaluate Safety and Efficacy of ALLO-ASC-SHEET in Subjects With Dystrophic Epidermolysis Bullosa
After confirming eligibility, a single subject with four selected target lesions will receive both ALLO-ASC-SHEET and Vehicle control, three target lesions for ALLO-ASC-SHEET and the other target for Vehicle control, and which…
- Trial name
- NCT05157958
- Testing
- ALLO-ASC-SHEET, Vehicle Control
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Anterogen Co., Ltd.
Aneurysm Arterial, Peripheral Arterial Disease
Safety and Performance of POLYTHESE® Vascular Prosthesis
POLYTHESE® study is a retrospective, observational, multicentre, case series which examine short and long-term outcomes of using POLYTHESE®.
- Conditions
- Aneurysm Arterial, Peripheral Arterial Disease, Marfan Syndrome, Arterial Dissections
- Trial name
- NCT05516043
- Testing
- Implantation with POLYTHESE®
- Where
- 3 sites in France
- Volunteers
- 256 people
- Sponsor
- Perouse Medical
Ligament; Laxity, Recurrent Patellar Dislocation
Clinical Significance and Coexistence of Polymorphisms of Individual Collagen-coding Genes
The purpose of this study is to assess correlation between recurrent patella dislocation and genetic polymorphism rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene.
- Trial name
- NCT05763108
- Testing
- genetic test, Beighton joint laxity test
- Where
- 2 sites in Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Epidermolysis Bullosa Dystrophica
Recessive Dystrophic Epidermolysis Bullosa Screening for Possible Gene Transfer
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a severe inherited blistering skin disease caused by absence of type VII collagen.
- Trial name
- NCT00533572
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Gastrointestinal Disorders
To Assess the Effect of Collagen on Gastrointestinal Discomfort in Healthy Adults With Gastrointestinal Symptoms.
This study will enroll healthy adults with perceived gastrointestinal symptoms to evaluate the effect of collagen peptides compared to placebo.
- Trial name
- NCT06937801
- Testing
- Collagen Peptide
- Where
- Canada
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB)
Pilot Study of ELK-003 Eye Drops for Treating Ocular Manifestations of Epidermolysis Bullosa
This study consists of two phases: an Observational Phase to evaluate the natural history of ocular manifestations in subjects with Dystrophic and Junctional Epidermolysis Bullosa, followed by a Treatment Phase to assess the…
- Conditions
- Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB), Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
- Trial name
- GOTAS-ELK-EB (NCT06713434)
- Testing
- ELK-003 (Standarized Amniotic Fluid Secretome Eye Drops)
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Fundación DEBRA Chile, Niños Piel de Cristal
Covid19, Rheumatic Fever
Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected Patients
Recent studies have highlighted the consequences of COVID-19 pandemic and social distancing on mental health of individuals. The aim of this study is to evaluate those consequences within a sample of inflammatory chronic…
- Conditions
- Covid19, Rheumatic Fever, Mental Disorder
- Trial name
- EMOPTION (NCT04798053)
- Testing
- Questionnaire, blood sample and salivary sample
- Where
- 7 sites in France
- Volunteers
- 259 people
- Sponsor
- University Hospital, Bordeaux
Osteoarthritis, Knee
Undenatured Type II Collagen for Knee Osteoarthritis Pain
This randomized, controlled, double-blind, three-arm parallel clinical trial will evaluate the efficacy and safety of undenatured type II collagen products on joint pain in adults diagnosed with knee osteoarthritis.
- Trial name
- NUVICOL (NCT07870967)
- Testing
- Nuvicol II, Nuvicol SII
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Musculoskeletal Pain Disorder
Risk Assessment for Prolonged Sickness Absence Due to Musculoskeletal Conditions
Musculoskeletal (MSK) conditions are a leading cause of years lived with disability worldwide and for the last decade they have also been the most common cause of sickness absence and disability pension in Norway.
- Trial name
- NCT04196634
- Testing
- Risk assessment
- Where
- Norway
- Volunteers
- 560 people
- Sponsor
- Oslo Metropolitan University
Bone Loss, Bone Remodeling Disorder
Socket Preservation Using Dentin Graft Autogenous Dentin Graft With Collagen Sponge on Dental Implant Stability AUTOGENOUS TOOTH GRAFT WITH COLLAGEN SPONGE ON DENTAL IMPLANT STABILITY
The present study was performed to evaluate socket preservation using collagen sponge with autogenous dentin graft versus collagen sponge with de-mineralised freez-dried bone graft on dental implant stability
- Conditions
- Bone Loss, Bone Remodeling Disorder, Bone Resorption
- Trial name
- NCT06853392
- Testing
- Demineralized freeze dried allograft with collagen sponge, autogenous dentin graft with collagen sponge
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Idiopathic Pulmonary Fibrosis
Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect
The primary purpose of this substudy is to determine if collagen-targeted PET using the type 1 collagen-targeted PET probe, Gallium-68 (68Ga)-labeled collagen binding probe 8 (CBP8) can inform as to drug effect of EGCG and assist…
- Trial name
- NCT06265532
- Testing
- EGCG 300 mg, EGCG 600 mg
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Hal Chapman
Chronic Inflammatory Disease
Chronic Inflammatory Rheumatism: Management of Comorbidities in Ambulatory Medicine
Identification of factors limiting compliance with the recommendations established during the evaluation of the SCORIC population by the rheumatology department of the CHU Grenoble Alpes
- Trial name
- SCORIC-A (NCT05613712)
- Testing
- Patients, Referring physician
- Where
- France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Grenoble
Keloid, Scleroderma, Localized
Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix
This research study will evaluate the effectiveness of high dose UVB light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne keloidalis nuchae, old burn scars, granuloma annulare or related conditions.
- Conditions
- Keloid, Scleroderma, Localized, Acne Keloidalis, Scars
- Trial name
- NCT00129428
- Testing
- UVB Irradiation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Michigan
Corneal Epithelial Wound Healing, Post Operative Pain
Insulin Eye Drops and Epithelial Healing After Corneal Cross-linking
The goal of this clinical trial was to learn if topical insulin eye drops affected corneal epithelial wound healing after corneal collagen cross-linking.
- Trial name
- NCT07812129
- Testing
- Insulin eye drops, standard post-operative topical drops
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Bone Loss
Lateral Ridge Augmentation Using Cross-linked or Non-cross-linked Collagen Membrane
The objective of the present trial is to test clinically, radiographically and histologically , in a lateral alveolar ridge augmentation model (without simultaneous implant placement) the efficiency in supporting bone formation…
- Trial name
- NCT04402671
- Testing
- non-cross-linked porcine skin collagen membrane, glutaraldehyde cross-linked bovine collagen membrane
- Where
- Lebanon
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University