Clinical trials: Common Bile Duct Diseases, open to volunteers
Bile Duct; Obstruction, With Calculus, Choledocholithiasis
Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage
Cholelithiasis occurs in 10-20% of the general population. Up to 18% of these subjects will present symptoms. In patients with symptomatic choledocholithiasis who are not candidates for surgery with indication for ERCP…
- Trial name
- PECAS (NCT03921502)
- Testing
- Gall bladder transmural drainage with LAMS
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital del Rio Hortega
Common Bile Duct Diseases
Diclofenac for Prevention of Post-ERC Pancreatitis
The study aims at assessing the effectiveness of Diclofenac for prevention of post-ERCP pancreatitis. It will be undertaken embedded in the Swedish national register for Gallstone surgery and ERCP (GallRiks).
- Trial name
- NCT03595150
- Testing
- Diclofenac
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
Irritable Bowel Syndrome, Gallstone Disease
Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
This study aims to evaluate pharmacokinetic profile, safety and establish bioequivalence of the investigational drug Trimedat® 76,95 mg orally disintegrating tablets compared to the reference drug Trimedat® 100 mg tablets in…
- Conditions
- Irritable Bowel Syndrome, Gallstone Disease, GERD, Biliary Dyskinesia
- Trial name
- NCT07421011
- Testing
- Trimedat®
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma (Icc)
Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III)
In the POELH-II trial (Clinicaltrials.gov ID NCT05678218) patients with presumed resectable perihilar (pCCA), intrahepatic (iCCA) or mid-common bile duct (CBD) cholangiocarcinoma had the outcomes of their preoperative endoscopic…
- Conditions
- Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma (Icc), Cholangiocarcinoma, Perihilar Cholangiocarcinoma
- Trial name
- POELH-III (NCT07161869)
- Testing
- Registration of all findings during preoperative Endoscopic Ultrasound
- Where
- 6 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Erasmus Medical Center
Common Bile Duct Calculi, Acute; Cholecystitis, Choledocholithiasis
Modified Laparoscopic Transcystic Biliary Drainage in the Management of Cholecystocholedocholithiasis
The modified laparoscopic transcystic biliary drainage which we developed in the treatment of cholecystocholedocholithiasis has some advantages over conventional techniques.
- Conditions
- Common Bile Duct Calculi, Acute; Cholecystitis, Choledocholithiasis, Acute Cholecystitis With Obstruction, Acute Cholangitis
- Trial name
- NCT06011941
- Testing
- Modified laparoscopic transcystic biliary drainage
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Peking University Third Hospital
Pancreaticoduodenectomy
Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the standard treatment for tumors of the pancreatic head, distal bile duct, duodenum, and ampulla of Vater.
- Trial name
- NCT06322680
- Testing
- Main pancreatic duct and biliary duct external drainage, Main pancreatic duct and biliary duct internal drainage
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Shanghai Zhongshan Hospital
Choledocholithiasis
Application of Machine Learning Models to Reduce Need for Diagnostic EUS or MRCP in Patients With Intermediate Likelihood of Choledocholithiasis
Machine learning predictive model can help in stratifying heterogenous intermediate likelihood group to reduce need for EUS or MRCP in selected subgroup of patients.
- Trial name
- NCT06066372
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Asian Institute of Gastroenterology, India
Cholangiocarcinoma, Cholangiopathy
Spanish Registry of Direct Cholangiopancreatoscopy by Single Operator
Endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) remain fundamental tools for the diagnosis and treatment of many pancreatobiliary diseases.
- Conditions
- Cholangiocarcinoma, Cholangiopathy, Biliary Stricture, Choledocholithiasis
- Trial name
- NCT07064447
- Testing
- Cholangiopancreatoscopy
- Volunteers
- 260 people
- Sponsor
- Germans Trias i Pujol Hospital
Gall Stone, Gall Stones, Common Bile Duct
Influence of Gut Microbiome in Gallstone Disease
The goal of this prospective observational study is to explore the role of the gut microbiome in patients with gallstone disease.
- Conditions
- Gall Stone, Gall Stones, Common Bile Duct, Pancreatitis, Acute Cholecystitis
- Trial name
- NCT05732480
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Choledocholithiasis, Common Bile Duct Stones
Hyoscine Butylbromide During Transcystic Papillary Balloon Dilation for Choledocholithiasis
The purpose of the PAPRELAX study is to evaluate the intraoperative effect of intravenous hyoscine butylbromide during laparoscopic transcystic balloon dilation of the papilla of Vater in adult patients undergoing surgical…
- Trial name
- PAPRELAX (NCT07814976)
- Testing
- Hyoscine Butylbromide
- Where
- Latvia
- Volunteers
- 50 people
- Sponsor
- Riga East Clinical University Hospital
Chronic Cholecystitis, Biliary Dyskinesia
Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Chronic Cholecystitis and Biliary Dyskinesia
The aim of the study is to evaluate the efficacy, safety, and tolerability of 4-MUST, 128 mg tablets compared to placebo in patients with chronic cholecystitis and biliary dyskinesia.
- Trial name
- NCT07595003
- Testing
- 4-MUST
- Where
- 10 sites in Russia
- Volunteers
- 300 people
- Sponsor
- Valenta Pharm JSC
Chronic Cholecystitis, Biliary Dyskinesia
Food-Effect, Single and Multiple Dose Pharmacokinetics, Safety and Tolerability Study of 4-MUST, 128 mg, Tablets in Healthy Volunteers
This open-label study will evaluate the effect of food on the bioavailability of a single dose of 4-MUST, tablets, 128 mg. Additionally, the study will assess the pharmacokinetics, safety, and tolerability of 4-MUST, tablets, 128…
- Trial name
- NCT07594977
- Testing
- 4-MUST
- Where
- Russia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Cholecystolithiasis, Common Bile Duct Gall Stones
ChOlanGiography Performed Routinely Versus Selectively During Cholecystectomy: A NAtional Registry-based Randomized Controlled Trial
Common bile duct stones (CBDS) may be asymptomatic but can cause pancreatitis, obstructive jaundice, and/or cholangitis. In Sweden, intraoperative cholangiography (IOC) is usually performed during gallstone surgery in order to…
- Trial name
- COGNAC (NCT07002619)
- Testing
- Routine cholangiography, Selective cholangiograpy
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Karolinska Institutet
Choledocholithiasis, Choledocholithiasis With Acute Cholangitis
Spanish Registry of Quality Indicators and Adverse Events of Endoscopic Retrograde Cholangiopancreatography
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique which combines endoscopic and radiological vision and allows for therapeutic procedures on pathologies of the pancreas and bile duct.
- Conditions
- Choledocholithiasis, Choledocholithiasis With Acute Cholangitis, Cholangiocarcinoma, Sclerosing Cholangitis
- Trial name
- NCT06670547
- Testing
- Endoscopic retrograde cholangiopancreatography (ERCP)
- Volunteers
- 3,000 people
- Sponsor
- Germans Trias i Pujol Hospital
Choledocholithiasis, Asymptomatic Condition
The Treatment Effect for Asymptomatic Common Bile Duct Stone
This study is prospective, multicenter study for identify the characteristics of asymptomatic common bile duct stones and effectiveness of treatment.
- Conditions
- Choledocholithiasis, Asymptomatic Condition, Quality of Life
- Trial name
- NCT06215040
- Testing
- Endoscopic retrograde cholangiopancratography
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Gall Stone, Common Bile Duct Calculi
Laparoendoscopic Rendezvous for Concomitant Gall Bladder Stones and Common Bile Duct Stones
Chronic calculous cholecystitis in pediatric patients leads to choledocholithiasis in about 12% of cases. These patients require removal of stones from the common bile duct.
- Conditions
- Gall Stone, Common Bile Duct Calculi, Cholecystitis, Chronic, Choledocholithiasis
- Trial name
- LERV (NCT07008170)
- Testing
- Laparoendoscopic rendezvous
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Minia University
ERCP, Choledocholithiasis
Pre-cut Versus Intentional Double Guidewire for ERCP Cannulation: Prospective, Randomized Controlled Trial
Endoscopic retrograde cholangiopancreatography (ERCP) is an indispensable therapeutic procedure in the management of a wide spectrum of pancreaticobiliary disorders, including choledocholithiasis, benign and malignant biliary…
- Conditions
- ERCP, Choledocholithiasis, Biliary Drainage, Biliary Strictures Caused by Malignant Neoplasms
- Trial name
- PRIDE (NCT07329803)
- Testing
- Precut Sphincterotomy, Double Guidewire Technique
- Volunteers
- 840 people
- Sponsor
- Asian Institute of Gastroenterology, India
Cholangiocarcinoma, Choledocholithiasis; Cholangitis
Efficacy of Fistulotomy for Biliary Cannulation
Access to the main bile duct is the first step in order to perform a therapeutic maneuver for biliary diseases. Early precut has been shown to ameliorate cannulation success rate, specially in difficult cannulation cases, when…
- Conditions
- Cholangiocarcinoma, Choledocholithiasis; Cholangitis, Pancreatic Cancer, Pancreatitis
- Trial name
- NCT04037007
- Testing
- Fistulotomy - High experienced., Fistulotomy - Low experienced., Conventional (guidewire) cannulation- High experienced
- Where
- Mexico
- Volunteers
- 320 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Cholecystectomy, Laparoscopic, Choledocholithiasis
ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly
The goal of this study is to compare safety and efficacy of laparoscopic cholecystectomy versus wait-and-see policy after endoscopic removal of common bile duct stones in elderly.
- Conditions
- Cholecystectomy, Laparoscopic, Choledocholithiasis, Cholelithiasis
- Trial name
- COFFEE (NCT07001423)
- Testing
- Laparoscopic cholecystectomy
- Where
- 12 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Choledocholithiasis
Prospective Comparison of the Carbon Footprint of EUS vs MRCP for Evaluation of Suspected Choledocholithiasis
MRCP and EUS are diagnostically equivalent in detecting CBD stones among patients with intermediate risk, as shown in a landmark RCT.
- Trial name
- NCT07283185
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India