Clinical trials: Colorectal Tumor
Solid Tumor, Lung Cancer
Safety and Efficacy of CEA-Targeted CAR-T Therapy for Relapsed/Refractory CEA+ Cancer
This is a single arm study to evaluate the efficacy and safety of CEA-targeted CAR-T cells therapy for patients with relapsed/refractory CEA+ Cancer,and obtain the recommended dose and infusion plan.
- Conditions
- Solid Tumor, Lung Cancer, Colorectal Cancer, Liver Cancer
- Trial name
- NCT04348643
- Testing
- CEA CAR-T cells
- Where
- 2 sites in China
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Colorectal Carcinoma
Irinotecan Hydrochloride Liposome Injection (Ⅱ) Combined with Fluorouracil, Folinic Acid, Vermofenib and Cetuximab in First-line Treatment of BRAFV600E Mutated Advanced Colorectal Cancer
Based on the upstream signaling features of BRAFV600E and the bypass feedback mechanisms, considering the pro-apoptotic effects of chemotherapy and the synergistic effects of targeted therapy, previous IMPROVEMENT trial…
- Trial name
- NCT06603376
- Testing
- FOLFIRI + Vemurafenib + Cetuximab, FOLFIRI ± Bevacizumab
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Shanghai Changzheng Hospital
Metastatic Colorectal Cancer
Sym004 in Metastatic Colorectal Cancer and ECD-EGFR Patients
This is a single arm, phase 2, open-label, multicenter trial in patients with metastatic colorectal cancer (mCRC) and acquired resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) and documented…
- Trial name
- NCT02965417
- Testing
- Sym004
- Sponsor
- Symphogen A/S
Rectum Cancer
A Lymph Node Metastasis Predictor (LN-MASTER) in Rectal Cancer
In this study, we aim to develop and validate an easy-to-use machine learning prediction model to preoperatively identify the lymph node metastasis status for rectal cancer patients by using these clinical data from three…
- Trial name
- NCT05493930
- Testing
- The hospital where the treatment is performed
- Volunteers
- 6,578 people
- Sponsor
- Peking Union Medical College
Cervical Cancer, Breast Cancer
Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
A Phase 1 Open-Label, First-in-human, Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, Pharmacokinetics, and Preliminary Efficacy of 212Pb-DOTAM-GRPR1 in Adult Participants with Recurrent or…
- Conditions
- Cervical Cancer, Breast Cancer, Colon Cancer, NSCLC
- Trial name
- NCT05283330
- Testing
- ²¹²Pb-DOTAM-GRPR1
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Orano Med Theranostics, SAS
Anastomotic Leak Rectum
Routine Endoscopic Evaluation of Colorectal Anastomoses for Early Detection of Anastomotic Leakage
The objective of this international prospective observational study is to evaluate the implementation of a point-of-care digital rectoscope (LumenEye) into routine care to detect colorectal anastomotic leakage in the early…
- Trial name
- REAL (NCT06493565)
- Testing
- Routine endoscopic anastomosis inspection
- Where
- 5 sites in France, Italy and 3 more
- Volunteers
- 150 people
- Sponsor
- Amsterdam UMC, location VUmc
Metastatic Colorectal Cancer
Escalated Dose of Irinotecan in mCRC
Metastatic diseases were found in 20-25% of patients with initial diagnosis of colorectal cancer and developed in up to 50% of patients.
- Trial name
- NCT02256800
- Testing
- UGT1A1 genotyping (6,6), UGTIA1 genotyping (6,7), UGTIA1 genotyping (7,7)
- Where
- Taiwan
- Volunteers
- 213 people
- Sponsor
- Jaw-Yuan Wang, MD, PhD
Colonic Polyps, Colonic Neoplasms
Endo-cuff Assisted Vs. Standard Colonoscopy for Polyp Detection in Bowel Cancer Screening
The study evaluates whether the use of a novel endoscopic cap (the endo-cuff) at the tip of a colonoscope improves the numbers of polyps detected during bowel cancer screening colonoscopy.
- Trial name
- E-CAP (NCT02529007)
- Testing
- Endo-cuff, Standard colonoscopy
- Where
- United Kingdom
- Volunteers
- 534 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Colorectal Cancer
A Study of Avastin (Bevacizumab) and Oxaliplatin Plus Xeloda (Capecitabine) in Patients With Advanced Colorectal Cancer.
This study will assess the efficacy and safety of treatment with the combination Avastin (bevacizumab) 5mg/kg iv every 2 weeks, Xeloda (capecitabine) 1000 mg po b.i.d.
- Trial name
- NCT01159171
- Testing
- bevacizumab [Avastin], capecitabine [Xeloda], oxaliplatin
- Where
- 6 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Colorectal Neoplasms, Neoplasm Metastasis
Resection Versus Microwave Ablation for Resectable Colorectal Cancer Liver Metastases
This single-center, prospective, randomized clinical trial is designed to compare the clinical characteristics and outcomes of hepatic resection and microwave ablation (MWA) to determine the optimal operative intervention for the…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Hepatic Neoplasms
- Trial name
- NCT02866344
- Testing
- Microwave ablation, Hepatic resection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Familial Adenomatous Polyposis
Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)
The purpose of this randomized, double-blind, Phase III trial is to determine if the combination of eflornithine plus sulindac is superior to sulindac or eflornithine as single agents in delaying time to the first occurrence of…
- Trial name
- NCT01483144
- Testing
- Eflornithine, Sulindac 150 MG
- Where
- 17 sites in United States, Belgium and 5 more
- Volunteers
- 171 people
- Sponsor
- Cancer Prevention Pharmaceuticals, Inc.
Colorectal Cancer
Systemic Neoadjuvant and Adjuvant Control by Precision Medicine in Rectal Cancer
Rectal cancer represents the most complex area of multidisciplinary treatment in bowel surgery. In 2017, there were 1221 new rectal cancers in Finland.
- Trial name
- SYNCOPE (NCT04842006)
- Testing
- Total neoadjuvant therapy (TNT), Minimal residual disease (MRD), Long radiation therapy
- Where
- 2 sites in Finland
- Volunteers
- 93 people
- Sponsor
- Helsinki University Central Hospital
Colorectal Cancer
FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of the Colon or Rectum
This is a randomized phase II study trial that has served as a screening trial to test the increased efficacy of chemotherapy + cetuximab versus chemotherapy alone among patients with untreated, advanced or metastatic colon…
- Trial name
- NCT00077233
- Testing
- cetuximab, 5-FU, irinotecan
- Where
- 77 sites in United States
- Volunteers
- 238 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Cancer
Incidence of Colorectal Cancer in Southwest China: Based on SCC Database
To evaluate recent trends in CRC incidence, treatment, and survival in the Southwest China.
- Trial name
- NCT06172049
- Testing
- treatment
- Where
- China
- Volunteers
- 5,838 people
- Sponsor
- West China Hospital
Colorectal Cancer, Colorectal Carcinoma
Microsatellite Instability in Colorectal Cancers
In this study, we aimed to identify the different histopathological features of tumors with microsatellite instability (MSI) compared to microsatellite stable (MSS) in patients who underwent surgery for colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Carcinoma, Microsatellite Instability High, Microsatellite Instability Low
- Trial name
- MSI-CRC (NCT05162248)
- Testing
- Microsatellite instability analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 231 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Colorectal Cancer
Protein Recommendation to Increase Muscle
This is a feasibility study to test the potential efficacy of diets of different amounts of protein and calories for patients with cancer.
- Trial name
- PRIMe (NCT02788955)
- Testing
- Dietary counselling, Dietary Protein
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Colorectal Adenomas
Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial
The trial was aimed at evaluating the efficacy of a multiagent antioxidant compound (vitamin A, C, E, selenium and zinc) in reducing the incidence of metachronous adenomas of the large bowel after endoscopic polypectomy.
- Trial name
- NCT01437826
- Testing
- antioxidants
- Where
- Italy
- Volunteers
- 411 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Colorectal Cancer Metastatic
Evaluation of CTCs Combined With Tumor Marker Detection of Efficacy of Chemotherapy in mCRC
Evaluation of individual peripheral blood circulating tumor cells combined with tumor marker detection of efficacy of chemotherapy in patients with advanced colorectal cancer: A observational clinical trial
- Trial name
- NCT02948985
- Testing
- treated with FOLFIRI±cetuximab
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cancer, Digestive System, Cancer, Rectum
PREHAB - Improving Condition Before Surgery
The pilot research project is focused on the feasibility of a prehabilitation program for two groups of diagnoses (esophageal and stomach cancer, rectal cancer).
- Trial name
- NCT05646043
- Testing
- Physical training, Muscle strength training
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Breast Cancer, Colon Cancer
Partnership for Healthy Seniors
The Centers for Medicare and Medicaid Services (CMS) has awarded cooperative agreements to 6 sites from across the country (Salt Lake City, UT, Molokai, HI, Houston, TX, Newark, NJ, Detroit, MI, and Baltimore City) to participate…
- Conditions
- Breast Cancer, Colon Cancer, Rectum Cancer, Cervix Cancer
- Trial name
- NCT00379743
- Testing
- Health coordinator (or patient navigator), Educational materials only
- Where
- United States
- Volunteers
- 2,593 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.