Clinical trials: Colorectal Carcinoma (CRC)
Impaired Cognition, Quality of Life
The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery
The primary aim of this study is to establish if it is possible for patients who have undergone major body surgery to complete a home based exercise training program and complete the assessments required to measure physical and…
- Conditions
- Impaired Cognition, Quality of Life, Surgery, Delirium
- Trial name
- POETold (NCT03064308)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
Breast Cancer, Prostate Cancer
Survivorship Care Plans in a Community Oncology Practice
This is a two part observational study evaluating the feasibility of implementing an EHR-based model within a community oncology practice.
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT03028584
- Testing
- Survey
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cancer, Cachexia; Cancer
Improvement of Neuromuscular Function, Fatigue and Quality of Life by Optimizing Muscle Building and Nutrition in Colorectal Cancer: a Pilot Study
This study is based on the assumption that muscle strength and muscle mass will be better preserved in an "intervention" group with specific management combining retraining and nutritional monitoring compared to the "no…
- Trial name
- ColCanter (NCT04136249)
- Testing
- Over physical activity
- Where
- France
- Volunteers
- 30 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Colorectal Cancer Metastatic
Evaluation of CTCs Combined With Tumor Marker Detection of Efficacy of Chemotherapy in mCRC
Evaluation of individual peripheral blood circulating tumor cells combined with tumor marker detection of efficacy of chemotherapy in patients with advanced colorectal cancer: A observational clinical trial
- Trial name
- NCT02948985
- Testing
- treated with FOLFIRI±cetuximab
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Colorectal Cancer
First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer
The CORRECT - MRD I study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer. Patients will be followed for up to 5 years for recurrence.
- Trial name
- MRD (NCT06398743)
- Testing
- MRD
- Where
- 22 sites in Israel, Italy and 3 more
- Volunteers
- 416 people
- Sponsor
- Exact Sciences Corporation
Colorectal Cancer
Chemotherapies Associated With Targeted Therapies on the Resection Rate of Hepatic Metastases
The main objective is to compare resection rates (R0 or R1) for hepatic metastases in the experimental arm (tri chemotherapy plus targeted therapy) versus the control arm (bi chemotherapy plus targeted therapy); in both arms the…
- Trial name
- NCT01442935
- Testing
- Oxaliplatin, Folinic Acid, 5-FU
- Where
- France
- Volunteers
- 256 people
- Sponsor
- UNICANCER
Colorectal Neoplasms
Low-dose Capecitabine Adjuvant Chemotherapy for Elderly Patients With Stage II/III Colorectal Cancer
Approximately half of colorectal cancer (CRC) patients were first diagnosed after 70 years old. However, compared with younger patients, elderly patients were often undertreated in chemotherapy due to their impaired tolerance.
- Trial name
- LcACEC (NCT02316535)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 710 people
- Sponsor
- West China Hospital
Gastric Cancer, Colorectal Cancer
Evaluation of Fecal Multi-target Biomarkers in the Screening of Digestive Tract Cancers
This study is a multi-center, observational study. Participants scheduled for gastroscopy and colonoscopy will undergo an epidemiological assessment and provide a stool sample prior to endoscopy for qualitative Fecal…
- Trial name
- NCT07600125
- Testing
- Qualitative Fecal Immunochemical Test (FIT), quantitative (FIT), and testing for new biomarkers
- Where
- 13 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Colorectal Cancer
Effect of Implementation of Enhanced Recovery After Surgery on 3-year Survival After Colorectal Surgery for Cancer
Several recent studies have shown that the Enhanced Recovery After Surgery (ERAS) protocol reduces morbidity and mortality and shortens the length of stay compared to conventional recovery strategy (pre-ERAS).
- Trial name
- RACCOR (NCT05002855)
- Testing
- Enhanced Recovery After Surgery (ERAS)
- Where
- France
- Volunteers
- 1,001 people
- Sponsor
- University Hospital, Grenoble
Locally Advanced Colorectal Carcinoma
Immune Checkpoint Inhibitors + Chemotherapy Versus Chemotherapy in the Neoadjuvant Treatment of Locally Advanced Colorectal Cancer
The goal of this clinical trial is to compare the efficacy and safety of the combination of immune checkpoint inhibitors (ICIs) and FOLFOX regimen compared to FOLFOX regimen alone in the neoadjuvant chemotherapy of locally…
- Trial name
- NCT06154538
- Testing
- Immune checkpoint inhibitor, FOLFOX regimen
- Where
- 3 sites in China
- Volunteers
- 170 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Cancer
Systemic Neoadjuvant and Adjuvant Control by Precision Medicine in Rectal Cancer
Rectal cancer represents the most complex area of multidisciplinary treatment in bowel surgery. In 2017, there were 1221 new rectal cancers in Finland.
- Trial name
- SYNCOPE (NCT04842006)
- Testing
- Total neoadjuvant therapy (TNT), Minimal residual disease (MRD), Long radiation therapy
- Where
- 2 sites in Finland
- Volunteers
- 93 people
- Sponsor
- Helsinki University Central Hospital
Colorectal Cancer, Metastatic Cancer
Chemotherapy and Bevacizumab With or Without Radiofrequency Ablation in Treating Unresectable Liver Metastases in Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways.
- Trial name
- NCT00043004
- Testing
- bevacizumab, FOLFOX regimen, fluorouracil
- Where
- 43 sites in Austria, Belgium and 8 more
- Volunteers
- 119 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer
A Study of Initiation Timing of VTE Prevention After Colorectal Cancer Surgery
This project intends to conduct a single-center, prospective, observational cohort study to explore the impact of the timing of drug prophylaxis on the risk of postoperative bleeding and the preventive effect of VTE in the…
- Trial name
- NCT06259149
- Testing
- Nardraparin calcium injection
- Where
- China
- Volunteers
- 914 people
- Sponsor
- RenJi Hospital
Cancer, Cancer Metastatic
Evaluating the Effect of a Mobile Audio Companion (Elly) to Reduce Anxiety in Cancer Patients
This is a single-arm, prospective, interventional study in cancer survivors and patients to examine the feasibility of a mobile health application, Elly (Elly Health Inc.), to reduce levels of anxiety, stress, loneliness, and…
- Conditions
- Cancer, Cancer Metastatic, Neoplasms, Breast Cancer
- Trial name
- NCT04604158
- Testing
- Elly Mobile Phone Application
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Gillian Gresham
Colorectal Cancer, Liver Metastasis
Compare FOFLOX4 in Preoperative and Postoperative and Postoperative in Resectable Liver Metastasis Colorectal Cancer (MCC)
This study is a multicenter, open-label, randomized ,controlled phase III study to compare preoperative and postoperative with FOFLOX4 chemotherapy and postoperative with FOFLOX4 chemotherapy in patients with resectable liver…
- Trial name
- NCT01035385
- Testing
- FOFLOX4
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Guangdong Provincial People's Hospital
Colorectal Cancer, KRAS Wildtype
A Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Advanced Colorectal Cancer
This is a phase 2 study (the second phase in testing a new drug or drug combination) to see how useful the combination of two drugs, panitumumab and trametinib, are in patients with advanced colorectal cancer with KRAS, NRAS, or…
- Conditions
- Colorectal Cancer, KRAS Wildtype, NRAS Wildtype, BRAF Wildtype
- Trial name
- NCT02399943
- Testing
- Trametinib, Panitumumab
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University Health Network, Toronto
Microscopic Colitis, Colorectal Cancer
Mucosa Adherent Intestinal Microbiome in Microscopic Colitis and Colorectal Cancer
Microscopic colitis (MC) is an inflammatory bowel disease characterized by chronic non-bloody watery diarrhoea and a macroscopically normal colonic mucosa upon endoscopic exploration (colonoscopy).
- Conditions
- Microscopic Colitis, Colorectal Cancer, Colon Adenoma
- Trial name
- CMBACT (NCT06172647)
- Testing
- Colonoscopy
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Locally Advanced Rectal Cancer (LARC), Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)
This study is a prospective, multi-cohort clinical trial designed to evaluate the preliminary efficacy and safety of zanidatamab in combination with tislelizumab and chemotherapy/radiotherapy for patients with HER2-positive…
- Conditions
- Locally Advanced Rectal Cancer (LARC), Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma, Metastatic Colorectal Cancer (mCRC), Neoadjuvant Therapy
- Trial name
- NCT07243938
- Testing
- short-course radiotherapy, Zanidatamab, Tisleizumab(BGB-A317)
- Volunteers
- 70 people
- Sponsor
- Tao Zhang
Stage I Adult Liver Cancer, Stage I Colorectal Cancer
Electronic Monitoring Device of Patient-Reported Outcomes and Function in Improving Patient-Centered Care in Patients With Gastrointestinal Cancer Undergoing Surgery
This pilot clinical trial studies an electronic monitoring device of patient-reported outcomes (PROs) and function in improving patient-centered care in patients with gastrointestinal cancer undergoing surgery.
- Conditions
- Stage I Adult Liver Cancer, Stage I Colorectal Cancer, Stage IA Gastric Cancer, Stage IA Pancreatic Cancer
- Trial name
- NCT02511821
- Testing
- Computer-Assisted Intervention, Vivofit watch, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- City of Hope Medical Center
Colorectal Cancer, Anastomotic Complication
Minimally Invasive Right Colectomy Anastomosis Study
Right colectomy (hemicolectomy) involves the removal of the cecum, the ascending colon, the hepatic flexure, the first one-third of the transverse colon, part of the terminal ileum, and the associated regional fat and lymph…
- Conditions
- Colorectal Cancer, Anastomotic Complication, Colectomy
- Trial name
- MIRCAST (NCT03650517)
- Testing
- Extracorporeal Anastomosis, Intracorporeal Anastomosis, Robotic Surgery
- Where
- 32 sites in Croatia, Denmark and 8 more
- Volunteers
- 1,200 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
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