Clinical trials: Colonic Neoplasm
Colorectal Neoplasms
S0820, Adenoma and Second Primary Prevention Trial
The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0…
- Trial name
- PACES (NCT01349881)
- Testing
- Eflornithine plus sulindac
- Where
- 989 sites in United States
- Volunteers
- 354 people
- Sponsor
- SWOG Cancer Research Network
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study
Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study.
- Trial name
- NCT07267767
- Testing
- nCRT, BMI, Distance from AV
- Volunteers
- 3,500 people
- Sponsor
- Northern Jiangsu People's Hospital
Colorectal Cancer, Pancreatic Adenocarcinoma
Circulating Tumor DNA Exposure in Peripheral Blood
This is a prospective, multi-center, blinded feasibility study. The objective of this study is to test the feasibility of the detection of tumor DNA of a variety of tumors in peripheral blood using a novel process for the…
- Conditions
- Colorectal Cancer, Pancreatic Adenocarcinoma, Gastric Cancer, Hepatocellular Carcinoma
- Trial name
- NCT03517332
- Where
- 6 sites in United States, Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Quantgene Inc.
Colorectal Neoplasms, Intestinal Neoplasms
Usefulness of GI-GENIUS in FIT-based Colorectal Cancer Screening Program.
Deep learning technology has an increasing role in medical image applications and, recently, an artificial intelligence device has been developed and commercialized by Medtronic for identification of polyps during colonoscopy…
- Conditions
- Colorectal Neoplasms, Intestinal Neoplasms, Gastrointestinal Neoplasms, Colonic Polyp
- Trial name
- CADILLAC (NCT04673136)
- Testing
- GI-GENIUS Medtronic, Colonoscopy
- Where
- 6 sites in Spain
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Asociación Española de Gastroenterología
Metastatic Colorectal Cancer
Sunitinib and Capecitabine for First Line Colon Cancer
This study is for patients with metastatic colorectal cancer who have not been treated with chemotherapy for their cancer. The purpose of this study is to find out if Capecitabine and Sunitinib can be used together to improve…
- Trial name
- NCT00961571
- Testing
- sunitinib and capecitabine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Georgetown University
Pancreatic Ductal Adenocarcinoma, Colorectal Cancer
Study to Assess the Safety and Efficacy of Intravenous Injection of the Imaging Agent 111In-IPN01087 in Patients With Locally Advanced or Metastatic Pancreatic or Colorectal Cancer.
111Indium-labelled IPN01087 (111In-IPN01087) is developed as a radioactive diagnostic imaging agent in patients with colorectal or pancreatic cancer.
- Trial name
- NCT04632199
- Testing
- 111In-IPN01087 Low dose, 111In-IPN01087 High dose
- Where
- 5 sites in Belgium, France
- Sponsor
- Ipsen
Diseases of Liver, Colon Carcinoma
Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques
To compare 2 different image creation/processing techniques during a standard CT scan in order to "see" problems in the liver and learn which method provides better image quality.
- Conditions
- Diseases of Liver, Colon Carcinoma, Colorectal Carcinoma, Liver Metastases
- Trial name
- NCT03151564
- Testing
- Computed Tomography Scan - 50% Dose Reduction, Computed Tomography Scan - 70% Dose Reduction, Deep Learning Image Reconstruction (DLIR)
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Neoplasms, Adenoma Colon
Omega-3 Fatty Acid and Colorectal Adenoma
Patients aged >40 years who underwent elective colonoscopies were recruited from ten institutions. Patients with a history of colorectal cancer or long-term dietary interventions were excluded.
- Trial name
- NCT06427109
- Testing
- Dietary intake of omega-3 fatty acid
- Where
- South Korea
- Volunteers
- 798 people
- Sponsor
- DongGuk University
Lung Neoplasms, Pancreatic Neoplasms
Diagnosis of Multiple Cancer and Monitoring of Minimal Residual Tumors After Treatment Using Blood and High-Sensitivity Genetic Analysis Techniques
This is a combined prospective and retrospective observational study aiming to validate a highly sensitive and specific blood-based method for the early diagnosis and post-treatment monitoring of multiple cancers.
- Conditions
- Lung Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Esophageal Neoplasms
- Trial name
- NCT07035587
- Testing
- Serial Blood Sampling for Molecular Profiling, One-Time Blood Sampling for Molecular Profiling
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Colorectal Cancer
Late Organ Specific Adverse Effects hiPec or pElvic eXenteration
The purpose of this study is to describe type and extent of organ specific late adverse effects in patients undergoing surgery for colorectal cancer with peritoneal metastases and after surgery for colorectal cancer with…
- Trial name
- LOSAPEX (NCT04970316)
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 225 people
- Sponsor
- University of Aarhus
Colorectal Neoplasms
Internet-Based Motivational Interviewing for Colonoscopy
Compared to other racial groups, African Americans have the highest colorectal cancer (CRC) morbidity and mortality rates. Although colonoscopies can prevent CRC, nearly one third of African Americans have not received a…
- Trial name
- NCT03595904
- Testing
- E-Motivate group, Usual Care Group
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Colonic Neoplasms, Colorectal Neoplasms
Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer
The primary objective is to assess and characterize the antitumor activity and safety and tolerability of adjuvant treatment with an individualized neoantigen vaccine called GRT-C901/GRT-R902 (chimpanzee adenovirus [ChAd] and…
- Trial name
- NCT05456165
- Testing
- GRT-C901, GRT-R902, Atezolizumab
- Where
- 3 sites in United States
- Sponsor
- Gritstone bio, Inc.
Colorectal Neoplasms, Digestive System Diseases
Exact CRC Screening Test: Stool Sample Collection Study to Support Assay Validation Testing
The objective of this study is to confirm the sensitivity and specificity of a stool DNA test for detection of colorectal cancer and pre-cancer.
- Conditions
- Colorectal Neoplasms, Digestive System Diseases, Colonic Diseases, Colorectal Cancer
- Trial name
- NCT01600209
- Where
- 13 sites in United States
- Volunteers
- 674 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Cancer, Colorectal Cancer
Comparison to Psychological, Medical and Emotional Influencing Communication and Achievement Factors to Oncogenetics Tests
The purpose of the study was to analyze the psychological and emotional determinants of domestic dissemination of information about genetic risk of cancer and to compare the level of diffusion syndromes in breast/ ovarian cancer…
- Conditions
- Cancer, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- PSICOM (NCT03889171)
- Testing
- Behaviour
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Colorectal Cancer
To Explore the Effect of Huaier Granule on the Negative Conversion Rate After the CEA Level Increases Again After Colorectal Cancer Surgery
This study is a prospective, observational and exploratory study to explore the effect of Huaier Granule on the negative conversion rate of patients with increased CEA levels after colorectal cancer surgery.
- Trial name
- NCT06665334
- Testing
- Huaier granule
- Volunteers
- 134 people
- Sponsor
- Fudan University
Breast Cancer, Non-Small Cell Lung Cancer
131-I-TM-601 Study in Adults With Solid Tumors
This study is designed to evaluate the ability of intravenously (IV)administered 131-I-labeled TM-601 (chlorotoxin) to provide tumor-specific localization(via radiographic imaging) in patients with recurrent or refractory primary…
- Conditions
- Breast Cancer, Non-Small Cell Lung Cancer, Melanoma, Colorectal Cancer
- Trial name
- NCT00379132
- Testing
- 131-I-TM-601 (chlorotoxin)
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- TransMolecular
Cancer, Breast Cancer
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
Genetic testing can alter therapy and surgical management for cancer patients and is therefore indicated as a first-line test for many newly diagnosed patients, including breast, ovarian, pancreatic, prostate and colon/GI…
- Conditions
- Cancer, Breast Cancer, Prostate Cancer, Colon Cancer
- Trial name
- NCT07387263
- Testing
- Genetics Adviser for Mainstream Care (GA-Mainstream), Mainstreaming Standard of Care
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- Unity Health Toronto
Colorectal Neoplasms, Metastatic Disease
Regorafenib in Frail and/or Unfit for Chemotherapy Patients With Metastatic Colorectal Cancer
The purpose of this study is to assess the efficacy and safety of single-agent regorafenib in the first line treatment of frail and/or unfit for polychemotherapy patients with metastatic colorectal cancer (mCRC)
- Trial name
- REFRAME (NCT01875380)
- Testing
- Regorafenib
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Lynch Syndrome
Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants
The goal of this trial is to determine whether the Sage eConsent framework (presented using an electronic application) is non-inferior to traditional, paper-based, human-mediated consent-and therefore could be part of an…
- Trial name
- NCT04131062
- Testing
- Electronic Consent (iPad)
- Where
- United States
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Minimal Residual Disease, Immunoscore
Neoadjuvant CAPEOX Versus Upfront Surgery for Locally Advanced Colon Cancer With Elevated CEA: A Single-Center, Open-Label, Randomized Controlled Trial
The goal of this interventional clinical trial is to compare the efficacy of neoadjuvant chemotherapy versus upfront surgery in adults aged 18-70 years with stage II (high-risk)-III, non-MSI-H colon adenocarcinoma and elevated…
- Conditions
- Minimal Residual Disease, Immunoscore, Neoadjuvant Chemotherapy, Colon Cancer (Stage II &Amp; III)
- Trial name
- NCT07413146
- Testing
- ctDNA-Based Molecular Residual Disease (MRD) Monitoring and Immunoscore Assessment, Neoadjuvant Chemotherapy, Adjuvant chemotherapy
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
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