Clinical trials: Colonic Neoplasm
Ulcerative Colitis
Dose-Ranging Phase 2b Study of ABX464 in Moderate to Severe Ulcerative Colitis
Phase 2b study to evaluate the efficacy and the safety of 3 dose-levels of ABX464, administered daily in patients with moderate to severe Ulcerative Colitis.
- Trial name
- NCT03760003
- Testing
- ABX464 100 mg, ABX464 50 mg, ABX464 25 mg
- Where
- 130 sites in United States, Austria and 15 more
- Volunteers
- 355 people
- Sponsor
- Abivax S.A.
Colorectal Cancer, Colon Rectal Resection
Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer
Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal…
- Conditions
- Colorectal Cancer, Colon Rectal Resection, Oxidative Stress
- Trial name
- NCT01470586
- Testing
- Surgery for colorectal cancer
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. Hatzikosta General Hospital
Metastatic Colorectal Cancer
Alpha-type-1 Dendritic Cell-based Vaccines in Patients With Metastatic Colorectal Cancer
The purpose of this study is to evaluate the administration, safety and immunologic effectiveness of an experimental vaccine for colorectal cancer patients.
- Trial name
- NCT00558051
- Testing
- DC-based vaccine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pawel Kalinski
Solid Cancers, BRCA Mutation
A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway
The primary objective of the study is to evaluate the safety, tolerability, PK, PD, and prilimary efficacy of a PARG inhibitor DAT-2645 in patients with advanced/metastatic solid tumors harboring BRCA1/2 loss of function…
- Conditions
- Solid Cancers, BRCA Mutation, HRD Cancer, Breast Cancer
- Trial name
- NCT06614751
- Testing
- DAT-2645 tablet
- Where
- 2 sites in China
- Volunteers
- 112 people
- Sponsor
- Danatlas Pharmaceuticals Co., Ltd
Temperament, Anxiety
Effect of Temperament, Anxiety and Depression on Immuninity in Colorectal Cancer Patients. Effetti Del Temperamento, Dell'Ansia e Della Depressione Sulla Sopravvivenza Globale e Sulla Risposta Immunitaria Del Paziente Affetto da Adenocarcinoma Colo-Rettale.
Aim of the study is to evaluate if Temperament, Anxiety and Depression can affect Immunity and influence Survival in Colorectal Cancer Patients
- Conditions
- Temperament, Anxiety, Depression, Colorectal Cancer
- Trial name
- NCT01433146
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Roma La Sapienza
Advanced Breast Carcinoma, Advanced Colon Carcinoma
Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial
The dose escalation phase of this trial identifies the safety, side effects and best dose of ceralasertib (AZD6738) when given in combination with trastuzumab deruxtecan (DS-8201a) in treating patients with solid tumors that have…
- Conditions
- Advanced Breast Carcinoma, Advanced Colon Carcinoma, Advanced Colorectal Carcinoma, Advanced Endometrial Carcinoma
- Trial name
- NCT04704661
- Testing
- Biopsy Procedure, Biospecimen Collection, Ceralasertib
- Where
- 23 sites in United States
- Volunteers
- 51 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Chemotherapeutic Toxicity
The Effects of Clostridium Butyricum on Adverse Events During Adjuvant Chemotherapy for Colorectal Cancer
This study is a multicenter randomized controlled trial designed to investigate the effects of Clostridium butyricum on adverse events during adjuvant treatment for colorectal cancer.
- Trial name
- NCT07152886
- Testing
- Clostridium butyricum capsules
- Where
- China
- Volunteers
- 238 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Colorectal Neoplasms, Nonalcoholic Fatty Liver Disease
Study of the Association of Nonalcoholic Fatty Liver Disease With Colorectal Malignant Neoplasm
The aim of this sudy is to investigate the prevalence of colorectal cancer (CRC) in patients with nonalcoholic fatty liver disease (NAFLD) and evaluate whether NAFLD is a risk factor for CRC.
- Trial name
- NWC (NCT01657773)
- Testing
- Ultrasound examination and Colonoscopy examination
- Where
- China
- Volunteers
- 2,315 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Anxiety Disorder, Colorectal Cancer
Moderate Physical Activity in Helping Patients Recover Physically and Emotionally From Stage II Or Stage III Colorectal Cancer
RATIONALE: Physical activity may prevent or lessen depression and anxiety and improve quality of life and immune function in patients with colorectal cancer.
- Conditions
- Anxiety Disorder, Colorectal Cancer, Depression, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00373022
- Testing
- exercise intervention, flow cytometry, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Arizona
Colorectal Cancer, Metastatic Cancer
Flt3L in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Flt3L may stimulate a person's immune system and help kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of flt3L given to patients before undergoing surgery to remove metastases from colorectal cancer.
- Trial name
- NCT00003431
- Testing
- recombinant flt3 ligand
- Where
- United States
- Sponsor
- Duke University
Colorectal Neoplasms
Pemetrexed and S-1 in Combination With Bevacizumab in Refractory Colorectal Cancer
Limited agents are optional after standard first and second line treatment for mCRC. Only Regorafenib and Fruquintinib are approved in China. PFS of these targeted drugs are not very long.
- Trial name
- NCT03843853
- Testing
- Pemetrexed, S-1, Bevacizumab
- Where
- China
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colorectal Cancer
Low Dose Metronomic Poly-chemotherapy for Metastatic CRC
This study investigates the activity of a new regimen of treatment for patients with metastatic colorectal carcinoma. This includes a combination of well-known chemotherapy agents and anti-inflammatory agents, when administered…
- Trial name
- LDMchemoCRC (NCT02280694)
- Testing
- Capecitabine, Cyclophosphamide, Methotrexate
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- HaEmek Medical Center, Israel
Colorectal Cancer
SWOG-9304 Chemotherapy Plus Radiation Therapy in Treating Patients With Rectal Cancer That Has Been Surgically Removed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002551
- Testing
- fluorouracil, leucovorin calcium, levamisole hydrochloride
- Where
- 37 sites in United States, Canada and 1 more
- Volunteers
- 1,917 people
- Sponsor
- SWOG Cancer Research Network
Colorectal Cancer
Dendritic Cell Vaccination in Patients With Lynch Syndrome or Colorectal Cancer With MSI
Objectives: In this Radboud University Nijmegen Medical Centre (RUNMC) initiated study our first objective is to investigate toxicity (safety and feasibility) of vaccination with frameshift-derived neoantigen-loaded DC of CRC…
- Trial name
- NCT01885702
- Testing
- DC vaccination
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Colon Cancer
Use of Text Messaging Reminders to Increase FIT Completion Among Patients at the NYU FHCs
The research team will compare the efficacy of targeted text message reminders against currently used phone call reminders at increasing patient completion of fecal immunochemical test (FIT) for colon cancer screening.
- Trial name
- NCT06632054
- Testing
- Text Message Reminders
- Where
- United States
- Volunteers
- 1,283 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Colorectal Cancer Stage IV, Mismatch Repair-deficient (dMMR)
Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer
KEYNOTE-177 is currently the only randomized controlled phase III clinical trial evaluating the efficacy and safety of pembrolizumab versus standard chemotherapy combined with targeted first-line therapy for dMMR/MSI-H metastatic…
- Conditions
- Colorectal Cancer Stage IV, Mismatch Repair-deficient (dMMR), Microsatellite Instability-high (MSI-H)
- Trial name
- NCT05426005
- Testing
- Cadonilimab
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
The Prognosis of Colorectal Cancer Patients After Indocyanine Green Fluorescence-guided Radical Surgery
Previous studies of Indocyanine green (ICG) in colorectal surgery have focused on lymphatic mapping, lymph node detection, and the number of harvested lymph nodes.
- Trial name
- NCT06508541
- Testing
- ICG Guided surgery, conventional surgery
- Where
- China
- Volunteers
- 235 people
- Sponsor
- Shanghai Tong Ren Hospital
Colorectal Cancer, Gastric Cancer
Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease
The purposes of this study are to collect and store samples including blood, normal and tumor tissue from patients with colorectal cancer or gastric cancer, to collect and store samples including blood and/or normal…
- Conditions
- Colorectal Cancer, Gastric Cancer, Inflammatory Bowel Diseases, Gastric Ulcer
- Trial name
- NCT03972956
- Testing
- No intervention will be given to patients.
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Renmin Hospital of Wuhan University
Colorectal Cancer, Precancerous Condition
Vitamin D Supplement in Preventing Colon Cancer in African Americans With Colon Polyps
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of vitamin D may keep colorectal cancer from forming in patients with colon polyps.
- Trial name
- NCT00870961
- Testing
- cholecalciferol
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Northwestern University
Incidence Rate of Perioperiative Venous Thromboembolism(VTE) in Colorectal Cancer Patients
Incidence Rate of Perioperiative VTE in Colorectal Cancer Patients : a Multicenter Prospective Observational Cohort Study
This is a multi-centered, prospective, observational study aimed at observing the Incidence Rate of Perioperiative VTE in Colorectal Cancer Patients
- Trial name
- NCT04588805
- Volunteers
- 1,217 people
- Sponsor
- Beijing Friendship Hospital
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