Clinical trials: Comatose
Coma, Heart Arrest
Predictive Outcome in Comatose Patients
Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers…
- Conditions
- Coma, Heart Arrest, Cardiopulmonary Resuscitation
- Trial name
- PRECOM (NCT05321459)
- Testing
- Neurological prognosis
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest, Postresuscitation Encephalopathy
Prehospital Non-invasive Cooling of Comatose Patients After Cardiac Arrest
Single centre randomized controlled two arm clinical trial of patients after out of hospital cardiac arrest with return of spontaneous circulation.
- Trial name
- NCT03829215
- Testing
- CAERVest cooling device
- Where
- Austria
- Sponsor
- Medical University of Vienna
Organ Transplant Failure or Rejection, Brain Death
Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)
The investigators hypothesize that preconditioning neurologically deceased organ donors with the calcineurin inhibitor tacrolimus will improve short and long-term transplant survival without causing harm.
- Conditions
- Organ Transplant Failure or Rejection, Brain Death, Ischemic Reperfusion Injury
- Trial name
- CINERGY (NCT05148715)
- Testing
- Tacrolimus
- Where
- 9 sites in Canada
- Volunteers
- 414 people
- Sponsor
- Université de Sherbrooke
Cardiac Arrest With Successful Resuscitation
A Novel Patient Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest
This study will test the feasibility and acceptability of deploying a decision aid for surrogate decision makers of comatose survivors of cardiac arrest early during hospitalization.
- Trial name
- NCT03908346
- Testing
- Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Minimally Conscious State, Vegetative State
Reliability and Validity of the NCS (NCS-R)-Chinese Version
The aim of this study was to translate the NCS from English into Chinese and determine the validity of this Chinese version.
- Trial name
- NCT03494218
- Testing
- Nociception Coma Scale (NCS)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Hangzhou Normal University
Infant, Extremely Premature, Brain Injuries
Safeguarding the Brain of Our Smallest Infants Phase III
the SafeBoosC-III trial investigates the benefit and harms of treatment based on near-infrared spectroscopy monitoring compared with treatment as usual.
- Conditions
- Infant, Extremely Premature, Brain Injuries, Death, Brain, Death; Neonatal
- Trial name
- SafeBoosC (NCT03770741)
- Testing
- Modify cardio-respiratory support to avoid cerebral hypoxia, Treatment as usual
- Where
- Denmark
- Volunteers
- 1,601 people
- Sponsor
- Gorm Greisen
Acute Brain Injury Coma, Neurocritical Care
Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help…
- Conditions
- Acute Brain Injury Coma, Neurocritical Care, Cerebral Infarction, Intracranial Hemorrhages
- Trial name
- NCT07115459
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Cardiac Arrest, Post-Anoxic Coma
QUality Of Life and surviVAl in carDIac arreSt Patients
QUO VADIS is a national observational study with the aim to describe clinical intervention and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest
- Conditions
- Cardiac Arrest, Post-Anoxic Coma, Central Nervous System Diseases
- Trial name
- QUOVADIS (NCT04129073)
- Testing
- Intensive care treatment
- Volunteers
- 1,600 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Unallocated Pancreas Organs
Expanding Pancreas Donor Pool by Evaluation of Unallocated Organs After Brain Death - The EXPLORE Study
Pancreas graft quality directly affects morbidity and mortality rates after pancreas transplantation (PTx). The criteria for pancreas graft allocation are restricted, which has decreased the number of available organs.
- Trial name
- NCT04127266
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. A. Mehrabi
Tissue and Organ Harvesting, Liver Transplantation
Evaluation of Liver Grafts With FibroScan® Before Organ Retrieval in Patients With Brain Death
According to the French Biomedicine Agency annual report on retrieval activities and transplants, 1,164 liver transplants were performed in 2011 and 1,161 in 2012.
- Conditions
- Tissue and Organ Harvesting, Liver Transplantation, Brain Death
- Trial name
- FIBROSCAME (NCT02460250)
- Testing
- Fibroscan
- Where
- 19 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Limoges
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Brain Death
ORI and ETCO₂ Relationship With Arterial Blood Gas During Apnea Test
This observational study aims to evaluate the relationship between the Oxygen Reserve Index (ORI) and End-Tidal Carbon Dioxide (ETCO2) values with arterial blood gas parameters in patients undergoing the apnea test for the…
- Trial name
- NCT06983990
- Testing
- No intervention (observational monitoring only)
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Coma
Optic Nerve Sheath Diameter as a Screening Test for Increased Intracranial Pressure
Patients admitted to the ICU may have delayed awakening after their critical illness has resolved. Though most either are due to metabolic causes or delayed elimination of sedative medications, more serious pathologies such as…
- Trial name
- NCT02338284
- Testing
- ultrasound of globe
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Sputum
Rapid and Safe Sputum Suction Method Validation
600 comatose patients admitted to the hospital in China from June 2024 to June 2028 were randomly divided into groups A and B. Group A used intermittent negative pressure suction through oral and pharyngeal ventilation, while…
- Trial name
- NCT06508008
- Testing
- continuous negative pressure suction, Intermittent negative pressure sputum suction through oral pharyngeal airway
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Affiliated Hospital of Nantong University
Cerebral Hypoxic Injury, Cardiac Arrest
Monitoring of Cerebral Oxygenation Using Jugular Oximetry in Comatose Patients After Cardiac Arrest
The use of protective ventilation (to maintain normoxia and normocapnia), optimise haemodynamics, diagnose/treat seizures, therapeutic hypotermia etc is recommended for ICU management of patients who have had cardiac arrest and…
- Trial name
- NCT02806778
- Testing
- BIS Monitor-guided sedation, Jugular bulb catheter
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Coma, Critical Illness
Effectiveness of Familiar Voices and Nature Sounds Among Critically Ill Comatose Patients
The goal of this clinical trial is to compare the effectiveness of auditory stimulation using familiar voices (FV) versus nature sounds (NS) on awakening critically ill comatose persons in the intensive care unit (ICU), reduce…
- Conditions
- Coma, Critical Illness, Unconsciousness
- Trial name
- NCT06470802
- Testing
- Familiar voice, Nature sounds, Control
- Where
- 2 sites in Vietnam
- Volunteers
- 90 people
- Sponsor
- Vo Thi Hong Nhan
Coma, Cardiac Arrest
Cognitive Auditory Evoked Potential After Cardiac Arrest: Interest of Mismatch negativiTY
Determination of vital and functional outcome in comatose survivors after cardiac arrest is principally based on the identification of predictors of non-awakening, using by clinical, biological and electrophysiological tools.
- Trial name
- CAPACITY (NCT01980446)
- Testing
- Auditory-evoked potentials
- Where
- 2 sites in France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation
Pupillometry and Somatosensory Evoked Potential in Cardiac Arrest
Somatosensory Evoked Potentials (SSEP) and Pupillary Light Reflex (PLR) are key methods for neurologic prognostication in comatose survivors of cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation, Resuscitation
- Trial name
- PASCA (NCT04720482)
- Testing
- Somatosensory Evoked Potentials, Automated Pupillometry
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Coma, Heart Arrest
Amantadine to Speed Awakening After Cardiac Arrest
This study evaluates if amantadine will increase the rate of awakening in patients resuscitated from cardiac arrest but comatose (not following commands) after their resuscitation.
- Conditions
- Coma, Heart Arrest, Anoxia
- Trial name
- AWAKE (NCT02486211)
- Testing
- Amantadine
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Jon Rittenberger, MD
Consciousness Disorders, Brain Injuries
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired…
- Conditions
- Consciousness Disorders, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- NCT03367078
- Testing
- Anodal tDCS, Usual care
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.