Clinical trials: Colonic Surgery
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Liver Metastasis, Colon Cancer
EPA for Metastasis Trial 2
A significant proportion of patients who undergo liver surgery to remove bowel cancer that has spread to the liver (metastases) develop disease recurrence and die from the disease.
- Trial name
- EMT2 (NCT03428477)
- Testing
- Icosapent Ethyl
- Where
- 13 sites in United Kingdom
- Volunteers
- 418 people
- Sponsor
- Mark A Hull, PhD FRCP
Colon Cancer Liver Metastasis, Inflammatory Response
Argipressin's Influence on Blood Loss During Hepatic Resection
Infusion of Argipressin during hepatic resection surgery may reduce blood loss. It may also reduce transfusion requirements, and mitigate the perioperative inflammatory response compared to placebo.
- Conditions
- Colon Cancer Liver Metastasis, Inflammatory Response, Vasopressin Causing Adverse Effects in Therapeutic Use
- Trial name
- ARG-01 (NCT05293041)
- Testing
- Argipressin
- Where
- Sweden
- Volunteers
- 248 people
- Sponsor
- Kristina Svennerholm
Colorectal Neoplasms, Anastomotic Leak
Anastomotic Leakage and Enhanced Recovery Pathways After Colorectal Surgery
Prospective observational multicenter study on the influence of adherence to enhanced recovery pathways on early outcomes (anastomotic leakage, morbidity, mortality, readmission, reoperation rates and length of postoperative…
- Conditions
- Colorectal Neoplasms, Anastomotic Leak, Surgery--Complications
- Trial name
- iCral2 (NCT03771456)
- Testing
- Colorectal resections
- Where
- 41 sites in Italy
- Volunteers
- 1,748 people
- Sponsor
- Ospedale C & G Mazzoni
Liver Metastases, Mucinous Adenocarcinoma of the Colon
Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surgery
This phase 0 trial is studying whether 2 weeks of cetuximab and dasatinib will change tumor cells in patients with colorectal cancer and liver metastases that can be removed by surgery.
- Conditions
- Liver Metastases, Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer
- Trial name
- NCT00835679
- Testing
- cetuximab, dasatinib, therapeutic conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Postoperative Complications
Measuring Quality in Colorectal Cancer Surgery in Low- and Middle-income Countries
To test the applicability of the Clavien-Dindo Classification (CDC) in an LMIC setting and to compare the prevalence and severity of complications in patients <60 and ≥60 years of age a retrospective medical records review is…
- Conditions
- Colorectal Cancer, Postoperative Complications, Surgical Complication, Non-communicable Disease
- Trial name
- NCT05182762
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Colon Cancer
The Relationship Between Relaxation or Wheat Germ Juice to the Immune Indices and Quality of Life (QoL) in Colorectal Cancer Patients on Adjuvant Chemotherapy
The immune system plays an important role in the fight against cancer. According to certain studies, Levels of cytokines secreted by the immune cells were found as predictors of prognosis and survival among cancer patients, as…
- Trial name
- NCT01991080
- Testing
- biofeedback, Wheatgerm juice
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Colorectal Neoplasms
Anti-OX40 Antibody (MEDI6469) in Patients With Metastatic Colorectal Cancer
This study will test the ability of an immune modulator, anti-OX40 (MEDI6469) to alter the immune cell environment within colorectal cancer metastases. The drug will be administered to patients before surgical treatment.
- Trial name
- NCT02559024
- Testing
- MEDI6469
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Providence Health & Services
Colon Cancer, Postoperative Complications
Multidisciplinary Prehabilitation and Postoperative Rehabilitation in Patients Undergoing Resection of Colon Cancer
ONCOFIT is a randomized clinical trial with a two-arm parallel design aimed at determining the influence of a multidisciplinary prehabilitation + postoperative program on post-surgery complications in patients undergoing…
- Trial name
- ONCOFIT (NCT05379205)
- Testing
- Prehabilitation program (4 week before the surgery), Postoperative program (12 week after the surgery), Usual Care
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Universidad de Granada
Ulcerative Colitis, Ileal Pouch
Short Versus Long Interval to Ileostomy Reversal After Ileal Pouch Surgery
In patients with ulcerative or indeterminate colitis who undergo ileal pouch anal anastomosis and diverting loop ileostomy (IPAA) surgery* a short interval to loop ileostomy reversal will result in differences in complications…
- Conditions
- Ulcerative Colitis, Ileal Pouch, Ileostomy - Stoma
- Trial name
- SLIRPS (NCT03587519)
- Testing
- Early, Late
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Liver Transplant Surgery, Colorectal Cancer Metastatic
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM).
- Conditions
- Liver Transplant Surgery, Colorectal Cancer Metastatic, Colon Cancer Liver Metastases
- Trial name
- CLEAR (NCT06698146)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Liver Metastases, Recurrent Colon Cancer
Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer
This phase II trial studies how well giving combination chemotherapy and bevacizumab before surgery and radiolabeled monoclonal antibody therapy works in treating liver metastases in patients with metastatic colorectal cancer.
- Conditions
- Liver Metastases, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IVA Colon Cancer
- Trial name
- NCT01320683
- Testing
- oxaliplatin, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- City of Hope Medical Center
Colostomy Stoma, Cancer of Colon
ExPECT: Extraperitoneal End Colostomy Trial
A randomised controlled feasibility study to compare two surgery techniques in the formation of a permanent end colostomy; the trans-peritoneal(TP) technique - currently, the most commonly used technique and the investigational…
- Conditions
- Colostomy Stoma, Cancer of Colon, Surgery, Quality of Life
- Trial name
- ExPECT (NCT05163873)
- Testing
- Extra-peritoneal
- Where
- 3 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- Swansea Bay University Health Board
Adenocarcinoma of the Colon
Extended Peri-operative Tinzaparin to Improve Disease-free Survival in Patients With Resectable Colorectal Cancer
The human body has a natural stress response to surgery, including the formation of blood clots. This response to surgery has been shown to increase metastases (the spread of cancer cells to other organs in the body).
- Trial name
- PERIOP-01 (NCT01455831)
- Testing
- Tinzaparin
- Where
- 16 sites in Belgium, Canada and 1 more
- Volunteers
- 616 people
- Sponsor
- Ottawa Hospital Research Institute
Colon Cancer
Regional Anesthesia in Colon Rectal Surgery
This study will compare recurrence rates in patients with colorectal cancer who will be randomly assigned to epidural anesthesia/analgesia combined with general anesthesia or to general anesthesia followed by opioid analgesia.
- Trial name
- NCT00684229
- Testing
- Regional anesthesia and analgesia, general anesthesia followed by opioid analgesia
- Where
- 3 sites in United States, Argentina and 1 more
- Sponsor
- The Cleveland Clinic
Colon Neoplasms
A Novel Technique of HALS With CME and CVL for RCC
The purpose of this study is to determine the short and long outcomes of the novel technique of hand-assisted laparoscopic right hemicolectomy with complete mesocolic excision and central vascular ligation for right colon cancer.
- Trial name
- NCT02625272
- Testing
- Group A
- Where
- China
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Colorectal Cancer
Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic Leakage
Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer in the world and the third in France. Its incidence is steadily rising in developing nations.
- Trial name
- FLUOCOL-1 (NCT05168839)
- Testing
- FLUO+ : Intraoperative fluorescence angiography (IOFA) with indocyanine green (ICG).
- Where
- 32 sites in France
- Volunteers
- 1,010 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Colorectal Cancer, Colorectal Surgery
Nutritional Supplementation to Improve Colorectal Cancer Surgery
This study aims to explore the effectiveness of perioperative Oral Nutritional Supplementation (ONS) combined with an optimized, tailored diet in reducing the risk of postoperative complications and improving the nutritional…
- Trial name
- NUTRICOLOR (NCT07599501)
- Testing
- Diet Optimization (DO), Oral Nutritional Supplement (ONS)
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Istituto Clinico Humanitas
Anastomotic Leak
Evaluation of Colonic Perfusion by Indocyanine Green Angiography During Colorectal Surgery
Despite advancements in technology and improved surgical techniques, the occurrence of anastomotic leakage (AL) after colorectal surgery remains between 4% and 30%.
- Trial name
- NCT06793280
- Testing
- intraoperative ICG angiography, No intraoperative ICG angiography
- Where
- Italy
- Volunteers
- 562 people
- Sponsor
- University of Roma La Sapienza
Colorectal Cancer
Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known whether celecoxib is effective in preventing polyps in patients with colon cancer.
- Trial name
- NCT00087256
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NSABP Foundation Inc