Clinical trials: Colorectal Tumor
Advanced Solid Tumors
Study of Continuous OSI-906 Dosing
Multicenter, open-label, phase 1, cohort dose escalation study to determine the Maximum Tolerated Dose (MTD) on both Once Daily (QD) and Twice Daily (BID) schedules.
- Trial name
- NCT00514007
- Testing
- OSI-906
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 95 people
- Sponsor
- Astellas Pharma Inc
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (Disorder)
Virtual Versus Dye-based Chromoendoscopy in Inflammatory Bowel Disease Surveillance Colonoscopy
People with inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease affecting the colon, have a higher risk of developing colon cancer over time.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (Disorder), Crohns Disease, Colorectal Neoplasms
- Trial name
- NCT07089771
- Testing
- Virtual Chromoendoscopy, Dye-Based Chromoendoscopy
- Where
- Sweden
- Volunteers
- 480 people
- Sponsor
- Region Stockholm
Colorectal Neoplasms
Randomized Trial Comparing Fecal Testing (FIT) to Colonoscopy for Post-polypectomy Surveillance
From observational studies, it is know that the risk of developing colorectal cancer after polyp removal is lower if the patients adheres to surveillance recommendations.
- Trial name
- NCT06983639
- Testing
- Fecal occult blood testing, Colonoscopy
- Where
- Norway
- Volunteers
- 4,000 people
- Sponsor
- Sorlandet Hospital HF
Bladder Cancer, Breast Cancer
Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)
This clinical trial studies the effect of four different intervention components "tools" on body weight, nutrition, and physical activity in cancer survivors.
- Conditions
- Bladder Cancer, Breast Cancer, Colon Cancer, Endometrial Cancer
- Trial name
- TTBF (NCT05056077)
- Testing
- Counseling, Educational Intervention, Health Education
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- University of California, San Francisco
Colonic Neoplasms, Colorectal Neoplasms
An Open Label Study of a Peptide Vaccine in Patients With Stage III Colon Cancer
EP2101 is a new cancer vaccine containing 10 different peptide antigens. The vaccine is designed to activate the immune system to develop a response against tumor cells in order to delay or prevent the recurrence of cancer.
- Trial name
- NCT00054912
- Testing
- EP2101
- Where
- 9 sites in United States
- Volunteers
- 18 people
- Sponsor
- Epimmune
Colorectal Neoplasms
Pemetrexed and TAS-102 in Combination With Bevacizumab in Refractory Colorectal Cancer
Limited agents are optional after standard first and second line treatment for mCRC. Only Regorafenib and Fruquintinib are approved in China. PFS of these targeted drugs are not very long.
- Trial name
- NCT04683965
- Testing
- Pemetrexed, TAS-102, Bevacizumab
- Where
- China
- Volunteers
- 27 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colorectal Liver Metastases
The Effect of Fish Oils on Human Hepatic Colorectal Metastases
The purpose of this study is to determine whether fish oils - a known source of omega-3 given intravenously (via a 'drip') will help cure secondary deposits in the liver from bowel cancer.
- Trial name
- NCT00942292
- Testing
- Lipidem- fish oil emulsion BBraun UK, Digital Contrast MRI scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospitals, Leicester
Metastatic Solid Tumor, Advanced Solid Tumor
A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.
- Trial name
- NCT06657144
- Testing
- CHS-114, Toripalimab, 5 Fluorouracil
- Where
- 30 sites in United States, Taiwan
- Volunteers
- 154 people
- Sponsor
- Coherus Oncology, Inc.
Colorectal Neoplasms
Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer
The objective of this trial is to evaluate the safety and tolerability of BI 695502 in combination with leucovorin/5-fluorouracil/oxaliplatin (mFOLFOX6) and as maintenance therapy (when applicable).
- Trial name
- INVICTAN®-3 (NCT02776683)
- Testing
- BI 695502, Avastin
- Where
- 46 sites in United States, Japan and 2 more
- Volunteers
- 123 people
- Sponsor
- Boehringer Ingelheim
Patient Preference
Tradeoffs in Patient Decision Making About Rectal Cancer Treatment: Benefits Compared to Quality Of Life.
This study is aiming to look into patients' treatment preferences and their socio economic background as well as the exploration of thought processes leading to these preferences.
- Trial name
- Pathos (NCT04925154)
- Testing
- The only intervention will be the information brochure that will be given after the first questionnaire.
- Where
- Canada
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Colon Cancer Patients Receiving Chemotherapy in the Adjuvant or Metastatic Setting, Aged 70 or Older
MOST: Mediterranean Oncology Senior Tests
MOST is a longitudinal study whose aim is to test the hypothesis that frailty markers are better at detecting vulnerable patients and that they are a better "Adverse Events" predictive tool than the CGA (Comprehensive Geriatric…
- Trial name
- MOST (NCT02148731)
- Testing
- Frailty markers
- Where
- 8 sites in France
- Volunteers
- 180 people
- Sponsor
- Association Sud pour la Recherche en Oncogériatrie
Sarcoma, Soft Tissue, Retroperitoneal Sarcoma
Colorectal Resections in Patients With Retroperitoneal Sarcoma
COLOSARC-Q is a multicenter study with the objective of providing an up-to-date assessment of colorectal resections and reconstruction techniques in the context of multivisceral resections for retroperitoneal sarcomas, as well as…
- Trial name
- COLOSARC-Q (NCT06943612)
- Where
- 16 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- Heidelberg University
Neoplasms, Gastric Cancer
Improving Complete Endoscopic Mucosal Resection (EMR) of Colorectal Neoplasia
The investigators seek to compare two techniques of removing pre-cancerous lesions from the colon. The investigators also will compare two solutions used during the procedure to determine if either solution allows for an improved…
- Trial name
- NCT01471756
- Testing
- Standard of Care Procedure as described in ARM
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Mayo Clinic
Colorectal Cancer
The Benefits of Deep Neuromuscular Block and Sugammadex in Laparoscopic Colorectal Surgery
Pneumoperitoneum, the use of carbon dioxide, presents some disadvantages, including a risk of hypercarbia and respiratory acidosis during surgery in the respiratory system, and of an increased mean arterial pressure and systemic…
- Trial name
- NCT02266056
- Testing
- Deep neuromuscular block using rocuronium and reversal with suggamadex, Moderate neuromuscular block using rocuronium and reversal with suggamadex
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hand and Foot Syndrome, Erythrodysesthesia Syndrome
Possible Protective Effect of Celecoxib Against Capecitabine Induced Hand and Foot Syndrome in Patients With Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of malignancy-related mortality. Capecitabine has been approved for the treatment of colorectal cancer as first-line therapy.
- Conditions
- Hand and Foot Syndrome, Erythrodysesthesia Syndrome, HFS, Colorectal Cancer
- Trial name
- HFS (NCT05327751)
- Testing
- Celecoxib 200mg, Capecitabine-based chemotherapy
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Colorectal Cancer, Liver Metastases
Conversion Therapy of RAS/BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastases
Evidence suggests that the addition of cetuximab or bevacizumab to doublet regimens could improve response rate and resectability rate of liver metastases and survival in colorectal liver metastases (CRLM).
- Trial name
- NCT04687631
- Testing
- mFOLFOXIRI plus Cetuximab, mFOLFOXIRI Plus Bevacizumab
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Fudan University
Anal Neoplasm
VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Virus (HIV)-1/2
This is a phase 2, open-label efficacy study of VGX-3100 administered by intramuscular (IM) injection followed by electroporation (EP) in adult men and women who are human immunodeficiency virus (HIV) negative with histologically…
- Trial name
- NCT03499795
- Testing
- VGX-3100, CELLECTRA™ 5PSP
- Where
- 3 sites in United States, Canada
- Volunteers
- 23 people
- Sponsor
- Inovio Pharmaceuticals
Colorectal Cancer Liver Metastasis
Prospective Validation of an AI Model for Predicting Liver Metastasis in Colorectal Cancer
This is a prospective, multicenter, observational study designed to validate the predictive accuracy of a pre-developed multimodal deep learning model.
- Trial name
- NCT07392567
- Testing
- Multimodal Deep Learning Prediction Model
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tongji Hospital
Colonic Neoplasms
Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.
- Trial name
- NCT00516230
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Oesophageal Tumour, Gastric Tumours
DESI - Düsseldorfer ESD Study
Safety and effectiveness of endoscopic submucosal dissection
- Conditions
- Oesophageal Tumour, Gastric Tumours, Duodenal Tumours, Colon Tumours
- Trial name
- NCT06993402
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Torsten Beyna
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