Clinical trials: Colorectal Cancer Metastatic to Liver
Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver
HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization
This phase IIb trial tests the effect of HRX215 in treating patients with colorectal cancer that has spread from where it first started to the liver (liver metastasis) after undergoing a portal vein embolization (PVE).
- Conditions
- Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Resectable Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- NCT07612007
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Colo-rectal Cancer, Liver Metastasis
The Role and Safety of Radiofrequency Ablation in Recurrent Liver Metastasis of Colorectal Cancer
The goal of this clinical trial is to learn if radiofrequency ablation works to treat recurrent colorectal cancer liver metastases after surgery in adults. It will also learn about the safety of radiofrequency ablation.
- Trial name
- NCT06609434
- Testing
- Radiofrequency ablation
- Volunteers
- 111 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer
ALPPS (Liver Partition and Portal Vein Ligation) for Two-stage Hepatectomy for Colorectal Liver Metastasis
The aim of this study is evaluate the feasibility of early two-stage hepatectomy in patients with liver metastasis from colorectal cancer.
- Trial name
- NCT01842971
- Testing
- two stage hepatectomy
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Colorectal Cancer, Liver Metastases
Cetuximab in Neoadjuvant Treatment of Non-Resectable Colorectal Liver Metastases (CELIM)
General Objectives: To test the feasibility of neoadjuvant treatment with cetuximab/chemotherapy followed by liver resection To determine the optimal combination (cetuximab/FOLFOX versus cetuximab/FOLFIRI) for further trials in…
- Trial name
- NCT00153998
- Testing
- Cetuximab, Liver resection, Cetuximab and FOLFIRI
- Where
- 21 sites in Austria, Germany
- Volunteers
- 135 people
- Sponsor
- Technische Universität Dresden
Breast Cancer, Head and Neck Cancers
Surgical Margin Assessment Using Intra-operative High-resolution PET/CT in Patients With Cancers Referred to Surgical Resection, an Exploratory Pilot Study
Reoperation is often required in surgical oncology because of positive resection margins and is associated with substantial physical, psychological, and economic consequences.
- Conditions
- Breast Cancer, Head and Neck Cancers, Lung Cancer, Sarcoma
- Trial name
- SMART-PET (NCT07884487)
- Testing
- FDG radiotracer
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Colorectal Cancer, Metastatic Cancer
Sunitinib Malate and Combination Chemotherapy as Front-Line Therapy in Treating Patients With Metastatic Rectal Cancer That Cannot Be Removed by Surgery
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00936832
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- France
- Sponsor
- Federation Francophone de Cancerologie Digestive
Melanoma, Cervical Carcinoma
A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors
This is a Phase 1, multiple dose, ascending-dose escalation study and expansion study designed to define a maximum tolerated dose and/or recommended dose of XmAb22841 monotherapy and in combination with pembrolizumab; to assess…
- Conditions
- Melanoma, Cervical Carcinoma, Pancreatic Carcinoma, Triple Negative Breast Cancer
- Trial name
- DUET-4 (NCT03849469)
- Testing
- XmAb®22841, Pembrolizumab (Keytruda®)
- Where
- 28 sites in United States
- Volunteers
- 78 people
- Sponsor
- Xencor, Inc.
HER2-positive, Adenocarcinoma
CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors
Phase 1, first-in-human, open label study of CAR macrophages in HER2 overexpressing solid tumors.
- Conditions
- HER2-positive, Adenocarcinoma, Bile Duct Cancer, Biliary Tract Cancer
- Trial name
- NCT04660929
- Testing
- CT-0508, Pembrolizumab
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Carisma Therapeutics Inc
Colorectal Cancer
Postoperative Hepatic Arterial Chemotherapy in High-risk Patients as Adjuvant Treatment After Resection of Colorectal Liver Metastases
Currently, no adjuvant study with hepatic arterial infusion in the adjuvant setting is opened. Recently, the results of a phase II study (NCT00268463, NSABP-C-09) assessing the potential benefit of systemic oxaliplatin and…
- Trial name
- PACHA-01 (NCT02494973)
- Testing
- Oxaliplatin HAI, Oxaliplatin IV, mFOLFOX6
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Cancer
Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients
RATIONALE: Palliative care may help patients with advanced cancer live more comfortably. PURPOSE: This randomized clinical trial is studying an early intervention palliative care program to see how well it works compared to a…
- Trial name
- NCT00253383
- Testing
- counseling intervention, educational intervention, psychosocial assessment and care
- Where
- 2 sites in United States
- Volunteers
- 329 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Colorectal Cancer Metastatic, Surgical Procedure, Unspecified
Perioperative Outcomes of Simultaneous Colorectal and Liver Resections
The use of a simultaneous resection in patients with synchronous colorectal liver metastases has increased over the past decades.
- Trial name
- SIMULT (NCT05475041)
- Testing
- Major liver resection, Technically major liver resection
- Where
- Italy
- Volunteers
- 766 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Rectal Cancer
The Role of TextRAd on Detection of Liver Metastasis in Rectal Cancer
This is a retrospective analysis of all patients diagnosed with LARC who received NCRT and had MRI scans between 2003-2014 at East Suffolk and North Essex NHS Foundation Trust.
- Trial name
- NCT05398822
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- East Suffolk and North Essex NHS Foundation Trust
Colorectal Cancer, Metastatic Cancer
S0408: Capecitabine, Oxaliplatin, and Bevacizumab in Pts Undergoing Surgery for Liver Mets From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00118105
- Testing
- bevacizumab, capecitabine, oxaliplatin
- Where
- 46 sites in United States
- Sponsor
- SWOG Cancer Research Network
Colorectal Cancer
TACE With Irinotecan Drug-eluting Beads and Intravenous (IV) Cetuximab in Refractory Colorectal Cancer
The primary objective of this study is to evaluate the efficacy of Irinotecan Beads in combination with intravenous cetuximab versus intravenous irinotecan in combination with intravenous cetuximab in the treatment of patients…
- Trial name
- DEBIRITUX (NCT01060423)
- Testing
- Cetuximab, Irinotecan, Irinotecan eluting BEADS
- Where
- 13 sites in Germany
- Volunteers
- 8 people
- Sponsor
- Hans-Joachim Schmoll, MD
Immunotherapy, Colorectal Cancer
TAS-102 Combined With Bevacizumab and Tislelizumab Third-line or Above in the Treatment of Liver Metastasis in Colorectal Cancer
To evaluate the clinical efficacy and safety of TAS-102 combined with bevacizumab and tislelizumab in third-line or above treatment in patients with advanced colorectal adenocarcinoma with liver metastasis.
- Trial name
- NCT05314101
- Testing
- Tislelizumab, bevacizumab, TAS-102
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fujian Cancer Hospital
Colorectal Cancer
Evaluation of Low-dose Irinotecan and Cyberknife® SBRT to Treat Colorectal Cancer With Limited Liver Metastasis
The purpose of this study is to determine the effects of CyberKnife stereotactic body radiotherapy in combination with irinotecan chemotherapy in patients with colon or rectal cancer that has spread to the liver.
- Trial name
- NCT01847495
- Testing
- Irinotecan, CyberKnife
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Colorectal Cancer, Liver Metastases
Conversion Therapy of RAS/BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastases
Evidence suggests that the addition of cetuximab or bevacizumab to doublet regimens could improve response rate and resectability rate of liver metastases and survival in colorectal liver metastases (CRLM).
- Trial name
- NCT04687631
- Testing
- mFOLFOXIRI plus Cetuximab, mFOLFOXIRI Plus Bevacizumab
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Fudan University
Colorectal Cancer Stage IV
Impact de la Marge de résection Sur la Survie à Long Terme et le Taux de récidive Des Patients Atteints de Cancers Colorectaux opérés au CHUS Entre 2006 et 2016 Pour Des métastases hépatiques
We retrospectively looks at the impact of the margin status and its size in mm on the recurrence rate in colo-rectal liver metastasis surgery.
- Trial name
- NCT05164419
- Volunteers
- 170 people
- Sponsor
- Université de Sherbrooke
Head & Neck Cancer, Pancreas Carcinoma
SL-28 for Advanced Solid Tumours
Second Life Therapeutics is developing SL-28, an allogeneic, non-genetically modified cell-based therapy for the treatment of advanced solid tumours.
- Conditions
- Head & Neck Cancer, Pancreas Carcinoma, Pancreas Cancer, Metastatic, Lung Adenocarcinoma
- Trial name
- NCT07341737
- Testing
- SL-28
- Where
- 3 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Second Life Therapeutics
Cancer, Cancer Metastatic
Colorectal Liver Metastases: Novel Assessment Tools for Technical Resectability
The CoNoR study aims to assess whether the use of the LiMAx test and the HepaT1ca pre-operative planning magnetic resonance scan impact upon technical resectability decision-making in colorectal liver metastases (CLM).
- Conditions
- Cancer, Cancer Metastatic, Colorectal Cancer, Liver Metastasis Colon Cancer
- Trial name
- CoNoR (NCT04270851)
- Testing
- LiMAx test, HepaT1ca magnetic resonance scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Manchester