Clinical trials: Colonic Inflammation
Inflammatory Bowel Diseases, Colitis, Ulcerative
Study of Relationship Between Vedolizumab Therapeutic Drug Monitoring, Biomarkers of Inflammation and Clinical Outcomes
The purpose of this study is to determine if a relationship exists between Week 6 vedolizumab therapeutic drug monitoring (TDM) and Week 30 Faecal calprotectin (FCP).
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- VEDO TDM RWE (NCT04567628)
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 7,873 people
- Sponsor
- Takeda
Ulcerative Colitis
Mini-MARVEL - Mitochondrial Antioxidant Therapy in Ulcerative Colitis
Mini-MARVEL study, children and young people with an active flare of UC requiring either the start of or an increase in existing mesalazine therapy will be given either MitoQ or placebo as a daily capsule for 24 weeks in the…
- Trial name
- Mini-MARVEL (NCT05539625)
- Testing
- MitoQ
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Irritable Bowel Syndrome
Genetic Contribution of Pain and Inflammation in IBS
The goal of the study is to identify possible polymorphisms on the loci of candidate genes that may be involved in modulation of pain and inflammation in irritable bowel syndrome.
- Trial name
- NCT01436760
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Florida
Colorectal Cancer
Effects of Weight on Inflammation and Colon Cancer Risk
An observational study designed to compare colonic cytokine concentrations in lean versus obese individuals
- Trial name
- NCT02884024
- Testing
- no intervention
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Tufts University
Colorectal Cancer, Resistance
Chronic Inflammation, Plasma Proteins Signature, Survival Outcomes and Clinical Response, in Patients Receiving Bevacizumab Combined With Oxaliplatin-based Chemotherapy (Bev/OX) or Bevacizumab Combined With Irinotecan-based Chemotherapy (Bev/IRI)
Cancer-derived inflammation attenuates the efficacy of adjuvant chemotherapy (CT) in postoperative or metastatic colorectal cancer (mCRC).
- Conditions
- Colorectal Cancer, Resistance, Bevacizimab, Inflamation
- Trial name
- NCT07241403
- Where
- China
- Volunteers
- 698 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Inflammatory Bowel Diseases, Crohn Disease
Thermal Measurements of the Gut With a Colonoscope Compatible Thermal Probe
The goal of this clinical trial is to use a modified thermal probe to measure temperature rise in the colonic mucosa of participants with inflammatory bowel disease, Crohn's disease, and/or ulcerative colitis.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT07352995
- Testing
- Feasibility of using a thermal probe to measure temperature rise in colonic mucosa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer
Inflammation Biomarkers in the Diagnosis of Postoperative Infectious Complications in Colorectal Cancer Surgery
This is a longitudinal, single-center, prospective study to determine the efficiency of WBC Count, CRP, PCT, Neutrophil CD64 and Monocyte Human Leukocyte Antigen- DR in the diagnosis of postoperative infectious complications in…
- Trial name
- NCT03559335
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Irritable Bowel Syndrome (IBS)
Confocal Endomicroscopy Utility (p-CLE) in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. It has prevalence in general population of 5-20% and is more common in women and young adults.
- Trial name
- NCT02651532
- Testing
- Confocal Laser Endomicroscopy
- Where
- Ecuador
- Volunteers
- 74 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Cancer-related Fatigue
The Effects of a Food Product Containing Mushroom Extracts (AndoSanTM) in Subjects With Colorectal Cancer-related Fatigue
Effects of a food product containing mushroom extracts (AndoSanTM) in subjects with colorectal cancer-related fatigue. AndoSanTM is a specialized liquid food product that includes fermented extracts from the fungi Agaricus…
- Trial name
- NCT06599710
- Testing
- AndoSanTM
- Where
- 3 sites in Germany
- Sponsor
- Mycotech Pharma AS
IBD (Inflammatory Bowel Disease), Colon Cancer
Microbiota: Its Role in Chronic Inflammation, IDB and Risk of Colorectal Cancer. Evaluation of a Predictive Prognostic Model With Therapeutic Implications
The gut microbiome is emerging as a crucial factor in several intestinal diseases, contributing to the etiopathogenesis of inflammatory disorders.
- Trial name
- NCT07106463
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Messina
Peritoneal Inflammation
Humidification in Laparoscopic Colonic Surgery
Laparoscopic surgery allows surgeons to remove bowel via small incisions. To allow insertion of a camera and instruments, cold and dry gas is blown into the abdominal cavity.
- Trial name
- NCT00642005
- Testing
- Fisher and Paykel Humidifier (MR860), Standard insufflation
- Where
- 3 sites in New Zealand
- Volunteers
- 82 people
- Sponsor
- University of Auckland, New Zealand
Inflammatory Bowel Diseases, Ulcerative Colitis
Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Specific Aim 1: Characterize the effects of vitamin D treatment on expression of α4β7 on B cells in patients with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT04828031
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University
Colorectal Cancer
Protective Role of Alpha-Lipoic Acid in Chemotherapy-Induced Mucositis
Colorectal cancer (CRC) represents one of the most common cancers worldwide and 5-Fluorouracil (5-FU) is still the mainstay of treatment.
- Trial name
- NCT07736495
- Testing
- alpha lipoic acid 600 mg twice daily
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Inflammatory Bowel Disease
The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America.
- Trial name
- EDICT (NCT07143188)
- Testing
- elemental diet (ED)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Stress
Brain-Gut Interactions in Overweight and Normal Weight Patients With Chronic Abdominal Pain
About 15 to 20 percent of individuals living in the United States have chronic abdominal pain, often of unknown origin, which is often difficult to diagnose and treat.
- Conditions
- Obesity, Stress, Irritable Bowel Syndrome, Women
- Trial name
- NCT00824941
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)