Clinical trials: Combined Spinal Epidural Anesthesia
Regional Anaesthesia, Cesarean Section
Dose-response Study of Spinally Administered Ropivacaine for Caesarean Section in Tall Parturients
The main goal is to determine the optimum dose of ropivacaine, a local anaesthetic, that provides regional anaesthesia with no or minimum adverse effects (i.e.
- Trial name
- NCT03936790
- Testing
- Ropivacaine, Fentanyl
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paraskevi Matsota
Pain, Breast Diseases
Thoracic Combined Spinal Epidural Anesthesia for Breast Surgery
The aim of the study is to investigate the efficacy of the thoracic combined spinal epidural anesthesia in breast surgery.
- Trial name
- NCT04706247
- Testing
- thoracic combined spinal epidural anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Antalya Training and Research Hospital
Effects of; Anesthesia, in Labor and Delivery, Pregnancy
Effects of Analgesic Techniques on Duration of Spontaneously Laboring Patients
The purpose of this study is to determine if there is a difference in the duration of the first stage of labor in nulliparous women in spontaneous labor with whom analgesia is maintained with a combined spinal epidural (CSE)…
- Conditions
- Effects of; Anesthesia, in Labor and Delivery, Pregnancy, Prolonged First Stage of Labor
- Trial name
- NCT01982838
- Testing
- Epidural de novo, CSE
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lower Limb Surgeries
Epidural Nalbuphine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Lower Limb Surgeries
Combined spinal epidural anesthesia (CSE) with bupivacaine alone is not sufficient to cover pain sequel during lower limb surgeries.
- Trial name
- NCT05041270
- Testing
- normal saline, Dexmedetomidine, Nalbuphine
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Zagazig University
Combined Spinal-epidural Anesthesia
The ED50 of DEX for Providing Sedation in Different Female Age Group
Dexmedetomidine(DEX) could provide dose-dependent sedation , analgesia , anti-anxiety and inhibition of sympathetic nerves and other effects.
- Trial name
- NCT02773017
- Testing
- Dexmedetomidine A, Dexmedetomidine B, Dexmedetomidine C
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Malondialdehyde, Heme Oxygenase
The Effects of Two Anesthetic Drugs on Some Enzyme Levels in Patients Undergoing Lower Extremity Surgery
The primary aim of this study was to compare the effects of dexmedetomidine and ketamine, which are administered intravenously during surgery, on the levels of malondialdehyde, an antioxidant, anti-inflammatory enzyme, heme…
- Conditions
- Malondialdehyde, Heme Oxygenase, C-Reactive Protein
- Trial name
- NCT05950555
- Testing
- Saline, Dexmedetomidine, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Labor Pain
Usefulness of the Tsui Test in Combined Spinal-Epidural Analgesia in Labour
Combined spinal epidural anesthesia (CSE) is a very effective technique to provide labor analgesia. One of the disadvantages of this technique is the delay in recognizing an error in the position of the epidural catheter because…
- Trial name
- NCT00464841
- Testing
- Combined spinal epidural, Tsui Test for intrathecal catheter
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Analgesia
The Effect of Combined Spinal Epidural Anaesthesia on QTc Interval Undergoing Cesarean Section
Cesarean section is the operation to deliver the fetus, placenta and membranes by making an abdominal incision in the uterus. Cesarean section is performed for reasons such as head-pelvis incompatibility, fetal malposition, fetal…
- Trial name
- NCT06018805
- Testing
- BMI≥30; Combined Spinal Epidural Anesthesia, BMI:18,5-24,9; Combined Spinal Epidural Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Elective Cesarean Section
Influence of Surgical Regional Anesthesia on Postoperative Pain
To compare three Types of anesthetic techniques (Spinal anesthesia, Combined spinal epidural anesthesia, Combined spinal epidural anesthesia with indwelling catheter for 24 hrs) on pain after elective cesarean section.
- Trial name
- CESAR (NCT01234662)
- Testing
- SPA, CSE, CSEPCEA
- Where
- Germany
- Volunteers
- 171 people
- Sponsor
- Charite University, Berlin, Germany
Labor Pain
Prophylactic Ephedrine and Combined Spinal Epidurals for Labor
The combined spinal epidural (CSE) technique has become increasingly popular for labor pain because of its rapid onset and superior first stage analgesia.
- Trial name
- CEASE (NCT02062801)
- Testing
- Ephedrine
- Where
- United States
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- Sharp HealthCare
Labor Pain
Changes in Velocimetric Indices of Uterine and Umbilical Arteries Before and After Combined Spinal-epidural Analgesia in Laboring Women
Combined spinal-epidural (CSE) for labor analgesia has been used for many years and is practiced commonly at our institution, especially when the patient requests immediate pain relief.
- Trial name
- NCT05512065
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Labor Epidural Analgesia, Perfusion Index
Perfusion Index Variability During Epidural Labor Analgesia
This prospective, single-centre observational study evaluates changes in the peripheral Perfusion Index (PI) - a non-invasive parameter derived from the pulse-oximetry photoplethysmographic waveform - in women receiving epidural…
- Conditions
- Labor Epidural Analgesia, Perfusion Index, Pain
- Trial name
- NCT07831967
- Testing
- Epidural (or opioid-only combined spinal-epidural) labor analgesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Gdansk
Postoperative Analgesia
Analgesic Effect of Ropivacaine Combined With Hydromorphone for CSEA After Total Knee Arthroplasty
The aim of this study is to investigate the continuous analgesic effect and side effects of ropivacaine combined with hydromorphone for combined spinal-epidural anesthesia(CSEA) after total knee arthroplasty and to explore its…
- Trial name
- NCT06205199
- Testing
- Hydromorphone was injected into the subarachnoid space
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Second Hospital of Jilin University
Labor Pain
Changes in Velocimetric Indices of Uterine and Umbilical Arteries Before and After Combined Spinal-epidural Analgesia in Laboring Women (PART II)
Combined spinal-epidural (CSE) for labor analgesia has been used for many years and is practiced commonly at our institution, especially when the patient requests immediate pain relief.
- Trial name
- NCT06655675
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Spinal Anesthesia
Application of Unilateral Epidural Anesthesia in Older Patients With Hip Fracture
Because of population ageing, fragility fractures have become a huge burden on healthcare systems and wider society. Fractures result in a sharp drop in both short-term and long-term quality of life, they have a strong influence…
- Trial name
- NCT06093412
- Testing
- unilateral epidural anesthesia, combined lumbar and epidural anesthesia
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Sichuan Provincial People's Hospital
Anesthesia
Epidural Technique: Does it Really Matter to the Patient?
The main objective of this study will be to determine if the dural puncture epidural (DPE) provides superior analgesia and better patient satisfaction when compared to traditional epidurals for cesarean sections, and to also…
- Trial name
- NCT03539796
- Testing
- Dural puncture epidurals (DPE), Traditional epidurals (EPI), Combined-spinal epidural technique (CSE)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy
Comparison of Three Different Sitting Positions for Performing Combined Spinal-Epidural Anesthesia
In this prospective and randomized study, we aimed to compare the effect of of three sitting positions (the traditional sitting position (TSP), the harmstring stretch position (HSP), and the squatting position on the success rate…
- Conditions
- Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy, Knee Arthropathy
- Trial name
- NCT03541798
- Testing
- positions of patients for combined spinal-epidural anesthesia, Combined spinal epidural anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Urinary Catheter
To Catheterize or Not? in Total Knee Arthroplasty With Combined Spinal-epidural Analgesia
The aim of this study was to investigate whether urinary catheterization could be avoided for all patients undergoing total knee arthroplasty under combined spinal-epidural analgesia plus multi-site infiltration analgesia.
- Trial name
- NCT02986061
- Testing
- Urinary catheter
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southwest Hospital, China
Ultrasound Therapy; Complications
Ultrasound-assisted Versus Real-time Ultrasound-guided Combined Spinal-epidural Anesthesia in Elderly Patients
This prospective randomized controlled trial aims to compare the clinical efficacy and safety of real-time ultrasound guidance (US-RTG) versus static ultrasound-assisted mapping (US-AS) for combined spinal-epidural anesthesia…
- Trial name
- NCT06241716
- Testing
- Ultrasound-assisted localization, US-AS, Real-time ultrasound guidance, US-RTG
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Tongji Hospital