Clinical trials: Colon Rectal Resection, open to volunteers
Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome
ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens
OBJECTIVE Low anterior resection syndrome (LARS) is a term for functional bowel complaints occurring after low anterior resection.
- Conditions
- Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome, Rectal Resection, Low Anterior Resection
- Trial name
- ProLARS (NCT07339904)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Rectal Cancer, Fecal Incontinence and Constipation
Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome
Low Anterior Resection Syndrome (LARS) is a common complication after sphincter-preserving rectal cancer surgery and may negatively affect bowel function and quality of life.
- Conditions
- Rectal Cancer, Fecal Incontinence and Constipation, Aerobic Exercise, Guided Imagery Exercise
- Trial name
- NCT07732894
- Testing
- Exercise, guided imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Biruni University
Colorectal Cancer
Partial Liver Segment 2/3 Transplantation Study
The patients will receive hepatectomy as a 2 stage procedure. In the first surgical procedure liver segments 2-3 are removed and liver donor segments 2-3 inserted.
- Trial name
- NCT02215889
- Testing
- Liver transplantation
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Trial name
- Treatable (NCT06274190)
- Testing
- bowel e-diary
- Where
- Belgium
- Volunteers
- 158 people
- Sponsor
- KU Leuven
Colorectal Polyp, Colon Adenoma
Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
- Conditions
- Colorectal Polyp, Colon Adenoma, Colon Cancer
- Trial name
- NCT05041478
- Testing
- Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Western Sydney Local Health District
Ovarian Cancer, Low Anterior Resection Syndrome
Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer
This study aims to evaluate the incidence of low anterior resection syndrome and quality of life after cytoreductive surgery for advanced ovarian cancer patients.
- Conditions
- Ovarian Cancer, Low Anterior Resection Syndrome, Quality of Life
- Trial name
- LAPSODY (NCT05431530)
- Testing
- Cytoreductive surgery
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Colorectal Neoplasms, Diverticular Diseases
Endoscopic Ultrasound- Guided Hartmann Reversal Procedure
The goal of this clinical trial is to learn about clinical usefulness endoscopic gastrointestinal anastomoses to restore the gastrointestinal continuity in patients with permanent colostomy after Hartmann procedure.
- Conditions
- Colorectal Neoplasms, Diverticular Diseases, Inflammatory Bowel Diseases
- Trial name
- EndoHARP (NCT06061432)
- Testing
- Endoscopic restoration of gastrointestinal continuity after Hartmann procedure
- Volunteers
- 100 people
- Sponsor
- Nicolaus Copernicus University
Endometriosis, Deep Endometriosis
The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma
The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma.
- Conditions
- Endometriosis, Deep Endometriosis, Bowel Endometriosis, Colorectal Carcinoma
- Trial name
- NCT07386431
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Colo-rectal Cancer, Colo-rectal Surgery
Post Operative Hospital at Home After Colorectal Surgery
The goal of this feasibility study is to investigate whether a virtual Hospital at Home is safe and possible for patients undergoing planned minimally invasive colorectal surgery.
- Conditions
- Colo-rectal Cancer, Colo-rectal Surgery, Colocolic and Ileocolic Anastomosis, Colon and/or Rectal Resection With Anastomosis for Cancer
- Trial name
- POPHaH (NCT07113717)
- Testing
- virtual Hospital at Home
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Nordsjaellands Hospital
Right-sided Colon Cancer, Colon Adenocarcinoma
Comparison of Laparoscopic and Open Total Mesocolic Excision With Central Vascular Ligation for Right Colon Carcinoma
The goal of this observational comparative study is to assess whether laparoscopic complete mesocolic excision with central vascular ligation (L-CME with CVL) provides improved short-term surgical outcomes compared with open…
- Conditions
- Right-sided Colon Cancer, Colon Adenocarcinoma, Colorectal Neoplasms
- Trial name
- NCT07361016
- Testing
- right hemicolectomy laparoscopic surgery, open rt hemicolectmy
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Colorectal Anastomosis, Left-sided Colon Resection
Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in…
- Conditions
- Colorectal Anastomosis, Left-sided Colon Resection, Anastomotic Leak, Anastomotic Complication
- Trial name
- SECURE (NCT07351071)
- Testing
- Signia™ circular stapler with Tri-Staple™ Technology (Signia™ Circular Stapling system)
- Where
- 10 sites in United States
- Volunteers
- 137 people
- Sponsor
- Medtronic - MITG
Low Rectal Cancer, Rectal Neoplasms
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing…
- Conditions
- Low Rectal Cancer, Rectal Neoplasms, Colorectal Cancer
- Trial name
- NCT07346534
- Testing
- Reinforced Anastomotic Suturing (8-10 Interrupted Sutures), Conventional Laparoscopic Dixon Procedure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Low Anterior Resection Syndrome, Rectal Cancer
The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer, Insomnia, Sleep Disorder
- Trial name
- TraLARS (NCT06222255)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Colon Cancer Metastatic
NIMBLE-CRC: NeoImmunoModulation Before Leveraging Excision in Colorectal Rectal Cancer
This is a Phase II, single-arm, open-label trial evaluating the feasibility, safety, and preliminary activity of neoadjuvant Zanzalintinib (a VEGFR-targeting TKI) and Retifanlimab (an anti-PD-1 antibody) in patients with…
- Trial name
- NIMBLE (NCT07677579)
- Testing
- Retifanlimab, Zanzalintinib
- Volunteers
- 26 people
- Sponsor
- Northwell Health
Gastroenterology, LARS - Low Anterior Resection Syndrome
A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients
The purpose of this post-market clinical follow up study is to assess the efficacy on clinical symptoms of LARS of low volume Transanal Irrigation by MiniGo in conjunction with conservative treatment versus conservative treatment…
- Conditions
- Gastroenterology, LARS - Low Anterior Resection Syndrome, Rectal Cancer
- Trial name
- MINIGO (NCT06923150)
- Where
- 9 sites in France
- Volunteers
- 78 people
- Sponsor
- Qufora A/S
Rectal Cancer
Timing to Minimally Invasive Surgery After Neoadjuvant Chemoradiotherapy for Rectal Cancer
The trial is a multicenter, prospective, randomized controlled, unblinded, parallel-group trial comparing standard and delayed surgery after neoadjuvant chemoradiotherapy for the curative treatment of rectal cancer.
- Trial name
- TiMiSNAR (NCT03465982)
- Testing
- Surgery after 8 weeks from chemoradiation treatment, Surgery after 12 weeks from chemoradiation treatment
- Where
- 14 sites in Italy
- Volunteers
- 340 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery
Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance
The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection.
- Conditions
- LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery, Rectal Cancer, Quality of Life (QOL)
- Trial name
- iRECOVER (NCT06936774)
- Testing
- Intensified follow-up program
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Colorectal Neoplasm, Endoscopic Mucosal Resection
ESD for Colorectal LSL Using a Selective Strategy - a Prospective Cohort Study
Colonic Laterally spreading lesions (LSL) => 20mm are at high risk to progress to cancer. Overt stigmata of submucosal invasive cancer (SMIC) has been well characterized and includes ulceration and surface pit pattern changes as…
- Trial name
- COVERT (NCT04008407)
- Testing
- Endoscopic Submucosal Dissection, Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 391 people
- Sponsor
- Western Sydney Local Health District
Postoperative Complications
Bioelectrical Response to Preoperative Hydration in Colorectal Surgery
This single-center study will evaluate whether short-term changes in bioelectrical impedance measurements after a standardized preoperative intravenous fluid infusion can help predict complications following elective colon or…
- Trial name
- BIA-HYD-CRC (NCT07823530)
- Testing
- Ionolyte Balanced Isotonic Crystalloid
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University Hospital of Split
Colorectal Cancer
Fruquintinib Combined With Capecitabine as Adjuvant Extended Therapy After R0 Resection and Perioperative Chemotherapy in Patients With Liver-Only Metastatic Colorectal Cancer
Colorectal cancer (CRC) is among the most common malignancies in China, and approximately half of all patients develop liver metastases.
- Trial name
- NCT07885384
- Testing
- Fruquintinib Combined With Capecitabine, Follow-up observation
- Volunteers
- 140 people
- Sponsor
- West China Hospital