Clinical trials: ColoRectal Cancer and Inflammatory Bowel Disease
Ulcerative Colitis, Colorectal Cancer
Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis
In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at three time points during ileal pouch…
- Conditions
- Ulcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous Polyposis
- Trial name
- NCT04695964
- Testing
- ICG-NIRF Imaging plus ingress and egress analysis
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Rectal Cancer, Colon Cancer
Perfusion Assessment in Laparoscopic Left Anterior Resection
The purpose of this study is to demonstrate that NIR fluorescence angiography using the PINPOINT Endoscopic Fluorescence Imaging System ("PINPOINT System" or "PINPOINT") can assess viability of colon tissue during laparoscopic…
- Conditions
- Rectal Cancer, Colon Cancer, Crohn's Disease, Polyp
- Trial name
- PILLAR II (NCT01560377)
- Testing
- PINPOINT Endoscopic Fluorescence Imaging System
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Complications of Surgical Procedures, Surgical Site Infection
Quick Skin Sealant in Closure of Surgical Wound After Laparoscopic Surgery
The purpose of this study is to evaluate the short-term effect of sealant-assisted skin closure in prevention of surgical site infection after laparoscopic surgery.
- Conditions
- Complications of Surgical Procedures, Surgical Site Infection, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT02426762
- Testing
- Laparoscopic surgery, Skin sealant
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Inflammatory Bowel Diseases, Colonic Neoplasms
IBD Neoplasia Surveillance Pilot RCT
To determine if random biopsies can be safely eliminated from screening of average risk persons with IBD, the investigators propose to carry out a pilot randomized control trial in which targeted biopsies in combination with…
- Conditions
- Inflammatory Bowel Diseases, Colonic Neoplasms, Dysplasia
- Trial name
- IBDDysplasia (NCT04067778)
- Testing
- Intervention Group, Control Group
- Where
- 12 sites in Canada
- Volunteers
- 600 people
- Sponsor
- Ottawa Hospital Research Institute
Anastomotic Leak, Colorectal Cancer
The Prediction of Anastomotic Insufficiency Risk After Colorectal Surgery (PANIC) Study
The Prediction of Anastomotic Insufficiency risk after Colorectal surgery (PANIC) study aims to establish a machine-learning-based application that allows for accurate preoperative prediction of patients at risk for anastomotic…
- Conditions
- Anastomotic Leak, Colorectal Cancer, Diverticulosis, Crohn Disease
- Trial name
- NCT04985981
- Where
- 2 sites in Switzerland
- Volunteers
- 11,000 people
- Sponsor
- Michel Adamina, MD
Ulcerative Colitis, Crohn's Disease
Study on Cannabinoid Receptor Expression in Gastrointestinal Diseases
The purpose of the study is to investigate phospholipid ligands and their receptors in inflammatory bowel diseases and colon cancer.
- Conditions
- Ulcerative Colitis, Crohn's Disease, Colon Cancer
- Trial name
- NCT02735941
- Where
- Austria
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Crohn Disease, Polyposis
Clinical Database of Colorectal Robotic Surgery
Evaluation of robot Da Vinci Xi by determining its learning curve.The operating time will be defined by patient then the operating average will be calculated.
- Conditions
- Crohn Disease, Polyposis, Ulcerative Colitis, Diverticulitis
- Trial name
- ROBOT CR (NCT04013152)
- Testing
- Clinical database
- Where
- 4 sites in France
- Volunteers
- 1,800 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colon Cancer
Dietary Supplement on the Intestinal Microbiota in Patients with Colon Cancer
Effect of a dietary supplement with antioxidant and anti-inflamatory properties on the intestinal microbiota in patients with colon cancer. Ramdonized placebo controlled clinical trial. Teratrophic study
- Trial name
- TERATROFO (NCT05472753)
- Testing
- Experimental Treatment, DCOOP Product, Hydroxytyrosol extract, Experimental Treatment,Indukern product, Curcumin and selenium extract, Control Treatment
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Colorectal Anastomosis, Endometrial
Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion
There are many indications for performing a fecal diversion stoma. In both scheduled and emergency situations, and whatever the context (indication or type of fecal diversion stoma), stomal complications can occur early (10-60%)…
- Conditions
- Colorectal Anastomosis, Endometrial, Anastomotic Leak Rectum, Ulcerative Colitis (Disorder)
- Trial name
- RESTODIG (NCT06881303)
- Testing
- preoperative stoma identification and education
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Colon Cancer
Effect of Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function
Ideally, the postoperative inflammatory response is part of a well-orchestrated mechanism that contributes to tissue healing and rapid recovery.
- Trial name
- EMPIRE (NCT02231203)
- Testing
- Omegaven
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Medical Center Alkmaar
Colonic Neoplasms, Colon Cancer
Systemic and Peritoneal Inflammatory Response In Robotic-assisted And Laparoscopic Surgery for Colon Cancer
The current hypothesis is that robotic-assisted surgery results in a reduced systemic and peritoneal inflammatory response (SIRS) compared to laparoscopic surgery in the treatment of colon cancer.
- Conditions
- Colonic Neoplasms, Colon Cancer, Systemic Inflammatory Response Syndrome, Inflammation
- Trial name
- NCT04687384
- Testing
- Robotic-assisted colectomy, Conventional laparoscopic colectomy
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Southern Denmark
Colo-rectal Cancer, Colo-rectal Surgery
Post Operative Hospital at Home After Colorectal Surgery
The goal of this feasibility study is to investigate whether a virtual Hospital at Home is safe and possible for patients undergoing planned minimally invasive colorectal surgery.
- Conditions
- Colo-rectal Cancer, Colo-rectal Surgery, Colocolic and Ileocolic Anastomosis, Colon and/or Rectal Resection With Anastomosis for Cancer
- Trial name
- POPHaH (NCT07113717)
- Testing
- virtual Hospital at Home
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Nordsjaellands Hospital
Inflammatory Bowel Diseases, Colorectal Neoplasms
Back-to-back Endoscopy Versus Single-pass Endoscopy and Chromoendoscopy in IBD Surveillance
The current international guidelines for CRC surveillance in IBD recommend as first choice the use of chromoendoscopy, and as an alternative high-definition white light endoscopy (HDWLE) for optimal dysplasia detection, based on…
- Trial name
- HELIOS (NCT04291976)
- Testing
- Back-to-back high-definition white light endoscopy, single-pass high-definition white light endoscopy, chromoendoscopy
- Where
- 4 sites in Netherlands
- Volunteers
- 563 people
- Sponsor
- Radboud University Medical Center
Colitis
Determination of the Aetiologies of Acute Colitis and Early Identification of Patients Requiring Diagnostic Colonoscopy
The aetiologies of computed tomography-diagnosed acute colitis remain surprisingly unknown. Moreover, no diagnostic tool or clinical score allow to quickly determine or at least stratify the exact cause of colitis in patients…
- Trial name
- NCT02709213
- Testing
- Diagnostic
- Where
- Switzerland
- Volunteers
- 182 people
- Sponsor
- University Hospital, Geneva
Colonic Neoplasms, Rectal Neoplasms
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery
After resection of diseased segments of the large intestine, the continuity of the intestine has to be restored. This can be done by suturing or with so called stapling devices.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases
- Trial name
- NCT01056913
- Testing
- Compression Anastomosis Device, follow-up colonoscopy
- Volunteers
- 62 people
- Sponsor
- St John of God Hospital, Vienna
Ulcerative Colitis, Familial Adenomatous Polyposis
Ten Versus Fifteen Centimeter Pouch in IPAA Surgery
The aim of this randomized controlled trial is to compare outcome after construction of an ileal (J-shaped) reservoir of 10 versus 15 centimeters in primary ileal pouch-anal anastomosis surgery.
- Trial name
- TESTIMONY (NCT06538402)
- Testing
- 10 cm pouch, 15 cm pouch
- Where
- 2 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Odense University Hospital
Colorectal Cancer, Inflammatory Bowel Diseases
Predictive Time-to-Event Model for Major Medical Complications After Colectomy
Purpose: The purpose of this study is to create prediction models for when major complications occur after elective colectomy surgery. Justification: After surgery, patients can have multiple complications.
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Diverticulitis, Colectomy
- Trial name
- NCT05150548
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 130,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ileal Pouch-Anal Anastomosis
Ileal Pouch-Anal Anastomosis Registry
Little is known about the factors that predispose patients to complications after an ileal pouch-anal anastomosis procedure (IPAA).
- Trial name
- IPAA (NCT01026480)
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Boston Medical Center
Cancer
Impact of Group Psychological Interventions on Extracellular Vesicles in People Who Had Cancer
Background: There is some evidence demonstrating the effect of psychological interventions in improvements in health biological parameters.
- Trial name
- MindGAP-P (NCT04298398)
- Testing
- Mindfulness Based-Cognitive Therapy (MBCT), Emotion Focused Therapy Group for Cancer Recovery (EFT-CR), Treatment as usual (no intervention)
- Volunteers
- 108 people
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Ulcerative Colitis (Disorder), Crohn Disease (CD)
Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction
This observational study evaluates whether adding Traditional Chinese Medicine (TCM)-related clinical features improves the performance of machine-learning models that estimate disease risk before colonoscopy.
- Conditions
- Ulcerative Colitis (Disorder), Crohn Disease (CD), Inflammatory Bowel Diseases, Colorectal Neoplasms
- Trial name
- NCT07784114
- Volunteers
- 1,500 people
- Sponsor
- Beijing University of Chinese Medicine