Clinical trials: Colorectal Tumor
Colorectal Cancer
Irinotecan With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if irinotecan is more effective with or without oxaliplatin in treating metastatic…
- Trial name
- NCT00012389
- Testing
- irinotecan hydrochloride, oxaliplatin
- Where
- 154 sites in United States, Brazil and 5 more
- Sponsor
- Sanofi
Colorectal Cancer Metastatic, Liver Metastases
Chemotherapy and Tumor Clearance in Hepatic Resections for Colorectal Liver Metastases.
Retrospective analysis of a prospectively collected database of 170 patients between 2004 and 2020, who underwent liver resections for CRLM (colorectal liver metastases) at The Queen Elizabeth Hospital trying to determine rates…
- Trial name
- NCT05273489
- Testing
- Hepatectomy
- Volunteers
- 170 people
- Sponsor
- Hospital Maciel
Rectal Cancer
Consolidation Chemotherapy for Locally Advanced Mid or Low Rectal Cancer After Neoadjuvant Concurrent Chemoradiotherapy
This trial is to assess the efficacy and feasibility of consolidation chemotherapy after neoadjuvant chemoradiotherapy for locally advanced mid or low rectal cancer.
- Trial name
- NCT02843191
- Testing
- Chemotherapy
- Where
- 14 sites in South Korea
- Volunteers
- 358 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Metastatic Colorectal Cancer (CRC), Liposomal Irinotecan
A Clinical Study of Liposomal Irinotecan for Second-Line Therapy in Metastatic Colorectal Cancer
Phase II - Treatment Regimen Exploration Stage: 1. Evaluate the safety and efficacy of the following three treatment regimens: Liposomal irinotecan + 5-FU/LV + bevacizumab + Enlonstobart (Group A) Liposomal irinotecan + 5-FU/LV +…
- Conditions
- Metastatic Colorectal Cancer (CRC), Liposomal Irinotecan, Second-Line
- Trial name
- NCT07585279
- Testing
- Liposomal irinotecan + 5-FU/LV + bevacizumab + Enlonstobart, Irinotecan liposome + 5-FU/LV + Bevacizumab, Irinotecan + 5-FU/LV + Bevacizumab
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Hebei Medical University Fourth Hospital
ctDNA, Chemotherapy
A Randomized Controlled Trial of Plasma ctDNA Methylation-Guided Adjuvant Chemotherapy Decision-Making in High-Risk Stage III (T4N+ or T1-3N2) Colorectal Cancer
Patients with T4N+ or T1-3N2 disease will be randomly assigned to either the control group (FOLFOX/CAPOX for 6 months) or the intervention group (FOLFOX/CAPOX plus bevacizumab for 6 months) to receive adjuvant therapy.
- Conditions
- ctDNA, Chemotherapy, Colorectal Cancer
- Trial name
- CLEAR-04 (NCT07562490)
- Testing
- FOLFOX, Folfox plus Bevacizumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Mesothelioma, Neoplasms
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
Background: Mesothelioma is an aggressive cancer that grows in the linings of the body; this can include the membranes that line the heart, lungs, and internal organs.
- Conditions
- Mesothelioma, Neoplasms, Stomach Neoplasms, Pancreatic Neoplasms
- Trial name
- NCT06885697
- Testing
- cyclophosphamide, fludarabine, TNhYP218 CAR T Cells
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Colonic Cancer, Postoperative Care
Rehabilitation Following Laparoscopic Colonic Surgery
The standard procedure for treating colonic cancer is changing from open surgery to laparoscopic surgery. Following open colonic surgery patients are fatigued and loss body mass and have a reduction in physical function, but the…
- Conditions
- Colonic Cancer, Postoperative Care, Fatigue
- Trial name
- NCT00938210
- Testing
- Laparoscopic colonic surgery
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Metastatic Colorectal Cancer, BRAF V600E Mutation Positive
A Clinical-biological Prospective Cohort of Patients With BRAFV600E-mutated Metastatic Colorectal Cancer
The study will be conducted in patients with metastatic colorectal cancer (mCRC) harboring a BRAFV600E mutation, to collect clinical data and biological samples to be used for research but also to gather real-world clinical data…
- Trial name
- COBRAF (NCT05639413)
- Testing
- Collection of blood samples
- Where
- 45 sites in France
- Volunteers
- 400 people
- Sponsor
- UNICANCER
Early Rectal Neoplasms
The Application of a Novel Endoluminal Robotic System for Colorectal Endoscopic Submucosal Dissection
Endoluminal surgery through natural orifices is an effective, "incisionless" treatment for benign lesions and early-stage cancers in the urinary tract and gastrointestinal (GI) tract.
- Trial name
- NCT07486180
- Testing
- Colorectal Endoscopic Submucosal Dissection (ESD) Using the Intilume Surgical System
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
HER2-positive Breast Cancer, HER2 Gene Mutation
Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene
Open-label, Phase I-II, first-in-human (FIH) study for A166 monotherapy in HER2-expressing or amplified patients who progressed on or did not respond to available standard therapies.
- Conditions
- HER2-positive Breast Cancer, HER2 Gene Mutation, HER-2 Gene Amplification, HER2 Positive Gastric Cancer
- Trial name
- NCT03602079
- Testing
- A166
- Where
- 10 sites in United States
- Volunteers
- 49 people
- Sponsor
- Klus Pharma Inc.
Lynch Syndrome
Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome
Lynch syndrome is the most common inherited condition that raises a person's risk of getting certain cancers. It happens because of changes in genes that normally fix damaged DNA.
- Trial name
- PREDI-ENDO (NCT07877779)
- Where
- United Kingdom
- Volunteers
- 1,450 people
- Sponsor
- University of Edinburgh
Colon Carcinoma Metastatic in the Liver, Colorectal Adenocarcinoma
VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer
This randomized phase I trial studies how well anti-semaphorin 4D (anti-SEMA4D) monoclonal antibody VX15/2503 with or without ipilimumab or nivolumab work in treating patients with stage I-III pancreatic cancer that can be…
- Conditions
- Colon Carcinoma Metastatic in the Liver, Colorectal Adenocarcinoma, Pancreatic Adenocarcinoma, Resectable Pancreatic Carcinoma
- Trial name
- NCT03373188
- Testing
- Anti-SEMA4D Monoclonal Antibody VX15/2503, Ipilimumab, Nivolumab
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Esophageal Neoplasm, Rectal Neoplasms
Prospective Study Evaluating the Feasibility of Fiducial Markers Placement for Patients With Esophageal or Rectal Cancer
It is a multicenter prospective observational study including consecutive patients with esophageal tumor or rectum with indication for radiotherapy The main objective of this study is to evaluate the feasibility of fiducial…
- Trial name
- FIDECHO (NCT03057288)
- Testing
- fiducial markers placement
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Société Française d'Endoscopie Digestive
Colorectal Cancer
Increasing Colorectal Cancer Screening in Urban African American Communities Via Churches
This is an intervention study to increase colorectal cancer screening and physical activity in members of African-American churches who are 50 years old and older.
- Trial name
- ACTS (NCT01139242)
- Testing
- Body & Soul nutritional intervention, Experimental: newsletters and peer counseling
- Volunteers
- 955 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Gastrointestinal Cancer, Colorectal (Colon or Rectal) Cancer
Non-Operative Management and Following Immunotherapy for Colorectal Cancer and Other GI Cancers
This is a single-center, bidirectional (retrospective and prospective) registry study aimed at evaluating the safety and efficacy of Non-Operative Management (NOM) and Organ-Preserving Functional Surgery (OPFS) in patients with…
- Conditions
- Gastrointestinal Cancer, Colorectal (Colon or Rectal) Cancer, Stomach (Gastric) Cancer
- Trial name
- NOMIC (NCT07656740)
- Testing
- NOM, RO
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer Survivor, Rehabilitation
Multidimensional Rehabilitation Intervention in Colorectal Cancer Survivors
A metaverse-based multidimensional rehabilitation program will be implemented for colorectal cancer survivors who have undergone curative surgery and adjuvant therapy.
- Conditions
- Colorectal Cancer Survivor, Rehabilitation, Quality of Life
- Trial name
- NCT05956990
- Testing
- multidimensional rehabilitation
- Volunteers
- 60 people
- Sponsor
- Qu Shen
Rectal Cancer
A Study Comparing Adjuvant Chemotherapy Versus Observation for Patients With Rectal Adenocarcinoma After Neoadjuvant Chemo-Radiotherapy Treatment.
Surgery is the most indicated curative treatment for rectal cancer when disease is diagnosed early, however local recurrence risk increases when the disease is diagnosed at advanced stage.T1-2 tumors have a recurrence rate lower…
- Trial name
- NCT01941979
- Testing
- 5-FU, Capecitabine, Oxaliplatin, Leucovorin.
- Where
- Brazil
- Volunteers
- 309 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Adenomatous Polyps
Managing Colorectal Cancer Prevention Procedure Wait Lists During the COVID-19 Pandemic
The main objective of this study is to offer and evaluate an interim triage approach for patients waiting for surveillance colonoscopies.
- Trial name
- NCT04964596
- Testing
- colonoscopy, FIT test, CT colonography
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Dose Dense Therapy and Bevacizumab in Solid Tumors and Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, irinotecan, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00296062
- Testing
- bevacizumab, capecitabine, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Case Comprehensive Cancer Center
Colonic Neoplasms
EndoMaster EASE System for Treatment of Colorectal Lesions
This is a prospective, single arm study to assess the safety and performance of the EndoMaster EASE (Endoluminal Access Surgical Efficacy) System for the treatment of patients with colorectal neoplasms.
- Trial name
- MASTERCESD (NCT04196062)
- Testing
- EndoMASTER EASE Robotic system for ESD
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Chinese University of Hong Kong
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