Clinical trials: Colorectal Carcinoma (CRC)
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS)
The Cancer of the Pancreas Screening-5 CAPS5)Study
Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.
- Conditions
- Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier
- Trial name
- CAPS5 (NCT02000089)
- Testing
- Secretin, MRI, Tumor marker gene test with CA19-9
- Where
- 9 sites in United States
- Volunteers
- 9,000 people
- Sponsor
- Johns Hopkins University
CRC, Colorectal Cancer
An Exploratory Clinical Study Evaluating the Efficacy and Safety of Tunlametinib Combined With Fruquintinib in the Third-line Treatment of Advanced Colorectal Cancer Patients With RAS Mutations.
This study is a prospective, open-label, single-arm clinical study aimed at evaluating the efficacy and safety of Tunlametinib combined with Fruquintinib in the third-line treatment of advanced colorectal cancer patients with RAS…
- Trial name
- NCT06985316
- Testing
- Tunlametinib combined with Fruquintinib
- Volunteers
- 34 people
- Sponsor
- Liu Huang
Colorectal Neoplasms, Neoplasm Metastasis
Study of Aflibercept And Modified FOLFOX6 As First-Line Treatment In Patients With Metastatic Colorectal Cancer
The primary objective of the study is to estimate the progression-free survival rate at 12 months for the two arms of the study.
- Trial name
- AFFIRM (NCT00851084)
- Testing
- aflibercept, oxaliplatin, 5-FU
- Where
- 37 sites in Australia, Germany and 5 more
- Volunteers
- 268 people
- Sponsor
- Sanofi
Metastatic Colorectal Cancer
Pattern of Use of Bevacizumab or Cetuximab + FOLFIRI Regimen as First-line Treatment in Metastatic Colorectal Cancer
Registry Multicenter, prospective observational study Observe adverse events and efficacy in recruited patients for 3 years under real world settings.
- Trial name
- NCT03286738
- Testing
- FOLFIRI, target agent
- Where
- South Korea
- Volunteers
- 1,800 people
- Sponsor
- Joong Bae Ahn
Colorectal Cancer
Capiri-sutent Phase-1 in Advanced Colo-rectal Cancer
The primary objective of this Phase 1 study is to identify the recommended dose of capiri and of sunitinib for combination therapy subsequent phase II trials.
- Trial name
- sutent-capiri (NCT00777478)
- Testing
- capiri-sutent
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer Stage IV
PET/CT Scan as a Tool to Rationalize the Treatment of Patients With Advanced ColoRectal Cancer Undergoing First-line Medical Treatment
The purpose of this study is to test whether an early metabolic response, measured by PET/CT scan after the first cycle of chemotherapy, is able to predict which patients with advanced CRC have a better prognosis.
- Trial name
- PETRA2 - CRC (NCT02618850)
- Testing
- PET/CT, first-line chemotherapy
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- National Cancer Institute, Naples
Colorectal Cancer Metastatic
METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin
This study aims to determine the efficacy, safety, and tolerability of the sequential addition of immune-modulating therapy to standard-of-care therapy of microsatellite-stable (MSS)/mismatch repair-proficient (pMMR) metastatic…
- Trial name
- METIMMOX (NCT03388190)
- Testing
- Nivolumab, FLOX
- Where
- 5 sites in Norway
- Volunteers
- 80 people
- Sponsor
- University Hospital, Akershus
CRC Screening, CRC (Colorectal Cancer)
Feasibility of a Multi-Channel Intervention to Promote Colorectal Cancer Screening Among American Indians in Oklahoma
The Accelerating Colorectal Cancer Screening and follow-up through Implementation Science (ACCSIS) Program addresses major regional CRC screening disparities among AI in Oklahoma.
- Trial name
- YVONNE (NCT07254910)
- Testing
- Narrative Testimonial Video, v-TCHE Interaction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00006115
- Testing
- FOLFIRI regimen, FOLFOX regimen, fluorouracil
- Where
- 16 sites in France
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Bladder Cancer, Breast Cancer
LMB-9 Immunotoxin in Treating Patients With Advanced Solid Tumors
RATIONALE: The LMB-9 immunotoxin may be able to locate tumor cells and kill them without harming normal cells. This may be an effective treatment for advanced solid tumors.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Esophageal Cancer
- Trial name
- NCT00019435
- Testing
- LMB-9 immunotoxin
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Colorectal Cancer
Satisfaction & Efficacy of Compression Using Surgical Gloves in Chemo-induced Peripheral Neuropathies
Evaluation of Satisfaction \& Efficacy of Compression Using Surgical Gloves in Peripheral Neuropathies Due to Chemotherapy
- Trial name
- ELEGANT (NCT03872908)
- Testing
- Chilled gloves, Surgical gloves
- Where
- 2 sites in France
- Volunteers
- 177 people
- Sponsor
- Centre Leon Berard
Advanced Colorectal Cancer
Efficacy, Safety and Exploratory Clinical Study of Bevacizumab Combined With Oxaliplatin and TAS-102 in First-line Treatment of Advanced Colorectal Cancer
This study is a single-arm, prospective, open-label observational clinical study to evaluate the efficacy and safety of Bevacizumab combined with Oxaliplatin and TAS-102 in patients with advanced unresectable rectal cancer.
- Trial name
- NCT05364489
- Testing
- Bevacizumab combined with Oxaliplatin and TAS-102
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Recurrent or Persistent Metastatic Colorectal Cancer
Phase I trial to study the effectiveness of radiolabeled monoclonal antibody therapy in treating patients who have recurrent or persistent metastatic colorectal cancer.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00023933
- Testing
- iodine I 131 monoclonal antibody CC49-deltaCH2
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Colorectal Cancer
ARQ 197 in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer
ARQ 197 or placebo in combination with irinotecan and cetuximab in participants with metastatic colorectal cancer (CRC), in participants with wild-type KRAS alleles who have failed front-line systemic therapy, to evaluate the…
- Trial name
- NCT01075048
- Testing
- Tivantinib, Cetuximab, Irinotecan
- Where
- 40 sites in United States, France and 3 more
- Volunteers
- 131 people
- Sponsor
- Daiichi Sankyo
Colorectal Cancer, ctDNA
The Implication of ctDNA in the Recurrence Surveillance of Stage II and III Colorectal Cancer
This study is to evaluate circulating tumor DNA (ctDNA) as a predictive and surveillant method for tumor recurrence in stage II and III colorectal cancer (CRC).
- Conditions
- Colorectal Cancer, ctDNA, Surveillance
- Trial name
- NCT03416478
- Testing
- ctDNA test
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Liver Cancer, Colorectal Cancer
The Inflammatory Response to Stress and Angiogenesis in Liver Resection
Patients with resectable liver metastases of colorectal origin will be assigned to laparoscopic liver resection or conventional open liver surgery. Blood samples will be drawn preoperatively and 24 hours after resection.
- Conditions
- Liver Cancer, Colorectal Cancer, Metastatic Cancer, Liver Metastases
- Trial name
- NCT03131778
- Testing
- Liver resection
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Colorectal Cancer
Tissue and Serum Collection From Colorectal Cancer Patients
To establish a serum and tissue bank with specimens form patients with colorectal cancer, for subsequent immunological and biochemical analysis.
- Trial name
- NCT00579891
- Where
- United States
- Volunteers
- 726 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
Research on the Treatment of Metastatic Colon Cancer Patients Treated by FOLFOXIRI
Colon cancer with metastase in the diagnose time account for one significant rate and has a increasing trend. The treatment result of this patient group rests modest.
- Trial name
- NCT03504618
- Testing
- FOLFOXIRI
- Where
- Vietnam
- Volunteers
- 39 people
- Sponsor
- Hanoi Medical University
Colorectal Cancer
The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal Cancer
Vitamin B-6, folate and homocysteine may play a critical role in the colorectal cancer progression. This is a 4-y study and the specific aims are: 1) to compare vitamin B-6, folate and homocysteine status, oxidative stress…
- Trial name
- NCT01426490
- Testing
- Vitamin C, Vitamin B6, Folic acid
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Colorectal Cancer
Health Behavior Intervention for Colorectal Cancer Patients
Develop a health behavior intervention plan based on patients' needs and preferences, and preliminarily apply and evaluate the feasibility and effectiveness of this intervention plan for patients with colorectal cancer.
- Trial name
- NCT07632313
- Testing
- health behavior intervention programs based on the temporal self-regulation theory are also received
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing Medical University
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