Clinical trials: Colorectal Diseases
Rectum Cancer
Rectal Study: Value of Repeated FDG-PET-CT Scans in Rectal Cancer
To investigate the evolution of the 18F-deoxyglucose (FDG) uptake and the tumour characteristics determined in the plasma of patients with rectal cancer during and after radiotherapy or combined radiotherapy and chemotherapy.
- Trial name
- NCT00576563
- Testing
- FDG
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Maastricht Radiation Oncology
Anal Cancer, Anxiety Disorder
Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer Either in a Clinical Trial or as Standard Off-Trial Therapy
RATIONALE: Gathering information from patients who received treatment for metastatic cancer while participating in a phase II or phase III randomized clinical trial and from patients receiving standard treatment off-trial may…
- Conditions
- Anal Cancer, Anxiety Disorder, Breast Cancer, Depression
- Trial name
- NCT00896467
- Testing
- questionnaire administration, psychosocial assessment and care, quality-of-life assessment
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Oscar Lambret
Lung Cancer, Gastric Cancer
CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors
This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CEA-targeted CAR-T cell preparations, and to preliminarily observe the study drug in…
- Conditions
- Lung Cancer, Gastric Cancer, Colon Cancer, Rectal Cancer
- Trial name
- NCT07179692
- Testing
- CEA-targeted CAR-T cells
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Colorectal Cancer (CRC)
Advances in Imaging to Assess Response in Rectal Cancer
The goal of this observational study is to determine the feasibility of acquiring serial MRI images for advanced radiotherapy planning in colorectal patients.
- Trial name
- AIR-REC (NCT06822634)
- Testing
- Observational single centre feasibility study
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Adenoma, Polyps
Prospective Trial to Compare ADR of G-EYE™ Colonoscopy With Standard Colonoscopy
The purpose of this study is to compare the adenoma detection rate (ADR) of the G-EYE™ colonoscopy with that of standard colonoscopy.
- Conditions
- Adenoma, Polyps, Colorectal Cancer
- Trial name
- NCT02545699
- Testing
- G-EYE™ Colonoscopy, Standard Colonoscopy
- Where
- Israel
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Smart Medical Systems Ltd.
Colonic Polyps, Polyposis Coli
Non-Invasive Prediction of Colorectal Neoplasia
Hypothesis:The Adnab-9 antigen is a predictive biomarker in individuals at risk of developing colorectal neoplasia. Study aim is to evaluate the potential of the Adnab-9 monoclonal antibody (MAb) as a marker of cancer risk in a…
- Conditions
- Colonic Polyps, Polyposis Coli, Colorectal Cancer
- Trial name
- NIPCON (NCT01815463)
- Where
- United States
- Volunteers
- 2,282 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Colorectal Cancer, Stage III Colon Cancer
Prognostic Value of the Immunoscore® Colon Test for Disease Free Survival Stratification in Stage III Patients Under Oxaliplatin Treatment
The primary objective is to validate that the Immunoscore® test (IS0 to IS4) is able to identify patients with high risk (IS 0-1) of relapse or death whichever occurs first among Stage III patients under oxaliplatin-based…
- Trial name
- NCT03422601
- Testing
- Immunoscore test
- Where
- France
- Volunteers
- 1,122 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Colorectal Cancer, Pancreas Tumor
Microenvironment and Immunity of Digestive Cancers - East Paris Multicentric Cohort
Colorectal and pancreatobiliary cancers are the most common digestive cancers. Their incidence has particularly increased over the last few decades, leading to suspicion that environmental factors are involved.
- Conditions
- Colorectal Cancer, Pancreas Tumor, Biliary Tract Tumor, Immune System and Related Disorders
- Trial name
- MICADO (NCT04707365)
- Testing
- Tumor samples
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colon Cancer, Primary Tumour
The Role of Surgery of the Primary Tumour in Patients With Synchronous Unresectable Metastases of Colorectal Cancer
The clinical benefit of resection of the primary tumour in patients with synchronous unresectable metastases is not known. In the literature studies usually describe retrospective selected patients with synchronous metastases…
- Conditions
- Colon Cancer, Primary Tumour, Rectal Cancer
- Trial name
- CAIRO4 (NCT01606098)
- Testing
- Surgery of the primary tumour, Systemic treatment
- Where
- 46 sites in Denmark, Netherlands
- Volunteers
- 206 people
- Sponsor
- Dutch Colorectal Cancer Group
Colorectal Cancer Screening, Colorectal Cancer (CRC)
Improving Colorectal Cancer Early Screening in Portugal: Identification of Gut Microbiome Biomarkers in Stool (GUTBIOME-PT)
Colorectal cancer (CRC) is a major public health problem, responsible for 2 million new cases and almost 1 million deaths annually worldwide.
- Conditions
- Colorectal Cancer Screening, Colorectal Cancer (CRC), Microbiome
- Trial name
- GUTBIOME-PT (NCT06741293)
- Testing
- No intervention: observational study
- Where
- Portugal
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Colon Cancer, Lymph Node Metastases
Lymph Node Yield in Colon Cancer Resection Specimens
In this study, we aimed to develop a predictive model of lymph node yield in a series of colon cancer resection specimens with detailed anatomic and surgical technique data.
- Trial name
- NCT04260139
- Testing
- Calculation of metric variables on the colectomy specimens.
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bagcilar Training and Research Hospital
Rectal Neoplasms
Neo-Adjuvant FOLFOX for Rectal Carcinoma
A Phase II open- labeled, prospective study to determine the efficacy of pre-operative chemotherapy with six cycles of modified FOLFOX 6 followed by total mesorectal excision (TME) followed by an additional six cycles of FOLFOX…
- Trial name
- NCT00832299
- Testing
- FOLFOX, total mesorectal excision (TME)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Beth Israel Medical Center
Low Anterior Resection Syndrome, Quality of Life (QOL)
Bowel Dysfunction After Low Rectal Resection. An Pilot Study Using Psyllium Husk In Rectal Cancer Patients.
Rectal cancer constitutes 1/3 of more than 4500 annually diagnosed cases of colorectal (CRC) in Norway. With the advances in radiochemotherapy, and surgical techniques, the long-term survival rate is increasing after surgery…
- Trial name
- NCT06724198
- Testing
- Psyllium husk
- Where
- Norway
- Volunteers
- 24 people
- Sponsor
- Sykehuset Telemark
Colorectal Cancer
The Microbrect-FFC Study
This study will focus on two points: 1. To determine if response to neoadjuvant chemoradiotherapy treatment in rectal cancer can be predicted by analysing data from Fast Field Cycling imaging (FFC), a novel type of MRI technique.
- Trial name
- NCT06236321
- Testing
- Fast Field Cycling MRI scan, Provision of saliva and faecal samples
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Aberdeen
Stomach Cancer, Pancreatobiliary Cancer
Effects of Red Ginseng on Gastrointestinal Symptoms and Microbiota After Surgery for Gastrointestinal Cancer
After surgery for gastrointestinal cancer (stomach cancer, pancreaticobiliary cancer, colorectal cancer), many patients experiences various symptoms such as weight loss, diarrhea, constipation and excessive gas due to structural…
- Conditions
- Stomach Cancer, Pancreatobiliary Cancer, Colorectal Cancer
- Trial name
- NCT06561516
- Testing
- Arm I (Red ginseng)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gangnam Severance Hospital
Colonic Neoplasms
Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.
- Trial name
- NCT00516230
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Colon Cancer, Pancreatic Cancer
Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer
The purpose of this research study is to evaluate if a negative-pressure dressing placed over a surgical incision can reduce the risk of developing a surgical site infection compared to a commonly-used sterile gauze incision…
- Conditions
- Colon Cancer, Pancreatic Cancer, Perioperative/Postoperative Complications, Primary Peritoneal Cavity Cancer
- Trial name
- NCT01656044
- Testing
- wound care management
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Wake Forest University Health Sciences
Colorectal Cancer
Fruquintinib Plus Capecitabine Versus Bevacizumab Plus Capecitabine as Maintenance Therapy Following First-line Treatment for Metastatic Colorectal Cancer
This is an open-label, multicenter, randomized phase 2 study evaluating the efficacy and safety of fruquintinib plus capecitabine versus bevacizumab plus capecitabine as maintenance therapy following first-line treatment for…
- Trial name
- NCT04733963
- Testing
- Fruquintinib Plus Capecitabine, Bevacizumab Plus Capecitabine
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer, Cancer of the Rectum
5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer
This phase II trial will investigate the combination of adjuvant 5-fluorouracil, radiation, and bevacizumab in patients with stage II and III rectal cancer, followed by FOLFOX6 and bevacizumab.
- Conditions
- Rectal Cancer, Cancer of the Rectum, Colorectal Cancer
- Trial name
- NCT00308516
- Testing
- 5-Fluorouracil, Bevacizumab, Radiation Therapy
- Where
- 14 sites in United States
- Volunteers
- 66 people
- Sponsor
- SCRI Development Innovations, LLC
Colorectal Cancer, Colon Cancer
Effect of Celecoxib on Perioperative Inflammatory Response in Colon Cancer
The proposed study aims to investigate how the administration of a drug known to reduce inflammation in humans, Celecoxib, will effect the peri-operative inflammatory response of a patient undergoing primary tumor resection…
- Trial name
- NCT01284504
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
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