Clinical trials: Colorectal Cancer Recurrent
Rectum Cancer, Recurrent, Brachytherapy, Radioisotope
The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy
This study observes the efficacy and side effects of 3D-printing non co-planar template(3D-PNCT) assisted with CT-guidance for radioactive Iodine-125 seed(RIS) brachytherapy in pelvic recurrent rectum carcinoma retrospectively…
- Trial name
- NCT03890926
- Testing
- radioactive Iodine-125 seed implantation under the guidance of 3D template
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
Colorectal Cancer
Prognostic Factors Influencing the Recurrence Rate and Survival of Patients With Colorectal Cancer: a Single Institution Experience
over the past decade colon cancer has emerged as the second most deadly and the third most common type of cancer in the world with increasing incidence in Egypt due to life style and diet change.
- Trial name
- NCT06325410
- Testing
- resection of colorectal cancer
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Zagazig University
Cancer
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer
Phase I trial to study the effectiveness of trastuzumab plus R115777 in treating patients who have advanced or metastatic cancer.
- Trial name
- NCT00005842
- Testing
- trastuzumab, tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Colorectal Cancer
Cyclophosphamide, Radiation Therapy, and Poly ICLC in Treating Patients With Unresectable, Recurrent, Primary, or Metastatic Liver Cancer
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Breast Cancer, Colorectal Cancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT00553683
- Testing
- cyclophosphamide, poly ICLC, hepatic artery embolization
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rutgers, The State University of New Jersey
Adenomatous Polyp, Recurrent Colon Cancer
Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma
This randomized phase II trial is studying how well erlotinib hydrochloride works in treating patients with stage I-III colorectal cancer or adenoma.
- Conditions
- Adenomatous Polyp, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage I Colon Cancer
- Trial name
- NCT00754494
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Inflammation, Prevention and Control
Effect of High-Legume Diet on Colorectal Cancer Risk
This study, sponsored by the National Cancer Institute and Penn State University, will examine how a diet high in legumes (dried beans) influences risk factors for colon cancer and polyps.
- Conditions
- Inflammation, Prevention and Control, Colonic Neoplasms, Diet
- Trial name
- NCT00339469
- Testing
- LIFE
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Kidney Cancer
Fluorouracil and Biological Therapy in Treating Patients With Metastatic Kidney or Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00016042
- Testing
- lymphokine-activated killer cells, recombinant interferon alfa, sargramostim
- Where
- United States
- Sponsor
- St. Luke's Medical Center
Colorectal Cancer
Irofulven in Treating Patients With Metastatic or Recurrent Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of irofulven in treating patients with metastatic or…
- Trial name
- NCT00003786
- Testing
- irofulven
- Where
- 9 sites in United States
- Sponsor
- University of Chicago
Colorectal Neoplasms, Adenoma Colon
Surveillance Intervals After Piecemeal Resection of Non-pedunculated Colorectal Lesions ≥20mm
Intensive endoscopic surveillance following piecemeal resection of non-pedunculated colorectal lesions (NPCL) ≥20 mm is the current standard of care, given the high recurrence rate of these lesions (15-30%).
- Conditions
- Colorectal Neoplasms, Adenoma Colon, Colonic Polyps, Serrated Adenoma
- Trial name
- NCT06791616
- Testing
- Colonoscopy
- Volunteers
- 746 people
- Sponsor
- Asociación Española de Gastroenterología
Colorectal Cancer
Dietary Bioflavonoid Supplementation for the Prevention of Neoplasia Recurrence
Prove the hypothesis that dietary supplementation with bioflavonoids will diminish the recurrence rate of colonic neoplasia, we will implement a clinical trial comparing bioflavonoids and placebo in a double blind randomized…
- Trial name
- NCT00609310
- Testing
- Flavonoids
- Where
- Germany
- Volunteers
- 382 people
- Sponsor
- Technische Universität Dresden
Colorectal Cancer
Liposomal SN-38 in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as liposomal SN-38, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00311610
- Testing
- SN-38 liposome
- Where
- 10 sites in United States
- Volunteers
- 30 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Rectal Cancer, Recurrence
Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients
This study investigates the potential benefit of re-irradiation of patients with locally advanced rectal recurrences, by a prospective phase II clinical, imaging and translational research study.
- Conditions
- Rectal Cancer, Recurrence, Radiation Toxicity
- Trial name
- Re-RAD-I (NCT05816980)
- Testing
- Hyperfractionated external beam radiation
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 16 people
- Sponsor
- Aarhus University Hospital
Colorectal Cancer
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer
RATIONALE: Vaccines may make the body build an immune response that will kill cancer cells. Combining vaccine therapy with interleukin-2 may kill more cancer cells.
- Trial name
- NCT00019591
- Testing
- aldesleukin, ras peptide cancer vaccine, adjuvant therapy
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving the drugs in different combinations may kill more tumor cells.
- Trial name
- NCT00003260
- Testing
- FOLFIRI regimen, FOLFOX regimen, fluorouracil
- Where
- France
- Volunteers
- 109 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Recurrent Colon Cancer, Recurrent Rectal Cancer
Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy
This pilot clinical trial studies short-infusion ziv-aflibercept in treating patients with metastatic colorectal cancer receiving combination chemotherapy.
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IVA Colon Cancer, Stage IVA Rectal Cancer
- Trial name
- NCT01941173
- Testing
- ziv-aflibercept, leucovorin calcium, irinotecan hydrochloride
- Where
- 3 sites in United States
- Sponsor
- City of Hope Medical Center
Colorectal Cancer
Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer
A randomized, paralleled control clinical study investigating Huaier Granule for prevention of recurrence and metastasis of colorectal cancer after radical surgery, to evaluate the efficacy and safety.
- Trial name
- NCT02785146
- Testing
- Huaier Granule, Oxaliplatin, Calcium folinate
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Recurrence, Survival Rate
Impact of Perioperative Hyperoxia on Cancer Recurrence and Mortality After Elective Colorectal Cancer Surgery
The goal of this observational study is to evaluate whether perioperative hyperoxia (FiO₂ > 0.8), compared to conventional oxygen therapy (FiO₂ < 0.4), is associated with increased cancer recurrence and mortality in patients…
- Conditions
- Recurrence, Survival Rate, Mortality, Colorectal Surgery
- Trial name
- OncO2 (NCT06989346)
- Where
- Spain
- Volunteers
- 403 people
- Sponsor
- Parc de Salut Mar
Colorectal Cancer
Bortezomib, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Advanced or Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00098982
- Testing
- bortezomib, fluorouracil, leucovorin calcium
- Where
- 3 sites in Italy, Switzerland and 1 more
- Volunteers
- 16 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Peritoneal Carcinomatosis, Peritoneal Metastases
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms
Diffusion-weighted magnetic resonance imaging (DWI/MRI) has been described in recent literature as a highly sensitive and specific modality for the detection of peritoneal metastases PM.
- Conditions
- Peritoneal Carcinomatosis, Peritoneal Metastases, Appendix Cancer, Appendix Neoplasm
- Trial name
- DWI-HighRisk (NCT05623787)
- Testing
- Whole-body diffusion-weighted magnetic resonance imaging
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Laval University