Clinical trials: Colonic Neoplasm
Colon Cancer, Precancerous Condition
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia
This randomized phase II trial is studying atorvastatin calcium to see how well it works compared to oligofructose-enriched inulin, sulindac, or a placebo in preventing cancer in patients at increased risk of developing…
- Conditions
- Colon Cancer, Precancerous Condition, Rectal Cancer
- Trial name
- NCT00335504
- Testing
- oligofructose-enriched inulin, sulindac, atorvastatin calcium
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Glioma
Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer
The objective of this study is to assess two novel positron emission tomography (PET) radiotracers, [64Cu]CM500 and [68Ga]CM500, for Positron Emission Tomography-Magnetic Resonance Imaging (PET-MR) and Positron Emission…
- Conditions
- Bladder Cancer, Glioma, Glioblastoma (GBM), Breast Cancer
- Trial name
- NCT07781852
- Testing
- [64Cu]CM500, [68Ga]CM500, PET/MR
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lumina Pharmaceuticals Inc
Colorectal Cancer, Colorectal Surgery
Assessing the Feasibility of Using Methylene Blue in Identifying Ureters During Colorectal Surgery
This study will assess whether methylene blue fluorescence imaging can help surgeons identify the ureters during colorectal surgery.
- Conditions
- Colorectal Cancer, Colorectal Surgery, Ureteric Injury
- Trial name
- NCT07861815
- Testing
- Intravenous Methylene Blue, Methylene Blue Fluorescence Imaging System
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Early Gastric Cancer, Colon Neoplasia
Magnetic Guided Counetrtraction During Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is a technique that allows curative treatment of early gastrointestinal neoplasia with organ preservation. However, it is a technically demanding procedure.
- Trial name
- NCT06962293
- Testing
- MAG-ESD assisted ESD
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer
Nitrous Oxide and Risk of Cancer Recurrence After Colorectal Surgery: A Randomized, Blinded Study
This study was developed to test the hypothesis that the risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery.
- Trial name
- NCT00781352
- Testing
- nitrous oxide, nitrogen
- Where
- Austria
- Volunteers
- 408 people
- Sponsor
- The Cleveland Clinic
Metastatic Colorectal Cancer
Study of CMAB009 to Treat KRAS Wild Type Metastatic Colorectal Cancer
The primary purpose of this study is to evaluate the clinical response and safety of CMAB009 plus irinotecan versus irinotecan-only as second-line treatment after fluoropyrimidine and oxaliplatin failure in KRAS wild-type…
- Trial name
- CRC009 (NCT01550055)
- Testing
- CMAB009 plus Irinotecan, Irinotecan-only and sequential-CMAB009
- Volunteers
- 512 people
- Sponsor
- Shanghai Zhangjiang Biotechnology Limited Company
Colorectal Neoplasms, Colorectal Polyp
Virtual Reality Colonoscopy : a Study From Nancy
Colonoscopy is an exam which can be responsible for pain and discomfort for the patient. Therefore colonoscopy is performed most of the time under general anaesthesia.
- Trial name
- NCT05203978
- Testing
- colonoscopy
- Volunteers
- 120 people
- Sponsor
- Central Hospital, Nancy, France
Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma
Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer
This phase II trial studies how well the combination of botensilimab, balstilimab and regorafenib works compared to botensilimab and balstilimab in treating patients with microsatellite stable colorectal cancer that may have…
- Conditions
- Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma, Advanced Rectal Adenocarcinoma, Metastatic Colon Adenocarcinoma
- Trial name
- NCT06575725
- Testing
- Balstilimab, Biopsy, Biospecimen Collection
- Sponsor
- City of Hope Medical Center
Colorectal Cancer
Avastin/FOLFIRI in Combination With Curcumin in Colorectal Cancer Patients With Unresectable Metastasis
Oral curcumin-containing supplement will be given to colorectal cancer patients with unresectable metastases who will be starting Avastin/FOLFIRI chemotherapy for up to completion of (or withdrawal from) chemotherapy.
- Trial name
- NCT02439385
- Testing
- Avastin/FOLFIRI, Curcumin
- Volunteers
- 44 people
- Sponsor
- Gachon University Gil Medical Center
Colorectal Neoplasms
Low-dose Capecitabine Adjuvant Chemotherapy for Elderly Patients With Stage II/III Colorectal Cancer
Approximately half of colorectal cancer (CRC) patients were first diagnosed after 70 years old. However, compared with younger patients, elderly patients were often undertreated in chemotherapy due to their impaired tolerance.
- Trial name
- LcACEC (NCT02316535)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 710 people
- Sponsor
- West China Hospital
Cancer Colorectal, Frailty
Digital Home-Based Prehabilitation Before Surgery
This clinical trial compares two different prehabilitation programs, with no organized prehabilitation, prior to major colorectal cancer surgery.
- Conditions
- Cancer Colorectal, Frailty, Surgery
- Trial name
- dHOPE (NCT06231576)
- Testing
- Prehabilitation
- Volunteers
- 140 people
- Sponsor
- Vestre Viken Hospital Trust
Colorectal Cancer, Mobile Phone Use
Investigation of the Effect of Training on the Side Effects of Chemotherapy Given Via the Mobile Health Application on the Quality of Life in Colorectal Cancer Patients
The incidence of colorectal cancer ranks fourth worldwide after lung, prostate and breast cancers. Although chemotherapy has an important place in the treatment of colorectal cancers, it can cause side effects such as diarrhea…
- Conditions
- Colorectal Cancer, Mobile Phone Use, Nurse's Role
- Trial name
- NCT05940740
- Testing
- Colorectal-Mobile application
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- NESLISAH YASAR KARTAL
Colorectal Cancer, Adenocarcinoma of the Colon
A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer
The purpose of this study is find out whether the combination of trastuzumab deruxtecan (T-DXd) and cetuximab is an effective treatment for participants with metastatic and/or unresectable colorectal cancer that expresses low…
- Conditions
- Colorectal Cancer, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
- Trial name
- NCT07691489
- Testing
- Fam-Trastuzumab Deruxtecan-Nxki
- Where
- 7 sites in United States
- Volunteers
- 27 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4, Peritoneal Carcinomatosis
Surgery With HIPEC in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis
Multicentric randomised trial. The goal of this clinical research study is to learn if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to decrease the rate of peritoneal carcinomatosis(PC) in patients with high risk…
- Trial name
- NCT02179489
- Testing
- Surgery and Hyperthermic Intraperitoneal Chemotherapy with MMC
- Where
- 9 sites in China
- Volunteers
- 271 people
- Sponsor
- Zhejiang University
Endoscopic Mucosal Resection, Colonic Neoplasms
Efficacy and Safety of a Solution for Endoscopic Mucosal Resection of Colonic Lesions
The objetive of this clinical trial is to evaluate the efficacy and safety of a solution for endoscopic mucosal resection of colonic lesions in patients undergoing endoscopic resection procedures.
- Conditions
- Endoscopic Mucosal Resection, Colonic Neoplasms, Therapeutic Irrigation, Treatment Outcome
- Trial name
- NCT06910514
- Testing
- Mucopolysaccharide saline solution 0.9%, Saline solution 0.9%
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Nakafarma S.L.
Metastatic Malignant Neoplasm in the Brain, Metastatic Solid Neoplasm
APN401 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer, Colorectal Cancer, or Other Solid Tumors That Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of APN401 in treating patients with pancreatic cancer, colorectal cancer, or other solid tumors that have spread to other places in the body or have come back.
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Metastatic Solid Neoplasm, Recurrent Colorectal Carcinoma, Recurrent Pancreatic Carcinoma
- Trial name
- NCT03087591
- Testing
- Laboratory Biomarker Analysis, siRNA-transfected Peripheral Blood Mononuclear Cells (PBMC) APN401
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
HIV, Cardiovascular Disease
Men Together Making a Difference: Health Promotion for Black Men
African American men infected with HIV are living longer and are acquiring the same chronic non-communicable diseases affecting the general population of African American men age 40 years and older.
- Conditions
- HIV, Cardiovascular Disease, Diabetes, Hypertension
- Trial name
- NCT02572414
- Testing
- Health Promotion Intervention, Health Awareness Control Intervention
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- University of Pennsylvania
Metastatic Colorectal Cancer (CRC), mCRC
A Clinical Study of Iparomlimab and Tuvonralimab Combined With Fruquintinib and Heterogeneous Radiotherapy Versus Fruquintinib as Third-Line and Subsequent-Line Treatment for Metastatic Colorectal Cancer
This is a randomized, parallel, open-label, multicenter exploratory clinical study designed to investigate the efficacy and safety of iparomlimab and tuvonralimab in combination with fruquintinib plus heterogeneous radiotherapy…
- Trial name
- NCT07502014
- Testing
- Iparomlimab and Tuvonralimab (QL1706), Fruquintinib, Heterogeneous Radiotherapy
- Volunteers
- 60 people
- Sponsor
- Huazhong University of Science and Technology
Colorectal Cancer, Obesity
Energy Balance Interventions for Colorectal Cancer Prevention
RATIONALE: Calories and physical exercise may affect the risk of developing cancer. It is not yet known whether a low-calorie diet and/or physical activity program is effective in preventing cancer in participants at increased…
- Trial name
- NCT00653484
- Testing
- Physical Activity, Energy Restriction, Physical Activity and Energy Restriction
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University
Colorectal Cancer
A Trial of the Implementation of iFOBT in General Practice
Background Colorectal cancer (CRC) is common, and a leading cause of cancer death. The evaluation of patients suspected to have CRC is difficult due to poorly predictive alarm symptoms and many patients present with…
- Trial name
- NCT02308384
- Testing
- Intervention
- Where
- Denmark
- Volunteers
- 825 people
- Sponsor
- University of Aarhus
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