Clinical trials: Colorectal Diseases
Breast Cancer, Melanoma
Immunological Variables Associated to ICI Toxicity in Cancer Patients
This is a monocentric, prospective, pilot study that will enrol 435 subjects with solid tumours that are treated with immune checkpoint inhibitor(s) (ICI) alone or in combination with chemotherapy or targeted therapy.
- Conditions
- Breast Cancer, Melanoma, Non Small Cell Lung Cancer, Non-melanoma Skin Cancer
- Trial name
- NCT05429866
- Testing
- Checkpoint Blockade, Immune
- Where
- Belgium
- Volunteers
- 441 people
- Sponsor
- Jules Bordet Institute
Rectal Cancer
Sexual Function and Wellbeing in Males With Rectal Cancer
Preoperative radiotherapy and pelvic surgery is recommended to many patients with rectal cancer. For men there are theoretical reasons to believe that the treatment may effect hormone levels, spermatogenesis, sexual function and…
- Trial name
- NCT01216202
- Testing
- Preoperative radiotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 178 people
- Sponsor
- Karolinska Institutet
Colorectal Cancer
Screen to Save: A Colorectal Cancer Educational Intervention
The purpose of this research is to understand if an educational program about colorectal cancer helps improve people's knowledge of colorectal cancer prevention and screening and their intention to get screened for colorectal…
- Trial name
- S2S (NCT03907579)
- Testing
- Inflatable colon educational module
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Anal Cancer
Topical MTS-01 for Dermatitis During Radiation and Chemotherapy for Anal Cancer
Background: Radiation and chemotherapy treatments for anal cancer can cause irritation of the skin that can lead to redness and tenderness, and in some cases can be so severe that it results in blistering or peeling of the skin…
- Trial name
- NCT01324141
- Testing
- Tempol, 5-Fluorouracil, Mitomycin-C
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Colorectal Cancer
A Study of HX008 Compared to Chemotherapy in the First-Line Treatment of Subjects With MSI-H/dMMR Metastatic Colorectal Cancer
The main purpose of this study is to compare the clinical benefit, as measured by Progression-Free Survival (PFS), achieved by HX008 or Investigator's Choice Chemotherapy in participants with Microsatellite Instability High…
- Trial name
- NCT05652894
- Testing
- HX008(Pucotenlimab), Investigator's Choice Chemotherapy
- Where
- 63 sites in China
- Volunteers
- 190 people
- Sponsor
- Taizhou Hanzhong biomedical co. LTD
Rectal Cancer
Rectal Washout in Transanal Total Mesorectal Excision and Presence of Intraluminal Malignant Cells
The study aims to assess the existence of intraluminal malignant cells and the appropriate fluid volume needed to perform rectal washout during transanal total mesorectal excision (taTME) for rectal cancer.
- Trial name
- NCT04730102
- Testing
- Rectal washout
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Slagelse Hospital
Solid Tumor, Adult, Lung Adenocarcinoma
TP53 R248Q TCR-T Cell Therapy for Advanced Solid Tumor
To evaluate the safety and efficacy of T cell therapy with mutated TP53 R248Q specific TCR transduction in patients with advanced solid tumor expressing the TP53 R248Q mutation and the HLA-A*11:01 allele.
- Conditions
- Solid Tumor, Adult, Lung Adenocarcinoma, Pancreas Cancer, Colorectal Cancer
- Trial name
- NCT06619886
- Testing
- Autologous, engineered T Cells targeting TP53 R248Q
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Colorectal Cancer
Mechanistic and Molecular Study of the Process of Metastatic Dissemination in Colorectal Cancer
To confirm the role of the collective dissemination in the mechanisms of tumoral invasion of colorectal cancers
- Trial name
- DISCOVER (NCT03613194)
- Testing
- Sampling
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Colorectal Cancer Stage IV, Colorectal Cancer Metastatic
Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis
Patients with peritoneal metastasis of colorectal or high grade appendiceal origin who are candidates for cytoreductive surgery with HIPEC (hyperthermic intraperitoneal chemotherapy) will be enrolled in this study.
- Conditions
- Colorectal Cancer Stage IV, Colorectal Cancer Metastatic, Colorectal Cancer, Genetics of, Appendix Cancer
- Trial name
- NCT04157322
- Testing
- prospective single arm biomarker (plasma cell-free DNA hydroxymethylation) study
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Chicago
Anal Squamous Cell Carcinoma, HIV Infection
Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection
This phase II trial studies surgery in treating patients with anal canal or perianal cancer that is small and has not spread deeply into the tissues and human immunodeficiency virus (HIV) infection.
- Conditions
- Anal Squamous Cell Carcinoma, HIV Infection, Stage 0 Anal Canal Cancer, Stage I Anal Canal Cancer
- Trial name
- NCT02437851
- Testing
- Therapeutic Conventional Surgery
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- AIDS Malignancy Consortium
Colorectal Carcinoma
Assessment of Tumor Vascular Effects of Axitinib With Dynamic Ultrasonography in Patients With Metastatic Colorectal Cancer
The purpose of this study is to evaluate and quantify the dynamic modifications of tumor blood perfusion on axitinib therapy in patients with refractory mCRC for each dose of Axitinib.
- Trial name
- AXUS (NCT01486251)
- Testing
- axitinib
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Refractory Metastatic Colorectal Cancer
Amplitude Modulated Radiofrequency Electromagnetic Field Treatment Combined With TAS-102 (Lonsurf) and Bevacizumab in Refractory Metastatic Colorectal Cancer
Combined chemotherapy and radiofrequency electromagnetic field treatment for patients with liver dominant refractory metastatic colorectal cancer
- Trial name
- Live-RF (NCT05991102)
- Testing
- Radiofrequency electromagnetic field treatment
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Charite University, Berlin, Germany
Colorectal Cancer, Metastatic Cancer
Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and/or Lung
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- ERBIFORT (NCT00557102)
- Testing
- cetuximab, filgrastim, fluorouracil
- Where
- France
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute, France
Neoplasms, Non-small-cell Lung Cancer
A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.
The purpose of this study is to learn about the: safety (the effect of the study medicine on the participant's body), effects of the study medicine alone or in combination with sasanlimab - the best amount of the study medicine.
- Conditions
- Neoplasms, Non-small-cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Renal Cell Carcinoma
- Trial name
- NCT06546553
- Testing
- PF-07826390, sasanlimab, SOC (anti-PD-1 + platinum -based chemo)
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Pfizer
Malignant Breast Neoplasm, Malignant Colorectal Neoplasm
18F-Fluoroazomycin Arabinoside PET-CT in Diagnosing Solid Tumors in Patients
This early phase I trial studies how well 18F-fluoroazomycin arabinoside positron emission tomography (PET)-computed tomography (CT) works in diagnosing solid tumors.
- Conditions
- Malignant Breast Neoplasm, Malignant Colorectal Neoplasm, Malignant Pancreatic Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT03168737
- Testing
- Computed Tomography, Fluorine F 18-fluoroazomycin Arabinoside, Positron Emission Tomography
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Guardant Shield Colorectal Cancer Screening
The purpose of this research is to identify individuals overdue for colon cancer screening and send them a reminder to complete their screening, which includes standard of care colonoscopy or stool-based testing.
- Trial name
- NCT07436637
- Testing
- Screening Reminder, Blood Sample Collection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Miami
Metastatic Colorectal Cancer
Study of Irinotecan and AZD1775, a Selective Wee 1 Inhibitor, in RAS or BRAF Mutated, Second-line Metastatic Colorectal Cancer
The purpose of this study is to determine whether combination therapy of irinotecan with AZD1775 is safe and effective in treating mutated metastatic colorectal cancer patients.
- Trial name
- NCT02906059
- Testing
- AZD1775, Irinotecan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- NYU Langone Health
Colorectal Neoplasms
De-escalation Chemotherapies Versus Escalation in Non Pre-treated Unresectable Patients With Metastatic Colorectal Cancer
The intensity of tumour response appears to be correlated with the feasibility and the duration of a therapeutic pause or of a reduced maintenance therapy maintained until progression in patients initially controlled by so-called…
- Trial name
- HIGH-LIGHT (NCT02842580)
- Testing
- 5 FLUOROURACYL, acide folinique, irinotecan
- Where
- 11 sites in France
- Volunteers
- 21 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Metastatic Colorectal Cancer
Pre- and Postoperative Chemotherapy Including Bevacizumab in Potentially Curable Metastatic Colorectal Cancer
Major attempt is being given to the potential of curing patients with metastatic colorectal cancer due to the recognition of dramatic change in survival figures achieved in palliative chemotherapy combination treatment protocols.
- Trial name
- ASSO-LM1 (NCT00444041)
- Testing
- Bevacizumab
- Where
- Austria
- Volunteers
- 43 people
- Sponsor
- Austrian Society Of Surgical Oncology
Breast Cancer, Prostate Cancer
Holistic Acupuncture for Patients With Chemotherapy Induced Nausea
The study explores whether acupuncture as a supplement to conventional antiemetic medicine is superior in reducing the level of chemotherapy induced nausea compared to conventional anitemetic medicine alone.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Gynaecologic Cancer
- Trial name
- NCT07201194
- Testing
- Holistic acupuncture and acupressure, Standard medical treatment
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Vejle Hospital
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