Clinical trials: Colonic Lesions
Colorectal Neoplasms
Observation of Microvessels and Invasion in Early Colorectal Lesions by NBI
Combined with magnifying endoscopy,narrow-band imaging (NBI) contrasts microvascular architecture on lesion surface.The histology of early colorectal lesions could be predicted under NBI view.However,its capability for estimating…
- Trial name
- NCT02047188
- Volunteers
- 418 people
- Sponsor
- Xiaobo Li
Irritable Bowel Syndrome
IBS Skin Patch Test Food Allergy Study
Participants with IBS are skin patch tested (no needles) to 80 different foods and food additives, compounded for patch testing, in search of food allergies. The testing requires 3 office visits within a 4 or 5 day period.
- Trial name
- NCT06288672
- Testing
- True avoidance diet
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- IBS-80, LLC
Colonic Adenoma, Colon Polyp
Comparison of the Benefit of Chromoendoscopy in Addition to High Definition White Light and Narrow Band Imaging for the Prediction of Submucosal Invasive Cancer in Colonic Lesions
To compare the incremental benefit of chromoendoscopy in addition to high definition white light and narrow band imaging in predicting submucosal invasion within laterally spreading lesions in the colon and in determining the…
- Conditions
- Colonic Adenoma, Colon Polyp, Submucosal Invasive Colon Adenocarcinoma, Colorectal Cancer
- Trial name
- LANS (NCT03506321)
- Testing
- chromoendoscopy, high definition white light and narrow band imaging
- Where
- Australia
- Volunteers
- 400 people
- Sponsor
- Western Sydney Local Health District
Colo-rectal Cancer
Efficacy of a Hemostatic Agent (PuraStat®) in Reducing Delayed Bleeding After Endoscopic Submucosal Dissection
The problem of delayed bleeding after endoscopic resection is becoming important due to the growing number of indications for anti-aggregation or anticoagulant treatment for cardiovascular reasons in the aging populations.
- Trial name
- NCT05031325
- Testing
- Endoscopic submucosal dissection with Purastat
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Mathieu Pioche
Colon Neoplasm, Malignant, Colo-rectal Cancer
Endoscopic Full-Thickness Resection In Colon
Endoscopic full-thickness resection (EFTR) in the colon using an over-the-scope clip (OTSC) as a closure mechanism is a recent technique that allows the endoscopic resection of colonic lesions that are poor candidates for…
- Conditions
- Colon Neoplasm, Malignant, Colo-rectal Cancer, Colonic Cancer, Colonic Adenoma
- Trial name
- EFTRICOM (NCT03803891)
- Testing
- Endoscopic full-thickness resection
- Where
- 17 sites in Spain
- Volunteers
- 65 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Colon Polyps
Prospective Study of Colonoscopic Resection of Large Polyps and Flat Lesions
With this study, the investigators plan to review the performance of colonoscopic resection of large (> 1 cm) and flat lesions in the colon.
- Trial name
- NCT02332772
- Testing
- Data Collection
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Colorectal Adenoma
FIT and Fecal Calprotectin in Patients With Chronic Lower GI Symptoms
Chronic lower gastrointestinal (GI) symptoms, including lower abdominal pain, bowel habit change, bleeding per rectum, and abdominal bloating, are caused by functional gastrointestinal disorders (FGID) and organic intestinal…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colitis
- Trial name
- NCT05514561
- Testing
- Fecal calprotectin, Fecal immunochemical test
- Where
- Thailand
- Volunteers
- 1,007 people
- Sponsor
- Mahidol University
Colorectal Cancer
Fluorescent Probe VGT-309 to ID Cancerous Colorectal Lesions During Augmented Colonoscopy
The purpose of this study is to determine the safety and feasibility of VGT-309 for the visualization of colorectal tumors in real-time using near-infrared (NIR) fluorescence endoscopy.
- Trial name
- NCT06034197
- Testing
- VGT-309
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stephan Rogalla
Rectal Cancer, Sigmoid Cancer
Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions
Background: Anastomotic leakage (AL) after colorectal surgery remains a significant challenge, associated with increased morbidity, mortality, poor oncological outcomes, and reduced quality of life.
- Conditions
- Rectal Cancer, Sigmoid Cancer, Premalignant Lesion, Colorectal Cancer
- Trial name
- ADAPT (NCT07056374)
- Testing
- C-REX RectoAid Cath
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- Amsterdam UMC, location VUmc
Colorectal Neoplasms, Colorectal Cancer
A Study Comparing Standard and AI-Assisted Colonoscopies for Detecting and Characterizing Colorectal Lesions in Adults Aged 50-74 Undergoing Cancer Screening
The goal of this clinical trial is to determine whether using artificial intelligence (AI) can improve the detection and characterization of abnormal growths (polyps) during colonoscopy in adults aged 50 to 74 years who are…
- Conditions
- Colorectal Neoplasms, Colorectal Cancer, Adenoma Colon Polyp
- Trial name
- NCT07125300
- Testing
- Artificial Intelligence-Assisted Colonoscopy
- Where
- Spain
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Javier Santos Fernández
Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection
Endoscopic Resection of Gastrointestinal Neoplasms
The study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare…
- Conditions
- Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Gastric Neoplasm, Colonic Neoplasms
- Trial name
- NCT04780256
- Testing
- Endoscopic resection
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Polyposis
Endocuff for Surveillance of Serrated Polyposis Syndrome
Serrated Polyposis Syndrome (SPS) is a high-risk condition for colorectal cancer (CRC). SPS patients have a cumulative CRC risk of 1.9% in 5 years despite a strict endoscopic surveillance in specialized centers.
- Trial name
- NCT02592603
- Testing
- Endocuff-assisted Colonoscopy
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- Hospital Clinic of Barcelona
Colonic Polyps
Diagnostic Accuracy of NICE Classification to Predict Deep Submucosal Invasion
The purpose of this study is to evaluate the diagnostic accuracy of NICE classification to predict deep submucosal invasion of colonic polyps > 1 cm, considering histology as the gold standard, in a group of endoscopists who…
- Trial name
- NICE (NCT02328066)
- Testing
- NBI used by trained endoscopists
- Where
- Spain
- Volunteers
- 2,171 people
- Sponsor
- Asociación Española de Gastroenterología
Colorectal Cancer, Polyp of Colon
EAGLE Trial CADDIE Artificial Intelligence Endoscopy
The EAGLE study is a prospective randomized controlled multicenter parallel design trial, for the assessment of clinical performance of the CADDIE device and to confirm that the device performs as expected.
- Conditions
- Colorectal Cancer, Polyp of Colon, Adenoma Colon
- Trial name
- EAGLE (NCT05730192)
- Testing
- Colonoscopy with CADDIE, Standard Colonoscopy
- Where
- 8 sites in Germany, Italy and 2 more
- Volunteers
- 985 people
- Sponsor
- Odin Medical
Colo-rectal Cancer
Safety,Usability and Compliance of Using C-Scan System for Providing Information on Colonic Polypoid Lesions and Masses
Protocol Title: Evaluation of safety, usability and subject compliance while using Check- Cap's C-Scan System for providing structural information on colonic polypoid lesions and masses Study Design: Prospective, Multi-center…
- Trial name
- C-Scan (NCT03735407)
- Testing
- C-Scan procedure
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC)
Narrow Band Imaging Versus Artificial Intelligence for Colonic Surveillance in Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) - ulcerative colitis or Crohn's disease - have a higher risk of developing colorectal cancer than the general population.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC), Crohn's Disease Colon, Colonic Dysplasia/Adenomata
- Trial name
- CLEAR-IBD (NCT07694362)
- Testing
- ENDO-AID CADe System (Olympus, Tokyo, Japan) (AI device)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vall d'Hebron Institute Research
Adenoma
The MORDIS Study Clinical Investigational Plan
To demonstrate the use of WavSTAT4 system during colonoscopy in identifying diminutive colorectal lesions (e.g. hyperplastic polyps) that can be resected and discarded (or even left in-situ) without adverse clinical impact.
- Trial name
- MORDIS (NCT01980134)
- Where
- 6 sites in Czechia, Denmark and 3 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- SpectraScience
Colonic Neoplasms, Colonic Polyps
Strigolactones and Dysplastic Colonic Lesions or Cancer
The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.
- Trial name
- NCT02824835
- Testing
- biopsy during colonoscopy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Colorectal Cancer, Premalignant Colon Lesions
A Mobile Application to Improve the Quality of Colonoscopy in Colorectal Cancer Screening Program (PrepColon APP)
Colonoscopy is the gold standard for the diagnosis and resection of preneoplastic lesions, allowing the prevention of colon cancer.
- Trial name
- PREPCOLON (NCT06314022)
- Testing
- Mobile application for colonoscopy preparation instructions
- Where
- 2 sites in Spain
- Volunteers
- 470 people
- Sponsor
- Hospital del Rio Hortega
Spondyloarthropathies
The Characterization of Small Bowel and Colonic Involvement in Patients With Seronegative Spondyloarthritides
Up to 60% of patients with Seronegative Spondyloarthritides have inflammation in the colon or ileum. This is usually asymptomatic, but in 5 to 10% of patients with SA, Frank IBD will develop.
- Trial name
- SPONDILENDO (NCT00768950)
- Testing
- Capsule endoscopy examination, Colonoscopy
- Where
- Romania
- Volunteers
- 65 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy