Clinical trials: Colorectal Tumor
Rectal Cancer, Retention, Urinary
Incidence of Acute Urine Retention: Randomized Clinical Trial Comparing Early, Mid or Late Urinary Catheter Removal in Patients With Rectal Resection
DESIGN: Randomized, open-label and parallel clinical trial, assigned to early, mid, or late withdrawal of urinary catheter with a 1: 1: 1 allocation ratio.
- Conditions
- Rectal Cancer, Retention, Urinary, Urinary Tract Infections, Surgical Site Infection
- Trial name
- RAOREC (NCT04751149)
- Testing
- Removal of Urinary Catheter
- Where
- Spain
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Hospital Donostia
Advanced Solid Tumors, Metastatic Solid Tumors
Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of RAS(ON) inhibitors in combination with ivonescimab in adults with advanced or metastatic solid tumors…
- Conditions
- Advanced Solid Tumors, Metastatic Solid Tumors, Non-small Cell Lung Cancer (NSCLC), NSCLC
- Trial name
- NCT07397338
- Testing
- Daraxonrasib, Elironrasib, Zoldonrasib
- Where
- 19 sites in United States
- Volunteers
- 370 people
- Sponsor
- Revolution Medicines, Inc.
Colorectal Cancer, ADCC
Study of Folfiri/Cetuximab in FcGammaRIIIa V/V Stage IV Colorectal Cancer Patients
Patients' selection thorough the identification of predictive factors still represent a challenge in metastatic colorectal cancer (mCRC).
- Trial name
- CIFRA (NCT03874026)
- Testing
- Folfiri/Cetuximab
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- National Cancer Institute, Naples
Rectal Cancer
Hypofractionated Palliative Radiotherapy in Patients With Advanced Non-operable Rectal Cancer
Many patients with rectal cancer were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases.
- Trial name
- NCT03853733
- Testing
- rectal cancer radiotherapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Colorectal (Colon or Rectal) Cancer
An Observational Cohort Study to Assess the Postop Activity of Colorectal Patients Undergoing Elective Surgery (PHYSPAL)
All participants will have a physical activity monitor placed onto the right thigh in the midline which will start collecting data at midnight on the first postoperative day.
- Trial name
- PHYSPAL (NCT05934643)
- Testing
- ActivPAL accelerometer, Hospital Anxiety and Depression Scale (HADS) Questionnaire
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Nottingham
Cancer, Breast Cancer
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
Add-Aspirin aims to assess whether regular aspirin use after standard curative therapy can prevent recurrence and improve survival in individuals with non-metastatic common tumours.
- Conditions
- Cancer, Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT02804815
- Testing
- Aspirin 100mg, Aspirin 300mg
- Where
- 82 sites in Ireland, United Kingdom
- Volunteers
- 11,000 people
- Sponsor
- University College, London
Neoplasms, Colorectal, Colorectal Cancer
Oxaliplatin Pharmacokinetics With and Without Ca2+/MG2+ Infusion in Colorectal Cancer Patients
The investigators hypothesize that Ca2+/MG2+ infusions will not have a significant effect on oxaliplatin pharmacokinetics.
- Conditions
- Neoplasms, Colorectal, Colorectal Cancer, Colorectal Carcinoma
- Trial name
- NCT01157052
- Testing
- (supplement) Calcium and Magnesium
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- AHS Cancer Control Alberta
Colorectal Cancer, Colorectal Adenocarcinoma
Stage II/III Colorectal Cancer Recurrence
This study will develop an assay to predict disease recurrence in patients with stage II/III CRC after receiving adjuvant chemotherapy, using genome-wide DNA methylation.
- Conditions
- Colorectal Cancer, Colorectal Adenocarcinoma, Colorectal Cancer Stage II, Colorectal Cancer Stage III
- Trial name
- CENSURE (NCT06314958)
- Testing
- CENSURE
- Where
- 4 sites in United States, China and 1 more
- Volunteers
- 400 people
- Sponsor
- City of Hope Medical Center
Colorectal Cancer
Safety & Effectiveness of Nurse Performed Colonoscopies Under Supervision
There is no theoretical or practical reason why non-medical personnel such as nurses could not be trained to perform diagnostic colonoscopy with comparable proficiency as medical endoscopists.
- Trial name
- NCT01923155
- Testing
- Colonoscopy
- Where
- Hong Kong
- Volunteers
- 731 people
- Sponsor
- Chinese University of Hong Kong
Advanced Solid Tumors, NSCLC
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Based on the overwhelming positive response to this survey and the large number of patients being treated with PD-1/PD-L1 therapy in the UPMC system, the investigators are proposing a trial that will randomize patients who have…
- Conditions
- Advanced Solid Tumors, NSCLC, Bladder Cancer, HNSCC
- Trial name
- NCT04157985
- Testing
- Continue PD-1/PD-L1 Inhibitors treatment, Discontinue PD-1/PD-L1-1 inhibitor
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Dan Zandberg
Colonoscopy, Colon Neoplasm
A Prospective Single-Blinded Randomized Trial Comparing Colonoscopic Preparation at Different Time
Colorectal cancer (CRC) is the leading cause of cancer death not only in the Western countries but also in Taiwan. Colonoscopy is now gradually accepted as one of the powerful tool for colorectal cancer screening.
- Trial name
- NCT00155415
- Testing
- Different timing of taking polyethylene glycol(PEG)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Colorectal Neoplasms
A Study of a Patient-Specific Neoantigen Vaccine in Combination With Immune Checkpoint Blockade for Patients With Metastatic Colorectal Cancer
The primary objective of the Phase 2 portion of the study is to characterize the clinical activity of maintenance therapy with GRT-C901/GRT-R902 (patient-specific vaccines) in combination with checkpoint inhibitors in addition to…
- Trial name
- NCT05141721
- Testing
- GRT-C901, GRT-R902, Atezolizumab
- Where
- 43 sites in United States
- Volunteers
- 700 people
- Sponsor
- Seattle Project Corporation
Rectal Cancer, Colon Cancer
Molecular Genetic and Pathological Studies of Anal Tumors
Study the Genetics of Anal Cancer
- Conditions
- Rectal Cancer, Colon Cancer, Colonic Neoplasms, Anal Cancer
- Trial name
- NCT00267787
- Testing
- genetic analysis
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stanford University
Colorectal Cancer, Neoplasm Metastasis
Study of Bevacizumab, Erlotinib, FOLFOX for Patients With Untreated Metastatic Colorectal Cancer
Despite recent advances, most patients with advanced colorectal cancer continue to have a poor prognosis. 5-FU, leucovorin, oxaliplatin and bevacizumab is a standard treatment option for patients with stage IV colorectal cancer.
- Trial name
- NCT00116506
- Testing
- erlotinib, FOLFOX, bevacizumab
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Dana-Farber Cancer Institute
Rectal Cancer
Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer
The concurrent neoadjuvant chemoradiation therapy is standard care for local advanced rectal cancer (LARC), however, this regimen may induce sorts of adverse events, and part of them even more severer.
- Trial name
- NCT02942563
- Testing
- FOLFOXIRI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Colorectal Cancer, Pancreatic Cancer
Radiolabeled Monoclonal Antibody Therapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Metastatic or Recurrent Colorectal Cancer or Pancreatic Cancer
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00004087
- Testing
- filgrastim, autologous bone marrow transplantation, peripheral blood stem cell transplantation
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Garden State Cancer Center at the Center for Molecular Medicine and Immunology
Gastric Cancer, Colorectal Cancer
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
This is a Phase 2 study to evaluate the efficacy of a non-myeloablative lymphodepleting preparative regimen followed by infusion of autologous TIL and high-dose aldesleukin in patients with locally advanced, recurrent, or…
- Conditions
- Gastric Cancer, Colorectal Cancer, Pancreatic Cancer, Sarcoma
- Trial name
- NCT03935893
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Fludarabine + Cyclophosphamide combination
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Udai Kammula
Colorectal Cancer
Multivisceral Radical Resection for Surgical T4b Colorectal Cancer: Propensity Score-matched Study Comparing the the Laparoscopic and Open Approaches
This study attempts to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical T4b Colorectal cancer.
- Trial name
- C-PelvEx-01 (NCT05707598)
- Testing
- Laparoscopic surgery
- Where
- China
- Volunteers
- 638 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Neoplasms
Serum Proteomic Profiling for the Early Diagnosis of Colorectal Cancer
No ideal serum biomarker currently exists for the early diagnosis of colorectal cancer (CRC). Therefore, it is urgent that accurate and reliable serum biomarkers be identified.
- Trial name
- NCT01604798
- Testing
- Serum proteomics
- Where
- China
- Volunteers
- 547 people, healthy volunteers welcome
- Sponsor
- Fudan University
Pain, Pain Management
The Effect of Music During Colonoscopy
Colonoscopy is an important examination used to diagnose conditions such as inflammatory bowel disease and colorectal cancer and plays a central role in colorectal cancer screening programs.
- Trial name
- NCT07454993
- Testing
- Music intervention
- Where
- Denmark
- Volunteers
- 1,042 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
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