Clinical trials: Colon Adenoma
Colonic Adenoma, Colonic Polyp
Evaluation of Endorings-2-assisted Colonoscopy: a New Accessory for Improvement of Adenoma Detection Rate?
Screening colonoscopy for colorectal cancer is essential to diagnose and remove adenomas, precancerous stages of colorectal cancer. Unfortunately approximately 25 % of all adenomas are missed during the examination.
- Conditions
- Colonic Adenoma, Colonic Polyp, Colonic Neoplasms, Colonoscopy
- Trial name
- Endorings-2 (NCT03385434)
- Testing
- Endorings-2
- Where
- Germany
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Colonic Adenomas
The Impact of Split Dose of Low-volume Polyethylene Glycol on Adenoma Detection Rate
An adequate level of bowel preparation is crucial for the efficacy and safety of colonoscopy. Strong evidences suggest that bowel-preparation quality shows an inverse correlation with length of the interval between the end of…
- Trial name
- NCT02178033
- Testing
- Split dose low-volume PEG solution
- Where
- 2 sites in Italy
- Volunteers
- 514 people
- Sponsor
- Valduce Hospital
Colorectal Cancer Screening, Colorectal Cancer Metastatic
Pilot Study for Colorectal Cancer and Advanced Adenoma Detection With the Mainz Biomed Colorectal Cancer Test
The Mainz Biomed Colorectal Cancer Screening Test is being studied for its performance in the identification of the presence of colorectal cancer (CRC) or advanced adenoma (AA) in the colon in patients at average risk for…
- Conditions
- Colorectal Cancer Screening, Colorectal Cancer Metastatic, Colon Adenocarcinoma
- Trial name
- eAArly DETECT (NCT06864338)
- Where
- United States
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed
Polyps
Prevalence of Small Bowel Polyps in Patients With Sporadic Duodenal Adenomas
Little is known about the prevalence of small bowel polyps in patients with sporadic Duodenal/Ampullary polyps. The investigators aim to investigate the prevalence of small bowel polyps in patients with sporadic (ie not related…
- Trial name
- SPIDA (NCT02470416)
- Testing
- Small bowel video capsule endoscopy (VCE) GIVEN/COVIDIEN LTD
- Where
- Australia
- Volunteers
- 177 people
- Sponsor
- Western Sydney Local Health District
Adenomatous Polyps
Detection of Ileoanal Pouch/Reservoir Adenomas
The detection of adenomas is the basis for the follow-up of patients with familial adenomatous polyposis, after colectomy, with a remnant rectum or an ileal pouch. The optimal method for the adenomas detection is not defined yet.
- Trial name
- DARIAC (NCT05954949)
- Testing
- Adenomas detection rate with the different observation methods
- Volunteers
- 40 people
- Sponsor
- Jean Christophe Saurin
Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms
Evaluation of Skin Tests in Biotherapy Allergies
Biotherapies are biological (extracted from an organism or living tissue) or biotechnological drugs used in the treatment of multiple conditions, such as autoimmune inflammatory diseases, cancers, and hematologic diseases.
- Conditions
- Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms, Small Cell Bronchial Carcinomas, Bronchial Carcinoma
- Trial name
- ETCABIO (NCT06971848)
- Testing
- Drug skin tests (investigating hypersensitivity to a biotherapy)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Polyp of Colon, Gastrointestinal Bleeding
Polypectomy With Hot vs Cold Snare in Small Colonic Lesions
Colonoscopy is the technique of choice for the diagnosis and prevention of colorectal cancer (CRC). The identification and extirpation of adenomas decreases the incidence of CRC by up to 76%.
- Conditions
- Polyp of Colon, Gastrointestinal Bleeding, Colonic Adenoma
- Trial name
- Polypech-c (NCT03783156)
- Testing
- hot snare, cold snare
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital del Rio Hortega
Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
The purpose of this study is to characterize the safety and tolerability of KFA115 and KFA115 in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Cutaneous Melanoma, Carcinoma, Renal Cell, Carcinoma, Ovarian Epithelial
- Trial name
- NCT05544929
- Testing
- KFA115, pembrolizumab
- Where
- 18 sites in United States, Canada and 10 more
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
Colorectal Cancer Prevention, Colorectal Adenoma
BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating…
- Trial name
- BILMOD (NCT07162337)
- Testing
- Increased Plant-Based Diet and Decreased Animal-Based Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Mesothelioma, Glioblastoma
Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
- Conditions
- Mesothelioma, Glioblastoma, Renal Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT04913337
- Testing
- NGM707, NGM707 plus pembrolizumab (KEYTRUDA®)
- Where
- 27 sites in United States, South Korea and 1 more
- Volunteers
- 179 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Colorectal Cancer, Colorectal Adenoma
Protocol to Validate the Performance of the LifeKit® Prevent Colorectal Neoplasia Test for CRC Screening
The purpose of this study is to determine the sensitivity and specificity for LifeKit Prevent Colorectal Neoplasia Test for colorectal cancer (CRC) and for adenoma, including advanced adenoma.
- Trial name
- PREVENT (NCT04693546)
- Testing
- LifeKit Prevent Colorectal Neoplasia Test, FIT Test
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Metabiomics Corp
Ileal Pouch-Anal Anastomosis
Ileal Pouch-Anal Anastomosis Registry
Little is known about the factors that predispose patients to complications after an ileal pouch-anal anastomosis procedure (IPAA).
- Trial name
- IPAA (NCT01026480)
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Boston Medical Center
Adenoma Detection Rate
Impact of SFV of Proximal Colon on ADR
To evaluate the impact of second forward view examination of the proximal colon on adenoma detection rate Inclusion criteria：Patients ≥18 years of age undergoing screening, follow-up monitoring, and diagnostic colonoscopy…
- Trial name
- NCT04963010
- Testing
- second forward view
- Where
- China
- Volunteers
- 910 people, healthy volunteers welcome
- Sponsor
- Zhu Xiaojia
Gut Microbiota, Metachronous Adenoma
Gut Microbiota Prediction of Metachronous Colorectal Neoplasms
Patients with colorectal cancer are known to be at high risk of developing metachronous adenoma, however, participation in colonoscopy are low.
- Trial name
- NCT03383159
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Colonic Polyps, Colorectal Adenomas
Impact of Automatic Polyp Detection System on Adenoma Detection Rate
In recent years, with the continuous development of artificial intelligence, automatic polyp detection systems have shown its potential in increasing the colorectal lesions.
- Trial name
- NCT03967756
- Testing
- Automatic polyp detection system
- Where
- China
- Volunteers
- 1,118 people
- Sponsor
- Changhai Hospital
Cancer, Solid Tumor
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
A Phase 1B/2A study will be conducted to establish safety and dose level of AMXT 1501 dicaprate in combination with IV DFMO, in cancer patients.
- Conditions
- Cancer, Solid Tumor, Solid Carcinoma, Advanced Cancer
- Trial name
- NCT05500508
- Testing
- AMXT1501, DFMO
- Where
- 7 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Aminex Therapeutics, Inc.