Clinical trials: Colorectal Cancer Liver Metastasis
Liver Metastasis Colon Cancer, ctDNA Genotype
Targeted Treatment Plus Tislelizumab and HAIC for Advanced CRCLM Failed From Standard Systemic Treatment
Hepatic arterial infuison chemothearpy (HAIC), targeted therapy, and programmed death-1 (PD-1) inhibitors have been demonstrated to be effective for colorectal cancer liver metastasis (CRCLM).
- Conditions
- Liver Metastasis Colon Cancer, ctDNA Genotype, MSS, Failed From Standard Treatment
- Trial name
- NCT06199232
- Testing
- HAIC+targeted therapy+PD-1 inhibitor
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking University
Liver Neoplasms, Colonic Neoplasms
Safety, Efficacy, and Dosing of Stereotactic Radiosurgery for Hepato-cellular Carc/Colo-rectal Liver Metastases
The purpose of this study is to determine a tolerable dose of radiation delivered by the CyberKnife system in two groups of patients with hepatocellular carcinoma (HCC).
- Conditions
- Liver Neoplasms, Colonic Neoplasms, Metastatic Cancer to Liver
- Trial name
- NCT01528878
- Testing
- Stereotactic Radiosurgery using the CyberKnife System.
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Liver Metastases, Colorectal Cancer
PrOspEctive Metastases Imaging (POEM)
This is a non-interventional, observational study with an optional interventional biobanking activity. Liver metastases of patients undergoing partial hepatectomy will be sampled completely while respecting the orientation used…
- Conditions
- Liver Metastases, Colorectal Cancer, Breast Cancer
- Trial name
- POEM (NCT07781306)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cancer Research Antwerp
Colorectal Cancer, Metastatic Cancer
Portal Vein Embolization in Treating Patients With Liver Metastases From Primary Colorectal Cancer
RATIONALE: Embolization blocks blood flow to part of an organ and/or tumor. Blocking the portal vein on one side of the liver may cause the opposite side of the liver to increase in size and decrease the risk of liver failure…
- Trial name
- NCT00028626
- Testing
- embolization therapy
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Liver Metastases
CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer
This is an open label, fixed dose, phase Ib trial of anti-CEA CAR-T cell infusions delivered via the hepatic artery or splenic vein using the Surefire Infusion System (SIS) for patients with CEA-expressing liver metastases or…
- Trial name
- HITM-SURE (NCT02850536)
- Testing
- anti-CEA CAR-T cells
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Roger Williams Medical Center
Colorectal Cancer Metastatic, Liver Metastases
A Trial of Camrelizumab Combined With Microwave Ablation and Chemotherapy in the Treatment of Colorectal Cancer Liver Metastasis/Pulmonary Metastasis
Currently, comprehensive treatments for liver metastasis/pulmonary metastasis that cannot reach NED include systemic chemotherapy, interventional chemotherapy, molecular targeted therapy, immunotherapy, and local treatments…
- Conditions
- Colorectal Cancer Metastatic, Liver Metastases, Lung Metastases
- Trial name
- NCT04888806
- Testing
- Camrelizumab, ablation, chemotherapy
- Volunteers
- 37 people
- Sponsor
- Harbin Medical University
Advanced Malignant Solid Tumor, Solid Tumor Cancer
A First in Human Study of PLT012 in Participants With Solid Tumor Cancers
The goal of this clinical trial is to learn about what doses of PLT012 are safe to use in adults with advanced cancers in solid tumors. It will also learn about how effective different doses of PLT012 are in treating cancer.
- Trial name
- NCT07337525
- Testing
- PLT012
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Pilatus Biosciences Inc
Colorectal Cancer
Combined Resection of Colorectal Metastases
This is a Phase II study of combined surgical resection for patients with both intra- and extra-hepatic metastases from colorectal cancer.
- Trial name
- CRC (NCT00606398)
- Testing
- surgical resection for patients with both intra- and extra-hepatic metastases
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer, Liver Metastases
Cetuximab Plus FOLFOXIRI vs Cetuximab Plus FOLFOX For CRCLM
The aim of the trial is to optimize response rates and rates of secondary resections of metastases in patients with initially non-resectable metastatic colorectal cancer Liver Metastasis of RAS wildtype.
- Trial name
- NCT03493048
- Testing
- Irinotecan, Cetuximab, 5-fluorouracil
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Sun Yat-sen University
DWI-MRI
The Value of Diffusion-weighted Imaging in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer
The study is designed to evaluate the value of DWI-MRI (Diffusion weighted magnetic resonance imaging) in predicting the efficacy of liver metastases after chemotherapy in colorectal cancer.
- Trial name
- NCT03088163
- Testing
- Diffusion weighted magnetic resonance imaging
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Colon Cancer Liver Metastasis
Safety of TACE With Oxaliplatin, Irinotecan and Raltitrexed for Refractory Colorectal Cancer Liver Metastasis
The purpose of this study is to observe whether hepatic infusion by oxaliplatin, irinotecan and raltitrexed with or without embolization by lipiodol or microspheres are effective in the treatment of refratory liver metastasis…
- Trial name
- NCT02631564
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Colorectal Cancer, Colorectal Adenocarcinoma
PI Pembro in Combination With Stereotactic Body Radiotherapy for Liver Metastatic Colorectal Cancer
The purpose of this research study is: To find out how safe the study drug, pembrolizumab, is when combined with stereotactic body radiotherapy (SBRT) to the liver.
- Conditions
- Colorectal Cancer, Colorectal Adenocarcinoma, Stage IVA Colorectal Cancer, Stage IVB Colorectal Cancer
- Trial name
- NCT02837263
- Testing
- Stereotactic body radiotherapy (SBRT), Pembrolizumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Colorectal Cancer, Colorectal Cancer Liver Metastasis
3D Bioprinted Models for Predicting Chemotherapy Response in Colorectal Cancer With/Without Liver Metastases
The therapeutic regimens of adjuvant and neoadjuvant chemotherapy for colorectal cancer (CRC) remain largely relied on clinical experience, and thus preclinical models are needed to guide individualized medicine.
- Trial name
- NCT04755907
- Testing
- surgical resection, adjuvant chemotherapy, neoadjuvant therapy
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Metastatic Colorectal Liver Cancer
Partial Liver Radiotherapy for Unresectable Liver Metastases
This study is designed to treat tumors in the liver that cannot be removed surgically and chemotherapy cannot control these tumors, using radiation therapy and a more precise delivery than has been used before.
- Trial name
- NCT01048216
- Testing
- radiation therapy
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Royal Marsden NHS Foundation Trust
CRC (Colorectal Cancer), Melanoma (Skin Cancer)
A Phase 1 Study of TGI-5 as Monotherapy and in Combination With Nivolumab in Subjects With Locally Advanced/Metastatic Solid Tumors
This is a Phase 1, multicenter, open-label, two-parts, FIH study to evaluate the tolerability, safety, PK/PD, and preliminary antitumor activity of TGI-5 as monotherapy and in combination with Nivolumab in subjects with…
- Conditions
- CRC (Colorectal Cancer), Melanoma (Skin Cancer), HCC - Hepatocellular Carcinoma, NSCLC (Non-small Cell Lung Cancer)
- Trial name
- TGI5 (NCT07376707)
- Testing
- TGI-5
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Hefei TG ImmunoPharma Co., Ltd.
Colorectal Liver Metastases, Hepatocellular Carcinoma
Alternative Surgical Policy for Central Liver Tumors
Major hepatectomies have not negligible morbidity and mortality. However, when tumors invade middle hepatic vein (MHV) at caval confluence major surgery is usually recommended.
- Trial name
- NCT00600522
- Testing
- Ultrasound-guided hepatectomy
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Milan
Colorectal Cancer, Metastatic Cancer
Chemotherapy and Internal Radiation in Treating Patients With Colorectal Cancer That Has Spread to the Liver
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00408551
- Testing
- floxuridine, fluorouracil, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Goshen Health System
Colorectal Cancer, Metastatic Cancer
S0408: Capecitabine, Oxaliplatin, and Bevacizumab in Pts Undergoing Surgery for Liver Mets From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00118105
- Testing
- bevacizumab, capecitabine, oxaliplatin
- Where
- 46 sites in United States
- Sponsor
- SWOG Cancer Research Network
Colorectal Cancer
Postoperative Hepatic Arterial Chemotherapy in High-risk Patients as Adjuvant Treatment After Resection of Colorectal Liver Metastases
Currently, no adjuvant study with hepatic arterial infusion in the adjuvant setting is opened. Recently, the results of a phase II study (NCT00268463, NSABP-C-09) assessing the potential benefit of systemic oxaliplatin and…
- Trial name
- PACHA-01 (NCT02494973)
- Testing
- Oxaliplatin HAI, Oxaliplatin IV, mFOLFOX6
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris