Clinical trials: Collagen Disorder
Fibrosis, Skin Scarring
Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention
Skin scarring (fibrosis) is a common complication in the wound healing process and remains a therapeutic challenge. Scar formation often occurs following injury to the skin such as surgery, trauma, and burns.
- Conditions
- Fibrosis, Skin Scarring, Skin Wound, Hypertrophic Scar
- Trial name
- NCT03795116
- Testing
- LED-RL phototherapy, Mock irradiation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Erythema, Sensitisation
Irritation Potential of Omeza Collagen Matrix Using Modified HRIPT
The primary objective of this study was to assess the sensitization potential of Omeza Collagen Matrix compared to that of a negative control based on a Modified Human Repeat Insult Patch Test.
- Trial name
- NCT04510675
- Testing
- Test Article, Negative Control
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Alport Syndrome, Kidney Disease
A Prospective Study of Microalbuminuria in Untreated Boys With Alport Syndrome
The goal of the Microalbuminuria in Untreated Boys with Alport Syndrome study is to gather information about critical clinical time points such as when patients with small amounts of protein (microalbuminuria) in their urine…
- Trial name
- MA (NCT00622544)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Diabetic Foot Ulcer
Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With a Mild Infection of a Foot Ulcer
The purpose of this study is to determine whether the gentamicin-collagen sponge when combined with standard of daily wound care is safe and effective in treating mildly infected skin ulcers compared to treatment with an oral…
- Trial name
- NCT00593567
- Testing
- gentamicin-collagen sponge, Levofloxacin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Innocoll
Progressive Keratoconus
Corneal Collagen Cross-linking for Progressive Keratoconus
Prospective, randomized multicenter study to determine the safety and effectiveness of performing cornea collagen cross-linking (CXL) using riboflavin and UVA light in eyes with progressive keratoconus.
- Trial name
- CXL (NCT00647699)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 147 people
- Sponsor
- Glaukos Corporation
Diabetic Foot Ulcer (DFU)
Multicentric RCT Comparing High Purity Type I Collagen-Skin Substitute vs dHACM in Treatment of Diabetic Foot Ulcers
This is a randomized controlled clinical investigation in patients suffering from diabetic foot ulcers at multiple centers. The study intends to compare patient outcome data using Standard of Care with Type-I Collagen-based Skin…
- Trial name
- NCT07046403
- Testing
- High Purity Type-I Collagen-based Skin Substitute and SOC, Dehydrated Human Amnion / Chorion Membrane and SOC
- Where
- 4 sites in India
- Volunteers
- 120 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Total Knee Replacement, Virtual Reality Therapy
Effects of Virtual Reality Rehabilitation in Patients With Total Knee Arthroplasty
The aim of this study is to assess the efficacy of virtual rehabilitation through the Virtual Reality Rehabilitation System (VRRS) versus traditional rehabilitation improving the functional outcomes after primary Total Knee…
- Conditions
- Total Knee Replacement, Virtual Reality Therapy, Osteoarthritis, Knee Arthroplasty
- Trial name
- NCT02413996
- Testing
- Kinetec® knee continuous passive motion (CPM ), Functional activities, VRRS rehabilitation
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteogenesis Imperfecta
Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric Patients
This study has been planned as part of the Orthofix Srl post-market active surveillance plan for the collection of data on both the clinical performance and the safety profile of the JTIN.
- Trial name
- JTIN (NCT05612139)
- Testing
- JTIN implantation surgery
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Orthofix s.r.l.
Keloid Scar
Assessing and Improving Patient Knowledge About Keloid Scars (Keloids)
The purpose of this study is: to identify how knowledge about keloid scars and self-treatments differs between patients who use the Internet as a source of information and patients who do not to determine if patients who are at a…
- Trial name
- NCT01176877
- Testing
- Scripted lecture ("educational information talk")
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Osteogenesis Imperfecta
Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI
This is a prospective, multicenter, single-arm study in children 2 to 17 years of age with OI to evaluate efficacy and safety of denosumab.
- Trial name
- OI (NCT02352753)
- Testing
- Denosumab
- Where
- 49 sites in United States, Australia and 11 more
- Volunteers
- 153 people
- Sponsor
- Amgen
Diabetic Foot Ulcer (DFU)
High Purity Type I Collagen Based Skin Substitute Vs Dehydrated Human Amnion/Chorion Membrane in Treatment of DFUs
This is a randomized controlled clinical investigation in patients suffering from diabetic foot ulcers. The study intends to compare patient outcome data using Standard of Care with Type-I Collagen-based Skin Substitute and…
- Trial name
- NCT06470087
- Testing
- SOC and Type-I Collagen-based Skin Substitute, SOC and Human Amnion/Chorion Membrane
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Keloid
RAPA-Keloid Study of Keloid Regression
1. To test whether topical rapamycin regresses established keloids in humans by measuring surface area and height changes in the scar over time (6 months) 2.
- Trial name
- NCT04049552
- Testing
- Rapamycin 8% Ointment
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio