Clinical trials: Colorectal Carcinoma (CRC)
Metastatic Colorectal Cancer, MSS
Combined PD-1 and CCR5 Inhibition for the Treatment of Refractory Microsatellite Stable mCRC
This is a monocentric, single arm, prospective, open-label trial of a combination treatment consisting of pembrolizumab and maraviroc in previously treated subjects who have refractory microsatellite stable (MSS) metastatic…
- Trial name
- PICCASSO (NCT03274804)
- Testing
- Pembrolizumab, Maraviroc
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Cancer Colorectal
Cetuximab as Salvage Therapy in Patients With Neo Wild-type RAS/RAF Metastatic Colorectal Cancer With Liver Metastases.
The purpose of this study is to investigate the efficacy of cetuximab or cetuximab-irinotecan in patients with neo wild-type colorectal cancer who have been previously treated for metastatic disease.
- Trial name
- CETIDYL (NCT04189055)
- Testing
- Cetuximab, Irinotecan
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Hôpital Franco-Britannique-Fondation Cognacq-Jay
Colorectal Cancer
Safety and Immune Response to FMPV-1
This is a single centre, open-label, non-randomized, Phase I study assessing safety and immune response of FMPV-1 in healthy male subjects.
- Trial name
- NCT05238558
- Testing
- FMPV-1, GM-CSF (as adjuvant)
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hubro Therapeutics AS
Colorectal Cancer
GW572016, An Oral Drug For Colorectal Cancer Patients Having Prior Therapy With 5-FU Plus CPT-11 And/Or Oxaliplatin
The purpose of this study is to determine the efficacy of an oral investigational drug in patients with refractory metastatic colorectal cancer after receiving prior therapy with 5-fluorouracil in combination with irinotecan…
- Trial name
- NCT00044343
- Testing
- lapatinib
- Where
- 57 sites in United States, Canada
- Volunteers
- 80 people
- Sponsor
- GlaxoSmithKline
Cancer Cachexia, Side Effects
The Effects of n-3 LCPUFAs in Patients With Colorectal Cancer
The aim of this study is to determine the effects of n-3 PUFAs on weight, physical funktion and quality of life in patients with colorectal cancer.
- Conditions
- Cancer Cachexia, Side Effects, Quality of Life
- Trial name
- NCT04699760
- Testing
- Fish Oil
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Copenhagen
Colorectal Cancer
Cetuximab in Third Line for Mutant APC, TP53 and RAS Patients With Refractory Metastatic Colorectal Cancer
A prospective, multi-center, phase II study of 21 patients to evaluate the efficacy of the epidermal growth factor receptor (EGFR) inhibitor, Cetuximab in patients with metastatic colorectal cancer (mCRC) harboring Adenomatous…
- Trial name
- APK Mutant (NCT04853043)
- Testing
- Cetuximab
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Utah
Metastatic Colorectal Cancer
Early Detection of Relapses in Stage IV Colorectal Cancer Patients
This study is a prospective, multicenter, observational study on metastatic, operable colorectal cancer to evaluate the proof of concept of the cfDNA analysis for the early detection of recurrences
- Trial name
- REDCLOUD (NCT04232891)
- Testing
- liquid biopsy
- Where
- 2 sites in Italy
- Volunteers
- 141 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Advanced Solid Tumors
A Study of BMS-986466 With Adagrasib With or Without Cetuximab in Participants With Kirsten Rat Sarcoma Virus Glycine 12 to Cysteine (KRAS G12C)-Mutant Solid Tumors
The purpose of this study is to find a safe, tolerable, and efficacious dose of BMS-986466 when given orally, in combination with adagrasib with or without cetuximab in participants with advanced KRAS G12C-mutant non-small cell…
- Trial name
- NCT06024174
- Testing
- BMS-986466, Adagrasib, Cetuximab
- Where
- 9 sites in United States, Australia and 3 more
- Volunteers
- 5 people
- Sponsor
- Bristol-Myers Squibb
Cancer Survivor, Colorectal Cancer
Internet-Based Weight-Loss Program for Colorectal Cancer Survivors
RATIONALE: A personalized Internet-based weight-loss program may help improve the quality of life for colorectal cancer survivors.
- Conditions
- Cancer Survivor, Colorectal Cancer, Weight Changes
- Trial name
- NCT01032590
- Testing
- Internet weight loss intervention
- Where
- 2 sites in United States
- Sponsor
- Rutgers, The State University of New Jersey
Colorectal Cancer, Colorectal Cancer Liver Metastasis
3D Bioprinted Models for Predicting Chemotherapy Response in Colorectal Cancer With/Without Liver Metastases
The therapeutic regimens of adjuvant and neoadjuvant chemotherapy for colorectal cancer (CRC) remain largely relied on clinical experience, and thus preclinical models are needed to guide individualized medicine.
- Trial name
- NCT04755907
- Testing
- surgical resection, adjuvant chemotherapy, neoadjuvant therapy
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer, Metastatic Cancer
Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer
This is an open-label, single-center, single-arm phase II clinical trial evaluating the combination of pembrolizumab, binimetinib, and bevacizumab in patients with metastatic colorectal adenocarcinoma who have not responded to…
- Trial name
- NCT03475004
- Testing
- Pembrolizumab, Bevacizumab, Binimetinib
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Colorado, Denver
Colorectal Cancer, Liver Metastases
Cetuximab Re-challenge for Colorectal Cancer Liver Metastasis
For patients with unresectable colorectal cancer liver metastases, preclinical studies have shown that after the resistance of cetuximab, the treatment sensitivity can be restored by stopping cetuximab for a period of time.
- Conditions
- Colorectal Cancer, Liver Metastases, Cetuximab
- Trial name
- NCT04509635
- Testing
- Cetuximab, Chemotherapy
- Volunteers
- 50 people
- Sponsor
- Fudan University
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs at the time of day that allows for the best drug response may allow the doctor to give higher…
- Trial name
- NCT00039208
- Testing
- fluorouracil, irinotecan hydrochloride, leucovorin calcium
- Where
- 20 sites in Belgium, France and 2 more
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Neoplasms
Efficacy of Web-based Self-management Support Intervention on Health Outcomes in Patients With Colorectal Cancer
The study aims to test the efficacy of a web-based interactive self-management support intervention on the primary outcome, quality of life, secondary outcomes, symptom distress, emotional distress, physical activity, and the…
- Trial name
- NCT05045976
- Testing
- Web-based interactive self-management support program
- Where
- 2 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Colorectal Cancer
Clinical Sequencing Project for Metastatic Cancer Patients for Personalized Cancer Clinic.
The next generation of personalized medical treatment according to the type of personal genetic information are evolving rapidly. The genome analysis needs systematic infra and database based on personal genetic information.
- Trial name
- NCT02593591
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
CRC
The Phase 1b/IIa, Open-label, Dose Escalation and Dose Expansion to Evaluate Safety, Tolerability, and Preliminary Efficacy of the Combination of HCB101, Cetuximab/Bevacizumab, and FOLFOX/FOLFIRI in Advanced or Metastatic Colorectal Cancer
This is a non-randomized, open-label, dose-escalation and dose-expansion phase I/II clinical study to evaluate the safety, tolerability, and efficacy of HCB101 in combination with Cetuximab/Bevacizumab, and FOLFOX/FOLFIRI in…
- Trial name
- NCT07204574
- Testing
- HCB101, Bevacizumab, Cetuximab (Erbitux)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Cancer, Cancer Metastatic
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors
The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors.
- Conditions
- Cancer, Cancer Metastatic, Neoplasms, Breast Cancer
- Trial name
- NCT05131815
- Testing
- Virtual group based physical activity (BurnAlong) and Social Media Discussion Board
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer With Liver Metastases
ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer ( MetaIRM)
Currently, the tumor response of operated colorectal liver metastases is assessed by histology of the resection specimen.The histological data make it possible to define categories (responder, partial responder, non-responder).
- Trial name
- MetaIRM (NCT06552117)
- Testing
- an elastoMRI sequence
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer Metastatic
Assessing How Normal Variations in CT Scanning Affects Its Interpretation
The purpose of the study is to see how measurements of tumor differences vary with slight changes in CT scan parameters. Reproducible radiomic features can be extracted for abdominal tumors, and specifically colorectal liver…
- Trial name
- NCT03038568
- Testing
- CT scan
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancers
Open-Label Phase IIb Efficacy Trial of Cancer Macrobeads Compared to Best Supportive Care in Colorectal Cancer Patients
This is a clinical research study of an investigational (FDA IND-BB 10091) treatment for patients with advanced colorectal cancer that no longer responds to standard therapies.
- Trial name
- NCT02046174
- Testing
- RENCA macrobeads
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- The Rogosin Institute
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