Clinical trials: Colorectal Carcinoma (CRC)
Rectum Cancer, Cancer of Colon
BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer
We collect prospectively and retrospectively, patients' demographic, pathological, surgical, therapeutic and prognosis informations in a database.
- Trial name
- BASE HSP110 (NCT02458664)
- Testing
- Genetic analysis on tumor kept in tumor bank
- Where
- France
- Volunteers
- 597 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Metastases, Colorectal Cancer
Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases
This is a Phase II study to determine the efficacy of SBRT to treat liver metastases in patients with Colorectal Adenocarcinoma, Carcinoma of the Anal Canal and Gastrointestinal Neuroendocrine Tumors that are not amenable to…
- Conditions
- Liver Metastases, Colorectal Cancer, Anal Canal Cancer, Gastrointestinal Neuroendocrine Tumors
- Trial name
- NCT02185443
- Testing
- SBRT
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- University of Sao Paulo
Colorectal Cancer, Adenomatous Polyps
Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)
The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- NCT06220617
- Where
- 6 sites in China
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colorectal Carcinoma Metastatic in the Liver
An Investigational Scan (MR DENSE) in Detecting Early Chemotherapy-Related Liver Injury Before Surgery in Patients With Resectable Colorectal Liver Metastases
This trial studies how well a magnetic resonance imaging technique called Displacement Encoding with Stimulated Echo (DENSE) works in detecting chemotherapy-related liver injury in patients with colorectal cancer that has spread…
- Trial name
- NCT05059717
- Testing
- Magnetic Resonance Imaging
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Single Center Randomized Pilot Study Of Colorectal Cancer Screening Outreach
A four arm randomized pilot study to assess if the rate of completion of Fecal Immunochemical Test is increased by the addition of financial incentives.
- Trial name
- CRCSO (NCT02594150)
- Testing
- Financial Incentive
- Volunteers
- 897 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Colorectal Cancer, Breast Cancer
Case Control Study to Identify Modifiable Risk Factors for Colorectal and Breast Cancer in Nigeria
This project is a case-control study which seeks to identify modifiable risk factors for breast and colorectal cancer in Nigeria.
- Trial name
- NCT05044689
- Testing
- Questionnaire, Bioimpedance/Body Composition Unit
- Where
- Nigeria
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Gastric Cancer, Colorectal Cancer
"The Impact of Immunonutrition on Gut Microbiota-related Aspects in Colorectal Cancer and Gastric Cancer Patients"
Enteral immunomodulating nutrition modifies the gastrointestinal microbiota as well as improves the intestinal barrier integrity in patients with gastric and colorectal cancer in the perioperative period.
- Trial name
- NCT04980950
- Testing
- Impact Oral Nestlé Health Science, Cubitan® Nutricia, Nutridrink® Nutricia, Resource 2.0 Nestlé Health Science
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Colorectal Cancer Screening
Impact of Protect Your Colon™ on CRC Screening
The purpose of the research is to assess the impact of Protect Your Colon™, a colorectal cancer (CRC) screening decision aid, on patients' CRC screening behaviors.
- Trial name
- NCT05929820
- Testing
- Protect Your Colon™
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer
Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. It is not yet known whether sulindac, aspirin, or ursodiol is more effective in preventing colorectal…
- Trial name
- NCT00062023
- Testing
- Acetylsalicylic acid (Aspirin), Sulindac, Ursodiol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
TRICC-C (AIO-KRK-0111): BIBF 1120 Versus Placebo in Patients Receiving Oxaliplatin Plus Fluorouracil and Leucovorin (mFOLFOX6) for Advanced, Chemorefractory Metastatic Colorectal Cancer (mCRC)
The purpose of this study: To explore the comparative effectiveness of BIBF 1120 in terms of : Progression-free survival (PFS), objective response, overall survival Evaluate and compare safety
- Trial name
- AIO-KRK-0111 (NCT01362361)
- Testing
- mFOLFOX6 + BIBF 1120
- Where
- 12 sites in Germany
- Volunteers
- 54 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Advanced Colorectal Carcinoma
A Dose Escalation Study of APR003 in Patients With Advanced Colorectal Cancer (CRC) With Malignant Liver Lesions
A Phase 1 dose escalation study to evaluate APR003 in patients with advanced colorectal cancer (CRC) with malignant liver lesions
- Trial name
- NCT04645797
- Testing
- APR003
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Apros Therapeutics, Inc
Metastatic Colorectal Cancer (CRC), Liposomal Irinotecan
A Clinical Study of Liposomal Irinotecan for Second-Line Therapy in Metastatic Colorectal Cancer
Phase II - Treatment Regimen Exploration Stage: 1. Evaluate the safety and efficacy of the following three treatment regimens: Liposomal irinotecan + 5-FU/LV + bevacizumab + Enlonstobart (Group A) Liposomal irinotecan + 5-FU/LV +…
- Conditions
- Metastatic Colorectal Cancer (CRC), Liposomal Irinotecan, Second-Line
- Trial name
- NCT07585279
- Testing
- Liposomal irinotecan + 5-FU/LV + bevacizumab + Enlonstobart, Irinotecan liposome + 5-FU/LV + Bevacizumab, Irinotecan + 5-FU/LV + Bevacizumab
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Hebei Medical University Fourth Hospital
Colorectal Cancer Metastatic
A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
This is a phase I, open-label clinical study of T3011 in combination with Toraplizumab and Regorafenib in patients with liver metastases from colorectal cancer.
- Trial name
- NCT06283303
- Testing
- T3011 hepatic artery infusion, toripalimab, regorafenib
- Volunteers
- 8 people
- Sponsor
- China Medical University, China
Colorectal Cancer, Immune Landscape
Comprehensive Immune-landscape in Localized Colorectal Cancer
Surgery still remains the mainstay of treatment for localized colorectal cancer. However, nearly 30% of patients with localized colorectal cancer (stage II and stage III) will present with recurrence.
- Trial name
- NCT02138370
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Cancer, Brain Injury
Prognostic Value of Neurometabolic Networks in CRC (PVNM-CRC)
Colorectal cancer (CRC), with annually increasing incidence and mortality worldwide, has become the second leading cause of cancer-related death.
- Trial name
- PVNM-CRC (NCT06930586)
- Where
- China
- Volunteers
- 213 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
CRC
Adjuvant Therapy(3 vs. 6 Months) With the FOLFOX 4 or XELOX for Stage II or Stage III Colon Cancer
The purpose of this study is to compare whether a 3-month treatment is at least not inferior to a 6-month treatment (FOLFOX-4 6 vs. 12 cycles or XELOX 4 cycles vs.
- Trial name
- NCT01308086
- Testing
- 5-Fluorouracil, Leucovorin, Oxaliplatin
- Where
- Greece
- Volunteers
- 2,000 people
- Sponsor
- Hellenic Oncology Research Group
Colorectal Cancer
Choose It and Use It: Choice, Implementation Intentions and At-Home Colorectal Cancer Screening
The goal of this study is to improve use of colorectal cancer screening among screening eligible African Americans who are served by Federally Qualified Health Centers in Michigan.
- Trial name
- NCT06085560
- Testing
- Usual Care Message, Implementation Intention Intervention: Standard Message, Implementation Intention Intervention: Culturally-Targeted Message
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Colon Cancer
The Relationship Between Relaxation or Wheat Germ Juice to the Immune Indices and Quality of Life (QoL) in Colorectal Cancer Patients on Adjuvant Chemotherapy
The immune system plays an important role in the fight against cancer. According to certain studies, Levels of cytokines secreted by the immune cells were found as predictors of prognosis and survival among cancer patients, as…
- Trial name
- NCT01991080
- Testing
- biofeedback, Wheatgerm juice
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Oxaliplatin-induced Peripheral Neuropathy
Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.
It is a phase II trial, randomized, parallel, double blind, multicenter, comparing riluzole versus placebo. The trial population is composed of patients ≥18 years old that have developed stage II/III colorectal cancer and are…
- Trial name
- RILUZOX-01 (NCT03722680)
- Testing
- Riluzole
- Where
- 16 sites in France
- Volunteers
- 80 people
- Sponsor
- UNICANCER
Colorectal Cancer
Implementing Fit Kit Colorectal Cancer (CRC) Screening in High Risk Populations
The purpose of this study is to understand best strategies for engaging high risk populations in a primary care setting to improved adherence to colorectal cancer screening guidelines.
- Trial name
- NCT04848051
- Testing
- CRC screening reminder, CRC Reminder & Short message, CRC Reminder and Navigation Program
- Where
- United States
- Volunteers
- 3,127 people, healthy volunteers welcome
- Sponsor
- Yale University
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