Clinical trials: Colorectal Tumor
Lynch Syndrome
High Definition White-Light Colonoscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome.
Adenomas in Lynch syndrome have an accelerated progression to colorectal cancer (CRC) which might occur despite a regular follow-up.
- Trial name
- EndoLynch (NCT02951390)
- Testing
- High-definition white-light endoscopy
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Clinic of Barcelona
Colorectal Cancer
The Role of Lipid Transporter MFSD2A in the Resolution of Colorectal Cancer-associated Inflammation
The intrinsic connection between inflammation and tumor promotion is well characterized and is a key pathogenic event in patients with colorectal cancer (CRC), the second most common cause of tumor-related death in western…
- Trial name
- NCT06071598
- Testing
- Surgical specimens of CRC-affected patients
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS San Raffaele
Colo-rectal Cancer, Anesthesia
Does IV Magnesium Improve Quality of Recovery With ERAS Protocols in Laparoscopic Colorectal Surgery?
This study is a randomized, double blind controlled trial examining the impact of incorporating a single intraoperative intravenous magnesium bolus and infusion into a preexisting Enhanced Recovery After Surgery (ERAS) protocol…
- Trial name
- NCT05021263
- Testing
- IV Medications
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Postoperative Complications, Psychosomatic Disorder
Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)
Our study aims to lay the basis for a predictive modeling service for postoperative complications and prolonged hospital stay in patients suffering from psychiatric diseases undergoing colorectal surgery.
- Conditions
- Postoperative Complications, Psychosomatic Disorder, Psychiatric Disorder, Cancer
- Trial name
- NCT05257863
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Dr. Med Anas Taha
Colon Cancer
Assessment of Adherence and Efficiency of a Home-based Training Program on Muscular Strength, Endurance and Qol for Colon Cancer Patients
The purpose is to assess the adherence and the efficiency of a home-based training program on muscular strength, endurance and the quality of life, fatigue, physical activity, anxiety and depression for colon cancer patient…
- Trial name
- NCT02512263
- Testing
- Home-based training program
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer
Domestic Surgical Robot Clinical Study
Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013.
- Conditions
- Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer, Cholecystolithiasis, Appendicitis
- Trial name
- NCT02752698
- Testing
- Micro Hand S robotic surgery, laparoscopic surgery, da Vinci robotic surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Advanced/Metastatic Colorectal Cancer
Combination of LTC004 and Regorafenib to Treat Patients With Advanced/Metastatic CRC
This is a phase II clinical study to evaluate the safety, tolerability and preliminary antitumor activity of LTC004 in combination with regorafenib in patients with mCRC.
- Trial name
- NCT06322563
- Testing
- LTC004+regorafenib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Familial Adenomatous Polyposis
Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance
Patients with Familial Adenomatous Polyposis (FAP) who are undergoing endoscopic surveillance will be given Encapsulated Rapamycin (eRapa) at one of three escalating doses/schedules for 12 months with the aim of reducing polyp…
- Trial name
- NCT04230499
- Testing
- Encapsulated Rapamycin (eRapa)
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rapamycin Holdings Inc.
Colorectal Neoplasms, Metastases, Neoplasm
Study of Erbitux (Cetuximab) in Patients With Metastatic Colorectal Carcinoma
This is a phase II, multicenter, target enrollment of 250 evaluable patients, open-label study of cetuximab in patients with refractory, metastatic colorectal carcinoma.
- Trial name
- NCT00044863
- Testing
- Erbitux (Cetuximab)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Eli Lilly and Company
Colorectal Cancer
Study of Oxaliplatin, Capecitabine and Bevacizumab as First Line Treatment for Patients With Advanced Colorectal Cancer
This study is for people with colorectal cancer, who have tumors that cannot be completely removed by surgery. This study is being done to find out how long it takes tumors to grow after patients receive the drugs capecitabine…
- Trial name
- NCT00159432
- Testing
- Oxaliplatin, Bevacizumab, Capecitabine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Southern California
Rectal Neoplasms, Drug Therapy
Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer
To evaluate the efficacy and safety of totally neoadjuvant FOLFOXIRI chemotherapy (irinotecan, oxaliplatin and fluorouracil) followed by short-course radiation therapy and XELOX chemotherapy in the patients with locally advanced…
- Conditions
- Rectal Neoplasms, Drug Therapy, Radiation
- Trial name
- NCT03484221
- Testing
- FOLFOXIRI, Short-Course Radiation Therapy(5Gy*5), XELOX
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China Medical University, China
Colorectal Cancer, Non-Small Cell Lung Cancer
A Study of Avastin in Combination With Chemotherapy for Treatment of Colorectal Cancer and Non-Small Cell Lung Cancer (ARIES)
This is an observational study designed to follow patients with metastatic or locally advanced and unresectable CRC or locally advanced or metastatic NSCLC (excluding predominant squamous histology) who are receiving Avastin in…
- Trial name
- ARIES (NCT00388206)
- Volunteers
- 3,998 people
- Sponsor
- Genentech, Inc.
Colorectal Cancer
Microbiome, Exercise Tracking Study: Among Individuals at High Risk for Colorectal Cancer
The purpose of this study has 2 aims: Aim 1: To demonstrate the feasibility of recruiting and retaining adults at high risk of colorectal cancer to a physical activity intervention trial.
- Trial name
- METS (NCT02780284)
- Testing
- Physical activity intervention
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Columbia University
Rectal Cancers.
Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer
The hypothesis of this study is that dose escalated intensity modulated radiotherapy (IMRT) to a dose of 55Gy in 25# to primary rectal tumor concurrent with oral capecitabine results in an improved pathological response rate from…
- Trial name
- NCT01340508
- Testing
- Intensity Modulated Radiotherapy
- Where
- Singapore
- Volunteers
- 63 people
- Sponsor
- National University Hospital, Singapore
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Colorectal Cancer
Head to Head Study Epi proColon and FIT
The study aims to show non-inferiority in the clinical performance of the investigational assay, Epi proColon, to FIT using matched blood and stool specimens from screening-guideline eligible subjects.
- Trial name
- NCT01580540
- Where
- 70 sites in United States, Puerto Rico
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Colorectal Cancer
Evaluation of NiTi Shape Memory End-to-End Compression Anastomosis Ring (CAR) for Compression Anastomosis in Anterior Resection
The purpose of this study is to evaluate the safety and effectiveness of the NiTi CAR device in the creation of colorectal anastomosis
- Trial name
- NCT00468416
- Testing
- Compression Anastomosis Ring (CAR)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colon Cancer
Novel Biophotonics Methodology for Colon Cancer Screening
The study is testing a new, safe and effective way for the early detection of colon cancer. The method uses Low-coherence Enhanced Backscattering Spectroscopy (LEBS).
- Trial name
- BRP (NCT01999478)
- Where
- 5 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Colorectal Cancer, Peritoneal Carcinomatosis
Near-Infrared Imaging of Peritoneal Carcinomatosis From Colorectal Cancer
The purpose of this study is to determine if Near-Infrared fluorescence imaging is an effective approach to detect the colorectal tumoral tissues and peritoneal implants in colorectal cancer patients.
- Trial name
- OC-AP-ICG-IV (NCT02032485)
- Testing
- Indocyanine Green
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Jules Bordet Institute
Colorectal Cancer
Survivorship in Lynch Syndrome Families
Objectives: Specific Aims: 1. Researchers will evaluate and compare predictors of health-related quality of life (QOL) among colorectal cancer (CRC) survivors who have Lynch syndrome (LS) with those patients who have sporadic CRC…
- Trial name
- NCT01126840
- Testing
- Telephone Interview, Questionnaire
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
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