Clinical trials: Colonic Adenomatous Polyps
Colorectal Cancer, Colorectal Adenomatous Polyp
Stool-based SDC2 DNA Methylation Test for the Detection of Colorectal Advanced Adenomatous Polyps and Cancer
The primary objective is to compare the performance of Stool-based SDC2 DNA Methylation Test and commercially available Fecal Immunochemical Test(FIT) , on the detection rate of advanced adenomatous polyps and colorectal cancer…
- Conditions
- Colorectal Cancer, Colorectal Adenomatous Polyp, Screening
- Trial name
- NCT04221854
- Testing
- Stool-based SDC2 DNA methylation test, Fecal immunochemical test
- Where
- 8 sites in China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Polyp, Adenomatous, Colo-rectal Cancer
Computer Aided Detection of Polyps in the Colon
The purpose of this study is to examine the role of an automatic polyp detection software (henceforth referred to as the research software) as a support system during colonoscopy; a procedure during which a physician uses a…
- Trial name
- NCT03925337
- Testing
- Computer Aided Diagnostic Software
- Where
- 4 sites in United States
- Volunteers
- 234 people
- Sponsor
- Beth Israel Deaconess Medical Center
Familial Adenomatous Polyposis, FAP
Turmeric Supplementation on Polyp Number and Size in Patients With Familial Adenomatous Polyposis.
A Phase 2, randomized, double blind, placebo controlled trial for the effectivness of wholistic turmeric supplementation on polyp burden mong patients with Familial Adenomatouse Polyposis (FAP).
- Conditions
- Familial Adenomatous Polyposis, FAP, FAP Gene Mutation
- Trial name
- NCT03061591
- Testing
- Wholistic Turmeric capsules
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colorectal Anastomosis, Endometrial
Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion
There are many indications for performing a fecal diversion stoma. In both scheduled and emergency situations, and whatever the context (indication or type of fecal diversion stoma), stomal complications can occur early (10-60%)…
- Conditions
- Colorectal Anastomosis, Endometrial, Anastomotic Leak Rectum, Ulcerative Colitis (Disorder)
- Trial name
- RESTODIG (NCT06881303)
- Testing
- preoperative stoma identification and education
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Colonic Polyps, Adenomatous Polyps
Traction Assisted Polypectomy of the Intestine
The purpose of the study is to verify if the ablation of lesions (polyps, adenomas) in the large (and small) intestine can be facilitated by using a traction on the lesions.
- Trial name
- TAEMR (NCT00966420)
- Testing
- traction assisted endoscopic mucosa resection
- Where
- Austria
- Volunteers
- 7 people
- Sponsor
- St John of God Hospital, Vienna
Lynch Syndrome
PD-1 Antibody for The Prevention of Adenomatous Polyps and Second Primary Tumors in Lynch Syndrome Patients
This study aims to explore the role of PD-1 Antibody in preventing adenomatous polyps and second primary tumors in patients with Lynch Syndrome.
- Trial name
- NCT04711434
- Testing
- PD-1 Antibody
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Sun Yat-sen University
Adenomatous Polyposis Coli
Sirolimus and Familial Adenomatous Polyposis (FAP)
The aim of the study is to investigate the effect of sirolimus on the progression of intestinal adenomas in patients with FAP and to assess the safety of this treatment.
- Trial name
- NCT03095703
- Testing
- Sirolimus
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Polyps
Prevalence of Small Bowel Polyps in Patients With Sporadic Duodenal Adenomas
Little is known about the prevalence of small bowel polyps in patients with sporadic Duodenal/Ampullary polyps. The investigators aim to investigate the prevalence of small bowel polyps in patients with sporadic (ie not related…
- Trial name
- SPIDA (NCT02470416)
- Testing
- Small bowel video capsule endoscopy (VCE) GIVEN/COVIDIEN LTD
- Where
- Australia
- Volunteers
- 177 people
- Sponsor
- Western Sydney Local Health District
FAP-Familial Adenomatous Polyposis
Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis
Colorectal cancer (CRC) is a leading cause for cancer related mortality in the western world with a lifetime risk of 6%. Etiology is complex, while genetic background significantly affects the risk.
- Trial name
- NCT02175914
- Testing
- Erythromycin
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- michal roll
Adenomatous Polyposis Coli
A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients
The purpose of this study is to determine in a randomized, placebo-controlled, phase II trial if the combination of sulindac and erlotinib causes a significant regression of duodenal and colorectal adenomas in familial…
- Trial name
- FAPEST (NCT01187901)
- Testing
- Erlotinib, Sulindac
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Utah
Colorectal Cancer, Precancerous Condition
S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000
RATIONALE: Studying tissue samples in the laboratory from participants receiving treatment on the Selenium and Vitamin E Cancer Prevention Trial (SELECT) SWOG-S0000 may help doctors predict a participant's response to treatment…
- Trial name
- ACP (NCT00706121)
- Testing
- Vitamin E, Selenium
- Where
- United States
- Volunteers
- 8,094 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Colorectal Adenomatous Polyps
Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
The study team has developed a set of biomarkers of risk for colon cancer; this study tests 1) whether or not calcium and/or vitamin D supplementation can favorably affect these biomarkers in persons who are at higher than…
- Trial name
- PPS4B (NCT00399607)
- Testing
- Rectal biopsy during colonoscopy, Rectal biopsy at randomization, Rectal biopsy at 1 year
- Where
- 9 sites in United States
- Volunteers
- 264 people
- Sponsor
- Emory University
Adenocarcinoma of Colon Recurrent
Estrogen Receptor Beta Agonists (Eviendep) and Polyp Recurrence
The decreased Estrogen Receptor beta (ERβ) expression in the non adenomatous mucosa of ApcMin/+ mice favours intestinal neoproliferation.
- Trial name
- CRC (NCT01402648)
- Testing
- Eviendep (CM&D Pharma Limited, UK), Maltodextrins
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- CM&D Pharma Limited
Colonic Polyps, Adenomatous Polyps
Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate, but considering the long…
- Conditions
- Colonic Polyps, Adenomatous Polyps, Adenoma Detection Rate, Chromoendoscopy
- Trial name
- NCT06961149
- Testing
- Chromoendoscopy with indigo carmine solution spray, Linked-color imaging endoscopy
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Shandong University
Adenomatous Polyp, New Imaging Techniques in Colonoscopy
Narrow Band Imaging Colon Polyp Study
In this study the investigators hypothesize that High Definition White Light colonoscopy and narrow band imaging (NBI) will detect a higher number of adenomas compared to standard definition white light colonoscopy.
- Trial name
- NCT00614770
- Testing
- standard of care colonoscopy, colonoscopy
- Where
- 2 sites in United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Kansas City Veteran Affairs Medical Center
Colorectal Cancer, Colon Cancer
Pilot Study of Colon Cancer Screening Tests
Colon cancer is the second leading cause of cancer death in North America. These deaths are preventable with proper screening. Fecal occult blood testing, virtual colonoscopy, and standard (optical) colonoscopy are all options…
- Conditions
- Colorectal Cancer, Colon Cancer, Adenomatous Polyps
- Trial name
- NCT00865527
- Testing
- Fecal occult blood test, Virtual colonoscopy, Optical colonoscopy
- Where
- Canada
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Colonic Polyps, Adenomatous Polyps
Practice-Based Learning to Predict Polyp Histology at Colonoscopy
Most colorectal cancers arise from polyps. Most polyps removed at colonoscopy are small. New technologies such as narrowband imaging (NBI) offer the possibility of in differentiation between precancerous and unimportant small…
- Trial name
- NCT01638091
- Testing
- Ex vivo module, In vivo practice-base learning phase
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colonic Polyps, Adenomatous Polyps
Impact of Indigo Carmine Pump Spraying on the Adenoma Detection Rate
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate.
- Conditions
- Colonic Polyps, Adenomatous Polyps, Adenoma Detection Rate, Chromoendoscopy
- Trial name
- NCT06596317
- Testing
- Chromoendoscopy, Conventional colonoscopy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shandong University