Clinical trials: Collagen Disorders
Osteoarthritis
Hydrolyzed Collagen in the Reduction of Osteoarticular Pain and Functional Limitation
This randomised study evaluates the efficacy of an oral dietary supplement of Hydrolyzed Collagen in reducing pain and improving physical function in subjects with osteoarthritis.
- Trial name
- NCT05149053
- Testing
- Hydrolyzed Collagen
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Francisco Jose Rodriguez Velasco
Scleroderma, Systemic, Skin Sclerosis
A Study of the Efficacy and Safety of Rituximab in Participants With Systemic Sclerosis
This study evaluates the efficacy and safety of rituximab compared with placebo in SSc patients. This study consists of a 24-week, double-blind, placebo-controlled period followed by a 24-week active drug treatment period.
- Conditions
- Scleroderma, Systemic, Skin Sclerosis, Lung Fibrosis, Autoimmune Diseases
- Trial name
- DesiReS (NCT04274257)
- Testing
- Double-Blind Rituximab
- Where
- 4 sites in Japan
- Volunteers
- 56 people
- Sponsor
- Tokyo University
Rheumatic Disease, Rheumatoid Arthritis
The Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Tuberculosis Infection
The purposes of this study 1. to compare the positivity of tuberculin skin test(TST) and QuantiFERON-TB Gold (QFT-G), and determine the level of agreement between two tests in patients with rheumatic diseases 2.
- Conditions
- Rheumatic Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Tuberculosis
- Trial name
- NCT01685905
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Hanyang University
Osteoarthritis, Post-traumatic Arthritis
A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement
The purpose of this study is to compare the performance of 4 designs of the DePuy Ultima LX hip stem in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Collagen Disorder, Avascular Necrosis
- Trial name
- NCT00208351
- Testing
- Ultima LX Collared Stem - Non-Polished/Blasted Finished, Ultima LX Collared Stem - Polished Finished, Ultima LX Collarless Stem - Non-Polished/Blasted Finished
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- DePuy International
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Hypertrophic Scar, Keloid Scar
A Substantial Equivalence Study of RD04723 and Predicate Device
The purpose of this study is to determine whether a developmental formulation is substantially equivalent to the predicate device in the treatment of hypertrophic and keloid scars.
- Trial name
- NCT01736969
- Testing
- RD047-023, Predicate Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oculus Innovative Sciences, Inc.
Primary Congenital Glaucoma, Developmental Glaucoma
Ologen® Collagen Matrix in Patients With Primary Congenital Glaucoma Undergoing Trabeculectomy
To the best of Investigator knowledge, no studies to this date have compared the safety and efficacy of ologen® Collagen Matrix in Primary congenital glaucoma (PCG) patients undergoing trabeculectomy.
- Conditions
- Primary Congenital Glaucoma, Developmental Glaucoma, Infantile Glaucoma
- Trial name
- NCT03541551
- Testing
- CTT with ologen® Collagen Matrix, Trab Trab
- Where
- India
- Volunteers
- 44 people
- Sponsor
- L.V. Prasad Eye Institute
Keloid Scar
Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery
The main purpose of this study is to see if there is clinical benefit of using Biovance in reduction of the recurrence of keloids when used to revise them. It will also assess the postoperative complications.
- Trial name
- NCT02521402
- Testing
- Biovance
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Golla Center for Plastic Surgery
Chronic Obstructive Bronchopneumopathy, Infectious Pneumonia
Study of Collagen IV and XIX in Bronchoalveolar Lavage, Pulmonary Aspiration and Bronchial Biopsies
Collagens are proteins present in all tissues. Besides their structural role, recent data showed that they were able to regulate many cellular functions.
- Conditions
- Chronic Obstructive Bronchopneumopathy, Infectious Pneumonia, Pneumonitis, Lung Cancer
- Trial name
- BRONCOLL (NCT02788643)
- Testing
- biological fluids (serum, bronchoalveolar lavage and pulmonary aspiration) and bronchial biopsies collection
- Where
- France
- Volunteers
- 51 people
- Sponsor
- CHU de Reims
Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa, Junctional
CACIPLIQ20 in Wound Healing in Subjects With Epidermolysis Bullosa
Epidermolysis bullosa (EB) is a group of inherited disorders characterized by fragility of the skin and mucous membranes within the basement membrane zone.
- Trial name
- MATHBULL (NCT06007235)
- Testing
- CACIPLIQ20
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement
Still's Disease Adult Onset
An Efficacy and Safety Study of GNR-086 (Canakinumab Biosimilar) and Ilaris® in Patients With Adult-onset Still's Disease
This is a randomized single-blind comparative parallel group study of the efficacy and safety of canakinumab biosimilar GNR-086 (JSC \"GENERIUM\", Russia) and Ilaris® (Novartis Pharma Stein AG, Switzerland) in the…
- Trial name
- NCT06497491
- Testing
- GNR-086, Ilaris®
- Where
- 17 sites in Russia
- Volunteers
- 118 people
- Sponsor
- AO GENERIUM
Alport Syndrome
A Study to Learn About How Well BAY 3401016 Works in Adults With Alport Syndrome
Alport syndrome (AS) is a rare genetic condition that causes kidney disease, hearing loss, and eye abnormalities that occur due to changes in specific genes (COL4A3, COL4A4, and COL4A5).
- Trial name
- ASSESS (NCT07211685)
- Testing
- BAY 3401016
- Where
- 58 sites in United States, Argentina and 13 more
- Volunteers
- 60 people
- Sponsor
- Bayer
Osteogenesis Imperfecta
Zoledronic Acid in Children (1 -17 Years) With Severe Osteogenesis Imperfecta
This is an extension study to examine the long-term safety and efficacy of zoledronic acid in patients who have completed the core CZOL446H2202 study.
- Trial name
- NCT00131118
- Testing
- Zoledronic Acid
- Where
- 10 sites in United States
- Volunteers
- 127 people
- Sponsor
- Novartis Pharmaceuticals
Gingival Recession, Root Planing
Gingival Recession Treatment Using Two Different Surgical Techniques
Coronally the advanced flap is considered a predictable treatment of gingival recession but in certain situations, it needs a filler like subperiosteal connective tissue graft (CTG) which is considered as the gold standard…
- Trial name
- NCT04966208
- Testing
- xenogeneic collagen matrix
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assiut University
Skin Diseases, Keloid
Phase 1 Study of HF-LED-RL in Fitzpatrick Skin Types I to III
The goal of this study is to establish the safety of high fluence LED-RL at fluence of 480 J/cm2 and 640 J/cm2 in healthy non-Hispanic, Caucasian subjects.
- Conditions
- Skin Diseases, Keloid, Scar, Fibrosis
- Trial name
- NCT03433222
- Testing
- HF-LED-RL Phototherapy, Mock Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Northern California Health Care System
Rheumatoid Arthritis, Spondyloarthritis, Axial
Cohort Project of Patients With Inflammatory Rheumatism
Chronic inflammatory rheumatism (CIR) is a group of inflammatory diseases that affect the joints and spine and are related to an abnormal immune response.
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Axial, Psoriatic Arthritis
- Trial name
- SMAP (NCT06059430)
- Testing
- no intervention
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Epidermolysis Bullosa, Epidermolysis Bullosa Simplex
A Pilot Study to Explore the Role of Gut Flora in Epidermolysis Bullosa
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Epidermolysis Bullosa, Epidermolysis Bullosa Simplex, Epidermolysis Bullosa Dystrophica
- Trial name
- NCT04213703
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Inflammatory Disease, Rheumatoid Arthritis
Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism
It is a prospective follow-up. The aim is to study the maintenance of therapeutic at 10 years and 20 years of inflammatory rheumatism (rheumatoid arthritis and spondyloarthritis)
- Conditions
- Inflammatory Disease, Rheumatoid Arthritis, Spondyloarthritis
- Trial name
- PPCRNice (NCT03076866)
- Testing
- observational follow-up:clinical, radiological et biological
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sars-CoV2, Rheumatoid Arthritis
Morbimortality of Covid-19 in Patients With Chronic Inflammatory Rheumatism Treated With Immunosuppressants
A retrospective monocentric study with large active files of patients monitored for rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus with as main endpoint the morbimortality of Covid-19 in these patients…
- Conditions
- Sars-CoV2, Rheumatoid Arthritis, Rheumatic Diseases
- Trial name
- CORhum (NCT04426279)
- Testing
- questionnaire assesment
- Where
- France
- Volunteers
- 539 people
- Sponsor
- University Hospital, Lille
Tooth Loss, Soft Tissue Deficiency
A Clinical Study to Investigate Collagen Matrix 10808 for Soft Tissue Volume Augmentation Around Single Implants
The objective of this study is to investigate the safety and the function of the collagen Matrix 10808 in humans and to compare it versus the standard therapy, the transplantation of the autologous connective tissue graft.
- Trial name
- NCT02356770
- Testing
- Collagen Matrix 10808, Connective tissue graft
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Geistlich Pharma AG