Clinical trials: Colonic Neoplasm
Rectal Neoplasms
Development of a Clinical and Biological Database in Rectum Cancer
A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical data to improve knowledge about cancer and help to develope new cancer treatments.
- Trial name
- BCBRectum (NCT04006951)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colorectal Neoplasms
An Endoscopic Barbed-clips Suturing for Colorectal ESD
Endoscopic submucosal dissection (ESD) was developed to allow en bloc resection of colorectal neoplasm. Although colorectal ESD has been widely accepted as a minimally invasive treatment option for early colorectal neoplasm…
- Trial name
- NCT05045911
- Testing
- Endoscopic Barbed-clips Suturing
- Where
- 2 sites in China
- Volunteers
- 35 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Colorectal Polyps
Discard:Characterisation of Colonic Polyps in Vivo
Prospective study of accuracy of colonic polyp characterisation in vivo using high resolution white light endoscopy, narrow band imaging and chromoendoscopy.
- Trial name
- DISCARD (NCT00888771)
- Where
- United Kingdom
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Colorectal Cancer
Oxaliplatin, Leucovorin, and Fluorouracil Before and After Radiation Therapy and Surgery in Treating Patients With Rectal Cancer That Can Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- COPERNICUS (NCT01263171)
- Testing
- Leucovorin, fluorouracil, leucovorin calcium
- Where
- 7 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cardiff University
Harm Reduction, Perforation During Colonoscopy
Fast Track Module Based Colonoscopy Training Programme for Surgical Trainees at North Jutland Surgical Departments
Specially educated trainers will be responsible for colonoscopy training of junior doctors. The educated trainers will have attended seminars held by Valori et al.
- Conditions
- Harm Reduction, Perforation During Colonoscopy, Colorectal Cancer
- Trial name
- NCT02425657
- Testing
- Training of junior doctors
- Where
- 3 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- Aalborg University Hospital
Colorectal Cancer
Studying Lymph Nodes in Patients With Stage II Colon Cancer
RATIONALE: Diagnostic procedures that look for micrometastases in lymph nodes removed during surgery for colon cancer may help doctors learn the extent of disease.
- Trial name
- NCT00949312
- Testing
- RNA marker analysis of lymph node and primary tumors, microarray profiling of primary tumors, reverse transcriptase-polymerase chain reaction of lymph node specimens
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Saint John's Cancer Institute
Liver Metastases, Colorectal Cancer
Study of Adecatumumab Relative to FOLFOX After R0 Resection of Colorectal Liver Metastases
The purpose of this study is to determine the effect of adecatumumab alone or following FOLFOX in patients with R0 resected liver metastases from CRC (colorectal carcinoma) and to compare the effect to FOLFOX alone.
- Trial name
- MT201-204 (NCT00866944)
- Testing
- Adecatumumab, Adecatumumab and FOLFOX, FOLFOX 4
- Where
- 16 sites in France, Germany
- Volunteers
- 35 people
- Sponsor
- Amgen Research (Munich) GmbH
Colonoscopy, Colorectal Cancer Screening
Robotic Colonoscopy Using the Triton 4.0 System in Adults for Screening, Surveillance, and Diagnosis of Lower Gastrointestinal Conditions
This study is a prospective, single-arm, non-randomized, single site first-in-human study and will be conducted in two phases, where Phase A will serve to evaluate the safety of the Triton 4.0 System to perform screening…
- Conditions
- Colonoscopy, Colorectal Cancer Screening, Colorectal Neoplasms, Gastrointestinal Endoscopy
- Trial name
- CARE I (NCT06935734)
- Testing
- Diagnostic Colonoscopy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Neptune Medical
Colorectal Adenomatous Polyps
Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention
Colorectal cancer is the second leading cause of cancer-related death within the United States. Animal models and observational studies have suggested that marine-derived n-3 polyunsaturated fatty acids [PUFA] such as…
- Trial name
- NCT01661764
- Testing
- Eicosapentanoic acid and docosahexanoic acid, Oleic Acid
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Vanderbilt University
Colorectal Carcinoma (CRC)
Patient-led Follow-up from Home After Surgery for Colorectal Carcinoma
The primary goal of the patient-led follow-up from home, is the improvement of quality of life and the reduction of stress in patients, while obtaining a more complete picture of their health status.
- Trial name
- PROMISE (NCT06613581)
- Testing
- Home-based follow-up
- Where
- 5 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Colorectal Cancer
Colorectal Cancer Screening Among Primary Care Physicians of the Swiss Sentinel Surveillance Network
Colorectal cancer (CRC) is the third leading cause of cancer mortality in Switzerland, and kills 1600 people annually. Most deaths could be prevented by screening, but the 2012 Swiss national health survey found that only 40% of…
- Trial name
- NCT03552744
- Testing
- Mailed training intervention
- Where
- Switzerland
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Bern
Colorectal Cancer
A Study of Avastin (Bevacizumab) and Oxaliplatin Plus Xeloda (Capecitabine) in Patients With Advanced Colorectal Cancer.
This study will assess the efficacy and safety of treatment with the combination Avastin (bevacizumab) 5mg/kg iv every 2 weeks, Xeloda (capecitabine) 1000 mg po b.i.d.
- Trial name
- NCT01159171
- Testing
- bevacizumab [Avastin], capecitabine [Xeloda], oxaliplatin
- Where
- 6 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Metastatic Colorectal Cancer, Advanced Colorectal Cancer
Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer
RBS2418 is a specific immune modulator that works through the inhibition of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and is designed to lead to anti-tumor immunity by protecting endogenous 2'-3'-cyclic guanosine…
- Trial name
- VISTA-1 (NCT06824064)
- Testing
- RBS2418
- Where
- 5 sites in United States, Puerto Rico and 1 more
- Volunteers
- 150 people
- Sponsor
- Riboscience, LLC.
Refractory Metastatic Colorectal Cancer
Trifluridine/Tipiracil Plus Fruquintinib vs. Trifluridine/Tipiracil Plus Bevacizumab in Refractory Metastatic Colorectal Cancer: A Randomized, Controlled, Open-Label, Non-Inferiority Trial
This study is an investigator-initiated, prospective, multicenter, randomized, controlled, open-label, non-inferiority trial designed to evaluate the efficacy and safety of trifluridine/tipiracil plus fruquintinib versus…
- Trial name
- NCT07261709
- Testing
- Trifluridine/tipiracil plus fruquintinib, trifluridine/tipiracil plus bevacizumab
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
Studying a Quality of Life Questionnaire in Patients With Colorectal Cancer
RATIONALE: Collecting information about the quality of life of patients with colorectal cancer may help doctors learn more about the disease.
- Trial name
- NCT00564694
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 350 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Colorectal Cancer
First Line mFOLFOXIRI + PANITUMUMAB vs mFOLFOX + PANITUMUMAB IN RAS AND BRAF WT METASTATIC COLORECTAL CANCER PATIENTS
The association of FOLFOX (5-fluoruracil, folinic acid, and oxaliplatin) and pan is a standard option for the first-line treatment of unresectable RAS and BRAF wt mCRC patients.
- Trial name
- TRIPLETE (NCT03231722)
- Testing
- Panitumumab, Irinotecan, Oxaliplatin
- Where
- 4 sites in Italy
- Volunteers
- 435 people
- Sponsor
- Gruppo Oncologico del Nord-Ovest
Colo-rectal Cancer, Surgery
The Impact of Physical Exercise on Sleep in Colorectal Cancer Patients During Prehabilitation Period
Main objective: To evaluate the bidirectional relationships between physical exercise and sleep parameters, as a part of multimodal prehabilitation intervention, on pre- and postoperative outcomes in surgical patients with…
- Trial name
- NCT04270500
- Testing
- Prehabilitation program
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Montreal General Hospital
Toxicity Due to Chemotherapy, Cancer Cachexia
Chemotherapy-related Toxicity, Nutritional Status and Quality of Life
Determine whether nutritional support with high protein ONS in adult oncologic patients in the first step of cancer cachexia - asymptomatic precachexia, influence on the toxicity of systemic therapy.
- Conditions
- Toxicity Due to Chemotherapy, Cancer Cachexia, Metastatic Colorectal Cancer, Quality of Life
- Trial name
- NCT02848807
- Testing
- NUTRIDRINK Compact Protein
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- University Clinical Centre, Gdansk
Rectal Cancer
Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer
The investigators propose a randomized non-inferiority trial that compares preoperative Fluoro Uracil (FU)-based chemoradiotherapy to radiotherapy with a simultaneous integrated boost.
- Trial name
- RectumSIB (NCT01224392)
- Testing
- Chemoradiotherapy, Radiotherapy with boost
- Where
- 2 sites in Belgium
- Volunteers
- 156 people
- Sponsor
- Universitair Ziekenhuis Brussel
Robotic Surgical Procedures, Right Colon Tumors
Comparison of Short- and Long-term Outcomes Between Robotic and Laparoscopic Hemicolectomy of Right Colon Cancer : A Multicenter Propensity Score Matching Analysis
This is a retrospective, multicenter cohort study to compare short- and long-term outcomes between robotic and laparoscopic hemicolectomy of right colon cancer.
- Conditions
- Robotic Surgical Procedures, Right Colon Tumors, Cancer, Laparoscopic Abdominal Surgery
- Trial name
- NCT07029464
- Volunteers
- 4,000 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
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