Clinical trials: Colorectal Carcinoma (CRC)
Colon Carcinoma, Colorectal Carcinoma
Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment
This phase II trial studies how well giving zanidatamab before surgery (neoadjuvant) works in treating patients with colon and rectal cancer that is human epidermal growth factor receptor 2 positive (HER2+ve) who are planned for…
- Conditions
- Colon Carcinoma, Colorectal Carcinoma, Rectal Carcinoma, Stage I Colon Cancer AJCC v8
- Trial name
- NCT07405476
- Testing
- Zanidatamab, Resection, Patient Observation
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Patients With Colorectal Cancer With Unresectable Synchronous Metastasis in Whom Resection of the Primitive Tumour is Indicated
Feasibility of an Immediate Preoperative Chemotherapy Before Resection fo Colorectal Cancer
The purpose of this study is to analyze the clinical tolerance of immediate preoperative chemotherapy in terms of toxicity and perioperative morbidity and mortality
- Trial name
- PRIMM (NCT01715363)
- Testing
- Oxaliplatin, Folinic Acid, Fluorouracile
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Recurrent Platinum-resistant Epithelial Ovarian Cancer, Triple Negative Breast Cancer (TNBC)
A Multicenter, Open-label Phase IIa Clinical Study to Evaluate the Efficacy and Safety of B1962 Injection in the Treatment of Advanced Malignant Solid Tumors
This is a multicenter, open-label Phase IIa clinical study to evaluate the efficacy and safety of B1962 in the treatment of ad-vanced solid tumors.
- Conditions
- Recurrent Platinum-resistant Epithelial Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Cervical Cancers, Small Cell Lung Cancer
- Trial name
- NCT06724263
- Testing
- B1962
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tasly Biopharmaceuticals Co., Ltd.
Metastatic Colorectal Cancer, Stage II/III Colon Cancer
A Screening Study Targeting Tumor-specific Antigens
The purpose of this study is to identify patients who may be eligible to participate in a separate Phase 2/3 treatment study evaluating an individualized neoantigen vaccine GRANITE for first line (1L) maintenance treatment of…
- Trial name
- NCT05158621
- Testing
- blood collection for research (next generation sequencing [NGS]), blood collection for research (HLA typing), blood collection for research (circulating tumor DNA [ctDNA])
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Gritstone bio, Inc.
Advanced Hepatocellular Carcinoma (HCC), Gastric Cancer Metastatic to Liver
A Study of exoASO-STAT6 (CDK-004) in Patients With Advanced Hepatocellular Carcinoma (HCC) and Patients With Liver Metastases From EIther Primary Gastric Cancer or Colorectal Cancer (CRC)
This is a first-in-human, Phase 1 open-label, multicenter, dose escalation, safety, pharmacodynamic, and PK study of exoASO-STAT6 (CDK-004) in patients with advanced Hepatocellular Carcinoma (HCC) and patients with liver…
- Conditions
- Advanced Hepatocellular Carcinoma (HCC), Gastric Cancer Metastatic to Liver, Colorectal Cancer Metastatic to Liver
- Trial name
- NCT05375604
- Testing
- CDK-004
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Codiak BioSciences
Advanced Cancer, Ovarian Cancer
COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.
This is a Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary clinical activity of COM701 as monotherapy and in combination with nivolumab.
- Conditions
- Advanced Cancer, Ovarian Cancer, Breast Cancer, Lung Cancer
- Trial name
- NCT03667716
- Testing
- COM701, COM701 with Opdivo (Nivolumab).
- Where
- 11 sites in United States
- Volunteers
- 121 people
- Sponsor
- Compugen Ltd
Colorectal Cancer
Phase I/II Study of SOL for Untreated Metastatic Colorectal Cancer
Introduction: S-1 is promising drug which could replace 5-fluorouracil plus l-leucovorin (5-FU/l-LV) in treatment of advanced colorectal cancer.
- Trial name
- NCT00524706
- Testing
- S-1, oral Leucovorin, Oxaliplatin
- Where
- Japan
- Volunteers
- 42 people
- Sponsor
- Shizuoka Cancer Center
Mesothelioma, Mesotheliomas Pleural
A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer
TC-510 is a novel cell therapy that consists of autologous genetically engineered T cells expressing two synthetic constructs: first, a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit…
- Conditions
- Mesothelioma, Mesotheliomas Pleural, Mesothelioma, Malignant, Mesothelioma Peritoneum
- Trial name
- NCT05451849
- Testing
- TC-510, Fludarabine, Cyclophosphamide
- Where
- 7 sites in United States
- Volunteers
- 14 people
- Sponsor
- TCR2 Therapeutics
Colorectal Cancer Stage II, Colorectal Cancer Stage III
the Role of ctDNA in Predicting the Recurrence Risk of Colorectal Cancer
The purpose of this study was to observe the relationship between ctDNA as a molecular marker of colorectal cancer and the risk of postoperative recurrence.
- Trial name
- NCT05131243
- Testing
- Chemotherapy time
- Volunteers
- 100 people
- Sponsor
- Fujian Cancer Hospital
Colorectal Cancer, Esophageal Cancer
Clinical Trial Protocol for Evaluating the Efficacy and Safety of Thoracoabdominal Endoscopic Surgery System in Remote Laparoscopic Surgery for Urology, General Surgery, Gynecology and Thoracic Surgery
Evaluation of the Efficacy and Safety of the Thoracoabdominal Endoscopic Surgery System Produced by Shenzhen Cornerstone Robotics Technology Co., Ltd.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Hepatectomy, Radical Hysterectomy
- Trial name
- NCT07382635
- Testing
- Robot-assisted surgery
- Volunteers
- 98 people
- Sponsor
- Cornerstone Robotics
Colorectal Cancer
Lymphatic Mapping and Sentinel Lymph Node Biopsy in the Treatment of Colorectal Cancer
RATIONALE: Diagnostic procedures, such as lymph node mapping and biopsy, may improve the ability to detect the extent of colorectal cancer.
- Trial name
- NCT00005640
- Testing
- Preoperative Endoscopy, Technetium Tc 99m Sulfur Colloid, Gamma Probe
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
GastroEsophageal Cancer, Colorectal Cancer
A Study to Evaluate Immunotherapy Combinations in Participants With Gastrointestinal Malignancies
This is a Phase 1/1b, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical activity of etrumadenant (AB928) in combination with…
- Trial name
- NCT03720678
- Testing
- etrumadenant, mFOLFOX
- Where
- 24 sites in United States, Australia
- Volunteers
- 44 people
- Sponsor
- Arcus Biosciences, Inc.
Locally Advanced Colorectal Cancer, Postoperative Adjuvant Therapy
Evaluating the Benefits of Personalized Traditional Chinese Medicine in Postoperative Treatment for Locally Advanced Colorectal Cancer
This study aims to explore the role of Traditional Chinese Medicine (TCM) based on syndrome differentiation in reducing chemotherapy side effects, lowering the risk of metastasis and recurrence, and improving survival rates in…
- Trial name
- NCT06596343
- Testing
- Adjuvant Chemotherapy Combined with Traditional Chinese Medicine (TCM) Supportive Therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sir Run Run Shaw Hospital
Colorectal Cancer Metastatic
Registry Platform Colorectal Cancer
The registry aims to collect and analyse information on the antineoplastic treatment of patients with metastatic colorectal cancer, treated in palliative intention in daily routine practice in Germany.
- Trial name
- AZURITE (NCT04867525)
- Testing
- Physician's choice according to patient's needs.
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- iOMEDICO AG
Colorectal Carcinoma
Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum
58 patients undergoing surgery of the large bowel are divided into two groups. The control group will receive standard care. The intervention group will receive standard care plus optimization of the blood circulation based on…
- Trial name
- HOC (NCT01175317)
- Testing
- Goal-directed fluid optimization, Regimen based on expertise anaesthesist
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Maastricht University Medical Center
Metastatic Colorectal Cancer
Sym004 in Metastatic Colorectal Cancer and ECD-EGFR Patients
This is a single arm, phase 2, open-label, multicenter trial in patients with metastatic colorectal cancer (mCRC) and acquired resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) and documented…
- Trial name
- NCT02965417
- Testing
- Sym004
- Sponsor
- Symphogen A/S
Colorectal Cancer
Hepatic RFA Increases T Cell Infiltraion and PD-L1 Expression in Primary Colorecatl Cancer
It has been shown that RFA induced systemic tumor antigen-specific T cell responses in human carcinoma. However, there are insufficient studies on the immune modulation of tumor microenviroment (TME) outside of the ablation zone.
- Trial name
- NCT02475889
- Testing
- Hepatic RFA, Primary tumor resection
- Volunteers
- 78 people
- Sponsor
- The First People's Hospital of Changzhou
Colorectal Cancer
Lifestyle Intervention Among Participants of the French Colorectal Cancer Screening Program
The investigators propose a randomized controlled trial to develop and evaluate the impact of promoting advice on diet and lifestyle recommendations for cancer prevention at colorectal cancer screening among individuals who may…
- Trial name
- LIFE-SCREEN (NCT04257526)
- Testing
- Diet and lifestyle advice following a positive FIT test and diagnostic colonoscopy.
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Biliary Tract Neoplasms, Gastric Cancer
Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics
This a prospective real-world navigation study using tumor DNA sequencing technology to sequence genes of previously treated and refractory gastrointestinal tumors, which are generally considered to be highly heterogeneous and…
- Conditions
- Biliary Tract Neoplasms, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Colorectal Cancer
- Trial name
- VISIONARY (NCT04584008)
- Testing
- FGFR Inhibitor, IDH1 Inhibitor, HER2 Inhibitor, PARP Inhibitor, BRAF Inhibitor, MEK Inhibitor, ICIs, EGFR-TKIs, NTRK-TKI, and et. al., Other Therapy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University
Colorectal Cancer
The PRIME-CRC Trial to Promote CRC Screening in Rural Communities
The investigators will expand an existing, patient-centered, health literacy strategy to promote longer-term adherence to colorectal cancer (CRC) screening in resource-limited, rural health clinics via colonoscopy or annual fecal…
- Trial name
- NCT04313114
- Testing
- health literacy appropriate education and demonstration, shared decision making, automated call reminders or automated texts
- Where
- 3 sites in United States
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
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