Clinical trials: Colon Resection
Polyp of Colon
The Non-Optical Resect and Discard Study (NORD)
Eliminating the need for conventional histopathological assessment of diminutive colon polyps - The Non-Optical Resect and Discard (NORD) study
- Trial name
- NORD (NCT04032912)
- Testing
- iScan
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Low Anterior Resection Syndrome
Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery
A randomized controlled trial (RCT) in patients who underwent sphincter preserving surgery due to rectal cancer. The study will analyze the effect of Transanal irrigation (TAI) and medication that can help control of the bowel…
- Trial name
- NCT03215017
- Testing
- Transanal irrigation, Medication
- Where
- 3 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Mirna Abraham-Nordling
Hypotension, Fluid Therapy
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery.
- Trial name
- NCT03215797
- Testing
- phenylephrine, Norepinephrine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Preoperative, Sleep Disturbance
Preoperative Oral Midazolam to Postoperative Pain Relief in Sleep Disturbance or Anxiety Patients With Colorectal Cancer
Previous studies have indicated a high incidence of sleep disturbances and anxiety symptoms in individuals with colorectal cancers prior to undergoing surgery, leading to worsened postoperative pain, slower recovery, and higher…
- Conditions
- Preoperative, Sleep Disturbance, Anxiety, Midazolam
- Trial name
- POMPPR (NCT06407518)
- Testing
- Midazolam oral solution
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer
Compression Anastomosis For Low Anterior Resection in Previously Radiated Patients Using the CAR™ 27
The purpose of this study is: Evaluation of the safety and effectiveness of the Compression Anastomosis Ring (CAR™ 27) device for creation of circular, colorectal anastomoses in previously radiated patients.
- Trial name
- NCT01056796
- Testing
- CAR™ 27
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Niti Medical Technologies Ltd.
Colon Rectal Resection
A Prospective Randomized Controlled Study of Natural Orifice Medium-low Rectal Endometriosis Resection
To evaluate the postoperative outcome of low medium-low rectal endometriosis: Natural orifice surgery VS transabdominal surgery.
- Trial name
- NCT01911962
- Testing
- transvaginal laparoscopic surgery
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Liver Transplant Surgery, Colorectal Cancer Metastatic
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM).
- Conditions
- Liver Transplant Surgery, Colorectal Cancer Metastatic, Colon Cancer Liver Metastases
- Trial name
- CLEAR (NCT06698146)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Neoplasms
A Study of ADH300004 in Surgically Resected Primary or Metastatic Colorectal Cancer and Liver Biopsy, or Planned Hepatic Resection
5 fluorouracil (5 FU), one of the most actively investigated anti-cancer drugs, is rapidly inactivated by the enzyme dihydropyrimidine dehydrogenase (DPD). ADH300004 blocks DPD.
- Trial name
- NCT00264446
- Testing
- ADH300004
- Where
- United States
- Sponsor
- Adherex Technologies, Inc.
Colon Cancer
Non-microradical Resection Margin as a Predictor for Recurrence After Complete Mesocolic Excision
The study aim to investigate the value of the current definition of microradical resection margin in colon cancer. Is the distance from tumor tissue to resection margin and the site of any clinically prognostic importance if…
- Trial name
- NCT04395534
- Testing
- Complete mesocolic excision
- Volunteers
- 276 people
- Sponsor
- Claus Anders Bertelsen, PhD, MD
Colorectal Cancer
Celecoxib Combined With Fluorouracil and Leucovorin in Treating Patients With Resected Stage III Adenocarcinoma (Cancer) of the Colon
RATIONALE: Drugs used in chemotherapy, such as fluorouracil and leucovorin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00085163
- Testing
- celecoxib, fluorouracil, leucovorin calcium
- Where
- 36 sites in Austria, Belgium and 1 more
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Neoplasms, Neoplasm Metastasis
New Adjuvant Chemotherapy of Asymptomatic Resectable Primary Lesion With Unresectable Liver-limited Metastases
To evaluate the survival benefit of pre-operation chemotherapy of primary tumor tesection (PTR) compared upfront PTR for colorectal cancer (CRC) patients with an asymptomatic resectable primary tumor and synchronous unresectable…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Liver Neoplasms, Chemotherapy; Maternal, Affecting Fetus
- Trial name
- NCT01307878
- Testing
- chemotherapy ± targeted therapy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Fudan University
Low Anterior Resection Syndrome
Effect of Gelsectan® in the Treatment of Low Anterior Resection Syndrome
Low Anterior Resection Syndrome (LARS) is an intestinal disorder affecting patients undergoing rectal resection for rectal cancer.
- Trial name
- GeLAR (NCT06162143)
- Testing
- Gelsectan®
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Istituto Clinico Humanitas
Colonic Polyp, Colonic Neoplasms
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
The investigators want to verify in a randomised trial, the effectiveness of EndoClotTM in preventing post-procedural bleeding after EMR (Endoscopic Mucosal Resection) or ESD (Endoscopic Submucosal Dissection) for sessile lesions…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT02688699
- Testing
- EndoClot
- Volunteers
- 288 people
- Sponsor
- University of Turin, Italy
Colon Cancer
Complete Mesocolic Excision With Central Vessel Ligation Compared With Conventional Surgery for Colon Cancer
The aim of this study is to compare between complete mesocolic excision with central vascular ligation and conventional surgery of colon cancer regarding number of harvested lymph nodes, surgical outcome and complications.
- Trial name
- NCT02526836
- Testing
- Conventional Surgery, Complete mesocolic excision with central vascular ligation
- Where
- 2 sites in Egypt, Italy
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Rectum Cancer, Faecal Incontinence
Exploring the Effect of Colonic J-pouch in Anorectal Preservation Surgery for Ultra-low Rectal Cancer.
The occurrence of colorectal cancer has increased from the third most common cancer in 2018 to the second most common cancer in 2023.
- Conditions
- Rectum Cancer, Faecal Incontinence, Faecal Incontinence with Faecal Urgency, Low Anterior Resection Syndrome
- Trial name
- NCT06601985
- Testing
- J-pouch anastomosis, direct anastomosis
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Shanghai 10th People's Hospital
Colorectal Cancer
Evaluation of NiTi Shape Memory End-to-End Compression Anastomosis Ring (CAR) for Compression Anastomosis in Anterior Resection
The purpose of this study is to evaluate the safety and effectiveness of the NiTi CAR device in the creation of colorectal anastomosis
- Trial name
- NCT00468416
- Testing
- Compression Anastomosis Ring (CAR)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colon Cancer
Comparison of D2 vs D3 Lymph Node Dissection for Right Colon Cancer (RICON)
Comparing different method of surgical technique D2 lymph node dissection vs D3 for right colon cancer.
- Trial name
- NCT03200834
- Testing
- Right Hemicolectomy with D2 lymph node dissection, Right Hemicolectomy with D3 lymph node dissection
- Where
- Ukraine
- Volunteers
- 239 people
- Sponsor
- G.V. Bondar Republican Cancer Center
Colon Adenoma, Colon Polyp
The Australian Colonic Large Sessile Lesion Endoscopic Resection Study
A prospective, multicentre, observational study of all patients referred for endoscopic resection of sessile colorectal polyps sized ≥20 mm conducted with intention to treat analysis
- Trial name
- ACE (NCT03471793)
- Where
- Australia
- Volunteers
- 5,000 people
- Sponsor
- Western Sydney Local Health District
Sigmoid Diverticulosis, Sigmoid Diverticulitis
Feasibility, Safety and Outcome of Transrectal Hybrid-NOTES Anterior Resection
Natural orifice transluminal endoscopic surgery has become an important topic. NOTES access routes give the opportunity to reduce surgical access trauma leading to a more painless surgery and enhancing a fast postoperative…
- Conditions
- Sigmoid Diverticulosis, Sigmoid Diverticulitis, Colon Adenoma, Rectal Prolapse
- Trial name
- NCT01992406
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Cantonal Hospital, Baselland
Colorectal Neoplasms
Anti-OX40 Antibody (MEDI6469) in Patients With Metastatic Colorectal Cancer
This study will test the ability of an immune modulator, anti-OX40 (MEDI6469) to alter the immune cell environment within colorectal cancer metastases. The drug will be administered to patients before surgical treatment.
- Trial name
- NCT02559024
- Testing
- MEDI6469
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Providence Health & Services