Clinical trials: Colorectal Obstruction
Colorectal Surgery, TAP Blocks
TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery
This is a prospective randomized study designed to compare the pain control from a single shot of liposomal bupivacaine (Exparel) against transversus abominus plane (TAP) catheters with ropivicaine bolus in patients undergoing…
- Trial name
- NCT03080142
- Testing
- Exparel, Ropivacaine
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of California, Davis
Pneumoperitoneum, Neuromuscular Blockade
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.
Substudy of the RECOVER trial (a randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during…
- Conditions
- Pneumoperitoneum, Neuromuscular Blockade, Surgery, Immune Suppression
- Trial name
- RECOVER-PLUS (NCT03572413)
- Testing
- Low pressure pneumoperitoneum, Rocuronium bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Postoperative Pain, Postoperative Nausea
Autonomic Neural Field Block for Visceral Pain in Minimally Invasive Left-Sided Colectomy
Effective postoperative pain control is a core component of enhanced recovery after surgery (ERAS) pathways in colorectal surgery; however, postoperative pain following minimally invasive left-sided colectomy remains a persistent…
- Conditions
- Postoperative Pain, Postoperative Nausea, Opioid Use
- Trial name
- ANfiELD (NCT07351994)
- Testing
- Autonomic Neural Field Block
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Antonio Caycedo, MD
Post Operative Pain, Laparoscopic Colorectal Surgery
Analgesic Effect of Bilateral Quadratus Lumborum Block in the End of Colorectal Laparosopic Surgery.
The primary purpose of COLOQUAL study is to demonstrate the superiority of analgesic effect of a bilateral quadratus lumborum block (QLB), performed at the end of laparoscopic colorectal surgery, compared to standard of care.
- Trial name
- Coloqual (NCT03966092)
- Testing
- Quadratus lumborum block
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ileostomy; Complications, Bowel Obstruction
Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies
The primary objective of this study is to prospectively evaluate rate of post-operative ileus or obstruction in patients with ileostomies receiving low fiber diet vs. regular diet starting post-operative day 1.
- Conditions
- Ileostomy; Complications, Bowel Obstruction, Postoperative Ileus
- Trial name
- NCT04675606
- Testing
- Regular diet, Low fiber diet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Postoperative Pain
Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery
Purpose: To explore effects of ultrasound-guided transversus abdominis plane block with compound lidocaine and esketamine on postoperative pain after colorectal cancer surgery.
- Trial name
- NCT05122338
- Testing
- Normal saline, Ropivacaine, Compound lidocaine
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University General Hospital
Ileus, Gastro-Intestinal Disorder
A Study to Evaluate LB1148 for Return of Bowel Function in Subjects Undergoing Bowel Resection
The purpose of this study is to evaluate the safety and efficacy of LB1148 in subjects undergoing planned bowel resection.
- Trial name
- INTEGRITY (NCT05470387)
- Testing
- LB1148
- Where
- 23 sites in United States
- Volunteers
- 23 people
- Sponsor
- Palisade Bio
Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer
Domestic Surgical Robot Clinical Study
Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013.
- Conditions
- Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer, Cholecystolithiasis, Appendicitis
- Trial name
- NCT02752698
- Testing
- Micro Hand S robotic surgery, laparoscopic surgery, da Vinci robotic surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction
Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction
RATIONALE: The use of endoscopy to place metal stents in the duodenum is less invasive than surgery for treating cancer-related duodenal obstruction and may have fewer side effects and improve recovery.
- Conditions
- Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction, Extrahepatic Bile Duct Cancer, Gastric Cancer
- Trial name
- NCT00004910
- Testing
- bowel obstruction management, quality-of-life assessment
- Where
- United States
- Sponsor
- Northwestern University
Post-operative Pain, Postoperative Nausea
Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery
Keyhole surgery for bowel disease has brought great benefits, enabling patients to recover quicker from surgery and so return to normal activities.
- Conditions
- Post-operative Pain, Postoperative Nausea, Postoperative Complications
- Trial name
- NCT00830089
- Testing
- Levobupivicaine 0.25%
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Nottingham
Quadratus Lumborum Block, Analgesia
Transversus Abdominis Plane Block Plus Quadratus Lumborum Block or Retrolaminar Block of Multiple Injections for Postoperative Analgesia Following Laparoscopic Colorectal Surgery
Our hypothesis was that transversus abdominis plane block plus retrolaminar block would reduce postoperative sufentanil consumption and provide superior analgesia compared with transversus abdominis plane block plus quadratus…
- Conditions
- Quadratus Lumborum Block, Analgesia, Laparoscopic, Colorectal
- Trial name
- NCT05416866
- Testing
- Retrolaminar block on the operative side, Quadratus lumborum block on the operative side, Transversus abdominis plane block on the nonoperative side
- Volunteers
- 100 people
- Sponsor
- dong zhang
Acute Malignant Colonic Obstruction, Colorectal Cancer
Colonic Stenting With Elective Surgery Versus Emergency Surgery in the Management of Acute Malignant Colonic Obstruction
The use of colonic stenting with elective surgery has been suggested as an alternative management for acute malignant colonic obstruction, as emergency surgery has a high risk of morbidity and mortality.
- Conditions
- Acute Malignant Colonic Obstruction, Colorectal Cancer, Colonic Obstruction
- Trial name
- NCT01997684
- Testing
- Colonic Stenting with Elective Surgery, Emergency Surgery
- Where
- 9 sites in China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Patients With Liver Metastases From Colorectal Cancer
Modelling Internal Hepatic Movement With an External Abdominal Marker
This study tests the feasibility and reproducibility of patient-specific motion models. These will be used for quantification of safe margin reduction.
- Trial name
- NCT00299299
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Colorectal Obstruction, Left Colonic Adenocarcinoma
Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A Randomized, Controlled Study
To evaluate wether colorectal stenting carry a significant clinical advantage
- Trial name
- NCT00514332
- Testing
- stent
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Surgery
ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery
This study is being done to compare 2 types of pain control methods and determine which is more effective postoperatively for laparoscopic colorectal surgery.
- Trial name
- NCT05257941
- Testing
- IT Injection, ESP Block
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Indiana University
Colorectal Cancer, Bowel Obstruction
Endolaparoscopic Versus Immediate Surgery for Obstructing Colorectal Cancers
The aim of this study is to compare the stoma rate, clinical efficacy, and safety of patients treated by endoscopic stenting followed by elective laparoscopic resection (the 'endolaparoscopic approach') versus immediate emergency…
- Trial name
- NCT00164879
- Testing
- Endoscopic stenting followed by elective laparoscopic resection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Postoperative Ileus, Ileus
Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery
Post-operative ileus is a common complication following abdominal surgery. It results in abdominal distension, nausea and vomiting as well as abdominal pain.
- Trial name
- NCT02161367
- Testing
- Simethicone, Oral Suspending Vehicle
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Colon Neoplasm, Surgery
Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Patients Undergoing Left Hemicolectomy
The enhanced recovery after surgery and laparoscopic approach have been proven beneficial in surgery of the colon. However, patients have still pain, nausea and vomiting postoperatively.
- Conditions
- Colon Neoplasm, Surgery, Pain, Postoperative
- Trial name
- NCT03458689
- Testing
- Left hemicolectomy, laparoscopic technique
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Ostfold Hospital Trust
Ileus, Gastrointestinal Dysfunction
Alvimopan as a Rescue Treatment of Postoperative Ileus
This study aims to evaluate the cost effectiveness of Alvimopan as rescue therapy in patients undergoing colorectal or small bowel resection who develop POI, and its safety and effectiveness in reducing LOS and POI duration.
- Trial name
- NCT04405037
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Scott Steele