Clinical trials: Colorectal Malignancy
Colorectal Cancer Screening
FLU-FIT Program at Kaiser Permanente Northern California
The investigators overall goal is to develop, implement, test, and disseminate an intervention to increase colorectal cancer screening rates at Kaiser Permanente (KP) by providing home fecal immunochemical test kits (FIT) to…
- Trial name
- NCT01210235
- Testing
- FLU-FIT Program
- Where
- United States
- Volunteers
- 7,465 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Colorectal Cancer
Colorectal Cancer Screening in the Homeless
This study is designed to assess the effect of implementing a text messaging strategy for colorectal cancer screening among homeless persons aged 45-75 years, who are not up to date on colorectal cancer screening, in shelter…
- Trial name
- NCT07220018
- Testing
- mHealth for Colorectal cancer screening in Homeless Persons, Control SMS Messages
- Where
- United States
- Volunteers
- 588 people
- Sponsor
- George Washington University
Colon Cancer, Rectal Cancer
Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND)
The goal of this observational study is to learn about the spatial distribution and significance of metastatic lymph nodes in colorectal cancer patients.
- Trial name
- DIAMOND (NCT07306390)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Metastatic Colorectal Cancer
The MAX Study: Mitomycin C, Avastin and Xeloda in Patients With Untreated Metastatic Colorectal Cancer
Although it is possible to cure bowel cancer when it is detected at an early stage, in many cases it may spread to involve other organs and in these cases is generally incurable.
- Trial name
- NCT00294359
- Testing
- Mitomycin C; Capecitabine; Bevacizumab
- Where
- 36 sites in Australia, New Zealand
- Volunteers
- 333 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Safety and Efficacy of Tattooing Substance
Endoscopic Tattooing and Colorectal Cancer
Endoscopic tattooing to facilitate colorectal lesions' identification during laparoscopic surgery is a reliable and widely used technique. India Ink is the standard option for colonic tattoing.
- Trial name
- NCT03637933
- Testing
- endoscopic tattooing
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federico II University
Colorectal Cancer
Attitudes Towards Prophylactic Colectomy in Hereditary Non-polyposis Colorectal Cancer (HNPCC) Patients
The purpose of this study is to learn more about individual's with a family history of colon cancer and the process by which they may decide to undergo or not undergo prophylactic colectomy.
- Trial name
- NCT00582452
- Testing
- Telephone survey
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Rectal Neoplasms
Neo-Adjuvant FOLFOX for Rectal Carcinoma
A Phase II open- labeled, prospective study to determine the efficacy of pre-operative chemotherapy with six cycles of modified FOLFOX 6 followed by total mesorectal excision (TME) followed by an additional six cycles of FOLFOX…
- Trial name
- NCT00832299
- Testing
- FOLFOX, total mesorectal excision (TME)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Beth Israel Medical Center
Left-sided Colorectal Cancer
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1)
The purpose of this trial is to evaluate how well petosemtamab in combination with chemotherapy works against colorectal cancer located on the left side of the colon that cannot be safely removed by surgery or has spread to other…
- Trial name
- NCT07702032
- Testing
- Petosemtamab, Cetuximab, FOLFIRI
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 960 people
- Sponsor
- Genmab
Colon Cancer Liver Metastasis
Irinotecan-Eluting Bead (DEBIRI) for Patients With Liver Metastases From Colorectal Cancer
This is a multicentre, open labeled, single arm study to determine effectiveness and safety of chemoembolization with Irinotecan-Eluting Bead(DEBIRI) in the treatment of unresectable liver metastases in patients with colorectal…
- Trial name
- DEBIRI-CRLM (NCT03175016)
- Testing
- TACE, Irinotecan, eluting-bead
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colo-rectal Cancer, Hereditary Diseases
Lynch Syndrome in Colorectal Cancer Surgery
Study Design (Material and Methods) This is a multicentre, prospective cohort and audit study conducted in Türkiye. The study aims to evaluate the incidence of Lynch syndrome among patients who undergo surgery for colorectal…
- Conditions
- Colo-rectal Cancer, Hereditary Diseases, Lynch Syndrome
- Trial name
- LYNX (NCT06990633)
- Testing
- diagnostic test
- Volunteers
- 180 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Head and Neck Cancer, Breast Cancer
FNA Tumor Sampling for CD137 Modulation: A Pilot Study
The purpose of this study is to better understand the biology of the body's immune response to monoclonal antibody therapy for cancer. Your health information will be used to identify your tissues.
- Conditions
- Head and Neck Cancer, Breast Cancer, Head and Neck Cancers, Non-Hodgkin Lymphoma
- Trial name
- NCT01114256
- Testing
- FNA Biopsy
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Stanford University
Colonic Cancer
Butyrophilins Role in Colon Cancer
quantification of BTNL molecules in colon cancer in order to determinate if their could be used as a prognostic marquer
- Trial name
- IMMUNOCOL (NCT04185272)
- Testing
- analysis of BTN and BTNL status
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Institut Paoli-Calmettes
Metastatic Colorectal Cancer
Phase II Trial of FOLFOXIGIL Versus FOLFOXIRI as First-line Therapy in Patients With mCRC
A randomized phase II trial of FOLFOXIRI in Combination With GM-CSF and IL-2 (FOLFOXIGIL) Versus FOLFOXIRI as First-line Treatment for Patients With Metastatic Colorectal Cancer.
- Trial name
- NCT03222089
- Testing
- Irinotecan, Oxaliplatin, Levoleucovorin
- Where
- China
- Sponsor
- Fujian Cancer Hospital
Rectal Adenocarcinoma
Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy
To learn if adding metronidazole to standard therapy can decrease populations of Fusobacterium nucleatum (F. nucleatum) and other anaerobes (small organisms that cause infections) in participants with rectal cancer receiving…
- Trial name
- NCT06569368
- Testing
- Metronidazole
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Urothelial Carcinoma, Renal Cell Carcinoma
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
This is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with atezolizumab in subjects with multiple tumor types…
- Conditions
- Urothelial Carcinoma, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Castration-resistant Prostate Cancer
- Trial name
- NCT03170960
- Testing
- cabozantinib, atezolizumab
- Where
- 124 sites in United States, Australia and 7 more
- Volunteers
- 914 people
- Sponsor
- Exelixis
Colorectal Cancer
Assessment of the Diagnostic Role of Serum Insulin-like Growth Factor Binding Protein-3 as a Potential Biomarker for Colorectal Cancer (CRC) in Egypt
1. evaluation of diagnostic importance of insulin like growth factor binding protein3 in patient with recently diagnosed as Colorectal cancer 2.
- Trial name
- NCT05850559
- Testing
- evaluation of diagnostic importance of insulin like growth factor binding protein3 in patient with recently diagnosed as Colorectal cancer
- Volunteers
- 50 people
- Sponsor
- Assiut University
Colorectal Cancer, Palliative Medicine
Efficacy of Ginseng for Patients on Regorafenib
This is a randomized, multi-center phase II study of ginseng in colorectal cancer patients treated with regorafenib to determine if ginseng will reduce fatigue in this patient population and improve adherence to regorafenib.
- Conditions
- Colorectal Cancer, Palliative Medicine, Supportive Care
- Trial name
- NCT02581059
- Testing
- Regorafenib, Ginseng
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Colorectal Neoplasms
The Safety and Tolerability of PD-L1 Monoclonal Antibody Plus Lenalidomide in The Treatment of Colorectal Cancer
This study proposed by increasing dosage and expand the "3 + 3" queue, main component is divided into two phases, phase 1 for dose escalation, according to preliminary data recommended doses starting dose of climbing, the purpose…
- Trial name
- NCT04326296
- Testing
- PD-L1 Monoclonal Antibody Combined With Lenalidomide
- Where
- China
- Volunteers
- 33 people
- Sponsor
- LiNing
Rectal Cancer
The Development of a Patient Reported Outcomes Measure Committed to the Watch-and-wait Program for Rectal Cancer
The purpose of this study to develop an international tool that can be used to assess burden of disease in patients enrolled in the W\&W program for rectal cancer
- Trial name
- NCT05040646
- Testing
- Delphi exercise
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Metastatic Colorectal Cancer
A Study of HX008 Compared to Chemotherapy in the First-Line Treatment of Subjects With MSI-H/dMMR Metastatic Colorectal Cancer
The main purpose of this study is to compare the clinical benefit, as measured by Progression-Free Survival (PFS), achieved by HX008 or Investigator's Choice Chemotherapy in participants with Microsatellite Instability High…
- Trial name
- NCT05652894
- Testing
- HX008(Pucotenlimab), Investigator's Choice Chemotherapy
- Where
- 63 sites in China
- Volunteers
- 190 people
- Sponsor
- Taizhou Hanzhong biomedical co. LTD