Clinical trials: Colorectal Adenoma
Colorectal Adenoma, Colorectal Polyps
Advanced Adenoma Detection With 3D Imaging Device During Colonoscopy
The goal of this clinical trial is to learn if 3-dimensional (3D) imaging device works to identify patients with high risk adenomas during colonoscopy to guide proper follow-up strategy.
- Trial name
- NCT06924489
- Testing
- Colonoscopy after bowel cleansing with 2D imaging device, Colonoscopy after bowel cleansing with 3D imaging device
- Where
- China
- Volunteers
- 1,566 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Colorectal Adenoma, Colorectal Carcinoma
Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma
This phase IIa trial studies how well aspirin works in preventing colorectal cancer in patients with colorectal adenoma. Aspirin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT02965703
- Testing
- Aspirin, Biospecimen Collection, Questionnaire Administration
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer (Diagnosis), Adenoma
S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas
This study will enroll a total of 18 patients who have undergone curative surgery for stage I or II colorectal cancer and are planned for post-surgical surveillance without any need for chemotherapy at Cedars-Sinai Medical…
- Trial name
- NCT07582003
- Testing
- S-Adenosylmethionine (SAMe)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jun Gong, MD
Colorectal Polyps, Colorectal Adenoma
AI-Assisted Optical Diagnosis (CADx) for Diminutive Colorectal Polyps
This study evaluates whether an artificial intelligence system (GI Genius, Medtronic), already approved by Health Canada, can help doctors accurately identify, in real time during colonoscopy, which small colorectal polyps (5 mm…
- Conditions
- Colorectal Polyps, Colorectal Adenoma, Diminutive Colorectal Polyp
- Trial name
- CADxGIG (NCT07738484)
- Testing
- GI Genius CADx module (Medtronic)
- Volunteers
- 840 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Polyp Colorectal, Rectal Adenoma
GelPOINT® Path-Assisted Endoscopic Removal of Colon and Rectal Polyps: A Feasibility and Safety Study
This prospective, single-center, observational feasibility and safety study will evaluate the use of the GelPOINT® Path transanal access platform during endoscopic submucosal dissection (ESD) for the removal of colorectal polyps.
- Conditions
- Polyp Colorectal, Rectal Adenoma, Adenoma Colon Polyp
- Trial name
- NCT07723937
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Colorectal Lesion, Colorectal Adenoma
PARADIGM - En Bloc Trial With the EndoQuest Endoluminal Surgical (ELS) System
The objective of this study is to evaluate the safety and effectiveness of the Endoluminal Surgical (ELS) System in subjects undergoing specified transanal endoluminal procedures in the rectum and sigmoid colon.
- Conditions
- Colorectal Lesion, Colorectal Adenoma, Colorectal Polyp, Rectal Lesion
- Trial name
- PARADIGM (NCT06133387)
- Testing
- Endoscopic submucosal dissection using the ELS System
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- EndoQuest Robotics, Inc.
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Adenoma and Carcinoma
Recurrence Mechanisms of Colorectal Adenoma After Resection and a Multi-Omics Research Protocol
We aim to establish a single-cell atlas of primary adenomas, recurrent adenomas, and paired normal mucosa, identify recurrence-associated cell subpopulations and transcriptional pathways, and construct a risk prediction model for…
- Trial name
- RM-CAR-MRP (NCT07683312)
- Volunteers
- 30 people
- Sponsor
- Zhongshan Hospital Xiamen University
Colorectal Cancer, Breast Cancer
Screening Colonoscopy in Breast Cancer Patients
Breast cancer survivors may be at increased risk for developing colorectal polyps and colorectal cancer because of shared genetic, hormonal, and lifestyle-related risk factors.
- Conditions
- Colorectal Cancer, Breast Cancer, Colorectal Adenoma
- Trial name
- NCT07678099
- Testing
- Screening colonoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Colorectal Cancer (CRC), Adenomatous Polyposis
Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions
The study aims to evaluate the effectiveness of artificial intelligence-assisted colonoscopy in increasing adenoma detection rate and the accuracy in the characterization of colorectal lesions, compared to standard colonoscopy…
- Conditions
- Colorectal Cancer (CRC), Adenomatous Polyposis, Colorectal Lesions, Colorectal Cancer
- Trial name
- NCT07066046
- Testing
- Colonoscopy
- Where
- Brazil
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Colorectal Cancer Prevention, Colorectal Adenoma
BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating…
- Trial name
- BILMOD (NCT07162337)
- Testing
- Increased Plant-Based Diet and Decreased Animal-Based Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Gastric Polyps, Intestinal Polyps
Recurrence After Gastric and Intestinal Polyp Resection
This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.
- Conditions
- Gastric Polyps, Intestinal Polyps, Colon Polyps, Colorectal Polyps
- Trial name
- RAGIP (NCT07314554)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- LanZhou University
Colorectal Cancer, Colorectal Adenoma
The Implementation of Genetic Risk for Colorectal Cancer Screening
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
- Trial name
- PRO-GENE-COLON (NCT07621757)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Colorectal Adenoma
Enhanced White Light Endoscopy Versus Conventional White Light Endoscopy for Colorectal Adenoma Detection: A Randomized Controlled Trial
1. Study on Adenoma Detection Rate (ADR) Comparing Enhanced White Light Endoscopy (E-WLI) versus Conventional White Light Endoscopy (WLI); 2.
- Trial name
- NCT06979232
- Testing
- Enhanced White Light Imaging, White Light lmaging
- Where
- 7 sites in China
- Volunteers
- 845 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Colorectal Adenoma, Probiotics
The Effect of Oral Clostridium Butyricum on the Recurrence After Colonoscopic Resection of Colorectal Adenoma
The prevention of recurrence after colorectal adenoma resection remains an urgent medical issue to be addressed. Previous studies have mainly focused on nonsteroidal anti-inflammatory drugs, calcium supplements, and vitamins.
- Trial name
- NCT07167342
- Testing
- Clostridium butyricum capsules, Live
- Where
- 2 sites in China
- Volunteers
- 294 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Colorectal Adenomas, Colorectal Cancers
Effects of Berberine on the Human Gut Microbiome
Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored.
- Trial name
- NCT07519681
- Testing
- Berberine Hydrochloride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jing-yuan Fang, MD, Ph. D
Colorectal Cancer, Colorectal Adenoma
Comparison of Expression of Carcinogenesis-related Molecular Markers in the Patients With Colon Cancer and Polyp
A study of carcinogenesis-related molecular markers in the patients with colorectal cancer and colorectal adenoma.
- Trial name
- NCT05638542
- Where
- South Korea
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Adenoma, Colorectal Cancer
Combination of Artificial Intelligence and Mucosal Exposure Device to Enhance Colorectal Neoplasia Detection
The investigators hypothesize that the combined use of CADe system (ENDOAID) and mucosal exposure device (Endocuff Vision®) would improve the adenoma detection rate when compared to CADe system alone.
- Conditions
- Adenoma, Colorectal Cancer, Colorectal Neoplasms
- Trial name
- AIDEN (NCT05414448)
- Testing
- ENDOCUFF
- Where
- Hong Kong
- Volunteers
- 1,726 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer, Adenoma
NORCCAP: Norwegian Colorectal Cancer Prevention Trial
The purpose of this study is to see if screening with flexible sigmoidoscopy (a flexible viewing tube) may reduce large bowel cancer and cancer deaths.
- Trial name
- NORCCAP (NCT00119912)
- Testing
- A 1 Intervention arm Flex Sig, A 2 Intervention arm Flex Sig + iFOBT
- Where
- Norway
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Colorectal Cancer, Colorectal Adenomas
Pilot Study of a National Screening Programme for Bowel Cancer in Norway
The Norwegian government has funded a pilot study of a national colorectal cancer screening programme. This implies initiation of a screening pilot in the catchment area for two hospitals in Norway.
- Trial name
- NCT01538550
- Testing
- Flexible sigmoidoscopy, iFOBT
- Where
- 2 sites in Norway
- Volunteers
- 140,000 people
- Sponsor
- Norwegian Institute of Public Health