Clinical trials: Colonic Dysplasia
Inflammatory Bowel Diseases, Colon Dysplasia
High Definition Colonoscopy (HDC) vs. Dye Spraying Chromo-colonoscopy (DSC) in Screening Patients With Long-standing Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease (IBD) involving the colon is a known risk for colon cancer. There are two standards-of-care colonoscopy techniques used for screening all patients who suffer from IBD for more than eight years.
- Conditions
- Inflammatory Bowel Diseases, Colon Dysplasia, Ulcerative Colitis, Crohn Colitis
- Trial name
- NCT04191655
- Testing
- High Definition Colonoscopy, Dye Spraying Chromocolonoscopy
- Where
- 2 sites in United States
- Volunteers
- 211 people
- Sponsor
- Beth Israel Deaconess Medical Center
Colorectal Dysplasia, Colorectal Neoplasms
CAD EYE Detection of Remaining Lesions After EMR
In the last decade, many innovative systems have been developed to support and improve the diagnosis accuracy during endoscopic studies.
- Trial name
- NCT05542030
- Testing
- EMR with CAD-Eye™, EMR without CAD-Eye™, Follow-up colonoscopy with CAD-Eye™
- Where
- Ecuador
- Volunteers
- 60 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Ulcerative Colitis
Comparison Between Chromoendoscopy and Virtual Chromoendoscopy (NBI, I-scan, FICE) for Detection of Neoplasia in Long Standing Ulcerative Colitis
The risk for colon cancer in patients with longstanding ulcerative colitis exceeding the rectum is increased and therefore patients should be enrolled in a surveillance program eight years after the diagnosis.
- Trial name
- NCT01882205
- Testing
- Virtual chromoendoscopy, Chromoendoscopy
- Where
- 5 sites in Belgium, Canada and 2 more
- Volunteers
- 402 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Ulcerative Colitis, Intraepithelial Neoplasia
Chromoscopic Guided Endomicroscpy to Diagnose Colitis Associated Dysplasia
Timely diagnosis of intraepithelial neoplasias (premalignant condition)is of crucial importance for clinical management of ulcerative colitis.
- Conditions
- Ulcerative Colitis, Intraepithelial Neoplasia, Cancer
- Trial name
- NCT00352404
- Testing
- Endomicroscope
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Johannes Gutenberg University Mainz
Colorectal Adenoma, Colorectal Carcinoma
Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps
This randomized phase II clinical trial studies how well MUC1 peptide-poly-ICLC adjuvant vaccine works in treating patients with newly diagnosed advanced colon polyps (adenomatous polyps).
- Conditions
- Colorectal Adenoma, Colorectal Carcinoma, Colorectal Conventional Adenoma With Severe Dysplasia, Colorectal Tubulovillous Adenoma
- Trial name
- NCT02134925
- Testing
- Laboratory Biomarker Analysis, MUC1 Peptide-Poly-ICLC Vaccine, Quality-of-Life Assessment
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 110 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms, Hereditary Nonpolyposis
Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance
The purpose of this study is to determine whether a new colonoscopic viewing technique called narrow band imaging (NBI)can help doctors detect more patients with at least one pre-cancerous area than conventional colonoscopy using…
- Trial name
- NCT00313755
- Testing
- Narrow Band Imaging
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- London North West Healthcare NHS Trust
Barrett's Esophagus, Intestinal Dysplasia
Endoscopic Sub-mucosal Dissection With the Nestis® Jet Injector System With a Bi-functional Catheter: First Prospective Trial
ESD (Endoscopic Sub-mucosal Dissection)is the first-intent method to treat superficial neoplasms of the digestive tract at it allows an en-bloc R0 resection.
- Conditions
- Barrett's Esophagus, Intestinal Dysplasia, Esophageal Dysplasia, Colorectal Neoplasms
- Trial name
- NESTIS (NCT01913223)
- Testing
- Nestis® jet injector system with a bi-functional catheter
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hospices Civils de Lyon
Colon Carcinoma, Dysplasia in Crohn Disease
Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia
This pilot, randomized phase I/II trial studies how well inositol works in preventing colorectal cancer in patients with abnormal cells (dysplasia) associated with inflammation of the colon (colitis).
- Conditions
- Colon Carcinoma, Dysplasia in Crohn Disease, Low Grade Dysplasia in Ulcerative Colitis, Rectal Carcinoma
- Trial name
- NCT01111292
- Testing
- Inositol
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Ulcerative Colitis, Dysplasia
Artificial Intelligence and Dysplasia Detection in Ulcerative Colitis (CUDISIA Study)
Prospective clinical study that analyzes the efficacy of colonoscopy assisted by an artificial intelligence system (DiscoveryTM) compared to virtual chromoendoscopy with iSCAN in the detection of colon dysplasia in patients with…
- Trial name
- CUDISIA (NCT05171634)
- Testing
- DiscoveryTM, iSCAN
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Colorectal Cancer, Colorectal Neoplasms
Investigating the Use of Fluorescent Lectins to Identify Dysplasia and Cancer During Endoscopy and Surgery
This is a feasibility study investigating the use of a fluorescently conjugated lectin to identify colorectal dysplasia and cancer during colonoscopy and surgery.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp
- Trial name
- NCT03070613
- Testing
- Fluorescent Lectin Application
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Oxford
Rare Diseases, Amyloidosis
Institutional Registry of Rare Diseases
The goal of this observational study is to create a single macro registry system with data collection on common clinical features, grouping the different rare diseases (RD).
- Conditions
- Rare Diseases, Amyloidosis, Sarcoidosis, Phacomatosis
- Trial name
- NCT06573723
- Where
- Argentina
- Volunteers
- 380 people
- Sponsor
- Hospital Italiano de Buenos Aires
Inflammatory Bowel Disease, Crohn's Disease
The Value of I-Scan and Confocal Laser Endomicroscopy for the Assessment of Chronic Inflammatory Bowel Disease
Recently, Confocal Laser Endomicroscopy (CLE) has been developed as a novel technique that actually enables in vivo microscopic analysis of the gastrointestinal tract, during ongoing endoscopy.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis, Dysplasia
- Trial name
- I-Scan-CLE-IBD (NCT02481687)
- Testing
- Confocal laser endomicroscopy
- Where
- Romania
- Volunteers
- 15 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Colonic Polyp, Colonic Neoplasms
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
The investigators want to verify in a randomised trial, the effectiveness of EndoClotTM in preventing post-procedural bleeding after EMR (Endoscopic Mucosal Resection) or ESD (Endoscopic Submucosal Dissection) for sessile lesions…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT02688699
- Testing
- EndoClot
- Volunteers
- 288 people
- Sponsor
- University of Turin, Italy
Colorectal Cancer
COLON-IM : Microbiota and Immune Infiltrate in Normal, Dysplastic and Neoplastic Colorectal Tissue
The primary objective of COLON-IM is to describe colorectal tissue microenvironment (neutrophils infiltrate) of patients with benign or malignant colorectal lesion (from stage I to III according to Tumor Node Metastasis (TNM)/…
- Trial name
- NCT03841799
- Where
- 3 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Leon Berard
Inflammatory Bowel Diseases, Colonic Neoplasms
IBD Neoplasia Surveillance Pilot RCT
To determine if random biopsies can be safely eliminated from screening of average risk persons with IBD, the investigators propose to carry out a pilot randomized control trial in which targeted biopsies in combination with…
- Conditions
- Inflammatory Bowel Diseases, Colonic Neoplasms, Dysplasia
- Trial name
- IBDDysplasia (NCT04067778)
- Testing
- Intervention Group, Control Group
- Where
- 12 sites in Canada
- Volunteers
- 600 people
- Sponsor
- Ottawa Hospital Research Institute
Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst
The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
The long-term goal of our PIC is to develop effective strategies that can be applied clinically at the point-of-care to prevent, intercept, or detect PDAC at an early stage, thereby reducing PDAC burden and saving lives.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst, Chronic Pancreatitis, Fatty Pancreas
- Trial name
- NCT05692596
- Testing
- Data collection
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Ulcerative Colitis, Crohn's Colitis
Chromoendoscopy for Dysplasia Detection in Chronic Inflammatory Bowel Disease
Patients with longstanding ulcerative colitis or crohn's disease in the large bowel have an increased risk of developing cancer.
- Trial name
- NCT01505842
- Testing
- Colonoscopy with Indigo-Carmine chromoendoscopy, Conventional white-light colonoscopy
- Where
- Sweden
- Volunteers
- 304 people
- Sponsor
- Karolinska University Hospital