Clinical trials: Colorectal Diseases
Colorectal Neoplasms
A Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer
This was a Phase 1, open-label, single-center study of CS-1008, an immunoglobulin G subclass 1 (IgG1) humanized monoclonal antibody, in subjects with advanced colorectal carcinoma who had received ≥ 1 prior chemotherapy regimen…
- Trial name
- NCT01220999
- Testing
- CS-1008
- Where
- Australia
- Volunteers
- 19 people
- Sponsor
- Ludwig Institute for Cancer Research
Rectal Cancer
LifeSeal™ Preliminary Study in Subjects Undergoing Low Anterior Resection
A preliminary Study in Subjects Undergoing Low Anterior Resection
- Trial name
- NCT01790230
- Testing
- LifeSeal™ Kit
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- LifeBond Ltd.
Cervical Cancer, Oropharyngeal Cancer
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers
Background: The human papillomavirus (HPV) can cause a number of cancers, including cervical and throat cancers. The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy that involves taking white…
- Conditions
- Cervical Cancer, Oropharyngeal Cancer, Vaginal Cancer, Anal Cancer
- Trial name
- NCT01585428
- Testing
- Fludarabine, Cyclophosphamide, Young TIL
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
A Trial to Evaluate Laparoscopic Versus Open Surgery for Colorectal Cancer
The purpose of this study is to evaluate oncological outcome of patients for T3 and T4 colorectal cancer undergoing laparoscopic versus open surgery.
- Trial name
- NCT00147134
- Testing
- open colectomy, laparoscopic colectomy
- Where
- 26 sites in Japan
- Volunteers
- 1,050 people
- Sponsor
- Haruhiko Fukuda
Metastatic Colorectal Cancer
A Trial of Perioperative CV301 Vaccination in Combination With Nivolumab and Systemic Chemotherapy for Metastatic CRC
This is a multi-center Phase II randomized study. We plan to enroll 78 patients with biopsy-proven hepatic-limited metastatic colorectal cancer deemed resectable after multi-disciplinary discussion.
- Trial name
- NCT03547999
- Testing
- mFOLFOX6, MVA-BN-CV301, FPV-CV301
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Patrick Boland
Human Papillomavirus Associated Carcinomas, Cervical Cancer
SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas
A multicenter, open, single arm dose escalation and dose expansion phase I study to evaluate the safety, tolerability, and efficacy of SCG142 TCR-T cells in Subjects with advanced HPV associated carcinomas.
- Conditions
- Human Papillomavirus Associated Carcinomas, Cervical Cancer, Head and Neck Cancers, Anal Cancer
- Trial name
- NCT06544720
- Testing
- SCG142 TCR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Colorectal Cancer
Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of oxaliplatin in treating patients who have recurrent…
- Trial name
- NCT00017082
- Testing
- oxaliplatin
- Where
- 10 sites in United States
- Sponsor
- Prologue Research International
Rectal Carcinoma
Outcome of Laparoscopic Total Mesorectal Excision Versus Open Technique in Management of Rectal Carcimoma
Colorectal cancer is the second leading cause of death in the West, and rectal cancer accounts for about 25% of colon cancers Low anterior resection has been the mainstay of rectal cancer surgery in low rectal cancer since the…
- Trial name
- NCT05685680
- Testing
- total mesorectal excision in rectal carcinoma
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Colonic Neoplasms
Trial of a Computer-Based Presentation of Quantitative Information About Colorectal Cancer Screening
Fifty thousand people die from colorectal cancer (CRC) every year, making it the second leading cause of death from cancer in the United States.
- Trial name
- NCT01415479
- Testing
- Control, Quantitative, Default
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Indiana University
Prostate Cancer, Breast Cancer
Exercise as Medicine for People With Cancer Sweden
Regular exercise has been shown to have beneficial health effects in cancer survivors, including improving quality of life and other important health outcomes.
- Conditions
- Prostate Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- EX-MED (NCT05064670)
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Colorectal Cancer
Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia
RATIONALE: Studying samples of blood and tissue from patients at risk of cancer in the laboratory may help doctors learn more about the effect of folate on DNA and identify biomarkers related to cancer.
- Trial name
- NCT00611000
- Testing
- folic acid, DNA methylation analysis, gene expression analysis
- Volunteers
- 20 people
- Sponsor
- Rockefeller University
Colorectal Cancer
S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum
RATIONALE: Drugs used in chemotherapy, such as irinotecan, leucovorin, fluorouracil, and oxaliplatin, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00070434
- Testing
- capecitabine, fluorouracil, irinotecan hydrochloride
- Sponsor
- SWOG Cancer Research Network
Solid Tumor, Colorectal Cancer
Safety and Tolerability of DS-7423 in Subjects With Advanced Solid Malignant Tumors
This will be a Phase 1, open-label study of DS-7423 to assess its safety and tolerability, identify a RP2D, (recommended Phase 2 Dose) and assess its Pharmacokinetics (PK) (what your body does to process the drugs and how your…
- Conditions
- Solid Tumor, Colorectal Cancer, Endometrial Cancer
- Trial name
- NCT01364844
- Testing
- DS-7423
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Daiichi Sankyo
Laparoscopic Colorectal Surgery, Acute Kidney Injury
The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese Patients
This study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatin in…
- Trial name
- NCT03408834
- Testing
- pulse variability index
- Volunteers
- 29 people
- Sponsor
- Ankara University
Colorectal Cancer
A Single Center Evaluation of AI Enabled SureForm Robotic Stapler (SureformTM) Compared to Conventional Stapler for Colorectal Cancer Procedures
Robotic-assisted surgeries are especially valuable for colorectal pathologies because they offer better vision and control for surgical manipulation given the narrow operative region within the pelvis .Some of the iatrogenic risk…
- Trial name
- NCT07371832
- Testing
- AI-enabled SureForm™ Robotic Stapler, Conventional Laparoscopic Stapler
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India
Non-small Cell Lung Cancer, Small Cell Lung Cancer
Early Palliative Care in Advanced Lung and Gastrointestinal Malignancies
The purpose of this study is to compare two types of care - standard oncology care and standard oncology care with early palliative care (started soon after diagnosis) to see which is better for improving the experience of…
- Conditions
- Non-small Cell Lung Cancer, Small Cell Lung Cancer, Mesothelioma, Esophageal Cancer
- Trial name
- NCT01401907
- Testing
- early palliative care
- Where
- United States
- Volunteers
- 351 people
- Sponsor
- Massachusetts General Hospital
Colorectal Neoplasms, Adenoma
Peripheral Blood DNA Methylation Markers for the Early Detection of Colorectal Carcinoma in the Egyptian Population
The incidence of colorectal cancer (CRC) is on the rise on a global scale. The number of cancer-related deaths related to CRC is also rising to an alarming level.
- Conditions
- Colorectal Neoplasms, Adenoma, Colorectal Tumors
- Trial name
- NCT01793207
- Where
- 2 sites in Egypt
- Volunteers
- 316 people
- Sponsor
- Cairo University
Metastatic Bone Sarcoma, Metastatic Malignant Neoplasm in the Lung
Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
This phase I/II trial studies the side effects of pulmonary suffusion in controlling minimal residual disease in patients with sarcoma or colorectal carcinoma that has spread to the lungs.
- Conditions
- Metastatic Bone Sarcoma, Metastatic Malignant Neoplasm in the Lung, Metastatic Soft Tissue Sarcoma, Metastatic Unresectable Sarcoma
- Trial name
- NCT03965234
- Testing
- Cisplatin, Isolated Chemotherapeutic Lung Perfusion, Metastasectomy
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Roswell Park Cancer Institute
Colorectal Cancer
Study to Assess Safety and Tolerability of G17DT in Patients With Colorectal Adenocarcinoma.
Pancreatic, gastric, and colorectal cancers have all been shown to overexpress the gastrin gene and to be sensitive to the trophic effects of the gastrin in animal models.
- Trial name
- CC1A&B (NCT02181465)
- Testing
- G17DT
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Cancer Advances Inc.
Colo-rectal Cancer, Rectal Prolapse
Evaluation of SINGLE PORT (SP) Robotic Technology in Colorectal Surgery
Currently a multiport robotic surgery platform (Intuitive Xi) is widely available and used for colorectal surgery indications. A Single port platform (Intuitive SP) is FDA approved for Head and Neck and Urology but has not been…
- Conditions
- Colo-rectal Cancer, Rectal Prolapse, Colostomy Stoma, Colorectal Disorders
- Trial name
- NCT05321134
- Testing
- Single port robotic colorectal surgical procedure
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, Davis
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