Clinical trials: Colorectal Cancer (Diagnosis)
Colon Cancer
Oral Green Tea Extract and Milk Thistle Extract to Colorectal Cancer Patients Undergoing Resection
Colorectal cancer is the third most common form of cancer found in the United States. To date surgical resection provides the best chance for cure.
- Trial name
- NCT01239095
- Testing
- Green Tea and Milk Thistle Supplements
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Richard Whelan
Metastatic Colorectal Cancer
Study of Bevacizumab in Combination with Alternating XELIRI and XELOX in Metastatic Colorectal Cancer
Open-label, single-arm, phase II study of bevacizumab (AvastinTM) in combination with alternating XELIRI (capecitabine+irinotecan) and XELOX (capecitabine+oxaliplatin) as first-line treatment of patients with metastatic…
- Trial name
- AXOAXI (NCT01531595)
- Testing
- Bevacizumab plus alternating XELOX/XELIRI
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Pia Osterlund
Metastatic Colorectal Cancer
A Clinical Trial of Panitumumab in Combination With FOLFIRI Chemotherapy as Second Line Treatment in Subjects With Metastatic Colorectal Cancer Expressing Wild-type KRAS and Who Had Progressed ≥ 6 Months After the Last Dose of the First Line Chemotherapy
First line chemotherapy treatment regimens for metastatic colorectal cancer (mCRC) present disease-free survival of more than 10 months, and as much as 12 and 15 months for many patients.
- Trial name
- ACTIVE (NCT01144195)
- Testing
- Panitumumab + FOLFIRI
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Associacio catalana per a la recerca oncologica i les seves implicacions sanitaries i socials
Advanced Solid Tumors, Locally Advanced or Metastatic Breast or Colorectal Cancer
A Trial of Tivozanib (AV-951) in Combination With Capecitabine (Xeloda®) in Subjects With Advanced Solid Tumors
This is an open-label, multi-center, dose-finding study of tivozanib administered in combination with capecitabine. During the dose-escalation portion, sequential cohorts of subjects with advanced solid tumors will be enrolled in…
- Trial name
- NCT01306630
- Testing
- tivozanib (AV-951) and capecitabine (Xeloda®)
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- AVEO Pharmaceuticals, Inc.
Colorectal Cancer, Liver Metastasis
LDRT Combined With Immunochemotherapy for Colorectal Cancer With Liver Metastasis
In recent years, growing evidences have demonstrated promising synergistic antitumor effects of radiotherapy combined with immunotherapy.
- Conditions
- Colorectal Cancer, Liver Metastasis, LDRT
- Trial name
- NCT06848465
- Testing
- Low Dose Radiotherapy, Short course Radiotherapy, XELOX
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Cancer Screening Tests
Helping Patients and Providers Make Better Decisions About Colorectal Cancer Screening
Precision prevention holds great promise for colorectal cancer (CRC) screening but has not been adequately explored. A patient's chance of having an advanced colorectal neoplasm (ACN), i.e.
- Trial name
- NCT04683731
- Testing
- Decision aid without personalized message, Decision aid with personalized message, Provider notification without personalized message
- Where
- 2 sites in United States
- Volunteers
- 1,111 people
- Sponsor
- Indiana University
Breast Neoplasm, Colorectal Neoplasm
Decision Aid Website in Helping to Make Decisions About Fertility in Participants With Cancer
This trial studies how well a decision aid website works in helping to make decisions about fertility in participants with cancer.
- Conditions
- Breast Neoplasm, Colorectal Neoplasm, Female Reproductive System Neoplasm, Health Care Provider
- Trial name
- NCT03141437
- Testing
- Best Practice, Educational Intervention, Internet-Based Intervention
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC
To explore the safety and efficacy of neoadjuvant therapy for locally advanced rectal cancer with short course radiotherapy followed by camrelizumab combined with fluzoparib and chemotherapy
- Trial name
- NCT06516445
- Testing
- SCRT, Camrelizumab, Fluzoparib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Huazhong University of Science and Technology
Colorectal Cancer
Association of Colorectal Cancer With Nutrition, Diet, Obesity, Diabetes Mellitus, and Genetic Alterations in Taiwan
We will explore the genetic (including APC, k-ras, p53, MSI, etc.) and environmental (including family history, life style, diet, nutritional status, DM, serum IGF-I, IGFBP-3, etc.) risk factors of colorectal tumorigenesis.
- Trial name
- NCT00172757
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer, Colorectal Carcinoma
The Problem of Colorectal Anastomosis Safety
This is a prospective cohort pilot study. The investigators are planning to develop an original, standardized colorectal anastomosis inspection method, which will systemically inspect the anastomosis vascularity using the…
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Colorectal Neoplasms, Colorectal Adenocarcinoma
- Trial name
- ANSCRS (NCT03958500)
- Testing
- Indocyanine green fluorescent angiography intraluminally and intraperitoneally
- Where
- 2 sites in Lithuania
- Volunteers
- 60 people
- Sponsor
- Vilnius University
Colorectal Cancer
Studying Tissue Samples From Patients With Stage II Colon Cancer Treated on Clinical Trial CLB-9581
This research trial studies tissue samples from patients with stage II colon cancer treated on Cancer and Leukemia Group B (CALGB)-9581 or CALGB-90903.
- Trial name
- NCT00897429
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 2,059 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Cancer
QUILT-3.050: NANT Colorectal Cancer (CRC) Vaccine: Combination Immunotherapy in Subjects With Recurrent or Metastatic CRC
This is a phase 1b/2 study to evaluate the safety and efficacy of metronomic combination therapy in subjects with recurrent and metastatic CRC.
- Trial name
- NCT03169777
- Testing
- avelumab, bevacizumab, capecitabine
- Sponsor
- ImmunityBio, Inc.
Colorectal Cancer, Adult
PIN in Combination With Sintilimab in Previously Treated pMMR/MSS CRC With Hepatic Metastases
In this single-center,open-label, phase I study, the safety and efficacy of PIN in combination with anti-programmed cell death -1 (anti-PD1) antibody therapeutic regimen (sintilimab) will be evaluated in patients with advanced…
- Trial name
- NCT07411781
- Testing
- PIN+sintilimab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Chinese PLA General Hospital
Rectal Adenocarcinoma, High-Risk Cancer
NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC
To explore the efficacy and safety of adding a ketogenic diet and/or high-dose intravenous vitamin C to neoadjuvant short-course radiotherapy followed by mFOLFOX6 chemotherapy combined with serplulimab in patients with locally…
- Conditions
- Rectal Adenocarcinoma, High-Risk Cancer, MSS
- Trial name
- CRI-KEV (NCT07765667)
- Testing
- Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Carcinoma, Endometrial Adenocarcinoma
PEN-866 in Patients With Advanced Solid Malignancies
Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.
- Conditions
- Carcinoma, Endometrial Adenocarcinoma, Neoplasms, Squamous Cell Carcinoma of the Anus
- Trial name
- NCT03221400
- Testing
- PEN-866 Sodium, fluorouracil, Folinic acid
- Where
- 16 sites in United States
- Volunteers
- 340 people
- Sponsor
- Tarveda Therapeutics
Metastatic Colorectal Cancer
Prospective Observational Study of 1st and 2nd Line Vectibix® Use in RAS-wt mCRC Pts to Evaluate Pattern of Use and ORR
The study will shed additional light on the impact of Vectibix® under the current, standard clinical conditions of mCRC treatment in Greece.
- Trial name
- VISION (NCT02322736)
- Where
- 20 sites in Greece
- Volunteers
- 218 people
- Sponsor
- Amgen
Breast Cancer, Colon Cancer
The Efficacy of Health Partnership Program for Cancer Patients
The Objectives of this study is 1. To evaluate the efficacy for exercise, diet, and posttraumatic growth as a result of participating in tailored program (Health Partnership Program) for 24 weeks 2.
- Conditions
- Breast Cancer, Colon Cancer, Gastric Cancer, Lung Cancer
- Trial name
- NCT01527409
- Testing
- Tailored health partnership program, Usual care and health education workshop
- Where
- 10 sites in South Korea
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Colon Cancer
Impact of Exercise and Hyperlipidic Meal on Free Circulating DNA in Patients With Metastatic Colonic Cancer and Healthy Subjects
The study of circulating tumoral DNA makes it possible to study, without invasive procedures or pathological studies, the tumoral DNA circulating in the blood of a patient and its various alterations.
- Trial name
- ASRHACOLS (NCT05147545)
- Testing
- Moderate intensity physical effort, Low intensity physical effort, Hyperlipidic meal
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colon Cancer
Robotic-assisted Left Hemicolectomy for Left Colon Cancer
The main goal of this study is to clarify if Robotic-assisted surgery could become the standard approach in patients undergoing left colonic resection.
- Trial name
- RALH (NCT03696472)
- Testing
- robotic assisted surgery, laparoscopic
- Where
- China
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Southwest Hospital, China
Colorectal Cancer, Metastatic Cancer
Surgery With or Without Radiofrequency Ablation Followed by Irinotecan in Treating Patients With Colorectal Cancer That is Metastatic to the Liver
RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. Combining radiofrequency ablation with surgery may kill more tumor cells.
- Trial name
- NCT00030563
- Testing
- irinotecan hydrochloride, adjuvant therapy, conventional surgery
- Where
- 3 sites in United States, Canada
- Sponsor
- University of Washington
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