Clinical trials: Colorectal Tumor
Adjuvant Chemotherapy, Colon Cancer
Modulation of Immune Response by Oral Zinc Supplementation in Chemotherapy for Colon Cancer
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and…
- Conditions
- Adjuvant Chemotherapy, Colon Cancer, Immunity
- Trial name
- NCT01261962
- Testing
- zinc
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Colorectal Cancer
Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
Colorectal cancer is a common disease worldwide. Increasing evidence is demonstrating that colorectal cancers arise from 'cancer stem cells.' Stem cells in the colon reside at the bottom of thousands of microscopic crypts…
- Trial name
- NCT01075893
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Metastatic Colorectal Cancer
A Study Evaluating S 95005 Plus Bevacizumab and Capecitabine Plus Bevacizumab in Patients With Previously Untreated Colorectal Cancer Who Are Non-eligible for Intensive Therapy
The main purpose of this study is to evaluate the progression-free survival (PFS) in patients receiving S 95005 + bevacizumab (experimental arm) or capecitabine + bevacizumab (control arm) as first-line treatment for unresectable…
- Trial name
- TASCO1 (NCT02743221)
- Testing
- Trifluridine/tipiracil + bevacizumab, Capecitabine + bevacizumab
- Where
- 57 sites in Australia, Belgium and 10 more
- Volunteers
- 154 people
- Sponsor
- Institut de Recherches Internationales Servier
Colorectal Cancer Screening
Pilot Testing of a Colorectal Cancer Education Program
The primary objective of this study is to assess the feasibility, acceptability, and preliminary efficacy of a culturally and linguistically targeted, colorectal cancer (CRC) education program to improve CRC screening completion.
- Trial name
- NCT07361614
- Testing
- Educational Program
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Colonic Neoplasms
Impact of Immunoscore Colon Test on Adjuvant Therapeutic Strategy in Non-Metastatic Colon Cancer
Immunoscore Colon Test (ICT) will be applied on tumor samples from curative surgery. In the Multidisciplinary Meeting (MM) evaluating the participant adjuvant strategy, a first decision will be taken, based on the participant…
- Trial name
- PROSCORE (NCT03946033)
- Testing
- Immunoscore Colon Test
- Where
- 21 sites in France
- Sponsor
- UNICANCER
Advanced Solid Tumor
A Study to Investigate Safety and Tolerability of SH3809 Tablet in Patients With Advanced Solid Tumors
The primary objective is to determine the safety and tolerability of SH3809 in subjects with advanced solid tumors. The second objective is to evaluate the PK profile and preliminary efficacy of SH3809 in solid tumors.
- Trial name
- NCT04843033
- Testing
- SH3809 tablet
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Nanjing Sanhome Pharmaceutical, Co., Ltd.
Colorectal Cancer
Study of Irinotecan Plus Capecitabine to Treat Advanced Colorectal Cancer
The objectives of this study are to evaluate the efficacy and tolerability of single-week regimen of irinotecan plus capecitabine in the first-line or second-line treatment of advanced colorectal cancer.
- Trial name
- NCT01322152
- Testing
- irinotecan, capecitabine
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Fudan University
Rectal Cancer
Proximally Extended Resection for Rectal Cancer After Neoadjuvant Chemoradiotherapy
Neoadjuvant chemoradiotherapy has been recommended as the standard preoperative treatment for locally advanced rectal cancer. However, preoperative radiotherapy increases the risk of bowel dysfunction after sphincter-preserving…
- Trial name
- PERN (NCT02649647)
- Testing
- Conventional resection, Proximally extended resection
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colonic Polyp, Colonic Neoplasms
Real-World Validation of an Artificial Intelligence Characterization Support (CADx) System
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, with rates of CRC predicted to increase. Colonoscopy is currently the gold standard of screening for CRC.
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT05034185
- Testing
- Computer-aided diagnosis (CADx) support tool
- Where
- Singapore
- Volunteers
- 450 people
- Sponsor
- Changi General Hospital
Advanced Colorectal Cancer
Regorafenib Monotherapy as Second-line Treatment of Patients With RAS-mutant Advanced Colorectal Cancer
The purpose of this study is to purpose of this study is to assess if regorafenib is active enough, in terms of 6-month progression-free rate, to warrant further comparative studies in patients with RAS-mutant advanced colorectal…
- Trial name
- STREAM (NCT02619435)
- Testing
- regorafenib
- Where
- 4 sites in Italy
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute, Naples
Colorectal Neoplasms
Surufatinib With or Wothout Immunotherapy for Advanced Colorectal Cancer in Later Line
This is a single-center, open-label, cohort clinical study to investigate the efficacy and safety of surufatinib with or without immunotherapy in patients with advanced colorectal cancer who failed front-line anti-angiogenic TKI…
- Trial name
- NCT05372198
- Testing
- Chohort 1: Surufatinib, Chohort 2: Immunotherapy, Chohort 2: Surufatinib
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Hubei Cancer Hospital
Metastatic Colorectal Cancer
Safety, Tolerability and Efficacy of Regorafenib in Combination With FOLFIRINOX in Patients With Colorectal Cancer
Safety, tolerability and efficacy of regorafenib in combination with FOLFIRINOX in patients with RAS-mutated metastatic colorectal cancer: a dose-escalation, phase I/II trial
- Trial name
- FOLFIRINOX-R (NCT03828799)
- Testing
- Folfirinox + regorafenib
- Where
- 4 sites in France
- Volunteers
- 13 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cancer Colorectal, Cancer Cervix
Building Connections
Building Connections seeks to address health and healthcare inequities in socially vulnerable communities. The project will be conducted in collaboration with clinical practices across Massachusetts, serving a diverse population…
- Conditions
- Cancer Colorectal, Cancer Cervix, Depression, Anxiety, Obesity
- Trial name
- NCT07091032
- Testing
- Treatment as Usual, Building Connections Intervention
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer, Chemotherapy
Supportive Cancer Care Networkers (SCAN)
Aim of the study is to increase the proportion of indicated patients with colorectal cancer undergoing adjuvant chemotherapy following surgical resection through an optimized symptom management and logistical support.
- Trial name
- SCAN (NCT01651832)
- Testing
- SCAN
- Where
- 9 sites in Germany
- Volunteers
- 261 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Colorectal Cancer, Gastrointestinal Complications
J-Pouch Colorectal Anastomosis or Straight Colorectal Anastomosis in Treating Patients With Rectal Cancer Who Have Undergone Surgery to Remove the Tumor
RATIONALE: It is not yet known whether a J-pouch colorectal anastomosis is more effective than a straight colorectal anastomosis in treating patients with rectal cancer who have undergone surgery to remove the tumor.
- Conditions
- Colorectal Cancer, Gastrointestinal Complications, Perioperative/Postoperative Complications
- Trial name
- NCT01110798
- Testing
- intraoperative complication management/prevention, assessment of therapy complications, gastrointestinal complications management/prevention
- Where
- 4 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Ospedaliera di Padova
Colorectal Cancer
A Study to Determine the Activity of Robatumumab (SCH 717454, MK-7454) in Participants With Relapsed or Recurrent Colorectal Cancer (P04721, MK-7454-003)
The purpose of this study was to determine the activity of two doses of robatumumab (SCH 717454, MK-7454) in participants with relapsed or recurrent colorectal cancer.
- Trial name
- NCT00551213
- Testing
- Robatumumab, Irinotecan, Cetuximab
- Volunteers
- 67 people
- Sponsor
- Merck Sharp & Dohme LLC
Diverticulitis, Colonic, Colonic Neoplasms
Acute Diverticulitis and Advanced Colonic Neoplasia. When to Perform Colonoscopy (ADACOLON Study)
This study evaluate the prevalence of advanced colonic neoplasia (ACN) in acute diverticulitis. A sub-analysis of complicated and uncomplicated acute diverticulitis will be made in order to determinate whether there are…
- Trial name
- ADACOLON (NCT03557216)
- Testing
- Colonoscopy, Fecal immunochemical and occult blood test, Fecal calprotectin test
- Where
- Spain
- Volunteers
- 313 people
- Sponsor
- Parc de Salut Mar
Colorectal Neoplasms, Neoplasm Metastasis
Study of Aflibercept And Modified FOLFOX6 As First-Line Treatment In Patients With Metastatic Colorectal Cancer
The primary objective of the study is to estimate the progression-free survival rate at 12 months for the two arms of the study.
- Trial name
- AFFIRM (NCT00851084)
- Testing
- aflibercept, oxaliplatin, 5-FU
- Where
- 37 sites in Australia, Germany and 5 more
- Volunteers
- 268 people
- Sponsor
- Sanofi
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Cancer Survivor, Stage I Breast Cancer AJCC v7
Ginseng in Decreasing Cancer-Related Fatigue After Treatment in Cancer Survivors
This randomized pilot trial studies how well North American ginseng extract AFX-2 (ginseng) works in decreasing cancer-related fatigue after treatment in cancer survivors.
- Conditions
- Cancer Survivor, Stage I Breast Cancer AJCC v7, Stage I Colon Cancer AJCC v6 and v7, Stage IA Breast Cancer AJCC v7
- Trial name
- NCT03407716
- Testing
- American Ginseng, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
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