Clinical trials: Colorectal Tumor
Ewing Sarcoma, Colorectal Adenocarcinoma
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody targeting the human death receptor 5 (DR5).
- Trial name
- NCT03715933
- Testing
- INBRX-109, Irinotecan, Temozolomide
- Where
- 37 sites in United States, France and 4 more
- Volunteers
- 411 people
- Sponsor
- Inhibrx Biosciences, Inc
Non Small Cell Lung Cancer, Colorectal Cancer
FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors
This is a Phase 1 dose-finding study of FT536 given in combination with a monoclonal antibody following lymphodepletion in participants with advanced solid tumors.
- Conditions
- Non Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT05395052
- Testing
- FT536, Cyclophosphamide, Fludarabine
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Fate Therapeutics
Colorectal Cancer, KRAS Wildtype
A Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Advanced Colorectal Cancer
This is a phase 2 study (the second phase in testing a new drug or drug combination) to see how useful the combination of two drugs, panitumumab and trametinib, are in patients with advanced colorectal cancer with KRAS, NRAS, or…
- Conditions
- Colorectal Cancer, KRAS Wildtype, NRAS Wildtype, BRAF Wildtype
- Trial name
- NCT02399943
- Testing
- Trametinib, Panitumumab
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University Health Network, Toronto
Colorectal Neoplasms
A Korean Post-marketing Surveillance Study on Erbitux® in Patients With Metastatic Colorectal Cancer Refractory to Irinotecan-containing Treatment
After consultation with the Korean Health Authorities, the two Post-Authorization Safety Studies EMR 62202-509 (NCT01082315) and EMR 62241-508 (NCT01075828) were combined within one study protocol EMR 062202-551.
- Trial name
- NCT01082315
- Testing
- Erbitux (Cetuximab)
- Where
- South Korea
- Volunteers
- 730 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Motor Function, Cognitive Function
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
This study is a postmarketing requirement jointly carried out by four NDA holders (Bayer AG, Bracco, GE Healthcare and Guerbet) and the CRO IQVIA.
- Conditions
- Motor Function, Cognitive Function, Contrast Media
- Trial name
- ODYSSEY (NCT04373564)
- Testing
- Motor Tests, Cognitive Tests, Unenhanced-MRI of the brain
- Where
- 51 sites in United States, Brazil and 6 more
- Volunteers
- 2,076 people
- Sponsor
- Guerbet
Early Diagnosis of Colorectal Cancer and Adenoma
Correlation Between SFRP1 and Colorectal Cancer and Adenoma
In summary, our study demonstrated the methylation sites of SFRP1 gene promoter in patients with colorectal cancer and adenoma and found SFRP1_16_17_18 CpG site was good performance as a diagnostic marker of colorectal cancer.
- Trial name
- NCT05204433
- Testing
- no intervention
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Breast Carcinoma, Colorectal Adenocarcinoma
Vaccine Response With NT-I7
Background: People with cancer, and especially older people, have a weakened immune system (the defense system of the body). This is often caused by the treatments for cancer.
- Conditions
- Breast Carcinoma, Colorectal Adenocarcinoma, Bladder Carcinoma
- Trial name
- NCT04054752
- Testing
- Recombinant human IL-7-hyFc (NT-I7), Vaccine sequence 1, Vaccine sequence 2
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer (CRC), Sarcopenia
TIVA Versus Balanced Anesthesia on Muscle Mass in CRC Surgery
This study is aimed at clarifying changes in body composition during the perioperative period and identifying risk factors for skeletal muscle mass loss in patients with colorectal cancer.
- Trial name
- TIVABAL-CRC (NCT07237438)
- Testing
- total intravenous anaesthesia, sevoflurane anaesthesia
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Lynch Syndrome
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer
The purpose of this study is to determine the proportion of patients diagnosed with Lynch syndrome in colorectal cancer patients with the loss of staining by immunohistochemistry (IHC) of any of the mismatch repair (MMR)…
- Trial name
- NCT03047226
- Testing
- next-generation sequencing
- Where
- 7 sites in China
- Volunteers
- 311 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colon Cancer, Cancer
Creating an Innovative AI-based Technology TCRact for Designing and Optimizing T-cell Receptors (TCR) for Use in Cancer Immunotherapies
The PROJECT OBJECTIVE is to create an innovative AI-based (Artificial Intelligence) IN SILICO TECHNOLOGY for the design and optimization of T-cell receptors (TCRs) capable of recognizing specific tumor antigens presented on Human…
- Trial name
- NCT04994093
- Testing
- Collection of blood (PBMC), biopsy (FFPE) and stool samples.
- Where
- Poland
- Volunteers
- 118 people
- Sponsor
- Ardigen
Rectal Cancer Stage III
Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk Rectal Cancer Patients
The hereby proposed ACO/ARO/AIO-18.1 randomized trial aims to directly compare the newly established TNT concepts applying either short-course RT according to RAPIDO, or CRT according to CAO/ARO/AIO-04/-12, both followed by…
- Trial name
- NCT04246684
- Testing
- Oxaliplatin, 85 mg/m2, 5FU; 2400 mg/m2, 5FU, 250 mg/m2
- Where
- 75 sites in Germany
- Volunteers
- 702 people
- Sponsor
- Prof. Dr. med. Claus Rödel
Colorectal Neoplasms, Colonic Polyp
Effectiveness of Artificial Intelligence-Assisted Colonoscopy for Adenoma Detection in Routine Clinical Practice : a Prospective Multicenter Randomized Trial
This study is a multi-center, randomized controlled trial designed to evaluate whether an artificial intelligence (AI) system can assist endoscopists to improve the detection rate of colorectal adenomas and cancers during…
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma, Colorectal Cancer
- Trial name
- AI-COLOADR (NCT07307547)
- Testing
- AI-Assisted Colonoscopy
- Where
- China
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colorectal Cancer
A Study of Avastin (Bevacizumab) in Combination With mFOLFOX6 in Treatment-Naïve Patients With Metastatic Colorectal Cancer With or Without K-RAS Mutations, and Comparison to Cetuximab
This randomized, open-label study will evaluate the safety and efficacy of Avastin (Bevacizumab) added to standard mFOLFOX6 chemotherapy in treatment-naïve patients with Stage IV metastatic colorectal cancer.
- Trial name
- NCT01338558
- Testing
- bevacizumab [Avastin], cetuximab, mFOLFOX6
- Sponsor
- Hoffmann-La Roche
Solid Tumors, Colorectal Cancer
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
The main purpose of this 3-part study is to evaluate the safety and efficacy of the study drug known as LY2880070 in participants with advanced or metastatic solid tumors.
- Conditions
- Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT02632448
- Testing
- LY2880070, Gemcitabine
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 229 people
- Sponsor
- Esperas Pharma Inc.
Liver Metastases, Colorectal Cancer
PrOspEctive Metastases Imaging (POEM)
This is a non-interventional, observational study with an optional interventional biobanking activity. Liver metastases of patients undergoing partial hepatectomy will be sampled completely while respecting the orientation used…
- Conditions
- Liver Metastases, Colorectal Cancer, Breast Cancer
- Trial name
- POEM (NCT07781306)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cancer Research Antwerp
Colorectal Cancer, Solid Tumors
Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors
This study will evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of revumenib in participants with colorectal cancer (CRC) or other solid tumors who have failed at least 1 prior line of therapy.
- Trial name
- NCT05731947
- Testing
- Revumenib, Chemotherapy
- Where
- 6 sites in United States
- Volunteers
- 41 people
- Sponsor
- Syndax Pharmaceuticals
Colorectal Cancer
Family Colorectal Cancer Awareness and Risk Education Project (Family CARE Project)
The Family Colorectal Cancer Awareness and Risk Education Project (Family CARE Project) is designed to determine whether a personalized telephone plus mailed print cancer risk assessment and behavior change counseling…
- Trial name
- Family CARE (NCT01274143)
- Testing
- TeleCARE, Pamphlet intervention
- Where
- 8 sites in United States
- Volunteers
- 496 people
- Sponsor
- University of Utah
Rectal Cancer
Sigmoid Take-off, New Rectum Definition
The diversity of definitions for the rectosigmoid junction is becoming a major obstacle to the standardization of optimal treatment of rectal cancers.
- Trial name
- NCT04293835
- Testing
- Whether to have intestinal-related disease
- Where
- China
- Volunteers
- 835 people
- Sponsor
- Peking University Third Hospital
Rectal Cancer, Radiotherapy
Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer
This is a open-label, single-arm study to investigate the safety and efficacy of Total neoadjuvant chemotherapy with camrelizumab, an anti-PD-1 antibody drug following short course radiotherapy in patients with rectal cancer.
- Conditions
- Rectal Cancer, Radiotherapy, Immunotherapy, Organ Preservation
- Trial name
- NCT04558684
- Testing
- Chemotherapy, Immunotherapy, IMRT
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Rectal Cancer
Oncological and Functional Result of AbdominoPerineal Extra Levator Resection for Distal Rectal Cancer
The aim of the project is to evaluate the oncological and functional outcome of the more extensive perineal dissection - i.e the extra levator resection - in abdominoperineal resections in patients with rectal cancer.
- Trial name
- APER (NCT01296984)
- Where
- Sweden
- Volunteers
- 1,319 people
- Sponsor
- Sahlgrenska University Hospital
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