Clinical trials: Colorectal Anastomosis
Anastomotic Leak Rectum, Rectal Cancer
Treatment of Anastomotic Leakage After Rectal Cancer Resection
The TENTACLE: Rectum study is a multinational retrospective cohort study that includes patients with anastomotic leakage after rectal cancer resection.
- Trial name
- TENTACLE:R (NCT04127734)
- Testing
- The efficacy of various interventions for anastomotic leakage after rectal cancer resection are investigated
- Volunteers
- 1,246 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Diverticulitis
Anastomotic Bleeding in Colorectal Anastomosis Relating to the Placement of the Stapler Spike to the Staple Line
Each colorectal anastomosis is routinely evaluated intraoperatively by sigmoidoscopy and, in the presence of signs of bleeding, also postoperatively (persistent rectal bleeding within 24 hours after surgery).
- Trial name
- NCT07506005
- Where
- Austria
- Volunteers
- 102 people
- Sponsor
- Kepler University Hospital
Postoperative Ileus, Anastomotic Leak
SANICS II Trial: Stimulation of the Autonomic Nervous System in Colorectal Surgery by Perioperative Nutrition
The main objective is to investigate the effects of perioperative nutrition on postoperative ileus and anastomotic leakage in patients undergoing colorectal surgery.
- Trial name
- SANICSII (NCT02175979)
- Testing
- enriched enteral nutrition, standard
- Where
- 5 sites in Denmark, Netherlands
- Volunteers
- 280 people
- Sponsor
- Misha D.P. Luyer
Rectal Cancer
Anastomotic Leakage After Anterior Resection of Rectal Cancer
Anastomotic leakage (AL) is one of the most-feared postoperative complications after anterior resection of rectal cancer. This complication compromises both short term and long term outcome of patients.
- Trial name
- NCT03281070
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Rectal Cancer
J-pouch Versus Side-to-end Coloanal Anastomosis After Preoperative Radiotherapy and Total Mesorectal Excision for Rectal Cancer
The objective of this study was to compare the functional and surgical results of the J-pouch with those of the side-to-end anastomosis and their impact on quality of life.
- Trial name
- NCT00956241
- Testing
- j-pouch coloanal anastomosis, side-to-end coloanal anastomosis
- Where
- Netherlands
- Volunteers
- 127 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rectal Cancer
Side-to-end Anastomosis Versus Colon J Pouch for Reconstruction After Low Anterior Resection for Rectal Cancer (SAVE)
Primary hypothesis: Side-to-end anastomosis is non-inferior to colon J pouch for reconstruction after low anterior resection for rectal cancer in fecal incontinence (Wexner score).
- Trial name
- SAVE (NCT01006577)
- Testing
- side-to-end anastomosis, colon j pouch
- Where
- Germany
- Volunteers
- 306 people
- Sponsor
- Charite University, Berlin, Germany
Embolism Mesenteric
Preoperative Embolization of the Inferior Mesenteric Artery in Colorectal Surgery
Preoperative embolization of the inferior mesenteric artery in colorectal surgery (EPAMIR). This is a prospective, monocentric, non-randomized study.
- Trial name
- EPAMIR (NCT05422560)
- Testing
- Embolization of the inferior mesenteric artery
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Rectal Neoplasms
Perfusion Outcomes With Near Infrared-Indocyanine Green Imaging System in Laparoscopic Total Mesorectal Excision for Mid- or Low-rectal CanceR
It is a multicenter, prospective, and randomized controlled clinical study of patients with mid- or low- rectal cancer who received laparoscopic TME surgery aims to explore whether the application of near infrared-indocyanine…
- Trial name
- POSTER (NCT04012645)
- Testing
- application of near infrared-indocyanine green imaging system, Non-application of near infrared-indocyanine green imaging system
- Where
- 2 sites in China
- Volunteers
- 547 people
- Sponsor
- Zhongtao Zhang
Anastomotic Leak
Anastomotic Leakage After Anterior Resection for Rectal Cancer - Predictive Biomarkers and Rectal Blood Flow
The purpose of this study is to determine whether reduced rectal blood flow is associated with the extent of surgery when performing an operation to remove rectal cancer.
- Trial name
- NCT02401100
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Umeå University
Medium and Lower Rectal Cancer
Efficacy of Delayed Coloanal Anastomosis for Medium and Lower Rectum Cancer Treatment. Phase 2 Clinical Trial (CASCADOR)
Hypothesis: In France, approximately 12,000 new rectal cancers are diagnosed each year. Frequency is one and a half times higher in men than in women. The average age of diagnosis is 65.
- Trial name
- CASCADOR (NCT01876901)
- Testing
- 2-stage pull-through colo-anal anastomosis without prophylactic derivation (2SCA), Colo-anal anastomosis (CAA)
- Where
- 9 sites in France
- Volunteers
- 124 people
- Sponsor
- Institut Bergonié
Colon Cancer, Anastomosis
Intracorporeal or Extracorporeal Anastomosis After Laparoscopic Right Colectomy.
During the last few years, the laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA) has been proposed as an alternative to laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA) for…
- Trial name
- NCT03045107
- Testing
- Laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA), Laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA)
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- University of Turin, Italy
TME, Rectal Cancer Surgery
REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department
The purpose of this multicenter randomized non-inferiority trial is to evaluate the safety of low anterior resection for rectal cancer performed with versus without a diverting stoma in patients with a low predicted risk of…
- Conditions
- TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer
- Trial name
- RELOAD (NCT07463261)
- Testing
- Without a preventive stoma, With a preventive stoma
- Where
- 7 sites in Russia
- Volunteers
- 442 people
- Sponsor
- ANO Scientific and Practical Club for the Development of Modern Medical Technologies
Colorectal Surgery
Transrectal Vacuum Assisted Drainage: A New Method of Treating Anastomotic Leakage After Rectal Resection
Anastomotic leakage is a major and potentially mortal complication with an incidence of 10-13% after resection of the rectum. For patients showing no clinical signs of peritonitis, the traditional method has been a conservative…
- Trial name
- NCT00773981
- Testing
- Transrectal vacuum assisted drainage
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hvidovre University Hospital
Anastomotic Leak, Platelet-Rich Fibrin
Leukocyte and and Platelet-rich Fibrin Plasma for the Prevention of Anastomotic Leakage in Colorectal Anastomosis
Anastomotic leak rate in colorectal surgery is estimated between 4 and 20 percent. Leukocyte and and platelet-rich fibrin plasma (L-PRF) is second generation platelet concentrate whose application in colorectal anastomosis in…
- Conditions
- Anastomotic Leak, Platelet-Rich Fibrin, Colorectal Surgery
- Trial name
- NCT05264467
- Testing
- Platelet rich fibrin on colorectal anastomosis
- Where
- Chile
- Volunteers
- 106 people
- Sponsor
- Universidad de Concepcion
Colorectal Neoplasms, Diverticular Diseases
Endoscopic Ultrasound- Guided Hartmann Reversal Procedure
The goal of this clinical trial is to learn about clinical usefulness endoscopic gastrointestinal anastomoses to restore the gastrointestinal continuity in patients with permanent colostomy after Hartmann procedure.
- Conditions
- Colorectal Neoplasms, Diverticular Diseases, Inflammatory Bowel Diseases
- Trial name
- EndoHARP (NCT06061432)
- Testing
- Endoscopic restoration of gastrointestinal continuity after Hartmann procedure
- Volunteers
- 100 people
- Sponsor
- Nicolaus Copernicus University
Gastrointestinal Stromal Tumors, Gastrointestinal Neoplasms
Gastrointestinal Anastomosis Using MonoPlus® Suture
The primary aim of this study is to collect clinical data on the performance of MonoPlus® suture applied in routine clinical practice.
- Conditions
- Gastrointestinal Stromal Tumors, Gastrointestinal Neoplasms, Digestive System Neoplasm, Stomach Tumor
- Trial name
- GASTROMO (NCT04811833)
- Where
- 2 sites in Spain
- Sponsor
- Aesculap AG
Adenocarcinoma of the Colon
Intracorporeal Versus Extracorporeal Anastomosis In Laparoscopic Right Colon Resection
STUDY DESIGN This study is a prospective, randomized, multi-center study comparing intracorporeal versus extracorporeal anastomosis in performing laparoscopic right colectomy. The study subjects will be randomly assigned to 1.
- Trial name
- NCT05077358
- Testing
- Intracorporeal anastomosis, Extracorporeal anastomosis
- Where
- South Korea
- Volunteers
- 241 people
- Sponsor
- Yonsei University
Low Anterior Resection Syndrome, Malignant Anal Neoplasm
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to…
- Conditions
- Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm
- Trial name
- NCT04066894
- Testing
- Explantation, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Anastomotic Leak
Colorectal Anastomotic Leak Management
Colorectal anastomotic leaks (AL) are associated with high morbidity and mortality. Management of AL and its intra-operative decision making is often difficult.
- Trial name
- CALM (NCT05000580)
- Testing
- Surgical
- Where
- United Kingdom
- Volunteers
- 201 people
- Sponsor
- Surgical Trainees East of England Research Collaborative
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Human Intestinal Microbiome and Surgical Outcomes in Patients Undergoing Colorectal Cancer Surgery
Intro: Recent studies on colorectal cancer surgery have been focusing on the role of intestinal microbiome on surgical outcomes.
- Trial name
- Microbiota (NCT04005118)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris